| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Eva, E Cost. In rat hippocampus, somatostatin 14 and muscarinic receptor ligands modulate an adenylate cyclase belonging to a common domain of the receptor. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2888875. |
in hippocampal slices, somatostatin 14 and its stable analog l363 [cyclo(phe-pro-phe-d-trp-lys-thr)] fail to modify muscarinic signal transduction mediated by stimulation of phosphoinositide breakdown, whereas somatostatin 14 mimics oxotremorine in inhibiting adenylate cyclase activity of hippocampal membranes. |
1987-11-05 |
2023-08-11 |
rat |
| C Eva, E Cost. In rat hippocampus, somatostatin 14 and muscarinic receptor ligands modulate an adenylate cyclase belonging to a common domain of the receptor. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2888875. |
this stimulation could be operative in mediating the convergent inhibition of adenylate cyclase activity elicited by the binding of specific ligands to somatostatin and muscarinic recognition sites present in hippocampal membranes. |
1987-11-05 |
2023-08-11 |
rat |
| T W Watson, Q J Pittma. Mechanism of action of somatostatin in the hippocampal slice. Proceedings of the Western Pharmacology Society. vol 30. 1987-10-16. PMID:2888131. |
mechanism of action of somatostatin in the hippocampal slice. |
1987-10-16 |
2023-08-11 |
Not clear |
| C A Whitford, J M Candy, C R Snell, B H Hirst, A E Oakley, M Johnson, J E Thompso. Autoradiographic visualization of binding sites for [3H]somatostatin in the rat brain. European journal of pharmacology. vol 138. issue 3. 1987-10-09. PMID:2887442. |
the distribution of binding sites using 0.7 nm [3h]somatostatin confirmed that previously described for iodinated tyrosyl analogues of somatostatin, with highest densities of sites in the cerebral cortex (particularly in laminae iii-v), amygdala, lateral septal nucleus, hippocampus and claustrum. |
1987-10-09 |
2023-08-11 |
rat |
| J Sirviö, J Jolkkonen, A Pitkänen, P J Riekkine. Age dependence of somatostatin levels and somatostatin binding in the rat brain. Comparative biochemistry and physiology. A, Comparative physiology. vol 87. issue 2. 1987-09-18. PMID:2886276. |
somatostatin binding was reduced in the striatum, frontal cortex, hypothalamus and hippocampus of the 8-month-old rats compared to the 1-month-old group. |
1987-09-18 |
2023-08-11 |
rat |
| J Sirviö, J Jolkkonen, A Pitkänen, P J Riekkine. Age dependence of somatostatin levels and somatostatin binding in the rat brain. Comparative biochemistry and physiology. A, Comparative physiology. vol 87. issue 2. 1987-09-18. PMID:2886276. |
somatostatin binding was reduced in the striatum, frontal cortex and hippocampus of the 18-month-old rats compared to the 1-month-old group. |
1987-09-18 |
2023-08-11 |
rat |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide y neurons, and effects in alzheimer-type dementia. |
1987-09-15 |
2023-08-11 |
human |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
axonal plexuses occurred throughout the hippocampal subfields but were particularly dense in those regions rich in somatostatin neurons. |
1987-09-15 |
2023-08-11 |
human |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
the distribution of somatostatin immunoreactive neurons and fibers parallels the distribution of neuropeptide y (npy) neurons and fibers in the hippocampus and cerebral cortex to a remarkable extent. |
1987-09-15 |
2023-08-11 |
human |
| C Köhler, L G Eriksson, S Davies, V Chan-Pala. Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region. Neuroscience letters. vol 78. issue 1. 1987-09-01. PMID:2886960. |
co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region. |
1987-09-01 |
2023-08-11 |
rat |
| J B Perlin, E W Lothman, W A Gear. Somatostatin augments the spread of limbic seizures from the hippocampus. Annals of neurology. vol 21. issue 5. 1987-07-14. PMID:2884925. |
