| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Pielak, A G Mauk, M Smit. Site-directed mutagenesis of cytochrome c shows that an invariant Phe is not essential for function. Nature. vol 313. issue 5998. 1985-02-15. PMID:2981414. |
because phe residues are not susceptible to chemical modification, no direct means of studying the functional role of phe 87 has been available, so we have chosen phe 87 as our initial target here to test the feasibility of using site-directed mutagenesis as a means of studying structure-function relationships in cytochrome c. we have changed the codon for phe 87 to that of either a ser, a tyr or a gly. |
1985-02-15 |
2023-08-11 |
Not clear |
| Z I Randhawat, R T Jones, L E Lie-Inj. Separation of the tryptic peptides and cyanogen bromide fragments of the human embryonic zeta chains of hemoglobin in Portland I and II by reverse phase high performance liquid chromatography. Hemoglobin. vol 8. issue 5. 1985-01-09. PMID:6500986. |
from this study and results of others, it can be deduced that trypsin will hydrolyze the tyr-x bond provided either ala or ile is bonded to the n-terminal side of tyr and ile, leu, or gly is bonded to the c-terminal side of the tyr residue. |
1985-01-09 |
2023-08-12 |
human |
| M D Aitowa, J Voig. [Effect of the content of crude plant protein in feed on the utilization of urea in dairy cattle. 4. Passage of amino acids through the duodenum]. Archiv fur Tierernahrung. vol 34. issue 7. 1984-11-02. PMID:6487083. |
with all rations there were always net losses of some amino acids (his, arg) and net gains (lys, thr, ser, gly, val, met and tyr) at the duodenum in comparison intake. |
1984-11-02 |
2023-08-12 |
cattle |
| G Martin, R Keller, G Kegel, G Besse, P P Jaro. The hyperglycemic neuropeptide of the terrestrial isopod, Porcellio dilatatus. I. Isolation and characterization. General and comparative endocrinology. vol 55. issue 2. 1984-11-01. PMID:6479568. |
the amino acid composition is (pro, ile)1; his1-2; (thr, ser, gly, met, tyr)2; (val, phe, lys)3; (ala, 1/2cys, leu, arg)4; glx5; asx7; trp, n.d. |
1984-11-01 |
2023-08-12 |
Not clear |
| D Jung, H P Richte. Transport of amino acids and nucleosides in metaphase-arrested unfertilized oocytes of Xenopus laevis. Cell differentiation. vol 14. issue 2. 1984-10-19. PMID:6467381. |
metaphase-arrested, unfertilized shed oocytes of xenopus laevis obtained after hormonal stimulation of the female are able to take up nucleosides (u, t) and amino acids (ala, gly, glu, gln, tyr). |
1984-10-19 |
2023-08-12 |
xenopus_laevis |
| D R Strombeck, D Harrold, Q R Roger. Effects of catecholamines and ammonia on plasma and brain amino acids in dogs. The American journal of physiology. vol 247. issue 2 Pt 1. 1984-09-14. PMID:6465311. |
cat decreased (p less than 0.05) plasma gly, thr, lys, pro, val, ser, arg, leu, trp, phe, asn, tyr, met, ile, cit, and asp. |
1984-09-14 |
2023-08-12 |
cat |
| O C Ivanov, P S Kenderov, J P Revalsk. The structural periodicity of E. coli ribosomal proteins. Origins of life. vol 14. issue 1-4. 1984-08-24. PMID:6379555. |
the conclusions support and supplement the concept about the presence of a trend in protein molecular evolution from universal (gly, ala) to specialized (phe, tyr, trp, cys) amino acids. |
1984-08-24 |
2023-08-12 |
Not clear |
| J D Glennon, D W Hughes, B Sarka. Nickel(II) binding to glycylglycyl-L-tyrosine-N-methyl amide, a peptide mimicking the NH2-terminal nickel(II)-binding site of dog serum albumin: a 1H- and 13C-nuclear magnetic resonance investigation. Journal of inorganic biochemistry. vol 19. issue 4. 1984-02-14. PMID:6655471. |
the greater chemical shift changes on ni(ii) coordination are observed from the protons nearest the peptide and amino nitrogens:amide ch3 (-0.704), tyr(3) alpha-ch (-0.667), gly(1) alpha-ch2 (-0.382), and gly(2) alpha-ch2 (-0.519, -0.487). |
1984-02-14 |
2023-08-12 |
dog |
| M Manning, A Olma, W A Klis, J Seto, W H Sawye. Potent antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-D- phenylalanine,4-valine]arginine-vasopressin at position 4. Journal of medicinal chemistry. vol 26. issue 11. 1983-12-17. PMID:6631916. |
as part of a program in which we are attempting (a) to delineate the structural features at positions 1-9 in our previously reported antidiuretic antagonists required for antidiuretic antagonism and (b) to obtain analogues with enhanced antiantidiuretic potency and/or selectivity, we have synthesized 14 new analogues of the antidiuretic antagonist [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-d-phenylalanine,4-valine]arginine-vasopressin [d-(ch2)5-d-phe2vavp), in which the valine residue at position 4 was replaced by the following l-amino acids and glycine: ile, abu, thr, ala, gln, lys, cha, nle, nva, phe, leu, gly, tyr, and pro. |
