| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siavash Fazel Darbandi, Joon-Yong An, Kenneth Lim, Nicholas F Page, Lindsay Liang, David M Young, Athena R Ypsilanti, Matthew W State, Alex S Nord, Stephan J Sanders, John L R Rubenstei. Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes. Cell reports. vol 43. issue 6. 2024-06-08. PMID:38850535. |
chromatin immunoprecipitation sequencing (chip-seq) was used to identify the regulatory targets of arid1b, bcl11a, foxp1, tbr1, and tcf7l2, asd-associated trs in the developing human and mouse cortex. |
2024-06-08 |
2024-06-11 |
mouse |
| Limin Gao, Shuqiang Gao, Hailei Shan, Yanqiu Wu, Qili Zho. GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats. Neuroreport. vol 35. issue 3. 2024-02-02. PMID:38305107. |
additionally, compared to the hi group, tws119 treatment up-regulated cend1 expression and promoted neuronal differentiation and cortex development based on neun and tbr1 expression. |
2024-02-02 |
2024-02-04 |
rat |
| Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Héctor R Méndez-Gómez, Miriam Esgleas, María José Román, Josep M Canals, Shubha Tole, Carlos Vicari. Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex. Molecular neurobiology. 2022-07-05. PMID:35781633. |
indeed, t-box brain1 (tbr1) is a tf crucial for the formation of neocortical layer vi, and mutations and microdeletions in that gene are associated with malformations in the human cerebral cortex, alterations that accompany autism spectrum disorder (asd). |
2022-07-05 |
2023-08-14 |
mouse |
| Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Héctor R Méndez-Gómez, Miriam Esgleas, María José Román, Josep M Canals, Shubha Tole, Carlos Vicari. Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex. Molecular neurobiology. 2022-07-05. PMID:35781633. |
tbr1 misexpression alters neuronal development in the cerebral cortex. |
2022-07-05 |
2023-08-14 |
mouse |
| Sophie Nambot, Laurence Faivre, Ghayda Mirzaa, Julien Thevenon, Ange-Line Bruel, Anne-Laure Mosca-Boidron, Alice Masurel-Paulet, Alice Goldenberg, Nathalie Le Meur, Aude Charollais, Cyril Mignot, Florence Petit, Massimiliano Rossi, Julia Metreau, Valérie Layet, Daniel Amram, Odile Boute-Bénéjean, Elizabeth Bhoj, Margot A Cousin, Teresa M Kruisselbrink, Brendan C Lanpher, Eric W Klee, Elise Fiala, Dorothy K Grange, Wendy S Meschino, Susan M Hiatt, Gregory M Cooper, Hilde Olivié, Wendy E Smith, Meghan Dumas, Anna Lehman, Cara Inglese, Mathilde Nizon, Renzo Guerrini, Annalisa Vetro, Eitan S Kaplan, Dolores Miramar, Julien Van Gils, Patricia Fergelot, Olaf Bodamer, Johanna C Herkert, Sander Pajusalu, Katrin Õunap, James J Filiano, Thomas Smol, Amélie Piton, Bénédicte Gérard, Sandra Chantot-Bastaraud, Thierry Bienvenu, Dong Li, Jane Juusola, Koen Devriendt, Frederic Bilan, Charlotte Poé, Martin Chevarin, Thibaud Jouan, Emilie Tisserant, Jean-Baptiste Rivière, Frédéric Tran Mau-Them, Christophe Philippe, Yannis Duffourd, William B Dobyns, Robert Hevner, Christel Thauvin-Robine. De novo TBR1 variants cause a neurocognitive phenotype with ID and autistic traits: report of 25 new individuals and review of the literature. European journal of human genetics : EJHG. vol 28. issue 6. 2021-05-27. PMID:32005960. |
tbr1, a t-box transcription factor expressed in the cerebral cortex, regulates the expression of several candidate genes for autism spectrum disorders (asd). |
2021-05-27 |
2023-08-13 |
mouse |
| Rocío Valle-Bautista, Berenice Márquez-Valadez, América D Fragoso-Cabrera, Guadalupe García-López, Néstor Fabián Díaz, Gabriel Herrera-López, Ernesto Griego, Emilio J Galván, José-Antonio Arias-Montaño, Anayansi Molina-Hernánde. Impaired Cortical Cytoarchitecture and Reduced Excitability of Deep-Layer Neurons in the Offspring of Diabetic Rats. Frontiers in cell and developmental biology. vol 8. 2020-10-13. PMID:33042999. |
through molecular, biochemical, morphological, and electrophysiological approaches, we provide evidence of impaired primary motor cerebral cortex lamination and neuronal function in pups from diabetic rats, showing an altered distribution of satb2, foxp2, and tbr1, impaired cell migration and polarity, and decreased excitability of deep-layer cortical neurons, suggesting abnormalities in cortico-cortical and extra-cortical innervation. |
2020-10-13 |
2023-08-13 |
rat |
| Elisenda Bueichekú, Maite Aznárez-Sanado, Ibai Diez, Federico d'Oleire Uquillas, Laura Ortiz-Terán, Abid Y Qureshi, Maria Suñol, Silvia Basaia, Elena Ortiz-Terán, Maria A Pastor, Jorge Sepulcr. Central neurogenetic signatures of the visuomotor integration system. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 12. 2020-07-07. PMID:32144139. |
our findings delineate gene expression traits underlying the vmi system in the human cortex, where specific genes, such as tbr1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes. |
2020-07-07 |
2023-08-13 |
human |
