| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Lin, Chen-Hsuan Wu, Hung-Chun Fu, Yu-Che O. Evolving treatment paradigms for platinum-resistant ovarian cancer: An update narrative review. Taiwanese journal of obstetrics & gynecology. vol 63. issue 4. 2024-07-14. PMID:39004472. |
biomarker testing such as analysis of the expression level of folate receptor alpha or mutation in tp53 may be applicable for identifying patients who are more likely to respond to the specific therapy, enabling a more personalized treatment approach. |
2024-07-14 |
2024-07-18 |
Not clear |
| L Cody Smith, Helen Abramova, Kinal Vayas, Jessica Rodriguez, Benjamin Gelfand-Titiyevksiy, Troy Roepke, Jeffrey D Laskin, Andrew J Gow, Debra L Laski. Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation. Toxicological sciences : an official journal of the Society of Toxicology. 2024-06-19. PMID:38897669. |
an interaction network analysis identified tumor suppressor 53 (tp53), e2f family of transcription factors (e2fs), cyclin dependent kinase inhibitor 1a (cdkn1a/p21), and cyclin d1 (ccnd1) as upstream regulators of cell cycle pathways at 24 hr and tp53, nuclear receptor subfamily 4 group a member 1 (nr4a1/nur77), and estrogen receptor alpha (esr1/erα) as central upstream regulators of mitochondrial respiration pathways at 72 hr. |
2024-06-19 |
2024-06-22 |
mouse |
| Yujing Xu, Jinrong Yang, Xiaoyu Han, Chunchun Gan, Xiaopeng We. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. vol 103. issue 15. 2024-04-12. PMID:38608062. |
tumor protein p53 (tp53), akt serine/threonine kinase 1 (akt1), estrogen receptor 1 (esr1), erb-b2 receptor tyrosine kinase 2 (erbb2), epidermal growth factor receptor (egfr), jun proto-oncogene (jun), and heat shock protein 90 alpha family class a member 1 (hsp90aa1) selected as the most important genes were used for verification by molecular docking and molecular dynamics simulation. |
2024-04-12 |
2024-04-15 |
Not clear |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Shaohua Wang, Zhengzhuang Zou, Zanmei Tang, Jian Den. AMPK/MTOR/TP53 Signaling Pathway Regulation by Calcitonin Gene-Related Peptide Reduces Oxygen-Induced Lung Damage in Neonatal Rats through Autophagy Promotion. Inflammation. 2024-03-19. PMID:38502251. |
furthermore, hyperoxia increased the expression levels of amp-activated protein kinase (ampk) alpha 1 (also known as protein kinase amp-activated catalytic subunit alpha 1 (prkaa1)) but inhibited tp53 and mechanistic target of rapamycin (mtor); these expression trends were regulated by cgrp treatment. |
2024-03-19 |
2024-03-23 |
rat |
| Kunze Yu, Xing Fan. Evaluating the role of wound-healing genes in conjunction with stool routine and serum tumor markers for colorectal cancer diagnosis and prognostic implications. International wound journal. vol 21. issue 3. 2024-03-06. PMID:38446012. |
exploring wound-healing genes like vascular endothelial growth factor a (vegfa), tumour protein 53 (tp53) and transforming growth factor alpha (tgfa) revealed heightened expression in colorectal cancer, suggesting their potential role in disease progression. |
2024-03-06 |
2024-03-08 |
Not clear |
| Wei-Xi Shen, Guang-Hua Li, Yu-Jia Li, Peng-Fei Zhang, Jia-Xing Yu, Di Shang, Qiu-Shi Wan. Prognostic Significance of Tumor Mutation Burden among Patients with Non-small Cell Lung Cancer Who Received Platinum-based Adjuvant Chemotherapy: An Exploratory Study. Journal of cancer prevention. vol 28. issue 4. 2024-01-11. PMID:38205359. |
