| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul W Fisher, Yingjie Zhao, Mario C Rico, Vicky S Massicotte, Christine K Wade, Judith Litvin, Geoffrey M Bove, Steven N Popoff, Mary F Barb. Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. Journal of cell communication and signaling. vol 9. issue 1. 2015-04-30. PMID:25617052. |
given the anti-fibrotic role of ifnγ, and to identify a mechanism for the continued grip strength losses and behavioral sensitivities, we evaluated the fibrogenic proteins ccn2, collagen type i and tgfb1, as well as the nociceptive/fibrogenic peptide substance p. each increased in and around flexor digitorum muscles and extracellular matrix in the mid-forearm, and in nerves of the forepaw at 18 weeks. |
2015-04-30 |
2023-08-13 |
rat |
| Michal Milgrom-Hoffman, Inbal Michailovici, Napoleone Ferrara, Elazar Zelzer, Eldad Tzaho. Endothelial cells regulate neural crest and second heart field morphogenesis. Biology open. vol 3. issue 8. 2014-08-16. PMID:24996922. |
insights into the molecular mechanisms reveal marked reduction in transforming growth factor beta 1 (tgfb1) along with changes in the extracellular matrix (ecm) composition. |
2014-08-16 |
2023-08-13 |
mouse |
| Lucas González-Herrera, Aurora Valenzuela, Juan A Marchal, José A Lorente, Enrique Villanuev. Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem stability. Forensic science international. vol 232. issue 1-3. 2014-06-05. PMID:24053884. |
gene expression of cardiac troponin i (tnni3), myosin light chain 3 (myl3), matrix metalloprotease 9 (mmp9), transforming growth factor beta 1 (tgfb1), and vascular endothelial growth factor a (vegfa) in myocardial zones and body fluids were subsequently studied by real-time quantitative pcr. |
2014-06-05 |
2023-08-12 |
human |
| Arnaud J Van Wettere, J Mac Law, David E Hinton, Seth W Kullma. Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury. Toxicologic pathology. vol 41. issue 5. 2014-04-24. PMID:23197195. |
stellate cell activation and development of fibrosis was associated with upregulation of transforming growth factor beta 1 (tgfb1), tgfb receptor 2, mothers against decapentaplegic homolog 3 (smad3a), smad3b, beta-catenin (ctnnb1), myc, matrix metalloproteinase (mmp2), mmp14a, mmp14b, tissue inhibitors of metalloproteinase (timp) 2a, timp2b, timp3, collagen type i alpha 1a (col1a1a), and col1a1b and a less pronounced increase in mmp13 and col4a1 expression. |
2014-04-24 |
2023-08-12 |
Not clear |
| Dulce Maroni, John S Davi. Transforming growth factor Beta 1 stimulates profibrotic activities of luteal fibroblasts in cows. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22811573. |
transforming growth factor beta 1 (tgfb1) is a potent mediator of wound healing and fibrotic processes through stimulation of the synthesis of extracellular matrix components. |
2013-04-22 |
2023-08-12 |
cattle |
| Dulce Maroni, John S Davi. Transforming growth factor Beta 1 stimulates profibrotic activities of luteal fibroblasts in cows. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22811573. |
we examined the actions of tgfb1 on luteal fibroblast proliferation, extracellular matrix production, floating gel contraction, and chemotaxis. |
2013-04-22 |
2023-08-12 |
cattle |
| Dulce Maroni, John S Davi. Transforming growth factor Beta 1 stimulates profibrotic activities of luteal fibroblasts in cows. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22811573. |
treatment of luteal fibroblasts with tgfb1 induced the expression of laminin, collagen 1, and matrix metalloproteinase 1 as determined by western blot analysis and gelatin zymography of conditioned medium. |
2013-04-22 |
2023-08-12 |
cattle |
| Dulce Maroni, John S Davi. Transforming growth factor Beta 1 stimulates profibrotic activities of luteal fibroblasts in cows. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22811573. |
