| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrice Coulon, Hélène Bras, Laurent Vina. Characterization of last-order premotor interneurons by transneuronal tracing with rabies virus in the neonatal mouse spinal cord. The Journal of comparative neurology. vol 519. issue 17. 2012-07-03. PMID:21800300. |
we also demonstrated a direct connection between a group of cholinergic interneurons observed ipsilaterally in l3 and the rostral part of l4, and ts mns. |
2012-07-03 |
2023-08-12 |
mouse |
| Yingfang Tian, Joan R Gunther, Isaac H Liao, Dazhi Liu, Bradley P Ander, Boryana S Stamova, Lisa Lit, Glen C Jickling, Huichun Xu, Xinhua Zhan, Frank R Shar. GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot study. Brain research. vol 1381. 2011-07-22. PMID:21241679. |
recently, altered numbers of gabaergic-parvalbumin (pv) and cholinergic interneurons were observed in the basal ganglia of individuals with ts. |
2011-07-22 |
2023-08-12 |
human |
| Yingfang Tian, Joan R Gunther, Isaac H Liao, Dazhi Liu, Bradley P Ander, Boryana S Stamova, Lisa Lit, Glen C Jickling, Huichun Xu, Xinhua Zhan, Frank R Shar. GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot study. Brain research. vol 1381. 2011-07-22. PMID:21241679. |
moreover, several gaba and ach-related genes were predicted to be alternatively spliced in ts compared to hc including gaba receptors gabra4 and gabrg1, the nicotinic ach receptor chrna4 and cholinergic differentiation factor (cdf). |
2011-07-22 |
2023-08-12 |
human |
| Yuko Kataoka, Paul S A Kalanithi, Heidi Grantz, Michael L Schwartz, Clifford Saper, James F Leckman, Flora M Vaccarin. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. The Journal of comparative neurology. vol 518. issue 3. 2010-03-08. PMID:19941350. |
ts patients demonstrated a 50%-60% decrease of both parvalbumin (pv)+ and choline acetyltransferase (chat)+ cholinergic interneurons in the cd and the putamen (pt). |
2010-03-08 |
2023-08-12 |
human |
| Yuko Kataoka, Paul S A Kalanithi, Heidi Grantz, Michael L Schwartz, Clifford Saper, James F Leckman, Flora M Vaccarin. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. The Journal of comparative neurology. vol 518. issue 3. 2010-03-08. PMID:19941350. |
cholinergic interneurons were decreased in ts patients in the associative and sensorimotor regions but not in the limbic regions of the striatum, such that the normal gradient in density of cholinergic cells (highest in associative regions, intermediate in sensorimotor and lowest in limbic regions) was abolished. |
2010-03-08 |
2023-08-12 |
human |
| Renee L Hayslett, Yousef Tizab. Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. Pharmacology, biochemistry, and behavior. vol 76. issue 3-4. 2004-08-24. PMID:14643839. |
this and the reports that nicotine may have clinical efficacy in reducing symptoms of ts suggest possible involvement of the nicotinic cholinergic system in this disorder. |
2004-08-24 |
2023-08-12 |
mouse |
| S D Masson, D M McKay, R H Stead, A Agro, A Stanisz, M H Perdu. Nippostrongylus brasiliensis infection evokes neuronal abnormalities and alterations in neurally regulated electrolyte transport in rat jejunum. Parasitology. vol 113 ( Pt 2). 1996-09-26. PMID:8760316. |
the ts response in tissue from infected rats had, unlike controls, no cholinergic component. |
1996-09-26 |
2023-08-12 |
rat |
| D M Holtzman, Y Li, K Chen, F H Gage, C J Epstein, W C Moble. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. vol 43. issue 12. 1994-01-13. PMID:8255474. |
we previously demonstrated that ts 16 basal forebrain cholinergic neurons (bfcns) undergo age-related atrophy similar to ds and ad, and now show that a specific neurotrophic factor, nerve growth factor (ngf), acts to reverse ts 16-induced atrophy of bfcns and stimulates hypertrophy of these cells. |
1994-01-13 |
2023-08-12 |
mouse |
| J M Rabey, A Lewis, E Graff, A D Korczy. Decreased (3H) quinuclidinyl benzilate binding to lymphocytes in Gilles de la Tourette syndrome. Biological psychiatry. vol 31. issue 9. 1992-09-02. PMID:1637929. |
