| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
tph2 mrna and tph2 protein in brainstem dorsal raphe nuclei was assayed by in situ hybridization and immunocytochemistry respectively. |
2011-11-01 |
2023-08-12 |
mouse |
| Willem Heydendael, Lauren Jacobso. Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression. Brain research. vol 1288. 2009-10-15. PMID:19577549. |
using in situ hybridization, we measured effects of chronic antidepressant treatment on brainstem gr, locus coeruleus and ventral tegmental area (vta) tyrosine hydroxylase (th), and dorsal raphé tryptophan hydroxylase (tph2) gene expression in male c57bl/6 mice that were adrenalectomized and replaced with defined levels of corticosterone. |
2009-10-15 |
2023-08-12 |
mouse |
| F Haghighi, H Bach-Mizrachi, Y Y Huang, V Arango, S Shi, A J Dwork, G Rosoklija, H T Sheng, I Morozova, J Ju, J J Russo, J J Man. Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Molecular psychiatry. vol 13. issue 8. 2008-10-08. PMID:18180764. |
here, we identify a novel tph2 short isoform with truncated catalytic domain expressed in human brainstem, prefrontal cortex, hippocampus and amygdala. |
2008-10-08 |
2023-08-12 |
human |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
using real-time reverse transcription-polymerase chain reaction (rt-pcr) and semi-quantitative rt-pcr techniques, we have examined the effects of fluoxetine administration with drinking water (7.5 mg/kg/day) for 2, 4 and 8 weeks on tph2 mrna expression in the midbrain part of the dorsal raphe nucleus (drn) and in the brainstem containing the rest of the raphe complex. |
2008-04-03 |
2023-08-12 |
rat |
| Kazuhiro Nakamura, Hiroyuki Hasegaw. Developmental role of tryptophan hydroxylase in the nervous system. Molecular neurobiology. vol 35. issue 1. 2007-10-23. PMID:17519505. |
tph1 showed greater affinity for tryptophan and stronger enzymic activity than tph2 under conditions reflecting those in the developing brain stem. |
2007-10-23 |
2023-08-12 |
Not clear |
| N N Dygalo, G T Shishkina, T S Kalinina, A M Yudina, E S Ovchinnikov. Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16982082. |
two-week fluoxetine treatment also significantly reduced expression of tryptophan hydroxylase-2 (tph2) and 5-ht transporter mrnas as determined by rt-pcr in the brainstem. |
2007-02-23 |
2023-08-12 |
human |
| Kazuhiro Nakamura, Yuko Sugawara, Keiko Sawabe, Akiko Ohashi, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji, Qing Shun Lin, Hiroyuki Nishimura, Hiroyuki Hasegawa, Sachiko Hiros. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407550. |
tph1 showed higher affinity to tryptophan and stronger enzyme activity than tph2 in a condition reflecting that of the developing brainstem. |
2006-03-17 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| David Sugde. Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911638. |
a second gene encoding a functional tryptophan hydroxylase activity has recently been described (tph2), which is expressed abundantly in brainstem, the primary site of serotonergic neurons in the cns. |
2003-11-12 |
2023-08-12 |
rat |