these results suggest that tgfb1 contributes to the structural regression of the corpus luteum by stimulating luteal fibroblasts to remodel and contract the extracellular matrix. |
2013-04-22 |
2023-08-12 |
cattle |
| Petra Stute, Sonja Sielker, Charles E Wood, Thomas C Register, Cynthia J Lees, Fitriya N Dewi, J Koudy Williams, Janice D Wagner, Ulrich Stefenelli, J Mark Clin. Life stage differences in mammary gland gene expression profile in non-human primates. Breast cancer research and treatment. vol 133. issue 2. 2012-09-28. PMID:22037779. |
gene families or pathways that changed across life stages included those related to estrogen and androgen (esr1, pgr, tff1, greb1, ar, 17hsdb2, 17hsdb7, sts, hsd11b1, akr1c4), prolactin (prlr, elf5, stat5, csn1s1), insulin-like growth factor signaling (igf1, igfbp1, igfbp5), extracellular matrix (postn, tgfb1, col5a2, col12a1, foxc1, lamc1, pdgfra, tgfb2), and differentiation (cd24, cd29, cd44, cd61, aldh1, brca1, foxa1, postn, dicer1, lig4, klf4, notch2, rif1, bmpr1a, tgfb2). |
2012-09-28 |
2023-08-12 |
monkey |
| Samir M Abdelmagid, Ann E Barr, Mario Rico, Mamta Amin, Judith Litvin, Steven N Popoff, Fayez F Safadi, Mary F Barb. Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. PloS one. vol 7. issue 5. 2012-09-17. PMID:22675458. |
specifically, we examined forearm flexor digitorum muscles for changes in connective tissue growth factor (ctgf; a matrix protein associated with fibrosis), collagen type i (col1; a matrix component), and transforming growth factor beta 1 (tgfb1; an upstream modulator of ctgf and collagen), in rats performing one of two repetitive tasks, with or without anti-inflammatory drugs. |
2012-09-17 |
2023-08-12 |
rat |
| O Yu Makarycheva, E Yu Tsareva, M A Sudomoina, O G Kulakova, B V Titov, O V Bykova, N V Gol'tsova, L M Kuzenkova, A N Boiko, O O Favorov. Family Analysis of Linkage and Association of HLA-DRB1, CTLA4, TGFB1, IL4, CCR5, RANTES, MMP9 and TIMP1 Gene Polymorphisms with Multiple Sclerosis. Acta naturae. vol 3. issue 1. 2012-08-23. PMID:22649676. |
proteins of the immune system, as well as proteins that are involved in the infiltration of activated immune cells in the cns, play an important role in the pathogenesis of ms. we investigated the association and linkage with ms of the following immune-system genes polymorphisms: hla-drb1,ctla4,tgfb1,il4,ccr5 andrantes, as well as of the matrix metalloproteinase 9 (mmp9) and tissue inhibitor of metalloproteinase 1 (timp1) genes polymorphisms. |
2012-08-23 |
2023-08-12 |
Not clear |
| Ignacio Fernández, Maria Darias, Karl B Andree, David Mazurais, Jose Luís Zambonino-Infante, Enric Gisber. Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A. BMC developmental biology. vol 11. 2011-07-22. PMID:21306609. |
therefore, in order to gain further knowledge of fish larval development and its disruption by nutritional va imbalance, the relative expression of some rars and rxrs, as well as several genes involved in morpho- and skeletogenesis such as peroxisome proliferator-activated receptors (ppara, pparb and pparg); retinol-binding protein (rbp); insulin-like growth factors i and ii (igf1 and igf2, respectively); bone morphogenetic protein 2 (bmp2); transforming growth factor β-1 (tgfb1); and genes encoding different extracellular matrix (ecm) proteins such as matrix gla protein (mgp), osteocalcin (bglap), osteopontin (spp1), secreted protein acidic and rich in cysteine (sparc) and type i collagen α1 chain (col1a1) have been studied in gilthead sea bream. |
2011-07-22 |
2023-08-12 |
Not clear |
| Sally K Martin, Stephen Fitter, Li Fei Bong, Jennifer J Drew, Stan Gronthos, Peter R Shepherd, Andrew C W Zannettin. NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 25. issue 10. 2011-02-10. PMID:20499346. |