ngs analysis exhibited that the most common mutated somatic genes among the 78 patients were tumor suppressor protein p53 (tp53), epidermal growth factor receptor, low-density lipoprotein receptor related protein 1b, dna methyltransferase 3 alpha and fat atypical cadherin 3, and their prevalence was 56.4%, 48.7%, 37.2%, 30.7%, and 25.6%, respectively. |
2024-01-11 |
2024-01-13 |
Not clear |
| Xiao-Qin Zhong, Da-Feng Hu, Yu Wang, Zhen-Qiu Ning, Min-Zhen Den. [Mechanism of Zhongfeng Xingnao Decoction in improving microcirculatory disorders in cerebral hemorrhage based on network pharmacology and molecular docking techniques]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114219. |
molecular docking results revealed that the common components β-sitosterol of rhei radix et rhizoma, notoginseng radix et rhizoma, and ginseng radix et rhizoma rubra showed good docking with proto-oncogene tyrosine-protein kinase(src), signal transducer and activator of transcription 3(stat3), phosphoinositide-3-kinase catalytic alpha polypeptide gene(pik3ca), recombinant protein tyrosine phosphatase non receptor type 11(ptpn11), akt1, epidermal growth factor receptor(egfr), calcium adhesion-associated protein beta 1(ctnnb1), vascular endothelial growth factor a(vegfa), and tumor protein p53(tp53). |
2023-12-19 |
2023-12-23 |
mouse |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Efstathios T Pavlidis, Konstantinos G Sapalidis, Theodoros E Pavlidi. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 3. 2023-01-02. PMID:36588487. |
the genes most frequently altered include kirsten rat sarcoma viral proto-oncogene (kras), tumor protein p53 (tp53), cyclin-dependent kinase inhibitor 2a (cdkn2a), smad family member 4 (smad4), and guanine nucleotide-binding protein, alpha stimulating (gnas). |
2023-01-02 |
2023-08-14 |
rat |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Zuoxiang Wang, Zhisong He, Qinkao Xuan, Yue Zhang, Jialiang Xu, Jia Lin, Hongxia Li, Weixiang Chen, Tingbo Jian. Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091399. |
a total of 43 defrgs and 7 hub genes (tumor protein p53 [tp53], tumor necrosis factor [tnf], hypoxia-inducible factor 1 subunit alpha [hif1a], interleukin 6 [il6], heme oxygenase 1 [hmox1], x-box binding protein 1 [xbp1], and caspase 8 [casp8]) were screened based on bioinformatics analysis. |
2022-09-12 |
2023-08-14 |
rat |
| Guanzheng Liu, Huan Li, Wanhong Zhang, Jiefeng Yu, Xu Zhang, Runqiu Wu, Mingshan Niu, Xuejiao Liu, Rutong Y. Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34216174. |
casein kinase 1 alpha 1 (ck1α) (encoded on chromosome 5q by csnk1a1) is considered an attractive target for tp53 wild-type acute myeloid leukaemia (aml) treatment. |
2021-10-15 |
2023-08-13 |
Not clear |
| Huiying Wan, Dingding Zhang, Weimin Hu, Zhen Xie, Qiu Du, Qiongrong Xia, Taishen Wen, Haiping Ji. Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. Medicine. vol 100. issue 30. 2021-08-20. PMID:34397726. |
this study aimed to investigate the expression of phosphatase and tensin homolog (pten), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), phosphorylated mitogen-activated kinase-like protein (pmapk), and tumor protein p53 (tp53) in scalp and face angiosarcoma and to assess tumor tissue apoptosis.the expression and intracellular distribution of pten, pik3ca, pmapk, and tp53 proteins in 21 specimens of human scalp and face angiosarcoma and 16 specimens of human benign hemangioma were evaluated using immunohistochemistry. |
2021-08-20 |
2023-08-13 |
human |
