All Relations between tg and astrocyte

Publication Sentence Publish Date Extraction Date Species
Margaret Bell, Mariame S Kane, Xiaosen Ouyang, Martin E Young, Anil G Jegga, John C Chatham, Victor Darley-Usmar, Jianhua Zhan. Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345543. when comparing acute to chronic tg treatment, protein autophosphorylation and kinase activity pathways were upregulated, whereas cell adhesion and astrocyte markers were downregulated in both datasets. 2024-09-30 2024-10-02 mouse
Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhan. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 5. 2021-11-22. PMID:33219470. proteins including glt1 and gfap, from sod1 g93a tg (transgenic) astrocyte lysate were determined by western blot. 2021-11-22 2023-08-13 Not clear
Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhan. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 5. 2021-11-22. PMID:33219470. ten micromolars ech could significantly rescue the suppressed glt1 level expressed by sod1 tg astrocyte. 2021-11-22 2023-08-13 Not clear
Donna L Gruol, Ruben V Hernandez, Amanda Robert. Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6. Cellular and molecular neurobiology. vol 41. issue 6. 2021-07-31. PMID:32562098. surprisingly, in our in vitro studies of ltp at the schaffer collateral to ca1 pyramidal neuron synapse in hippocampus from transgenic mice that express elevated levels of astrocyte produced il-6 (tg), ltp was not altered by the increased levels of il-6. 2021-07-31 2023-08-13 mouse
Yongmin Mason Park, Heejung Chun, Jeong-Im Shin, C Justin Le. Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions. Experimental neurobiology. vol 27. issue 6. 2020-10-01. PMID:30636902. astrocyte specificity and coverage of hgfap-creert2 [tg(gfap-cre/ert2)13kdmc] mouse line in various brain regions. 2020-10-01 2023-08-13 mouse
Min-Fang Guo, Hui-Yu Zhang, Yan-Hua Li, Qing-Fang Gu, Wen-Yue Wei, Yu-Yin Wang, Xiao-Juan Zhang, Xiao-Qin Liu, Li-Juan Song, Zhi Chai, Jie-Zhong Yu, Cun-Gen M. Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway. Journal of neuroimmunology. vol 346. 2020-07-22. PMID:32652366. in the present study, we observed an obvious microglial activation and a1-specific astrocyte response in the brain tissue of app/ps1 tg mice. 2020-07-22 2023-08-13 mouse
Tauqeerunnisa Syeda, Mónica Sanchez-Tapia, Laura Pinedo-Vargas, Omar Granados, Daniel Cuervo-Zanatta, Eleazar Rojas-Santiago, Sof A Díaz-Cintra, Nimbe Torres, Claudia Perez-Cru. Bioactive Food Abates Metabolic and Synaptic Alterations by Modulation of Gut Microbiota in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30475761. in addition, bf decreased mda levels, astrocyte and microglial activation, psd-95, synaptophysin, glur1 and arc protein levels in tg mice. 2019-11-25 2023-08-13 mouse
Shao-Qin Zheng, Zi-Yi Gong, Chen-Di Lu, Pu Wan. Prostaglandin I Oncotarget. vol 8. issue 61. 2019-11-20. PMID:29262525. using mouse-derived astrocyte and app/ps1 transgenic (tg) mice as model systems, we firstly elucidated the mechanisms underlying cox-2 metabolic production including prostaglandin (pg)e 2019-11-20 2023-08-13 mouse
Donna L Gruol, Salvador Huitron-Resendiz, Amanda J Robert. Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6. Neuropharmacology. vol 138. 2019-02-13. PMID:29787738. to gain insight into il-6/alcohol/withdrawal interactions and how these interactions affect the brain, we are studying the effects of chronic binge alcohol exposure on transgenic mice that express elevated levels of il-6 in the brain due to increased astrocyte expression (il-6 tg) and their non-transgenic (non-tg) littermate controls. 2019-02-13 2023-08-13 mouse
Alexander A Sosunov, Guy M McKhann, James E Goldma. The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28359321. we have used mouse models of axd based on the overexpression of human gfap (transgenic, tg) and a point mutation in mouse gfap (knock-in, ki) to examine the formation of rfs and to find astrocyte changes that correlate with the appearance of rfs. 2017-10-25 2023-08-13 mouse
