| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adela Kratochvilova, Lucia Knopfova, Janka Gregorkova, Reinhard Gruber, Eva Janeckova, Yang Chai, Eva Matalov. FasL impacts Tgfb signaling in osteoblastic cells. Cells & development. 2024-06-09. PMID:38810946. |
tgfb subfamily members (tgfb1, tgfb2, tgfb3) represent major components in osteogenic pathways and extracellular matrix. |
2024-06-09 |
2024-06-11 |
Not clear |
| Di Hu, Zenan Lin, Pan Li, Zhehuan Zhang, Junhong Jiang, Chenhao Yan. Investigation of Potential Crucial Genes and Key Pathways in Keratoconus: An Analysis of Gene Expression Omnibus Data. Biochemical genetics. 2023-05-26. PMID:37233843. |
the results revealed that extracellular matrix remodeling and immune inflammatory response could be the key links of keratoconus, tnf, il6, il1a, il1b, ccl3, mmp3, mmp9, mmp1, and tgfb1 may be potential crucial genes, and tnf signaling pathway and il-17 signaling pathway were the potential pathways accounting for pathogenesis and development of keratoconus. |
2023-05-26 |
2023-08-14 |
Not clear |
| Kirsten B Kluivers, Sabrina L Lince, Alejandra M Ruiz-Zapata, Wilke M Post, Rufus Cartwright, Manon H Kerkhof, Joanna Widomska, Ward De Witte, Jakub Pecanka, Lambertus A Kiemeney, Sita H Vermeulen, Jelle J Goeman, Kristina Allen-Brady, Egbert Oosterwijk, Geert Poelman. Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047060. |
the pop landscape is located in and around epithelial cells and fibroblasts of the urogenital tract and harbors four interacting biological processes-epithelial-mesenchymal transition, immune response, modulation of the extracellular matrix, and fibroblast function-that are regulated by sex hormones and tgfb1. |
2023-04-13 |
2023-08-14 |
Not clear |
| Sjors Maassen, Britt Coenen, Melina Ioannidis, Karl Harber, Pieter Grijpstra, Jan Van den Bossche, Geert van den Bogaar. Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages. Redox biology. vol 59. 2022-12-27. PMID:36574745. |
on the transcriptional level, 4-oi increased expression of the gene coding for tgf-β (tgfb1), whereas expression of the collagenase matrix metalloprotease-8 (mmp8) was reduced. |
2022-12-27 |
2023-08-14 |
human |
| Tomas Novotny, Adam Eckhardt, Martina Doubkova, Jarmila Knitlova, David Vondrasek, Eliska Vanaskova, Martin Ostadal, Jiri Uhlik, Lucie Bacakova, Jana Musilkov. The possible role of hypoxia in the affected tissue of relapsed clubfoot. Scientific reports. vol 12. issue 1. 2022-03-16. PMID:35292718. |
we found a significant increase in the levels of smooth muscle actin, transforming growth factor-beta, hypoxia-inducible factor 1 alpha, lysyl oxidase, lysyl oxidase-like 2, tenascin c, matrix metalloproteinase-2, matrix metalloproteinase-9, fibronectin, collagen types iii and vi, hemoglobin subunit alpha and hemoglobin subunit beta, and an overexpression of acta2, fn1, tgfb1, hif1a and mmp2 genes in the contracted medial side tissue of clubfoot. |
2022-03-16 |
2023-08-13 |
Not clear |
| Maddison Archer, Pallave Dasari, David Walsh, Kara L Britt, Andreas Evdokiou, Wendy V Ingma. Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density. Journal of clinical medicine. vol 11. issue 3. 2022-02-15. PMID:35160252. |
mammary fibroblasts were isolated from women with high and low mammographic density and exposed to immune factors myeloperoxidase (mpo), eosinophil peroxidase (epo), transforming growth factor beta 1 (tgfb1) and tumour necrosis factor alpha (tnfa) for 72 h and profiled for expression of cancer-associated fibroblast and extracellular matrix regulation markers. |
2022-02-15 |
2023-08-13 |
Not clear |
| Mai Abdel Mouti, Siim Paukli. TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 3. 2021-11-18. PMID:33429081. |