| Seok Won Ham, Hee-Young Jeon, Xiong Jin, Eun-Jung Kim, Jun-Kyum Kim, Yong Jae Shin, Yeri Lee, Se Hoon Kim, Seon Yong Lee, Sunyoung Seo, Min Gi Park, Hye-Mi Kim, Do-Hyun Nam, Hyunggee Ki. TP53 gain-of-function mutation promotes inflammation in glioblastoma. Cell death and differentiation. vol 26. issue 3. 2020-06-03. PMID:29786075. |
the tp53 gof mutant showed upregulated c-c motif chemokine ligand 2 (ccl2) and tumor necrosis factor alpha (tnfa) expression via nuclear factor kappa b (nfκb) signaling, consequently increasing microglia and monocyte-derived immune cell infiltration. |
2020-06-03 |
2023-08-13 |
Not clear |
| Zelin Tian, Jianing Tang, Qian Yang, Xin Li, Jian Zhu, Gaosong W. Atypical ubiquitin-binding protein SHARPIN promotes breast cancer progression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 119. 2020-02-25. PMID:31518875. |
abnormal oncogenic signaling has important effects on the development of breast cancer, such as erα/ esr1 (estrogen receptor alpha), pten (gene of phosphate and tension homology deleted on chromsome ten), nfκb(nuclear factor κb), and tumor protein p53 (p53 / tp53). |
2020-02-25 |
2023-08-13 |
Not clear |
| Hai Xiao, Xinyue Qin, Jinping Wan, Rong L. Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-16. PMID:31175839. |
results seven key target genes for formononetin in the treatment of patients with ad were identified, including estrogen receptor alpha (esr1), peroxisome proliferator-activated receptor gamma (pparg), tumor protein p53 (tp53), sirtuin 1 (sirt1), tumor necrosis factor (tnf), cytochrome p450 19a1 (cyp19a1), and nuclear factor (erythroid-derived 2)-like 2 (nfe2l2). |
2020-01-16 |
2023-08-13 |
Not clear |
| Marianna Sztán, Zsuzsa Pápai, Miklós Szendrôi, Marco van der Looij, Edith Olá. Allelic Losses from Chromosome 17 in Human Osteosarcomas. Pathology oncology research : POR. vol 3. issue 2. 2019-11-20. PMID:11173637. |
loss of heterozygosity at the tp53 locus was detected in 40% (6/15) of informative cases while it was 14% (2/14) at the locus of thyroid hormone receptor alpha (thra1), 21% (3/14) at the d17s855 locus intragenic to brca1 and 27% (4/15) at the d17s579 locus. |
2019-11-20 |
2023-08-12 |
human |
| Shotaro Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka, Sayumi Yoshikawa, Noriyuki Akahoshi, Isao Ishi. 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice. FEBS open bio. vol 8. issue 9. 2019-11-20. PMID:30186752. |
upstream regulator analysis highlighted transcriptional regulation by peroxisome proliferator-activated receptor alpha (pparα) in the liver and kidney and by tumor protein/suppressor p53 (tp53) in the thymus, spleen, and liver. |
2019-11-20 |
2023-08-13 |
mouse |
| M Arias-Álvarez, R M García-García, J López-Tello, P G Rebollar, A Gutiérrez-Adán, P L Lorenz. α-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during in vitro maturation and enhances the developmental competence of rabbit oocytes. Reproduction, fertility, and development. vol 30. issue 12. 2019-09-30. PMID:29966585. |
the present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µm) during ivm on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (sod2), glutathione peroxidase 1 (gpx1), catalase (cat)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (tp53), caspase 3, apoptosis-related cysteine protease (casp3)), cell cycle progression (cellular cycle v-akt murine thymoma viral oncogene homologue 1 (akt1)), cumulus expansion (gap junction protein, alpha 1, 43 kda (gja1) and prostaglandin-endoperoxide synthase 2 (prostaglandin g/h synthase and cyclo-oxygenase) (ptgs2)) and metabolism (glucose-6-phosphate dehydrogenase (g6pd)). |
2019-09-30 |
2023-08-13 |
rabbit |