Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Margaret Bell, Mariame S Kane, Xiaosen Ouyang, Martin E Young, Anil G Jegga, John C Chatham, Victor Darley-Usmar, Jianhua Zhan. Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345543. |
when comparing acute to chronic tg treatment, protein autophosphorylation and kinase activity pathways were upregulated, whereas cell adhesion and astrocyte markers were downregulated in both datasets. |
2024-09-30 |
2024-10-02 |
mouse |
Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhan. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 5. 2021-11-22. PMID:33219470. |
proteins including glt1 and gfap, from sod1 g93a tg (transgenic) astrocyte lysate were determined by western blot. |
2021-11-22 |
2023-08-13 |
Not clear |
Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhan. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 5. 2021-11-22. PMID:33219470. |
ten micromolars ech could significantly rescue the suppressed glt1 level expressed by sod1 tg astrocyte. |
2021-11-22 |
2023-08-13 |
Not clear |
Donna L Gruol, Ruben V Hernandez, Amanda Robert. Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6. Cellular and molecular neurobiology. vol 41. issue 6. 2021-07-31. PMID:32562098. |
surprisingly, in our in vitro studies of ltp at the schaffer collateral to ca1 pyramidal neuron synapse in hippocampus from transgenic mice that express elevated levels of astrocyte produced il-6 (tg), ltp was not altered by the increased levels of il-6. |
2021-07-31 |
2023-08-13 |
mouse |
Yongmin Mason Park, Heejung Chun, Jeong-Im Shin, C Justin Le. Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions. Experimental neurobiology. vol 27. issue 6. 2020-10-01. PMID:30636902. |
astrocyte specificity and coverage of hgfap-creert2 [tg(gfap-cre/ert2)13kdmc] mouse line in various brain regions. |
2020-10-01 |
2023-08-13 |
mouse |
Min-Fang Guo, Hui-Yu Zhang, Yan-Hua Li, Qing-Fang Gu, Wen-Yue Wei, Yu-Yin Wang, Xiao-Juan Zhang, Xiao-Qin Liu, Li-Juan Song, Zhi Chai, Jie-Zhong Yu, Cun-Gen M. Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway. Journal of neuroimmunology. vol 346. 2020-07-22. PMID:32652366. |
in the present study, we observed an obvious microglial activation and a1-specific astrocyte response in the brain tissue of app/ps1 tg mice. |
2020-07-22 |
2023-08-13 |
mouse |
Tauqeerunnisa Syeda, Mónica Sanchez-Tapia, Laura Pinedo-Vargas, Omar Granados, Daniel Cuervo-Zanatta, Eleazar Rojas-Santiago, Sof A Díaz-Cintra, Nimbe Torres, Claudia Perez-Cru. Bioactive Food Abates Metabolic and Synaptic Alterations by Modulation of Gut Microbiota in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30475761. |
in addition, bf decreased mda levels, astrocyte and microglial activation, psd-95, synaptophysin, glur1 and arc protein levels in tg mice. |
2019-11-25 |
2023-08-13 |
mouse |
Shao-Qin Zheng, Zi-Yi Gong, Chen-Di Lu, Pu Wan. Prostaglandin I Oncotarget. vol 8. issue 61. 2019-11-20. PMID:29262525. |
using mouse-derived astrocyte and app/ps1 transgenic (tg) mice as model systems, we firstly elucidated the mechanisms underlying cox-2 metabolic production including prostaglandin (pg)e |
2019-11-20 |
2023-08-13 |
mouse |
Donna L Gruol, Salvador Huitron-Resendiz, Amanda J Robert. Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6. Neuropharmacology. vol 138. 2019-02-13. PMID:29787738. |
to gain insight into il-6/alcohol/withdrawal interactions and how these interactions affect the brain, we are studying the effects of chronic binge alcohol exposure on transgenic mice that express elevated levels of il-6 in the brain due to increased astrocyte expression (il-6 tg) and their non-transgenic (non-tg) littermate controls. |
2019-02-13 |
2023-08-13 |
mouse |
Alexander A Sosunov, Guy M McKhann, James E Goldma. The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28359321. |
we have used mouse models of axd based on the overexpression of human gfap (transgenic, tg) and a point mutation in mouse gfap (knock-in, ki) to examine the formation of rfs and to find astrocyte changes that correlate with the appearance of rfs. |
2017-10-25 |
2023-08-13 |
mouse |
