| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen, Zhiqiang Li, Jincao Chen, Lianrong Wang, Shi Che. Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-03. PMID:39225620. |
when sorl1 is depleted, the endolysosome takes up more of the lysosome flux and damages lysosomal digestion, leading to pathological lysosomal storage and disturbance of cholesterol and iron homeostasis in the hippocampus. |
2024-09-03 |
2024-09-05 |
rat |
| Zhen Jin, Kyung Eun Kim, Hyun Joo Shin, Eun Ae Jeong, Kyung-Ah Park, Jong Youl Lee, Hyeong Seok An, Eun Bee Choi, Jae Hun Jeong, Woori Kwak, Gu Seob Ro. Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob/ob Mice. Journal of neuropathology and experimental neurology. vol 79. issue 5. 2020-12-04. PMID:32296847. |
using rna-seq analysis, we found that neurodegeneration- sortilin-related receptor 1 (sorl1) and brain-derived neurotrophic factor (bdnf) genes were significantly reduced in the hippocampus of ob/ob mice. |
2020-12-04 |
2023-08-13 |
mouse |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
here, we systematically investigated the main effects of sorl1 rs2070045, and apoe, and their interaction effects on hippocampal rsfc in healthy young adults. |
2018-01-30 |
2023-08-13 |
human |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
these findings suggest that sorl1 and apoe genes modulate different hippocampal rsfcs and have a complex interaction. |
2018-01-30 |
2023-08-13 |
human |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
apolipoprotein e (apoe) and sortilin-related receptor (sorl1) genes act on the same metabolic pathway and have been associated with alzheimer's disease (ad) characterized by hippocampal impairment. |
2018-01-30 |
2023-08-13 |
human |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
modulation of apoe and sorl1 genes on hippocampal functional connectivity in healthy young adults. |
2018-01-30 |
2023-08-13 |
human |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
although the effects of apoe on hippocampal resting-state functional connectivity (rsfc) have been reported, the main effects of sorl1 and sorl1 × apoe interactions on hippocampal rsfc in healthy subjects remain largely unknown. |
2018-01-30 |
2023-08-13 |
human |
| Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Y. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28229235. |
the main effect of sorl1 showed that risk g-allele carriers had decreased positive rsfc between the hippocampus and middle temporal gyrus compared with tt carriers. |
2018-01-30 |
2023-08-13 |
human |
| Ji-Young Na, Kibbeum Song, Ju-Woon Lee, Sokho Kim, Jungkee Kwo. Sortilin-related receptor 1 interacts with amyloid precursor protein and is activated by 6-shogaol, leading to inhibition of the amyloidogenic pathway. Biochemical and biophysical research communications. vol 484. issue 4. 2017-06-06. PMID:28188785. |
to clarify the effect of 6-shogaol as a possible activator of sorl1, we used sorl1 sirna as a blockade of sorl1 in hippocampal neuronal cells (ht22). |
2017-06-06 |
2023-08-13 |
mouse |
| Eva Louwersheimer, Alfredo Ramirez, Carlos Cruchaga, Tim Becker, Johannes Kornhuber, Oliver Peters, Stefanie Heilmann, Jens Wiltfang, Frank Jessen, Pieter Jelle Visser, Philip Scheltens, Yolande A L Pijnenburg, Charlotte E Teunissen, Frederik Barkhof, John C van Swieten, Henne Holstege, Wiesje M Van der Flie. Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25659857. |
in conclusion, we found that sorl1 snp rs2070045-g allele was related to csf-tau and hippocampal atrophy, 2 endophenotype markers of ad, suggesting that sorl1 may be implicated in the downstream pathology in ad. |
2015-11-24 |
2023-08-13 |
Not clear |
| Amelia A Assareh, Olivier Piguet, Tanya C Lye, Karen A Mather, Gerald A Broe, Peter R Schofield, Perminder S Sachdev, John B J Kwo. Association of SORL1 gene variants with hippocampal and cerebral atrophy and Alzheimer's disease. Current Alzheimer research. vol 11. issue 6. 2015-02-26. PMID:24938503. |
association of sorl1 gene variants with hippocampal and cerebral atrophy and alzheimer's disease. |
2015-02-26 |
2023-08-13 |
Not clear |
| Tatiane Katsue Furuya, Patrícia Natália Oliveira da Silva, Spencer Luiz Marques Payão, Lucas Trevizani Rasmussen, Roger Willian de Labio, Paulo Henrique Ferreira Bertolucci, Ianna Lacerda Sampaio Braga, Elizabeth Suchi Chen, Gustavo Turecki, Naguib Mechawar, Jonathan Mill, Marília de Arruda Cardoso Smit. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22836009. |
as sorl1 (sortilin-related receptor) and sirt1 (sirtuin 1) genes have been linked to ad pathogenesis, we aimed to investigate their mrna expression and promoter dna methylation in post mortem brain tissues (entorhinal and auditory cortices and hippocampus) from healthy elderly subjects and ad patients. |
2013-06-05 |
2023-08-12 |
human |
| Janita Bralten, Alejandro Arias-Vásquez, Remco Makkinje, Joris A Veltman, Han G Brunner, Guillén Fernández, Mark Rijpkema, Barbara Frank. Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults. The American journal of psychiatry. vol 168. issue 10. 2011-12-08. PMID:21730226. |
association of the alzheimer's gene sorl1 with hippocampal volume in young, healthy adults. |
2011-12-08 |
2023-08-12 |
Not clear |
| Janita Bralten, Alejandro Arias-Vásquez, Remco Makkinje, Joris A Veltman, Han G Brunner, Guillén Fernández, Mark Rijpkema, Barbara Frank. Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults. The American journal of psychiatry. vol 168. issue 10. 2011-12-08. PMID:21730226. |
the authors used a gene-wide approach to test whether sorl1 is associated with volume of the hippocampus, one of the first structures to be affected by alzheimer's disease in young, healthy individuals, in an attempt to map potential pathways from gene to disease. |
2011-12-08 |
2023-08-12 |
Not clear |