| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew E Christie, Meredith E Stanhope, Helen I Gandler, Tess J Lameyer, Micah G Pascual, Devlin N Shea, Andy Yu, Patsy S Dickinson, J Joe Hul. Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus. Invertebrate neuroscience : IN. vol 18. issue 4. 2019-05-28. PMID:30276482. |
similarly, transcripts encoding full complements of the enzymes responsible for dopamine [tryptophan-phenylalanine hydroxylase (tph), tyrosine hydroxylase and dopa decarboxylase (ddc)], octopamine (tph, tyrosine decarboxylase and tyramine β-hydroxylase), serotonin (tph or tryptophan hydroxylase and ddc) and histamine (histidine decarboxylase) biosynthesis were identified from the eyestalk ganglia, as were those responsible for the generation of the gases nitric oxide (nitric oxide synthase) and carbon monoxide (heme oxygenase), and the small molecule transmitters acetylcholine (choline acetyltransferase), glutamate (glutaminase) and gaba (glutamic acid decarboxylase). |
2019-05-28 |
2023-08-13 |
lobster |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
the levels of dopamine, tyrosine hydroxylase (th), serotonin or 5-hydroxytryptamine (5-ht) receptor 1a and b (5-htr1a and 5-htr1b), and 5-ht1b were significantly increased in scz patients, while the levels of gamma-aminobutyric acid (gaba), 5-ht transporter (5-htt), and 5-ht receptor 2a (5-htr2a) were decreased. |
2019-01-16 |
2023-08-13 |
human |
| Ila Mishra, Devraj Singh, Vinod Kuma. Temporal Expression of c-fos and Genes Coding for Neuropeptides and Enzymes of Amino Acid and Amine Neurotransmitter Biosynthesis in Retina, Pineal and Hypothalamus of a Migratory Songbird: Evidence for Circadian Rhythm-Dependent Seasonal Responses. Neuroscience. vol 371. 2018-11-09. PMID:29273324. |
during all four seasonal states, we measured in the retina, pineal and hypothalamus, which together form avian cps, 4-hourly mrna expression of c-fos (a neuronal-activity marker) and of genes coding for neuropeptides (vasoactive intestinal peptide, vip; somatostatin, sst; neuropeptide y, npy) and for intermediary enzymes of amino acid (glutamate: glutaminase, gls and glutamic-oxaloacetic transaminase 2, got2; gaba: glutamic acid decarboxylase, gad65) and amine (dopamine: tyrosine hydroxylase, th) neurotransmitters biosynthetic pathway. |
2018-11-09 |
2023-08-13 |
Not clear |
| Hong-Li Gao, Xiao-Jing Yu, Kai-Li Liu, Xiao-Lian Shi, Jie Qi, Yan-Mei Chen, Yan Zhang, Juan Bai, Qiu-Yue Yi, Zhi-Peng Feng, Wen-Sheng Chen, Wei Cui, Jin-Jun Liu, Guo-Qing Zhu, Yu-Ming Kan. PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress. Scientific reports. vol 7. 2018-10-29. PMID:28225041. |
hs resulted in higher mean arterial pressure (map) and fra-like (fra-li) activity, and plasma and pvn levels of norepinephrine (ne), tyrosine hydroxylase (th), nox2 and nox4, lower pvn levels of gamma-aminobutyric acid (gaba), copper/zinc superoxide dismutase (cu/zn-sod) and the 67-kda isoform of glutamate decarboxylase (gad67), as compared with ns group. |
2018-10-29 |
2023-08-13 |
rat |
| Hong-Li Gao, Xiao-Jing Yu, Jie Qi, Qiu-Yue Yi, Wang-Hui Jing, Wen-Yan Sun, Wei Cui, Jian-Jun Mu, Zu-Yi Yuan, Xiu-Fang Zhao, Kai-Li Liu, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kan. Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus. Scientific reports. vol 6. 2018-04-23. PMID:27452860. |
these hs rats had higher pvn levels of norepinephrine (ne), tyrosine hydroxylase (th), interleukin (il)-1β, nox2 and nox4, lower pvn levels of gamma-aminobutyric acid (gaba), il-10, copper/zinc superoxide dismutase (cu/zn-sod) and the 67-kda isoform of glutamate decarboxylase (gad67), as compared with ns group. |
2018-04-23 |
2023-08-13 |
rat |
| Yoon-Mi Oh, Fuyuki Karube, Susumu Takahashi, Kenta Kobayashi, Masahiko Takada, Motokazu Uchigashima, Masahiko Watanabe, Kayo Nishizawa, Kazuto Kobayashi, Fumino Fujiyam. Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations. Brain structure & function. vol 222. issue 5. 2018-04-17. PMID:27995326. |
we initially found that (1) 57% of pv neurons co-expressed lim-homeobox 6, (2) the pv-gp terminals were preferentially distributed in the ventral part of dorsal tier of snc, (3) pv-gp neurons formed basket-like appositions with the somata of tyrosine hydroxylase, pv, calretinin and cholecystokinin immunoreactive neurons in the sn, and (4) in vitro whole-cell recording during optogenetic photo-stimulation of pv-gp terminals in snc demonstrated that pv-gp neurons strongly inhibited dopamine neurons via gaba |