if ts is due to alterations of cholinergic activity, this may also be expressed at postsynaptic levels. |
1992-09-02 |
2023-08-11 |
Not clear |
| D M Holtzman, Y W Li, S J DeArmond, M P McKinley, F H Gage, C J Epstein, W C Moble. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 4. 1992-03-23. PMID:1741393. |
denervation of the hippocampus produced a significant increase in the size of ts 16 cholinergic neurons. |
1992-03-23 |
2023-08-11 |
mouse |
| D M Holtzman, Y W Li, S J DeArmond, M P McKinley, F H Gage, C J Epstein, W C Moble. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 4. 1992-03-23. PMID:1741393. |
we sought an experimental system in which the survival and development of ts 16 basal forebrain cholinergic neurons could be examined beyond the fetal period. |
1992-03-23 |
2023-08-11 |
mouse |
| D M Holtzman, Y W Li, S J DeArmond, M P McKinley, F H Gage, C J Epstein, W C Moble. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 4. 1992-03-23. PMID:1741393. |
over time, we observed selective atrophy of cholinergic neurons in ts 16 grafts. |
1992-03-23 |
2023-08-11 |
mouse |
| L Sterin-Borda, G Gorelik, A Genaro, J C Goin, E S Bord. Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 4. issue 6. 1990-05-01. PMID:2156743. |
the stimulation of ts cell muscarinic cholinergic receptors by chagas igg or the corresponding f(ab)'2 fraction triggers the release of the immunomodulatory substance pge2. |
1990-05-01 |
2023-08-11 |
human |
| C S Kim, W M Abraham, L Garcia, M A Sackne. Enhanced aerosol deposition in the lung with mild airways obstruction. The American review of respiratory disease. vol 139. issue 2. 1989-03-09. PMID:2913890. |
we investigated the sensitivity of aerosol deposition to airways obstruction by measuring total deposition fraction of inert aerosol in normal conscious sheep (n = 6) after challenging cholinergic agent, pilocarpine (pl) (0.5 mg/kg intravenously) with and without a prior challenge of beta 2-adrenergic agonist, terbutaline sulfate (ts) (0.025 mg/kg subcutaneously). |
1989-03-09 |
2023-08-11 |
Not clear |
| M H Perdue, R Galbraith, J S Daviso. Evidence for substance P as a functional neurotransmitter in guinea pig small intestinal mucosa. Regulatory peptides. vol 18. issue 2. 1987-10-06. PMID:2442802. |
tetrodotoxin abolished the response to ts, inhibited approximately 70% of the response to sp but did not affect the response to urecholine, a cholinergic muscarinic agonist. |
1987-10-06 |
2023-08-11 |
Not clear |
| O G Kenunen, E L Shchelkuno. [Changes in neurovegetative regulation in the Tourette syndrome (according to ECG findings)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 87. issue 6. 1987-09-30. PMID:3477050. |
it is suggested that increase in the parasympathetic tone may be secondary to weakened central cholinergic processes while a complex of the peculiarities associated with ts may be considered as physiologic evidence of the shift of the neuromediator balance in the direction of dopaminergic processes with a simultaneous deficit of the central cholinergic component. |
1987-09-30 |
2023-08-11 |
Not clear |
| S M Stahl, P A Berge. Neuroleptic effects in Tourette syndrome predict dopamine excess and acetylcholine deficiency. Biological psychiatry. vol 17. issue 9. 1983-01-07. PMID:6128037. |
these data also suggest that cholinergic activity may be relatively deficient in ts, which is consistent with the dopamine-acetylcholine imbalance hypothesis of hyperkinetic movement disorders. |
1983-01-07 |
2023-08-12 |
Not clear |
| S M Stahl, P A Berge. Neuroleptic effects in Tourette syndrome predict dopamine excess and acetylcholine deficiency. Biological psychiatry. vol 17. issue 9. 1983-01-07. PMID:6128037. |
new evidence for this hypothesis derives from comparisons of neuroleptic effects in ts with neuroleptic ability to block in vitro and in vivo assays of dopamine and cholinergic muscarinic receptors. |
1983-01-07 |
2023-08-12 |
Not clear |