| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenge. Sex differences in the distribution and density of regulatory interneurons in the striatum. Frontiers in cellular neuroscience. vol 18. 2024-07-24. PMID:39045533. |
regulatory interneurons, such as cholinergic interneurons (cins) and parvalbumin-expressing gabaergic fast spiking interneurons (fsis), are implicated in human neuropsychiatric disorders such as ts, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females. |
2024-07-24 |
2024-07-26 |
mouse |
| Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F Leckman, Alexej Abyzov, Flora M Vaccarin. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464084. |
postmortem immunocytochemical analyses of brains with severe ts revealed decreases in cholinergic, fast-spiking parvalbumin, and somatostatin interneurons within the striatum (caudate and putamen nuclei). |
2024-03-11 |
2024-03-14 |
human |
| Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenge. Sexual dimorphism in the distribution and density of regulatory interneurons in the striatum. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464268. |
regulatory interneurons, including cholinergic interneurons (cins) and parvalbumin-expressing gabaergic fast spiking interneurons (fsis), are implicated in human neuropsychiatric disorders such as ts, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females. |
2024-03-11 |
2024-03-14 |
mouse |
| Jung-Chieh Du, Man-Hsin Chang, Chen-Jiun Yeh, Ming Tatt Lee, Hsin-Jung Lee, Shu-Hui Chuang, Lih-Chu Chio. Pivotal role of Slitrk1 in adult striatal cholinergic neurons in mice: Implication in Tourette syndrome. Annals of neurology. 2023-09-30. PMID:37776102. |
the slit and ntrk-like 1 (slitrk1) gene mutation and striatal cholinergic interneurons (chis) loss are associated with tourette syndrome (ts). |
2023-09-30 |
2023-10-07 |
mouse |
| Roberto Cadeddu, Meghan Van Zandt, Luca Spiro Santovito, Karen Odeh, Collin J Anderson, Deirdre Flanagan, Peter Nordkild, Graziano Pinna, Christopher Pittenger, Marco Bortolat. Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-17. PMID:37198434. |
to verify the relevance of this mechanism to tic pathophysiology, here we tested the effects of ap in a mouse model recapitulating the partial depletion of dorsolateral cholinergic interneurons (cins) seen in post-mortem studies of ts. |
2023-05-17 |
2023-08-14 |
mouse |
| Melanie V Brady, Jessica Mariani, Yildiz Koca, Anna Szekely, Robert A King, Michael H Bloch, Angeli Landeros-Weisenberger, James F Leckman, Flora M Vaccarin. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular psychiatry. 2022-11-29. PMID:36447010. |
bg organoids from ts individuals manifested an impaired medial ganglionic eminence fate and a decreased differentiation of cholinergic and gabaergic interneurons. |
2022-11-29 |
2023-08-14 |
Not clear |
| Shigeru Ogata, Yuta Miyamoto, Naoki Shigematsu, Shigeyuki Esumi, Takaichi Fukud. The tail of the mouse striatum contains a novel large type of GABAergic neuron incorporated in a unique disinhibitory pathway that relays auditory signals to subcortical nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-09-14. PMID:36104279. |
their somata were larger than cholinergic giant aspiny neurons, were located in a narrow space adjacent to the globus pallidus (gp), and extended long dendrites laterally toward the intermediate division (id) of the tri-laminar part of the ts, the region targeted by axons from the primary auditory cortex (a1). |
2022-09-14 |
2023-08-14 |
mouse |
| Gabriel Crevier-Sorbo, Vladimir V Rymar, Raphael Crevier-Sorbo, Abbas F Sadiko. Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington's disease. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32033588. |
furthermore, behavioural experiments demonstrate that the ts system and striatal cholinergic interneurons are key motor-network structures involved in the pathogenesis of dystonia. |
2020-12-23 |
2023-08-13 |
mouse |
| Christy M Kelley, Stephen D Ginsberg, Melissa J Alldred, Barbara J Strupp, Elliott J Mufso. Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome. Developmental neurobiology. vol 79. issue 7. 2020-03-27. PMID:31120189. |
findings revealed upregulation of select transcripts in classes of genes related to the cytoskeleton (tubb4b), ad (cav1), cell death (bcl2), presynaptic (syngr1), immediate early (fosb, arc), g protein signaling (gabarap, rgs10), and cholinergic neurotransmission (chrnb3) in ts compared to 2n mice, which were normalized with mcs. |
2020-03-27 |
2023-08-13 |
mouse |
| b' Noem\\xc3\\xad Rueda, Ver\\xc3\\xb3nica Vidal, Susana Garc\\xc3\\xada-Cerro, Josep Oriol Narc\\xc3\\xads, Mar\\xc3\\xada Llorens-Mart\\xc3\\xadn, Andrea Corrales, Sara Lantigua, Marcos Iglesias, Jes\\xc3\\xbas Merino, Ram\\xc3\\xb3n Merino, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29758264.' |