2018-04-17 |
2023-08-13 |
rat |
| Olalekan M Ogundele, Philip J Ebenezer, Charles C Lee, Joseph Franci. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy. Neuroscience. vol 353. 2018-03-14. PMID:28438613. |
these animals showed a significant loss of presynaptic markers (synaptophysin; p<0.001), and changes in neurotransmitters (vglut2, tyrosine hydroxylase, gaba, chat). |
2018-03-14 |
2023-08-13 |
rat |
| Wei Song, Marisa Cressatti, Hillel Zukor, Adrienne Liberman, Carmela Galindez, Hyman M Schippe. Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment. Neurobiology of aging. vol 58. 2018-02-14. PMID:28746897. |
here, we show that selective overexpression of the stress protein, heme oxygenase-1 (ho-1) in astrocytes of gfap.hmox1 transgenic mice between 8.5 and 19 months of age results in nigrostriatal hypodopaminergia associated with locomotor incoordination and stereotypy; downregulation of tyrosine hydroxylase, dat, lmx1b, nurr1, pitx3 and dj-1 mrna and/or protein; overproduction of α-synuclein and ubiquitin; oxidative stress; basal ganglia siderosis; mitochondrial damage/mitophagy; and augmented gabaergic systems (increased gaba, gad67 and reelin). |
2018-02-14 |
2023-08-13 |
mouse |
| Ila Mishra, Devraj Singh, Vinod Kuma. Daily expression of genes coding for neurotransmitters in central and peripheral tissues of redheaded bunting: Implication for circadian regulation of physiology in songbirds. Chronobiology international. vol 33. issue 3. 2016-12-15. PMID:26930260. |
the present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide y, npy; vasoactive intestinal peptide, vip; somatostatis, sst) and intermediary enzymes of amine and amino acid neurotransmitters (dopamine [tyrosine hydroxylase, th]; glutamate [glutaminase, gls; glutamate oxaloacetate transaminase 2, got2]; gamma amino butyric actid, gaba [glutamic acid decarboxylase 65, gad65]) biosynthetic pathway, along with c-fos as an activation marker, in different tissues of migratory redheaded buntings, emberiza bruniceps. |
2016-12-15 |
2023-08-13 |
Not clear |
| Motokazu Uchigashima, Toshihisa Ohtsuka, Kazuto Kobayashi, Masahiko Watanab. Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2016-12-13. PMID:27035941. |
the presynaptic structure expressed tyrosine hydroxylase, vesicular monoamine transporter-2, and plasmalemmal dopamine transporter, which are essential for dopamine synthesis, vesicular filling, and recycling, but was below the detection threshold for molecules involving gaba synthesis and vesicular filling or for gaba itself. |
2016-12-13 |
2023-08-13 |
Not clear |
| L M A Oliveira, L J Falomir-Lockhart, M G Botelho, K-H Lin, P Wales, J C Koch, E Gerhardt, H Taschenberger, T F Outeiro, P Lingor, B Schüle, D J Arndt-Jovin, T M Jovi. Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells. Cell death & disease. vol 6. 2016-09-14. PMID:26610207. |
this delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mrna for genes implicated in neuronal differentiation such as delta-like homolog 1 (dlk1), gamma-aminobutyric acid type b receptor subunit 2 (gababr2), nuclear receptor related 1 protein (nurr1), g-protein-regulated inward-rectifier potassium channel 2 (girk-2) and tyrosine hydroxylase (th). |
2016-09-14 |
2023-08-13 |
human |
| Hong-Bao Li, Da-Nian Qin, Yu-Ping Suo, Jing Guo, Qing Su, Yu-Wang Miao, Wen-Yan Sun, Qiu-Yue Yi, Wei Cui, Kang Cheng, Guo-Qing Zhu, Yu-Ming Kan. Blockade of Salusin-β in Hypothalamic Paraventricular Nucleus Attenuates Hypertension and Cardiac Hypertrophy in Salt-induced Hypertensive Rats. Journal of cardiovascular pharmacology. vol 66. issue 4. 2016-08-12. PMID:26038832. |
compared with ns rats, hs rats had higher levels of glutamate, norepinephrine, tyrosine hydroxylase, proinflammatory cytokines, and lower levels of gamma-aminobutyric acid, interleukin 10, and the 67-kda isoform of glutamate decarboxylase (gad67) in the pvn, and higher plasma levels of proinflammatory cytokines. |
2016-08-12 |
2023-08-13 |
rat |
| Ozlem Akman, Medine I Gulcebi, Nihan Carcak, Sema Ketenci Ozatman, Tugba Eryigit, Solomon L Moshé, Aristea S Galanopoulou, Filiz Yilmaz Ona. The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy. Epilepsia. vol 56. issue 11. 2016-02-11. PMID:26471261. |