Manuel van Gijsel-Bonnello, Kévin Baranger, Philippe Benech, Santiago Rivera, Michel Khrestchatisky, Max de Reggi, Bouchra Ghari. Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine. PloS one. vol 12. issue 4. 2017-04-25. PMID:28410378. |
we used the 5xfad transgenic mouse model of ad (tg thereafter) to generate astrocyte cultures and investigate the impact of the genotype on metabolic changes and astrocytes activation. |
2017-04-25 |
2023-08-13 |
mouse |
Hyung-Mun Yun, Dong Young Choi, Ki Wan Oh, Jin Tae Hon. PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease. Molecular neurobiology. vol 52. issue 1. 2016-05-02. PMID:25193021. |
immunohistochemistry (ihc) and western blot data for tyrosine hydroxylase (th) showed that prdx6 tg mice had much higher loss of dopaminergic neurons by mptp administration compared to non-tg mice, as well as there was much higher behavioral impairment and astrocyte activation in prdx6 tg mice. |
2016-05-02 |
2023-08-13 |
mouse |
Arumugam R Jayakumar, Xiao Y Tong, Roberto Ruiz-Cordero, Amade Bregy, John R Bethea, Helen M Bramlett, Michael D Norenber. Activation of NF-κB mediates astrocyte swelling and brain edema in traumatic brain injury. Journal of neurotrauma. vol 31. issue 14. 2015-03-31. PMID:24471369. |
by contrast, traumatized astrocyte cultures derived from nf-κb tg mice showed no swelling. |
2015-03-31 |
2023-08-12 |
mouse |
Arumugam R Jayakumar, Xiao Y Tong, Roberto Ruiz-Cordero, Amade Bregy, John R Bethea, Helen M Bramlett, Michael D Norenber. Activation of NF-κB mediates astrocyte swelling and brain edema in traumatic brain injury. Journal of neurotrauma. vol 31. issue 14. 2015-03-31. PMID:24471369. |
we also examined the role of nf-κb in the mechanism of cell swelling by using astrocyte cultures derived from transgenic (tg) mice with a functional inactivation of astrocytic nf-κb. |
2015-03-31 |
2023-08-12 |
mouse |
Jean Kim, Tae-Youn Kim, Kyung-Sook Cho, Ha Na Kim, Jae-Young Ko. Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Neurobiology of disease. vol 59. 2014-05-05. PMID:23891729. |
pg treatment increased autophagic flux in g93a-sod1 tg spinal cord astrocyte cultures and mice. |
2014-05-05 |
2023-08-12 |
mouse |
Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. |
to study the effects of gfap mutations on astrocyte morphology and physiology, we have examined hippocampal astrocytes in three mouse models of axd, a transgenic line (gfap(tg)) in which the normal human gfap is expressed in several copies, a knock-in line (gfap(+/r236h)) in which one of the gfap genes bears an r236h mutation, and a mouse derived from the mating of these two lines (gfap(tg); gfap(+/r236h)). |
2013-06-25 |
2023-08-12 |
mouse |
Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. |
we report changes in astrocyte phenotype in all lines, with the most severe in the gfap(tg);gfap(+/r236h), resulting in the conversion of protoplasmic astrocytes to cells that have lost their bushy-like morphology because of a reduction of distal fine processes, and become multinucleated and hypertrophic. |
2013-06-25 |
2023-08-12 |
mouse |
A R Jayakumar, J R Bethea, X Y Tong, J Gomez, M D Norenber. NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:21087666. |
astrocyte cultures derived from tg mice showed no cell swelling nor morphological abnormalities when exposed to ammonia for 24h. |
2011-11-22 |
2023-08-12 |
mouse |
A R Jayakumar, J R Bethea, X Y Tong, J Gomez, M D Norenber. NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:21087666. |
moreover, we observed a lesser increment in inos and nadph oxidase activity (the latter is also known to be activated by nf-κb and to contribute to astrocyte swelling) in astrocyte cultures from tg mice treated with ammonia, as compared to ammonia-treated wt mice astrocytes. |
2011-11-22 |
2023-08-12 |
mouse |
Yea-Hyun Leem, Young-Ik Lee, Hee-Jeong Son, Sang-Ho Le. Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23. Biochemical and biophysical research communications. vol 406. issue 3. 2011-05-12. PMID:21329662. |
the brains of tg mice exhibited increased immunoreactivity and active morphological changes in gfap (astrocyte marker) and mac-1 (microglia marker) expression in an age-dependent manner. |
2011-05-12 |
2023-08-12 |
mouse |