in this review, we mainly focus on the transforming growth factor beta 1 (tgfb1)/inhibin subunit beta a (inhba) homodimer/nodal-smad2/3 signaling network in pancreatic cancer as a pivotal central node that regulates multiple key mechanisms involved in the development of chemoresistance, including enhancement of the stem cell-like properties and tumorigenicity of pancreatic cancer cells, mediating cooperative interactions between pancreatic cancer cells and the surrounding stroma, as well as regulating the deposition of extracellular matrix proteins within the tumor microenvironment. |
2021-11-18 |
2023-08-13 |
Not clear |
| Sonu Subudhi, Hannah K Drescher, Laura E Dichtel, Lea M Bartsch, Raymond T Chung, Matthew M Hutter, Denise W Gee, Ozanan R Meireles, Elan R Witkowski, Louis Gelrud, Ricard Masia, Stephanie A Osganian, Jenna L Gustafson, Steve Rwema, Miriam A Bredella, Sangeeta N Bhatia, Andrew Warren, Karen K Miller, Georg M Lauer, Kathleen E Core. Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients With Obesity. Hepatology communications. 2021-09-24. PMID:34558849. |
in the presence of nash f1-f4, extracellular matrix degrading proteinases and profibrotic/scar deposition genes, such as collagens and transforming growth factor beta 1 (tgfb1), were simultaneously increased, suggesting a dynamic state of tissue remodeling. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yue Fan, Tianyu Li, Lili Xu, Tiantao Kuan. Comprehensive Analysis of Immunoinhibitors Identifies LGALS9 and TGFBR1 as Potential Prognostic Biomarkers for Pancreatic Cancer. Computational and mathematical methods in medicine. vol 2020. 2021-07-09. PMID:33062039. |
and tgfb1 was related to mesoderm formation, cell matrix adhesion, tgf-beta signaling pathway, and hippo signaling pathway. |
2021-07-09 |
2023-08-13 |
Not clear |
| Eszter Emri, Elod Kortvely, Sascha Dammeier, Franziska Klose, David Simpson, Eye-Risk Consortium, Anneke I Den Hollander, Marius Ueffing, Imre Lengye. A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium. Nutrients. vol 12. issue 10. 2021-04-16. PMID:33036197. |
gene set enrichment analysis revealed changes in specific molecular pathways related to cell adhesion/polarity, extracellular matrix organization, protein processing/transport, and oxidative stress response by zinc and identified a key upstream regulator effect similar to that of tgfb1. |
2021-04-16 |
2023-08-13 |
human |
| Katalin Kiss, Eszter Regős, Kristóf Rada, Gábor Firneisz, Kornélia Baghy, Ilona Kovalszk. Chronic Hyperglycaemia Induced Alterations of Hepatic Stellate Cells Differ from the Effect of TGFB1, and Point toward Metabolic Stress. Pathology oncology research : POR. vol 26. issue 1. 2021-01-13. PMID:30109568. |
whereas tgfb1 induced the production of extracellular matrix proteins, high glucose exposure resulted in decreased mmp2 activity, retardation of type i collagen in the endoplasmic reticulum, with decreased ps6 expression, pointing to development of endoplasmic stress and sequestration of p21 |
2021-01-13 |
2023-08-13 |
human |
| Heather D E Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G Evetts, Michele T Hu, Sally A Cowley, Caleb Webber, Richard Wade-Martin. RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes. Neurobiology of disease. vol 129. 2020-03-24. PMID:31085228. |
in particular, transforming growth factor beta 1 (tgfb1), which has been shown to inhibit microglial inflammatory response in a rat model of pd, and matrix metallopeptidase 2 (mmp2), which has been shown to degrade α-synuclein aggregates, were found to be down-regulated in lrrk2 g2019s astrocytes. |
2020-03-24 |
2023-08-13 |
human |
| Yanning Li, Yan Zhong, Wenjian Gong, Xuehan Gao, Huanli Qi, Kun Liu, Jinsheng Q. C-peptide prevents SMAD3 binding to alpha promoters to inhibit collagen type IV synthesis. Journal of molecular endocrinology. vol 61. issue 1. 2019-10-28. PMID:29844093. |
activation of transforming growth factor β1 (tgfb1)/smad3 signaling may lead to additional synthesis of collagen type iv (col4), which is a major contributor to extracellular matrix (ecm) accumulation in diabetic nephropathy (dn). |
