| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soo Jung Park, Jee Hoon Lee, Hee Young Kim, Youn Hee Choi, Jung Sup Park, Young Ho Suh, Sang Myun Park, Eun-hye Joe, Ilo Jo. Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 10. 2012-08-07. PMID:22504638. |
in the current study, we demonstrated that astrocytes sense h(2)o(2) by rapidly phosphorylating the transcription factor stat6, a response not observed in microglia. |
2012-08-07 |
2023-08-12 |
Not clear |
| Thomas Zeis, Ursula Graumann, Richard Reynolds, Nicole Schaeren-Wiemer. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:18056737. |
immunofluorescence colocalization analysis revealed expression of stat6, jak1, il-4r and il-13r mainly in oligodendrocytes, whereas stat4 expression was detected predominantly in microglia. |
2008-03-06 |
2023-08-12 |
Not clear |
| Thomas Zeis, Ursula Graumann, Richard Reynolds, Nicole Schaeren-Wiemer. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:18056737. |
the consistency of the expression levels of stat6, jak1, jak3 and il-4r between the multiple sclerosis cases suggests an overall activation of the stat6-signalling pathway in oligodendrocytes, whereas the expression of stat4 and hla-dralpha indicates the activation of pro-inflammatory pathways in microglia. |
2008-03-06 |
2023-08-12 |
Not clear |
| Pablo Iribarren, Keqiang Chen, Jinyue Hu, Xia Zhang, Wanghua Gong, Ji Ming Wan. IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 9. 2005-11-29. PMID:16237106. |
the effect of il-4 was not dependent on stat6 but rather required the protein phosphatase 2a (pp2a) as demonstrated by the capacity of pp2a small interfering rna to reverse the effect of il-4 in tnf-alpha-activated microglia. |
2005-11-29 |
2023-08-12 |
mouse |
| Y Jee, G Kim, N Tanuma, Y Matsumot. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. Journal of neuroimmunology. vol 114. issue 1-2. 2001-04-12. PMID:11240014. |
immunohistochemical examinations revealed that stat3 and stat4, but not stat1 and stat6, immunoreactivities were mainly expressed in astrocytes and microglia, respectively, and were closely associated with inflammatory lesions. |
2001-04-12 |
2023-08-12 |
rat |
| S M Liva, M A Kahn, J M Dopp, J de Velli. Signal transduction pathways induced by GM-CSF in microglia: significance in the control of proliferation. Glia. vol 26. issue 4. 1999-09-09. PMID:10383053. |
primary microglia and bv-2 cells expressed identical jak/stats: jakl, jak2, jak3, tyk2, stat1alpha/beta, stat3, stat5a, stat5b, and stat6. |
1999-09-09 |
2023-08-12 |
Not clear |