| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. |
in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. |
2024-05-13 |
2024-05-27 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Na Luo, Ioanna Mosialou, Mattia Capulli, Brygida Bisikirska, Chyuan-Sheng Lin, Yung-Yu Huang, Peter Timothy Shyu, X Edward Guo, Aris Economides, J John Mann, Stavroula Kousten. A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice. The Journal of clinical investigation. 2022-10-04. PMID:36194488. |
sirt1 did so by increasing expression of monoamine oxidase a (mao-a), a sirt1 target that reduces brain serotonin levels by inducing its catabolism, and by suppressing tph2 expression and serotonin synthesis in the brainstem. |
2022-10-04 |
2023-08-14 |
mouse |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 shows a greater affinity for tryptophan, an amino acid used in the production of serotonin, and has a stronger enzymatic activity than tph2 for a developing brain stem. |
2022-05-13 |
2023-08-13 |
Not clear |
| Gary C Mouradian, Madeline Kilby, Santiago Alvarez, Kara Kaplan, Matthew R Hodge. Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex. Physiological reports. vol 9. issue 13. 2021-11-10. PMID:34228894. |
infants that succumb to sudden infant death syndrome (sids) have reduced brainstem 5-ht levels and tryptophan hydroxylase 2 (tph2). |
2021-11-10 |
2023-08-13 |
rat |
| Lauren A Jones, Emily W Sun, Alyce M Martin, Damien J Keatin. The ever-changing roles of serotonin. The international journal of biochemistry & cell biology. vol 125. 2021-01-12. PMID:32479926. |
tph2 is primarily expressed in neurons of the raphe nuclei of the brain stem and a subset of neurons in the enteric nervous system (ens) (yabut et al., 2019). |
2021-01-12 |
2023-08-13 |
Not clear |
| James E Hassell, James H Fox, Mathew R Arnold, Philip H Siebler, Margaret W Lieb, Dominic Schmidt, Emma J Spratt, Tessa M Smith, Kadi T Nguyen, Chloé A Gates, Kaley S Holmes, K'loni S Schnabel, Kelsey M Loupy, Maike Erber, Christopher A Lowr. Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175996. |
rats were euthanized on day 21 and brain tissue was sectioned for analysis of tph2, htr1a, slc6a4, slc22a3, and crhr2 mrna expression throughout the brainstem dorsal and median raphe nuclei. |
2020-08-04 |
2023-08-13 |
rat |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
this study aims to investigate the effects of different light intensity and dual light intensity choice (dlic) lighting program on plasma corticosterone (cort), and tryptophan hydroxylase 2 (tph2, the rate-limiting enzyme of serotonin biosynthesis) and tyrosine hydroxylase (th, the rate-limiting enzyme of dopamine biosynthesis) gene expression in the brainstem of male chickens. |
2020-03-13 |
2023-08-13 |
Not clear |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
differential tph2 expression in the drn and crn observed in the dlic birds indicate a significant effect of dlic lighting program on the serotonergic activity in the avian brainstem. |
2020-03-13 |
2023-08-13 |
Not clear |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
tph2 expression in the dorsal raphe nucleus (drn) and caudal raphe nucleus (crn) of brainstem, and tph2 and th expression in ventral tegmental areas (vtn) of the midbrain were determined by qpcr. |
2020-03-13 |
2023-08-13 |
Not clear |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
tryptophan hydroxylase-2 null mice (tph2(-/-)) and their littermates, tph2(+/-) and tph2(+/+), by using whole-cell patch-clamp recordings in a brainstem slice preparation and single unit recording in anesthetized animals. |
2016-08-26 |
2023-08-13 |
mouse |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Joon W Shim, Todd R Dodge, Max A Hammond, Joseph M Wallace, Feng C Zhou, Hiroki Yokot. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416346. |
expression of tph2 was determined 30 min - 2 h in three brain regions --frontal cortex (fc), ventromedial hypothalamus (vmh), and brain stem (bs). |
2014-09-02 |
2023-08-12 |
mouse |
| C M Ragan, J S Lonstei. Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats. Neuroscience. vol 256. 2014-08-27. PMID:24161285. |
levels of dopamine β-hydroxylase (dbh, norepinephrine synthesizing enzyme) and tryptophan hydroxylase-2 (tph2, serotonin synthesizing enzyme) were measured in the brainstem and dorsal raphe, respectively. |
2014-08-27 |
2023-08-12 |
rat |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
it was confirmed that ium produces an increase in 5-ht in the brainstem and also showed increased expression of tph1 at birth, with decreased expression of tph2. |
2013-02-05 |
2023-08-12 |
Not clear |
| Ilan A Kerman, Sarah M Clinton, Tracy A Bedrosian, Antony D Abraham, Devin T Rosenthal, Huda Akil, Stanley J Watso. High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups. Brain research. vol 1419. 2012-08-03. PMID:21925645. |
our data demonstrate that when compared to blr rats, bhrs express increased baseline tph2 and sert in select brainstem nuclei, and when tested on the resident-intruder test they exhibited: 1) increased aggressive behavior; 2) potentiated corticosterone and testosterone secretion; and 3) diminished intrusion-induced c-fos expression in select 5-htergic brainstem cell groups. |
2012-08-03 |
2023-08-12 |
rat |
| Nina C Donner, Christian D Montoya, Jodi L Lukkes, Christopher A Lowr. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. vol 37. issue 5. 2012-07-27. PMID:21924839. |
remarkably, all doses of corticosterone treatment abolished the diurnal variation of tph2 mrna expression in the brainstem dorsal raphe nucleus (dr) by elevating the gene's expression during the animals' inactive (light) phase. |
2012-07-27 |
2023-08-12 |
rat |