| Elisenda Bueichekú, Maite Aznárez-Sanado, Ibai Diez, Federico d'Oleire Uquillas, Laura Ortiz-Terán, Abid Y Qureshi, Maria Suñol, Silvia Basaia, Elena Ortiz-Terán, Maria A Pastor, Jorge Sepulcr. Central neurogenetic signatures of the visuomotor integration system. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 12. 2020-07-07. PMID:32144139. |
tbr1 gene transcripts, an asd gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the vmi system. |
2020-07-07 |
2023-08-13 |
human |
| Ming-Wei Chao, Hui-Chuan Kuo, Sih-Yu Tong, Yu-Shiu Yang, Yu-Chen Chuang, Chia-Yi Tsen. In Vitro and In Vivo Analysis of the Effects of 3,5-DMA and Its Metabolites in Neural Oxidative Stress and Neurodevelopmental Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 168. issue 2. 2020-03-12. PMID:30590852. |
to detect the laminar position of newly generated neurons, cortex layer markers such as satb2, ctip2, and tbr1 were used. |
2020-03-12 |
2023-08-13 |
rat |
| E K Stachowiak, C A Benson, S T Narla, A Dimitri, L E Bayona Chuye, S Dhiman, K Harikrishnan, S Elahi, D Freedman, K J Brennand, P Sarder, M K Stachowia. Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1. Translational psychiatry. vol 7. issue 11. 2018-12-24. PMID:30446636. |
tbr1 pioneer neurons and reelin, which guides cortico-petal migration, were restricted from the schizophrenia cortex. |
2018-12-24 |
2023-08-13 |
human |
| Ming-Wei Chao, Chie-Pein Chen, Yu-Hsiu Yang, Yu-Chen Chuang, Tzu-Yun Chu, Chia-Yi Tsen. N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain. Scientific reports. vol 6. 2018-05-22. PMID:27577752. |
in the enlarged fetal cortex, laminar positioning of the early born cortical cells expressing tbr1 and ctip2 was disrupted, with a scattered distribution. |
2018-05-22 |
2023-08-13 |
rat |
| Ayman Alzu'bi, Susan Lindsay, Janet Kerwin, Shi Jie Looi, Fareha Khalil, Gavin J Clowr. Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. Brain structure & function. vol 222. issue 5. 2018-04-17. PMID:27905023. |
dividing coup-tfii+ progenitor cells were localized to ventral cge as previously described but were also numerous in adjacent ventral cortex; in both the cases, coup-tfii was co-expressed with pax6 in proliferative zones and tbr1 or calretinin in post-mitotic cortical neurons. |
2018-04-17 |
2023-08-13 |
human |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
it is known that glutamatergic cells are disordered with tbr1 ko such that normal laying of the cortex, with newer born cells residing in superficial layers, does not occur. |
2017-10-13 |
2023-08-13 |
mouse |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by tbr1 ko. |
2017-10-13 |
2023-08-13 |
mouse |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
however, the fate of cortical interneurons is not well studied, nor is the ability of tbr1 deficient cortex to express normal physiological activity. |
2017-10-13 |
2023-08-13 |
mouse |
| C R Easton, C W Dickey, S P Moen, K E Neuzil, Z Barger, T M Anderson, W J Moody, R F Hevne. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Developmental neurobiology. vol 76. issue 7. 2017-10-13. PMID:26473411. |
in cortex, glutamatergic neurons express tbr1 just before the onset of population electrical activity that is accompanied by intracellular ca(2+) increases. |
2017-10-13 |
2023-08-13 |
mouse |
| A B Mihalas, R F Hevne. Control of Neuronal Development by T-Box Genes in the Brain. Current topics in developmental biology. vol 122. 2017-05-08. PMID:28057268. |
in developing cerebral cortex, tbr2 and tbr1 are expressed during successive stages of differentiation in the pyramidal neuron lineage, from tbr2+ intermediate progenitors to tbr1+ postmitotic glutamatergic neurons. |
2017-05-08 |
2023-08-13 |
Not clear |
| A B Mihalas, R F Hevne. Control of Neuronal Development by T-Box Genes in the Brain. Current topics in developmental biology. vol 122. 2017-05-08. PMID:28057268. |
the tbr1 subfamily of t-box genes is particularly important in development of the cerebral cortex, olfactory bulbs (obs), and cerebellum. |
2017-05-08 |
2023-08-13 |
Not clear |
| Lauren F Harkin, Dianne Gerrelli, Diana C Gold Diaz, Chloe Santos, Ayman Alzu'bi, Caroline A Austin, Gavin J Clowr. Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon. Journal of anatomy. vol 228. issue 3. 2016-10-28. PMID:26612825. |
in the cortex, top2b is expressed in cell nuclei in both proliferative (svz) and post-mitotic compartments (intermediate zone and cortical plate) as revealed by comparison with immunostaining for pax6 and the post-mitotic neuron marker tbr1. |
2016-10-28 |
2023-08-13 |
human |
| Tzyy-Nan Huang, Yi-Ping Hsue. Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders. Frontiers in neuroscience. vol 9. 2015-11-20. PMID:26578866. |
although neuronal migration and axonal projection defects of cerebral cortex are the most prominent phenotypes in tbr1 (-∕-) mice, these features are not found in tbr1 (+∕-) mice. |
2015-11-20 |
2023-08-13 |
mouse |