somatostatin augments the spread of limbic seizures from the hippocampus. |
1987-07-14 |
2023-08-11 |
rat |
| J B Perlin, E W Lothman, W A Gear. Somatostatin augments the spread of limbic seizures from the hippocampus. Annals of neurology. vol 21. issue 5. 1987-07-14. PMID:2884925. |
the role of the neuropeptide somatostatin in limbic seizures was studied using electrical stimulation of the hippocampus in kindled rats. |
1987-07-14 |
2023-08-11 |
rat |
| R Widmann, N Mensdorff-Pouilly, K Pfaller, G Sper. Evidence for somatostatin-containing fibers projecting from the pallidal complex to the striatum of the rat. Journal of neurochemistry. vol 48. issue 6. 1987-06-25. PMID:2883260. |
lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopamine and 5,7-dihydroxytryptamine failed to decrease striatal somatostatin levels. |
1987-06-25 |
2023-08-11 |
rat |
| R D Terry, L A Hansen, R DeTeresa, P Davies, H Tobias, R Katzma. Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. Journal of neuropathology and experimental neurology. vol 46. issue 3. 1987-05-19. PMID:2881985. |
the following indices were examined: degree of dementia, rate of progression of dementia, age at death, brain weight, cerebral hemispheric weight, cortical cell counts from the frontal, temporal, and parietal lobes, the number of neocortical np, the number of hippocampal np and nft, and the levels of neocortical choline acetyltransferase and somatostatin. |
1987-05-19 |
2023-08-11 |
Not clear |
| R McCarty, L M Plunket. Quantitative autoradiographic analysis of somatostatin binding sites in discrete areas of rat forebrain. Brain research bulletin. vol 18. issue 1. 1987-05-04. PMID:2881615. |
highest concentrations of somatostatin binding sites (fmol/mg protein) were found in the claustrum (151), basolateral nucleus of the amygdala (90), deep layers of the cerebral cortex (61), lateral olfactory nuclei (58), ca1 and ca2 areas of hippocampus (57), medial and lateral septal nuclei (54), and the medial habenula (44). |
1987-05-04 |
2023-08-11 |
rat |
| S R Weiss, T Nguyen, D R Rubinow, C J Helke, P K Narang, R M Post, D M Jacobowit. Lack of effect of chronic carbamazepine on brain somatostatin in the rat. Journal of neural transmission. vol 68. issue 3-4. 1987-04-27. PMID:2881977. |
following 12 days of carbamazepine treatment, no changes in somatostatin levels were found in any of the brain areas examined which included: amygdala, hippocampus, caudate-putamen, median eminence, arcuate nucleus, nucleus accumbens, nucleus interstitialis of the stria terminalis, nucleus periventricularis, parietal cortex, and occipital cortex. |
1987-04-27 |
2023-08-11 |
rat |
| J R Mancillas, G R Siggins, F E Bloo. Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 19. 1986-10-30. PMID:2876428. |
somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex. |
1986-10-30 |
2023-08-11 |
rat |
| R Miyoshi, S Kito, K Mizuno, H Matsubayash. Is the effect of somatostatin on muscarinic receptors selective to M1 type? Brain research. vol 377. issue 2. 1986-09-17. PMID:2873870. |
somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebral cortex whose machr were dominantly of m1 type. |
1986-09-17 |
2023-08-11 |
Not clear |
| J M Palacios, J C Reubi, R Maure. Somatostatin receptors in rat hippocampus: localization to intrinsic neurons. Neuroscience letters. vol 67. issue 2. 1986-08-15. PMID:3014397. |
somatostatin receptors in rat hippocampus: localization to intrinsic neurons. |
1986-08-15 |
2023-08-11 |
rat |
| G Fuhrmann, M T Strosser, F Besnard, E Kempf, J Kempf, A Ebe. Genotypic differences in age and chronic alcohol exposure effects on somatostatin levels in hippocampus and striatum in mice. Neurochemical research. vol 11. issue 5. 1986-07-30. PMID:2873520. |
genotypic differences in age and chronic alcohol exposure effects on somatostatin levels in hippocampus and striatum in mice. |
1986-07-30 |
2023-08-11 |
mouse |