| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alisa Boucsein, Mohammed Z Rizwan, Alexander Tup. Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 11. 2020-05-28. PMID:31366239. |
specifically, when trf occurred from zt21 to zt3 (when leptin resistance in hfd-fed mice was most profound), it resulted in a disruption of the daily rhythms of locomotor activity and energy expenditure and in increased plasma insulin levels compared with other trf periods. |
2020-05-28 |
2023-08-13 |
mouse |
| Amirah Salwani Zaulkffali, Nurliyana Najwa Md Razip, Sharifah Sakinah Syed Alwi, Afifah Abd Jalil, Mohd Sokhini Abd Mutalib, Banulata Gopalsamy, Sui Kiat Chang, Zaida Zainal, Nafissa Nadia Ibrahim, Zainul Amiruddin Zakaria, Huzwah Khaza'a. Vitamins D and E Stimulate the Nutrients. vol 11. issue 10. 2020-03-18. PMID:31635074. |
the effects of vitamin d (10 and 20 ng/ml), vitamin e in the form of tocotrienol-rich fraction (trf) (200 ng/ml) and the combination of vitamins d and e on insulin signalling markers ( |
2020-03-18 |
2023-08-13 |
Not clear |
| Paul de Goede, Ewout Foppen, Wayne I G R Ritsema, Nikita L Korpel, Chun-Xia Yi, Andries Kalsbee. Time-Restricted Feeding Improves Glucose Tolerance in Rats, but Only When in Line With the Circadian Timing System. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31496992. |
however, experiments that directly measure the effects of trf on glucose tolerance and/or insulin sensitivity at different time points throughout the 24 h cycle are lacking. |
2020-02-25 |
2023-08-13 |
rat |
| Paul de Goede, Ewout Foppen, Wayne I G R Ritsema, Nikita L Korpel, Chun-Xia Yi, Andries Kalsbee. Time-Restricted Feeding Improves Glucose Tolerance in Rats, but Only When in Line With the Circadian Timing System. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31496992. |
here we show, in rats, that trf in line with the circadian timing system (i.e., feeding during the active phase) improves glucose tolerance during intravenous glucose tolerance tests (ivgtt) in the active phase, as lower insulin levels were observed with similar levels of glucose clearance. |
2020-02-25 |
2023-08-13 |
rat |
| Heaji Lee, Yunsook Li. Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice. The Journal of nutritional biochemistry. vol 57. 2019-10-29. PMID:29679925. |
trf supplementation ameliorated muscle atrophy, plasma insulin concentration and homeostatic model assessment estimated insulin resistance in diabetic mice. |
2019-10-29 |
2023-08-13 |
mouse |
| Heaji Lee, Yunsook Li. Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice. The Journal of nutritional biochemistry. vol 57. 2019-10-29. PMID:29679925. |
taken together, these results suggest that trf might be useful as a beneficial nutraceutical to prevent skeletal muscle atrophy associated with diabetes by regulating insulin signaling via ampk/sirt1/pgc1α pathways in type 2 diabetic mice. |
2019-10-29 |
2023-08-13 |
mouse |
| Jesús E Villanueva, Christopher Livelo, Adriana S Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D Le, Uri Manor, Satchidananda Panda, Girish C Melkan. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Nature communications. vol 10. issue 1. 2019-07-09. PMID:31221967. |
imposing time-restricted feeding (trf) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, phospho-akt level, mitochondrial aberrations, and markers of insulin resistance. |
2019-07-09 |
2023-08-13 |
human |
| Mark P Mattson, Valter D Longo, Michelle Harvi. Impact of intermittent fasting on health and disease processes. Ageing research reviews. vol 39. 2018-03-22. PMID:27810402. |
studies of if (e.g., 60% energy restriction on 2days per week or every other day), pf (e.g., a 5day diet providing 750-1100kcal) and time-restricted feeding (trf; limiting the daily period of food intake to 8h or less) in normal and overweight human subjects have demonstrated efficacy for weight loss and improvements in multiple health indicators including insulin resistance and reductions in risk factors for cardiovascular disease. |
2018-03-22 |
2023-08-13 |
mouse |
| Sneha Sundaram, Lin Ya. Time-restricted feeding reduces adiposity in mice fed a high-fat diet. Nutrition research (New York, N.Y.). vol 36. issue 6. 2018-01-30. PMID:27188906. |
elevations of plasma concentrations of insulin, leptin, monocyte chemoattractant protein-1, and tissue inhibitor metalloproteinase-1 by high-fat ad lib feeding were reduced by trf to the levels of mice fed the ain93g diet. |
2018-01-30 |
2023-08-13 |
mouse |
| C García-Luna, P Soberanes-Chávez, P de Gortar. Prepuberal light phase feeding induces neuroendocrine alterations in adult rats. The Journal of endocrinology. vol 232. issue 1. 2017-06-26. PMID:27729464. |
time-restricted feeding schedules (trf) during resting phase change energy homeostasis regulation, disrupting the circadian release of metabolism-regulating hormones, such as leptin, insulin and corticosterone and promoting body weight gain. |
2017-06-26 |
2023-08-13 |
rat |