here, we analyzed the ability of an anti-il17a antibody to reduce the neuropathological alterations that are present in ts mice during early neurodevelopmental stages (i.e., hippocampal neurogenesis and hypocellularity) or that are aggravated in later-life stages (i.e., cognitive abilities, cholinergic neuronal loss and increased cellular senescence, app expression, aβ peptide expression and neuroinflammation). |
2019-07-31 |
2023-08-13 |
mouse |
| Xiuling Yang, Wenmiao Liu, Mingji Yi, Ru Zhang, Yinglei Xu, Zuzhou Huang, Shiguo Liu, Tang L. Choline acetyltransferase may contribute to the risk of Tourette syndrome: Combination of family-based analysis and case-control study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 19. issue 7. 2019-01-14. PMID:28090804. |
twin and family analyses have revealed a genetic contribution to tourette syndrome (ts) and post-mortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin ts patients. |
2019-01-14 |
2023-08-13 |
Not clear |
| Wenmiao Liu, Shiyan Qiu, Chuanping Gao, Guiju Wang, Shiguo Liu, Hongzai Gua. Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population. Neuroscience letters. vol 658. 2018-07-26. PMID:28830823. |
a variety of studies have been shown that the candidate genes related to cholinergic neurons may be associated with the onset of ts. |
2018-07-26 |
2023-08-13 |
Not clear |
| Roger L Albin, Christine Minderovic, Robert A Koepp. Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome. eNeuro. vol 4. issue 4. 2018-04-25. PMID:28791334. |
to assess the integrity of striatal cholinergic interneurons in ts, we used [ |
2018-04-25 |
2023-08-13 |
Not clear |
| Maximiliano Rapanelli, Luciana Romina Frick, Meiyu Xu, Stephanie Mary Groman, Kantiya Jindachomthong, Nobuaki Tamamaki, Chiyoko Tanahira, Jane Rebecca Taylor, Christopher Pittenge. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological psychiatry. vol 82. issue 3. 2018-04-02. PMID:28347488. |
interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (fsis) and the large cholinergic interneurons (cins), are affected in patients with ts and in preclinical models of both asd and ts. |
2018-04-02 |
2023-08-13 |
mouse |
| Eduardo B Parisotto, Verónica Vidal, Susana García-Cerro, Sara Lantigua, Danilo Wilhelm Filho, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rued. Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27450081. |
this functional benefit of melatonin was accompanied by protection from cholinergic neurodegeneration and the attenuation of several hippocampal neuromorphological alterations in ts mice. |
2017-04-05 |
2023-08-13 |
mouse |
| Meiyu Xu, Andrew Kobets, Jung-Chieh Du, Jessica Lennington, Lina Li, Mounira Banasr, Ronald S Duman, Flora M Vaccarino, Ralph J DiLeone, Christopher Pittenge. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 3. 2015-04-27. PMID:25561540. |
these results support the causal sufficiency of cholinergic interneuron deficits in the dls to produce some, but not all, of the characteristic symptoms of ts. |
2015-04-27 |
2023-08-13 |
mouse |
| Andrea Corrales, Rebeca Vidal, Susana García, Verónica Vidal, Paula Martínez, Eva García, Jesús Flórez, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rued. Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome. Journal of pineal research. vol 56. issue 1. 2014-08-25. PMID:24147912. |
we have previously demonstrated that chronic melatonin treatment improves learning and memory and reduces cholinergic neurodegeneration in ts mice. |
2014-08-25 |
2023-08-12 |
mouse |
| Andrea Corrales, Paula Martínez, Susana García, Verónica Vidal, Eva García, Jesús Flórez, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rued. Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. Journal of pineal research. vol 54. issue 3. 2013-11-19. PMID:23350971. |
in this study, we evaluated the potentially beneficial effects of long-term melatonin treatment on the cognitive deficits, cholinergic degeneration, and enhanced aβpp and β-amyloid levels of ts mice. |
2013-11-19 |
2023-08-12 |
mouse |
| Andrea Corrales, Paula Martínez, Susana García, Verónica Vidal, Eva García, Jesús Flórez, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rued. Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. Journal of pineal research. vol 54. issue 3. 2013-11-19. PMID:23350971. |
both ts mice and ds individuals present cognitive disturbances, age-related cholinergic degeneration, and increased brain expression of β-amyloid precursor protein (aβpp). |
2013-11-19 |
2023-08-12 |
mouse |
| Andrea Corrales, Paula Martínez, Susana García, Verónica Vidal, Eva García, Jesús Flórez, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rued. Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. Journal of pineal research. vol 54. issue 3. 2013-11-19. PMID:23350971. |
our results suggest that melatonin administration might improve the cognitive abilities of both ts and co mice, at least partially, by reducing the age-related degeneration of basal forebrain cholinergic neurons. |
2013-11-19 |
2023-08-12 |
mouse |