1983-12-17 |
2023-08-12 |
rat |
| M J McKay, M K Offermann, A J Barrett, J S Bon. Action of human liver cathepsin B on the oxidized insulin B chain. The Biochemical journal. vol 213. issue 2. 1983-10-08. PMID:6351842. |
five major and six minor cleavage sites were identified; the major cleavage sites were gln(4)-his(5), ser(9)-his(10), glu(13)-ala(14), tyr(16)-leu(17) and gly(23)-phe(24). |
1983-10-08 |
2023-08-12 |
human |
| T Towatari, N Katunum. Selective cleavage of peptide bonds by cathepsins L and B from rat liver. Journal of biochemistry. vol 93. issue 4. 1983-08-11. PMID:6345516. |
a polar amino acid, such as tyr, ser, gly, glu, asp, gln, or asn, in position p1. |
1983-08-11 |
2023-08-12 |
rat |
| A H Brush, J A Wyl. Molecular organization of avian epidermal structures. Comparative biochemistry and physiology. B, Comparative biochemistry. vol 73. issue 2. 1983-02-14. PMID:6184193. |
differences in the size of the monomers is due to the presence of an insoluble tryptic peptide high in gly, phe, leu and tyr. |
1983-02-14 |
2023-08-12 |
Not clear |
| M Jandrot-Perrus, M H Aurousseau, M J Rabiet, F Joss. Fibrinogen Bondy: a new case of dysfibrinogenemia. Isolation of the abnormal fibrinogen molecules. Thrombosis research. vol 27. issue 6. 1983-02-14. PMID:6217586. |
the presence of ala, in addition to gly and tyr in the fibrin clot and its supernatant, showed that a part of fibrinogen molecules was not clotted, i.e. |
1983-02-14 |
2023-08-12 |
Not clear |
| M L Huhtala, K Pesonen, N Kalkkinen, U H Stenma. Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. The Journal of biological chemistry. vol 257. issue 22. 1983-01-07. PMID:7142173. |
the amino acid composition of the peptide is: lys (4), arg (3), asx (8), thr (4), ser (3), glx (6), pro (3), gly (5), ala (1), val (2), ile (3), leu (4), tyr (3), phe (1), and cys (6). |
1983-01-07 |
2023-08-12 |
human |
| G M Barashkova, A A Fokina, M V Andrianov. [Action of enkephalins and their analogs on gastric secretion]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 68. issue 5. 1982-09-24. PMID:7095197. |
the gastric secretion induced by histamine increased under the influence of enkephalin analog tyr--d--ala--gly--phe(no2)nh2. |
1982-09-24 |
2023-08-12 |
Not clear |
| G M Barashkova, A A Fokina, M V Andrianov. [Action of enkephalins and their analogs on gastric secretion]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 68. issue 5. 1982-09-24. PMID:7095197. |
the enkephalin analog tyr--gly--gly--phe--leu--d--arg increased the amount of gastric juice and pepsin, but the debit of hydrochloric acid was lower than in perfusion of histamine alone. |
1982-09-24 |
2023-08-12 |
Not clear |
| G M Barashkova, A A Fokina, M V Andrianov. [Action of enkephalins and their analogs on gastric secretion]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 68. issue 5. 1982-09-24. PMID:7095197. |
another analog of enkephalin tyr--d--ala--gly--phe--d--leu--arg administered together with histamine decreased the gastric juice secretion only within 90--105 min after the beginning of the perfusion. |
1982-09-24 |
2023-08-12 |
Not clear |
| H Kedziora, A Lao, A Goliński, D Cieślińska, J Kedziora, W Tkaczewsk. Myocardial infarction. Changes in the concentrations of high-energy compounds and free amino acids in erythrocytes. Atherosclerosis. vol 40. issue 3-4. 1982-04-20. PMID:7332615. |
quantitative determination of the nucleotides amp, adp, atp, gtp, nad, nadp, 2,3-dpg and the free amino acids lys, his, gly, ala, val, met, phe, tyr, pro, thr, ser, glu, asp in erythrocytes was carried out in early and late stages of myocardial infarction. |
1982-04-20 |
2023-08-12 |
Not clear |
| H Kedziora, A Lao, A Goliński, D Cieślińska, J Kedziora, W Tkaczewsk. Myocardial infarction. Changes in the concentrations of high-energy compounds and free amino acids in erythrocytes. Atherosclerosis. vol 40. issue 3-4. 1982-04-20. PMID:7332615. |
the concentrations of his, gly, ala, val, met, phe, thr and glu increased, while those of tyr, ser and asp decreased in the first stage of myocardial infarction. |
1982-04-20 |
2023-08-12 |
Not clear |
| A T Tu, T Nikai, J O Bake. Proteolytic specificity of hemorrhage toxin a isolated from western diamondback rattlesnake (Crotalus atrox) venom. Biochemistry. vol 20. issue 24. 1982-03-13. PMID:7032585. |
the toxin appears highly specific for x--leu bonds (cleaving the his10--leu11, ala14--leu15, and tyr16--leu17 bonds), with no detectable activity against the gly--phe, phe--phe, phe--tyr, and leu--tyr bonds also present in the insulin b chain. |
1982-03-13 |
2023-08-12 |
cattle |