| Jeff Rothschild, Kristin K Hoddy, Pera Jambazian, Krista A Varad. Time-restricted feeding and risk of metabolic disease: a review of human and animal studies. Nutrition reviews. vol 72. issue 5. 2014-11-21. PMID:24739093. |
results from animal studies show trf to be associated with reductions in body weight, total cholesterol, and concentrations of triglycerides, glucose, insulin, interleukin 6, and tumor necrosis factor-α as well as with improvements in insulin sensitivity. |
2014-11-21 |
2023-08-13 |
human |
| Weng-Yew Wong, Hemant Poudyal, Leigh C Ward, Lindsay Brow. Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats. Nutrients. vol 4. issue 10. 2013-05-10. PMID:23201770. |
trf treatment improved ventricular function, attenuated cardiac stiffness and hypertension, and improved glucose and insulin tolerance, with reduced left ventricular collagen deposition and inflammatory cell infiltration. |
2013-05-10 |
2023-08-12 |
human |
| Harumi Uto-Kondo, Reiko Ohmori, Chikako Kiyose, Yoshimi Kishimoto, Hisako Saito, Osamu Igarashi, Kazuo Kond. Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes. The Journal of nutrition. vol 139. issue 1. 2009-02-11. PMID:19056650. |
the objective of this study was to evaluate the effect of trf and its components on adipocyte differentiation in 3t3-l1 preadipocytes, which differentiated into adipocytes in the presence of 1.8 micromol/l insulin. |
2009-02-11 |
2023-08-12 |
rat |
| Harumi Uto-Kondo, Reiko Ohmori, Chikako Kiyose, Yoshimi Kishimoto, Hisako Saito, Osamu Igarashi, Kazuo Kond. Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes. The Journal of nutrition. vol 139. issue 1. 2009-02-11. PMID:19056650. |
trf suppressed the insulin-induced mrna expression of adipocyte-specific genes such as ppargamma, adipocyte fatty acid-binding protein (ap2), and ccaat/enhancer-binding protein-alpha (c/ebpalpha) compared with the differentiation of 3t3-l1 preadipocytes into adipocytes only in the presence of insulin. |
2009-02-11 |
2023-08-12 |
rat |
| Annette L Fitzpatrick, Richard A Kronmal, Jeffrey P Gardner, Bruce M Psaty, Nancy S Jenny, Russell P Tracy, Jeremy Walston, Masyuki Kimura, Abraham Avi. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. American journal of epidemiology. vol 165. issue 1. 2007-02-15. PMID:17043079. |
significant or borderline inverse associations were found between trf length and diabetes, glucose, insulin, diastolic blood pressure, carotid intima-media thickness, and interleukin-6. |
2007-02-15 |
2023-08-12 |
human |
| S Demissie, D Levy, E J Benjamin, L A Cupples, J P Gardner, A Herbert, M Kimura, M G Larson, J B Meigs, J F Keaney, A Avi. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging cell. vol 5. issue 4. 2006-11-13. PMID:16913878. |
we explored the relations of leukocyte telomere length, expressed by terminal restriction fragment (trf) length, with insulin resistance, oxidative stress and hypertension. |
2006-11-13 |
2023-08-12 |
human |
| S Demissie, D Levy, E J Benjamin, L A Cupples, J P Gardner, A Herbert, M Kimura, M G Larson, J B Meigs, J F Keaney, A Avi. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging cell. vol 5. issue 4. 2006-11-13. PMID:16913878. |
trf length was inversely correlated with age (r = -0.41, p < 0.0001) and age-adjusted trf length was inversely correlated with the homeostatic model assessment of insulin resistance (homa-ir) (r =-0.16, p = 0.007) and urinary 8-epi-pgf(2alpha) (r = -0.16, p = 0.005) - an index of systemic oxidative stress. |
2006-11-13 |
2023-08-12 |
human |
| J F Poduslo, G L Curran, C T Ber. Macromolecular permeability across the blood-nerve and blood-brain barriers. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 12. 1994-07-06. PMID:8202551. |
the permeability of insulin (ins), nerve growth factor (ngf), albumin (alb), transferrin (trf), and igg across the blood-nerve barrier (bnb) and blood-brain barrier (bbb) in normal adult rats was quantified by measuring the (permeability coefficient x surface area) product (ps) with the i.v. |
1994-07-06 |
2023-08-12 |
rat |
| H Hong, A C Heringto. Differentiation between the effects of IGF-1 and GH on PMSG-induced progesterone production by rat granulosa cells. Growth regulation. vol 1. issue 2. 1993-01-13. PMID:1842563. |
rat granulosa cells were cultured in different concentrations of pmsg (0-100 mu/ml) plus or minus igf-1 (4 nm) or gh (hgh, 2.5 or 10 nm) in the presence or absence of cortisol (2.4 micrograms/ml) and/or insulin (68 nm) in low (5 micrograms/ml) or high (50 micrograms/ml) concentrations of transferrin (trf). |
1993-01-13 |
2023-08-11 |
rat |
| J H Yu, J K Findla. An inhibitory effect of transferrin on differentiation of rat granulosa cells in vitro. Endocrinology. vol 128. issue 4. 1991-04-23. PMID:1900779. |
on the other hand, high concentrations of insulin and cortisol completely counteracted the inhibitory effect of trf on fsh-induced progesterone production but only partially counteracted the inhibitory effect of trf on fsh-induced inhibin production. |
1991-04-23 |
2023-08-11 |
human |