| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhang, Rong Wu, Feng Zhang, Yizhi Xu, Bo Liu, Yingying Yang, Huamei Zhou, Lulu Wang, Keqiang Wan, Xiaoqiu Xiao, Xia Zhan. Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway. Clinical and experimental pharmacology & physiology. vol 39. issue 12. 2014-01-21. PMID:23127227. |
pioglitazone significantly reduced the degree of hepatic steatosis and fibrosis, as well as serum concentrations of aminotransaminase, tg, ffa, glucose, insulin and tgf-β1 and hepatic expression of α-sma and collagen i protein. |
2014-01-21 |
2023-08-12 |
rat |
| Rebecca A Haeusler, Brenno Astiarraga, Stefania Camastra, Domenico Accili, Ele Ferrannin. Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids. Diabetes. vol 62. issue 12. 2014-01-17. PMID:23884887. |
furthermore, ratios of 12α-hydroxylated/non-12α-hydroxylated bas were associated with key features of ir, including higher insulin, proinsulin, glucose, glucagon, and triglyceride (tg) levels and lower hdl cholesterol. |
2014-01-17 |
2023-08-12 |
human |
| Olivia R L Wright, Ingrid J Hickman, William G Petchey, Clair M Sullivan, Cynthia Ong, Felicity J Rose, Choaping Ng, Johannes B Prins, Jonathan P Whitehead, Trisha M O'Moore-Sulliva. The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin? Canadian journal of physiology and pharmacology. vol 91. issue 6. 2014-01-13. PMID:23746304. |
we examined cross-sectional associations between serum 25-hydroxyvitamin d (25(oh)d) and insulin sensitivity (matsuda index), parathyroid hormone (pth), waist circumference, body mass index (bmi), triglycerides (tg), total and high molecular weight (hmw) adiponectin, hmw : total adiponectin ratio (hmw : total adiponectin), and total cholesterol : hdl cholesterol ratio (tc:hdl cholesterol) in 137 caucasian adults of mean age 43.3 ± 8.3 years and bmi 38.8 ± 6.9 kg/m(2). |
2014-01-13 |
2023-08-12 |
Not clear |
| Yang Shen, Yuyan Zhao, Delu Zheng, Xiaocen Chang, Shujing Ju, Lei Gu. Effects of orexin A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1 adipocytes. The Journal of steroid biochemistry and molecular biology. vol 138. 2014-01-08. PMID:23907013. |
we observed that ox1r protein expression was decreased in obese rats, and ox1r protein level was negatively correlated with body fat, lee's index, tg, total cholesterol, and fasting insulin levels. |
2014-01-08 |
2023-08-12 |
rat |
| Anne E Sumner, Jeremy D Furtado, Amber B Courville, Madia Ricks, Novie Younger-Coleman, Marshall K Tulloch-Reid, Frank M Sack. ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women. Nutrition & metabolism. vol 10. issue 1. 2013-12-27. PMID:24365086. |
our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (vat) and the apolipoproteins, b, c-iii and e, on race differences in tg content of very low density lipoproteins (vldl). |
2013-12-27 |
2023-08-12 |
Not clear |
| E Valle, D Storace, R Sanguineti, R Carter, P Odetti, R Geor, D Berger. Association of the glycoxidative stress marker pentosidine with equine laminitis. Veterinary journal (London, England : 1997). vol 196. issue 3. 2013-12-23. PMID:23206662. |
age, body condition score (bcs) and bodyweight were recorded and blood samples collected for the measurement of plasma concentrations of pent, glucose, insulin, triglycerides (tg), non-esterified fatty acids (nefa) and cortisol. |
2013-12-23 |
2023-08-12 |
human |
| E Valle, D Storace, R Sanguineti, R Carter, P Odetti, R Geor, D Berger. Association of the glycoxidative stress marker pentosidine with equine laminitis. Veterinary journal (London, England : 1997). vol 196. issue 3. 2013-12-23. PMID:23206662. |
significant (p<0.05) correlations were also evident between pent and insulin, risqi, tg and age. |
2013-12-23 |
2023-08-12 |
human |
| Do Yeon Kim, Jinkyung Kim, Hye Jin Ham, Ryowon Chou. Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model. Nutrition research and practice. vol 7. issue 6. 2013-12-19. PMID:24353834. |
the results showed that the hf diet induced insulin resistance and altered the lipid profile, specifically the triglyceride (tg) and total cholesterol (tc) levels (p < 0.05). |
2013-12-19 |
2023-08-12 |
mouse |
| Do Yeon Kim, Jinkyung Kim, Hye Jin Ham, Ryowon Chou. Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model. Nutrition research and practice. vol 7. issue 6. 2013-12-19. PMID:24353834. |
in this animal model, supplementation with d-α-tocopherol improved insulin resistance as well as the serum levels of tg and very-low-density lipoprotein-cholesterol (vldl-c) (p < 0.05). |
2013-12-19 |
2023-08-12 |
mouse |
| Yoshimasa Aso, Tomoko Terasawa, Kanako Kato, Teruo Jojima, Kunihiro Suzuki, Toshie Iijima, Yoshiaki Kawagoe, Shigeru Mikami, Yoshiro Kubota, Toshihiko Inukai, Kikuo Kasa. The serum level of soluble CD26/dipeptidyl peptidase 4 increases in response to acute hyperglycemia after an oral glucose load in healthy subjects: association with high-molecular weight adiponectin and hepatic enzymes. Translational research : the journal of laboratory and clinical medicine. vol 162. issue 5. 2013-12-17. PMID:23994650. |