under osteoinductive conditions, bez235 strongly promotes osteogenic differentiation, as evidenced by an increase in mineralized matrix production, an upregulation of genes involved in osteogenesis, including bone morphogenetic proteins (bmp2, -4, and -6) and transforming growth factor β1 (tgf-β1) superfamily members (tgfb1, tgfb2, and inhbe), and increased activation of smad signaling molecules. |
2011-02-10 |
2023-08-12 |
human |
| A Cyniak-Magierska, J Januszkiewicz-Caulier, E Brzeziańska, A Lewińsk. Analysis of correlation between the process of thyroid fibrosis and TGFB1 gene expression level in fine-needle aspiration biopsy (FNAB) thyroid specimens collected from patients with Hashimoto's thyroiditis and non-toxic goitre. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 118. issue 7. 2010-10-21. PMID:20191437. |
transforming growth factor beta 1 (tgfb1) stimulates the production of various extracellular matrix components; at the same time, it inhibits matrix degradation. |
2010-10-21 |
2023-08-12 |
Not clear |
| Nadine Matti, Helen F Irving-Rodgers, Nicholas Hatzirodos, Thomas R Sullivan, Raymond J Rodger. Differential expression of focimatrix and steroidogenic enzymes before size deviation during waves of follicular development in bovine ovarian follicles. Molecular and cellular endocrinology. vol 321. issue 2. 2010-09-29. PMID:20176077. |
what regulates dominance is not known but candidates include oestradiol, transforming growth factor beta beta1 (tgfb1), and recently cyp11ai (cholesterol side-chain cleavage) and focal intra-epithelial matrix (focimatrix). |
2010-09-29 |
2023-08-12 |
cattle |
| C C van Diemen, D S Postma, Y S Aulchenko, P J L M Snijders, B A Oostra, C M van Duijn, H M Boeze. Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. The European respiratory journal. vol 35. issue 4. 2010-06-18. PMID:19797132. |
in 91 subjects with global initiative for chronic obstructive lung disease (gold) stage >or=1 copd, who were members of an extended pedigree including 6,175 people from the genetic research in isolated populations study, 32 snps were analysed in 13 candidate genes: a disintegrin and metalloprotease domain 33 gene (adam33), transforming growth factor-beta1 gene ( tgfb1), matrix metalloprotease-1 gene (mmp1), mmp2, mmp9, mmp12, tissue inhibitor of metalloprotease-1 gene (timp1), surfactant protein a1 gene (sftpa1 ), sftpa2, sftpb, sftpd, glutathione s-transferase p1 gene (gstp1), and haem oxygenase 1 gene ( hmox1). |
2010-06-18 |
2023-08-12 |
human |
| Shinji Okada, Takumi Misaka, Yasuko Tanaka, Ichiro Matsumoto, Kenichi Ishibashi, Sei Sasaki, Keiko Ab. Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18606867. |
furthermore, three genes associated with the remodeling of the extracellular matrix, mmp12, timp1, tgfb1, were up-regulated in the fibroblasts. |
2008-10-21 |
2023-08-12 |
mouse |
| Akihiko Ishimura, Jennifer K Ng, Masanori Taira, Stephen G Young, Shin-Ichi Osad. Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development (Cambridge, England). vol 133. issue 19. 2006-11-28. PMID:16943282. |
we have demonstrated, in man1-deficient embryos, the expression of tgfb1 is upregulated and smad2/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis. |
2006-11-28 |
2023-08-12 |
Not clear |
| Massimo Marenzana, Nick Wilson-Jones, Vivek Mudera, Robert A Brow. The origins and regulation of tissue tension: identification of collagen tension-fixation process in vitro. Experimental cell research. vol 312. issue 4. 2006-03-02. PMID:16337188. |
this was differentially enhanced by tgfb1 and mechanical loading to give subtle control of the new, remodeled matrix material properties. |
2006-03-02 |
2023-08-12 |
Not clear |
| J C Grutters, R M du Boi. Genetics of fibrosing lung diseases. The European respiratory journal. vol 25. issue 5. 2005-08-04. PMID:15863652. |
intriguingly, associations with tgfb1 and genes involved in extracellular matrix homeostasis have been reported in this disease. |
2005-08-04 |
2023-08-12 |
human |