Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Matthias Woenckhaus, Johannes Merk, Robert Stoehr, Frank Schaeper, Andreas Gaumann, Karsten Wiebe, Arndt Hartmann, Ferdinand Hofstaedter, Wolfgang Dietmaie. Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer. Human pathology. vol 39. issue 1. 2008-02-14. PMID:17949785. |
to evaluate the prognostic relevance of these proteins in nsclcs, we used immunohistochemistry to investigate the expression of beta-catenin (ctnnb1), dickkopf, xenopus, homolog of 3 (dkk3 gene), fibroblast growth factor receptor 3 (fgfr3), fragile histidine triad (fhit), tumor protein p53 (tp53), mucin1 (muc1), topoisomerase ii alpha (top2a), and glutathione s-transferase-pi (gst) in a cohort of patients (n = 125). |
2008-02-14 |
2023-08-12 |
xenopus_laevis |
A M Diab, T A S Tawfeek, F Moeity, M Elsamma. Mutations in exons 6 and 7 of TP53 gene correlate positively with serum tumor necrosis factor alpha independent of microsatellite instability in BAT26 gene in Egyptian patients with endometrial carcinoma. The International journal of biological markers. vol 21. issue 3. 2006-12-11. PMID:17013801. |
mutations in exons 6 and 7 of tp53 gene correlate positively with serum tumor necrosis factor alpha independent of microsatellite instability in bat26 gene in egyptian patients with endometrial carcinoma. |
2006-12-11 |
2023-08-12 |
human |
Aimee S Payne, Albert C Yan, Erum Ilyas, Weijie Li, John T Seykora, Terri L Young, Bruce R Pawel, Paul J Honig, Jeanette Camacho, Sonia Imaizumi, Warren R Heymann, Rhonda E Schnu. Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. Archives of dermatology. vol 141. issue 12. 2006-02-21. PMID:16365259. |
ankyloblepharon, ectodermal defects, and cleft lip and palate (aec) syndrome is a rare autosomal dominant disorder caused by mutations in the sterile alpha motif region of tp63, a homologue of the tumor suppressor tp53. |
2006-02-21 |
2023-08-12 |
Not clear |
Guang Yang, Anpuchchelvi Rajadurai, Hensin Tsa. Recurrent patterns of dual RB and p53 pathway inactivation in melanoma. The Journal of investigative dermatology. vol 125. issue 6. 2006-01-26. PMID:16354195. |
although homozygous deletion of all three critical cdkn2a exons (exons 1 beta, 1 alpha, and 2) represent the most common mechanism, concurrent loss of cdkn2a(exon1 alpha) and cdkn2a(exon1 beta) and simultaneous point mutagenesis of cdk4 and tp53 reflect alternative cassettes of dual inactivation. |
2006-01-26 |
2023-08-12 |
human |
Yutaka Yamada, Yoichi Oghiso, Jean-Paul Morlier, Kristell Guillet, Paul Fritsch, Nicolas Dudoignon, Georges Monchau. Comparative study on Tp53 gene mutations in lung tumors from rats exposed to 239Pu, 237Np and 222Rn. Journal of radiation research. vol 45. issue 1. 2004-08-10. PMID:15133292. |
these results indicate that the abnormalities of the tp53 gene might not be so critical for the pulmonary carcinogenesis after the inhalation of different alpha emitters, even though the presence and frequencies of the tp53 gene mutations were different. |
2004-08-10 |
2023-08-12 |
rat |
R Iyer, B E Lehnert, R Svensso. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer research. vol 60. issue 5. 2000-04-11. PMID:10728689. |
our results indicate that alpha particle-associated increases in cell growth correlate with intracellular increases in ros along with decreases in tp53 and cdkn1a, and that these cellular responses are mechanistically coupled. |
2000-04-11 |
2023-08-12 |
human |
I Wada, H Horiuchi, M Mori, Y Ishikawa, M Fukumoto, T Mori, Y Kato, T Kitagawa, R Machinam. High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis. Radiation research. vol 152. issue 6 Suppl. 1999-12-22. PMID:10564952. |
therefore, the low frequency of such changes (27%) compared to point mutations (47%) suggests that the genetic changes in the tp53 gene in the liver tumors related to thorotrast were not caused mainly by direct actions of alpha particles but rather by indirect effects that may have been due to cycles of necrosis and regeneration. |
1999-12-22 |
2023-08-12 |
Not clear |
J A Macoska, I J Powell, W Sakr, M A Lan. Loss of the 17p chromosomal region in a metastatic carcinoma of the prostate. The Journal of urology. vol 147. issue 4. 1992-04-29. PMID:1552612. |
these genes include 1) those important to androgen metabolism in the prostate, the androgen receptor and steroid 5 alpha reductase genes; 2) those that map to the 10q (plau) and 7q (met) chromosomal regions found deleted in some prostate carcinomas, and 3) proto-oncogenes (erbb2, int2, and myc) and tumor suppressor gene loci (rb1, tp53 and d17s5) found altered in adenocarcinomas of the breast, colon and lung. |
1992-04-29 |
2023-08-11 |
Not clear |