the peak scd26/dpp4 level correlated positively with the baseline age and body mass index, and fasting plasma glucose (fpg), homeostasis model assessment of insulin resistance (homa-ir), triglycerides (tg), alanine aminotransferase, and γ-glutamyl transpeptidase (ggt) levels whereas it correlated negatively with high-density lipoprotein (hdl) cholesterol and the serum levels of total and high-molecular weight (hmw) adiponectin. |
2013-12-17 |
2023-08-12 |
human |
| Alan K L Kai, Amy K M Lam, Yingxian Chen, Andrew C P Tai, Xinmei Zhang, Angela K W Lai, Patrick K K Yeung, Sidney Tam, Jian Wang, Karen S Lam, Paul M Vanhoutte, Johannes L Bos, Stephen S M Chung, Aimin Xu, Sookja K Chun. Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 10. 2013-12-16. PMID:23825225. |
interestingly, epac1(-/-) mice also showed metabolic defects, including increased respiratory exchange ratio (rer) and plasma triglyceride (tg), and more severe diet-induced obesity with insulin resistance, which may contributed to β-cell dysfunction. |
2013-12-16 |
2023-08-12 |
mouse |
| Jiyin Zhou, Shiwen Zhou, Shengya Zen. Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters. Fundamental & clinical pharmacology. vol 27. issue 3. 2013-12-10. PMID:22172053. |
after 4-week treatment, blood glucose, serum insulin, total cholesterol (tc), and triglyceride (tg) levels, insulin content in pancreas, and oxidative stress parameters in pancreatic homogenate were assayed. |
2013-12-10 |
2023-08-12 |
rat |
| Min Park, Donghai Wu, Taesik Park, Cheol-soo Choi, Ren-Ke Li, Kenneth K Y Cheng, Aimin Xu, Gary Sweene. APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction. American journal of physiology. Endocrinology and metabolism. vol 305. issue 7. 2013-12-09. PMID:23921137. |
a glucose tolerance test indicated less peripheral insulin resistance in response to hfd in tg mice, which was also apparent by measuring cardiac akt phosphorylation and cardiomyocyte glucose uptake. |
2013-12-09 |
2023-08-12 |
mouse |
| Min Park, Donghai Wu, Taesik Park, Cheol-soo Choi, Ren-Ke Li, Kenneth K Y Cheng, Aimin Xu, Gary Sweene. APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction. American journal of physiology. Endocrinology and metabolism. vol 305. issue 7. 2013-12-09. PMID:23921137. |
in summary, appl1 tg mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin sensitivity. |
2013-12-09 |
2023-08-12 |
mouse |
| Adam Gesing, Andrzej Bartke, Michal M Masterna. Pioglitazone does not improve insulin signaling in mice with GH over-expression. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23946430. |
transgenic (tg) mice over-expressing bovine gh are short-living and characterized, among other traits, by hyperinsulinemia and increased insulin resistance in comparison with normal (n) mice. |
2013-12-03 |
2023-08-12 |
mouse |
| Adam Gesing, Andrzej Bartke, Michal M Masterna. Pioglitazone does not improve insulin signaling in mice with GH over-expression. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23946430. |
in the liver, pio decreased the phosphorylation of insulin receptor substrate-1 (irs1) at a serine residue (ser(307)-ps-irs1), which inhibits insulin action, and had a tendency to increase tyrosine phosphorylation of irs2 (tyr-py-irs2) only in n mice but did not affect either of these parameters in tg mice. |
2013-12-03 |
2023-08-12 |
mouse |
| Adam Gesing, Andrzej Bartke, Michal M Masterna. Pioglitazone does not improve insulin signaling in mice with GH over-expression. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23946430. |
in conclusion, the lack of improvement of insulin sensitivity in insulin-resistant tg mice during pio treatment indicates that chronically elevated gh levels can inhibit the beneficial effects of pio on insulin signaling. |
2013-12-03 |
2023-08-12 |
mouse |
| Seyyedeh Elaheh Mousavi, Ali Shahriari, Akram Ahangarpour, Hossein Vatanpour, Abbas Joloda. Effects of Teucrium polium Ethyl acetate Extract on Serum, Liver and Muscle Triglyceride Content of Sucrose-Induced Insulin Resistance in Rat. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 1. 2013-11-19. PMID:24250458. |
the treatment with t. polium ethyl acetate extract (tp-eae) induced a dose-dependent reduction in serum, liver and muscle triglyceride (tg) and liver glycogen content levels, as well as serum insulin. |
2013-11-19 |
2023-08-12 |
rat |
| Farzad Shidfar, Shima Seyyed Ebrahimi, Sharieh Hosseini, Iraj Heydari, Shahrzad Shidfar, Giti Hajhassan. The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 2. 2013-11-19. PMID:24250489. |
there were significant decreases in serum tg, tc, ldl-c, apo b, glucose, and insulin and also a significant increase in tac at the end of the study in bvfe group compared to the control group (p = 0.001, p = 0.001, p = 0.001, p = 0.001, p = 0.002, p = 0.01 and p = 0.0001 respectively). |
2013-11-19 |
2023-08-12 |
Not clear |
| Farzad Shidfar, Shima Seyyed Ebrahimi, Sharieh Hosseini, Iraj Heydari, Shahrzad Shidfar, Giti Hajhassan. The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 2. 2013-11-19. PMID:24250489. |
there were significant differences in serum tg (p = 0.0001), tc (p = 0.001), ldl-c (p = 0.001), apob (p = 0.001), glucose (p = 0.002), insulin (p = 0.01), tac (p = 0.005), and insulin resistance (p = 0.01) between the two groups at the end of the study; but homocysteine, hba1c and hdl-c showed no significant changes between the two groups at the end of study. |
2013-11-19 |
2023-08-12 |
Not clear |