subsequently, to determine whether kindling resistance relates to differential sensitivity of γ-aminobutyric acid γ-aminobutyric acid (gaba)ergic or dopaminergic snr neurons to kindling, we studied the effects of kindling-inducing stimulations on parvalbumin (prv; gabaergic neuron marker) or tyrosine hydroxylase (th; dopaminergic neuron marker) immunoreactivity (ir), respectively, in gaers and in nonepileptic control (nec) wistar rats that lack kindling resistance. |
2016-02-11 |
2023-08-13 |
rat |
| Mats Julius Stensrud, Maja Puchades, Vidar Gunderse. GABA is localized in dopaminergic synaptic vesicles in the rodent striatum. Brain structure & function. vol 219. issue 6. 2015-07-07. PMID:23851655. |
to clarify this, in particular to determine whether gaba is responsible for the inhibitory response at dopaminergic synapses, we used the electron microscopic immunogold method to label in vivo perfusion fixed striatal tissue with antibodies recognising gaba, vgat, vmat2 and tyrosine hydroxylase. |
2015-07-07 |
2023-08-12 |
Not clear |
| Mats Julius Stensrud, Maja Puchades, Vidar Gunderse. GABA is localized in dopaminergic synaptic vesicles in the rodent striatum. Brain structure & function. vol 219. issue 6. 2015-07-07. PMID:23851655. |
we show that about 13 % of tyrosine hydroxylase positive and 11 % of vmat2 axonal terminals in the caudo-putamen contain significant labelling for gaba. |
2015-07-07 |
2023-08-12 |
Not clear |
| Mats Julius Stensrud, Maja Puchades, Vidar Gunderse. GABA is localized in dopaminergic synaptic vesicles in the rodent striatum. Brain structure & function. vol 219. issue 6. 2015-07-07. PMID:23851655. |
quantitative analyses of the distance between gold particles signalling gaba and synaptic vesicles showed that gaba was as closely associated with synaptic vesicles in tyrosine hydroxylase positive as in tyrosine hydroxylase negative nerve terminals. |
2015-07-07 |
2023-08-12 |
Not clear |
| Alida Filippi, Thomas Mueller, Wolfgang Drieve. vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain. The Journal of comparative neurology. vol 522. issue 9. 2015-01-27. PMID:24374659. |
here, we analyze vglut2, gad1b and gad2 expression in combination with tyrosine hydroxylase immunoreactivity in 4-day-old larval and 30-day-old juvenile zebrafish brains to determine which dopaminergic and noradrenergic groups may use gaba or glutamate as a second transmitter. |
2015-01-27 |
2023-08-12 |
zebrafish |
| Yi-Chao Hsu, Su-Liang Chen, Ya-Jean Wang, Yun-Hsiang Chen, Dan-Yen Wang, Linyi Chen, Chia-Hsiang Chen, Hwei-Hsien Chen, Ing-Ming Chi. Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem cells translational medicine. vol 3. issue 6. 2014-08-11. PMID:24736401. |
these sh2b1-enhanced ins (s-ibm) showed canonical neuronal morphology, and expressed multiple neuronal markers, such as tuj1, neun, and synapsin, and functional proteins for neurotransmitter release, such as gaba, vglut2, and tyrosine hydroxylase. |
2014-08-11 |
2023-08-13 |
mouse |
| Yu-Ming Kang, Dong-Mei Zhang, Xiao-Jing Yu, Qing Yang, Jie Qi, Qing Su, Yu-Ping Suo, Li-Ying Yue, Guo-Qing Zhu, Da-Nian Qi. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Toxicology and applied pharmacology. vol 274. issue 3. 2014-03-21. PMID:24342267. |
these ang ii-infused rats had higher pvn levels of glutamate, norepinephrine, tyrosine hydroxylase, pro-inflammatory cytokines (pics) and the chemokine monocyte chemoattractant protein-1, and lower pvn levels of gamma-aminobutyric acid, interleukin (il)-10 and the 67-kda isoform of glutamate decarboxylase (gad67), and higher plasma levels of pics, norepinephrine and aldosterone, and lower plasma il-10, and higher renal sympathetic nerve activity. |
2014-03-21 |
2023-08-12 |
rat |
| Xueping Li, Jia Qi, Tsuyoshi Yamaguchi, Hui-Ling Wang, Marisela Morale. Heterogeneous composition of dopamine neurons of the rat A10 region: molecular evidence for diverse signaling properties. Brain structure & function. vol 218. issue 5. 2014-03-10. PMID:22926514. |
the a10 region contains different neurons: dopamine (expressing tyrosine hydroxylase; th), gaba, glutamate-only (expressing the vesicular glutamate transporter 2; vglut2), and th-vglut2 (coexpressing th and vglut2). |
2014-03-10 |
2023-08-12 |
rat |