2019-10-28 |
2023-08-13 |
Not clear |
| Victoria G Shuttleworth, Luke Gaughan, Lotfia Nawafa, Caitlin A Mooney, Steven L Cobb, Neil S Sheerin, Ian R Loga. The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD3. Journal of cell science. vol 131. issue 1. 2019-04-23. PMID:29222115. |
on a cellular level, we demonstrate that set9 is broadly required for the effects of tgfb1 in diseased primary renal fibroblasts; set9 promotes fibroblast migration into wounds, expression of extracellular matrix proteins, collagen contractility and myofibroblast differentiation. |
2019-04-23 |
2023-08-13 |
Not clear |
| Kais Hussein, Angelika Stucki-Koch, Hans Kreip. Profile of fibrosis-related gene transcripts and megakaryocytic changes in the bone marrow of myelodysplastic syndromes with fibrosis. Annals of hematology. vol 97. issue 11. 2018-10-09. PMID:29961094. |
mds-mf showed increased expression of thrombospondin 1 (thbs1), timp metallopeptidase inhibitor 1 (timp1), transforming growth factor beta 1 (tgfb1), matrix metallopeptidases 2 and 14 (mmp2, mmp14), smad family members 3 and 4 (smad3, smad4), and mir-146b. |
2018-10-09 |
2023-08-13 |
Not clear |
| P M Angel, D A Narmoneva, M K Sewell-Loftin, C Munjal, L Dupuis, B J Landis, A Jegga, C B Kern, W D Merryman, H S Baldwin, G M Bressan, Robert B Hinto. Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. Annals of biomedical engineering. vol 45. issue 11. 2018-06-18. PMID:28812215. |
protein alterations due to emilin1 deficiency, including changes in pathways and functions, preceded biomechanical aberrations, resulting in marked depletion of extracellular matrix (ecm) proteins interacting with tgfb1, including latent transforming growth factor beta 3 (ltbp3), fibulin 5 (fbln5), and cartilage intermediate layer protein 1 (cilp1). |
2018-06-18 |
2023-08-13 |
mouse |
| Ying Fang, Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Peter C K Leung, Xiaokui Yan. Transforming growth factor-β1 increases lysyl oxidase expression by downregulating MIR29A in human granulosa lutein cells. Reproduction (Cambridge, England). vol 152. issue 3. 2017-10-06. PMID:27335131. |
our findings suggest that tgfb1 and mir29a may play essential roles in the regulation of extracellular matrix remodeling during the periovulatory phase. |
2017-10-06 |
2023-08-13 |
human |
| Angela Gullard, Christina M Croney, Xiangwei Wu, Olga Mamaeva, Philip Sohn, Xu Cao, Mary MacDougal. Reduced Dentin Matrix Protein Expression in Camurati-Engelmann Disease Transgenic Mouse Model. Journal of cellular physiology. vol 231. issue 5. 2016-06-07. PMID:26427011. |
a tgfb1 point mutation (h222d), derived from published cases of camurati-engelmann disease (ced), has been shown to constitutively activate tgf-β1, leading to excess bone matrix production. |
2016-06-07 |
2023-08-13 |
mouse |
| Marc C Moore, Vittoria Pandolfi, Peter S McFetridg. Novel human-derived extracellular matrix induces in vitro and in vivo vascularization and inhibits fibrosis. Biomaterials. vol 49. 2015-11-17. PMID:25725553. |
gene expression profiles of endothelial cells seeded onto the matrix displayed upregulation of angiogenic genes (tgfb1, vegfa), remodeling genes (mmp9, lama5) and vascular development genes (hand2, lect1). |
2015-11-17 |
2023-08-13 |
human |
| Gretchen J Mahler, Christopher M Frendl, Qingfeng Cao, Jonathan T Butche. Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells. Biotechnology and bioengineering. vol 111. issue 11. 2015-05-22. PMID:24898772. |
low steady shear stress (2 dyne/cm(2) ) and oscillatory shear stress upregulated endmt (acta2, snail, tgfb1) and inflammation (icam1, nfkb1) related gene expression, endmt-related (αsma) protein expression, and matrix invasion when compared with static controls or cells exposed to high steady shear (10 and 20 dyne/cm(2) ). |
2015-05-22 |
2023-08-13 |
Not clear |