Manuel van Gijsel-Bonnello, Kévin Baranger, Philippe Benech, Santiago Rivera, Michel Khrestchatisky, Max de Reggi, Bouchra Ghari. Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine. PloS one. vol 12. issue 4. 2017-04-25. PMID:28410378. we used the 5xfad transgenic mouse model of ad (tg thereafter) to generate astrocyte cultures and investigate the impact of the genotype on metabolic changes and astrocytes activation. 2017-04-25 2023-08-13 mouse
Hyung-Mun Yun, Dong Young Choi, Ki Wan Oh, Jin Tae Hon. PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease. Molecular neurobiology. vol 52. issue 1. 2016-05-02. PMID:25193021. immunohistochemistry (ihc) and western blot data for tyrosine hydroxylase (th) showed that prdx6 tg mice had much higher loss of dopaminergic neurons by mptp administration compared to non-tg mice, as well as there was much higher behavioral impairment and astrocyte activation in prdx6 tg mice. 2016-05-02 2023-08-13 mouse
Arumugam R Jayakumar, Xiao Y Tong, Roberto Ruiz-Cordero, Amade Bregy, John R Bethea, Helen M Bramlett, Michael D Norenber. Activation of NF-κB mediates astrocyte swelling and brain edema in traumatic brain injury. Journal of neurotrauma. vol 31. issue 14. 2015-03-31. PMID:24471369. by contrast, traumatized astrocyte cultures derived from nf-κb tg mice showed no swelling. 2015-03-31 2023-08-12 mouse
Arumugam R Jayakumar, Xiao Y Tong, Roberto Ruiz-Cordero, Amade Bregy, John R Bethea, Helen M Bramlett, Michael D Norenber. Activation of NF-κB mediates astrocyte swelling and brain edema in traumatic brain injury. Journal of neurotrauma. vol 31. issue 14. 2015-03-31. PMID:24471369. we also examined the role of nf-κb in the mechanism of cell swelling by using astrocyte cultures derived from transgenic (tg) mice with a functional inactivation of astrocytic nf-κb. 2015-03-31 2023-08-12 mouse
Jean Kim, Tae-Youn Kim, Kyung-Sook Cho, Ha Na Kim, Jae-Young Ko. Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Neurobiology of disease. vol 59. 2014-05-05. PMID:23891729. pg treatment increased autophagic flux in g93a-sod1 tg spinal cord astrocyte cultures and mice. 2014-05-05 2023-08-12 mouse
Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. to study the effects of gfap mutations on astrocyte morphology and physiology, we have examined hippocampal astrocytes in three mouse models of axd, a transgenic line (gfap(tg)) in which the normal human gfap is expressed in several copies, a knock-in line (gfap(+/r236h)) in which one of the gfap genes bears an r236h mutation, and a mouse derived from the mating of these two lines (gfap(tg); gfap(+/r236h)). 2013-06-25 2023-08-12 mouse
Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. we report changes in astrocyte phenotype in all lines, with the most severe in the gfap(tg);gfap(+/r236h), resulting in the conversion of protoplasmic astrocytes to cells that have lost their bushy-like morphology because of a reduction of distal fine processes, and become multinucleated and hypertrophic. 2013-06-25 2023-08-12 mouse
A R Jayakumar, J R Bethea, X Y Tong, J Gomez, M D Norenber. NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:21087666. astrocyte cultures derived from tg mice showed no cell swelling nor morphological abnormalities when exposed to ammonia for 24h. 2011-11-22 2023-08-12 mouse
A R Jayakumar, J R Bethea, X Y Tong, J Gomez, M D Norenber. NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:21087666. moreover, we observed a lesser increment in inos and nadph oxidase activity (the latter is also known to be activated by nf-κb and to contribute to astrocyte swelling) in astrocyte cultures from tg mice treated with ammonia, as compared to ammonia-treated wt mice astrocytes. 2011-11-22 2023-08-12 mouse
Yea-Hyun Leem, Young-Ik Lee, Hee-Jeong Son, Sang-Ho Le. Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23. Biochemical and biophysical research communications. vol 406. issue 3. 2011-05-12. PMID:21329662. the brains of tg mice exhibited increased immunoreactivity and active morphological changes in gfap (astrocyte marker) and mac-1 (microglia marker) expression in an age-dependent manner. 2011-05-12 2023-08-12 mouse