| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suryanarayan Biswal, Deepti Sharma, Kushal Kumar, Tapas Chandra Nag, Kalpana Barhwal, Sunil Kumar Hota, Bhuvnesh Kuma. Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiology of learning and memory. vol 133. 2018-02-15. PMID:27246251. |
a single episode of chronic hypobaric hypoxia exposure also resulted in the up-regulation of pro-aging protein, s100a9 and down regulation of tau, snap25, apoe and sod2 in the hippocampus similar to that in aged rats indicating hypoxia induced accelerated aging. |
2018-02-15 |
2023-08-13 |
rat |
| Hu Erxidan Sikandaner, So Young Park, Min Jung Kim, Shi Nae Park, Dong Won Yan. Neuroprotective effects of sildenafil against oxidative stress and memory dysfunction in mice exposed to noise stress. Behavioural brain research. vol 319. 2017-12-21. PMID:27836585. |
interestingly, sildenafil administration increased memory performance, decreased oxidative stress, and increased neuroprotection in the hippocampus region of noise alone-induced mice likely through affecting memory related pathways such as cgmp/pkg/creb and p25/cdk5, and induction of free radical scavengers such as sod1, sod2, sod3, prdx5, and catalase in the brain of stressed mice. |
2017-12-21 |
2023-08-13 |
mouse |
| Ning Jia, Qinru Sun, Qian Su, Shaokang Dang, Guomin Che. Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway. Redox biology. vol 10. 2017-11-16. PMID:27768969. |
meanwhile, taurine administration diminished the increase in mitochondrial ros, and recovered the reduction of mmp, atp level and the activities of cco, superoxide dismutase 2 (sod2) and catalase induced by ps in the hippocampus. |
2017-11-16 |
2023-08-13 |
rat |
| Hyun Young Choi, Joon Ha Park, Bai Hui Chen, Bich Na Shin, Yun Lyul Lee, In Hye Kim, Jeong-Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Moo-Ho Won, Ji Hyeon Ahn, Hyun-Jin Tae, Bing Chun Yan, In Koo Hwang, Jun Hwi Cho, Young-Myeong Kim, Sung Koo Ki. Increases of Catalase and Glutathione Peroxidase Expressions by Lacosamide Pretreatment Contributes to Neuroprotection Against Experimentally Induced Transient Cerebral Ischemia. Neurochemical research. vol 41. issue 9. 2017-04-17. PMID:27209305. |
in this study, we examined the neuroprotective effect of lacosamide against transient ischemic damage and expressions of antioxidant enzymes such as zn-superoxide dismutase (sod1), mn-superoxide dismutase (sod2), catalase (cat) and glutathione peroxidase (gpx) in the hippocampal cornu ammonis 1 (ca1) region following 5 min of transient global cerebral ischemia in gerbils. |
2017-04-17 |
2023-08-13 |
cat |
| Fengling Li, Lei Li. SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2. Frontiers in cellular neuroscience. vol 10. 2016-07-22. PMID:27445698. |
sirt5 deficiency enhances susceptibility to kainate-induced seizures and exacerbates hippocampal neurodegeneration not through mitochondrial antioxidant enzyme sod2. |
2016-07-22 |
2023-08-13 |
mouse |
| Fengling Li, Lei Li. SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2. Frontiers in cellular neuroscience. vol 10. 2016-07-22. PMID:27445698. |
unexpectedly, sirt5 seems not to apparently alter the decline of antioxidant enzymes superoxide dismutase 2 (sod2) and glutathione peroxidase (gpx) in hippocampus caused by ka exposure in our paradigm, which indicates the protective role of sirt5 on seizures and cellular degeneration might through different regulatory mechanism that would be explored in the future. |
2016-07-22 |
2023-08-13 |
mouse |
| Bertrand R Huber, James S Meabon, Tobin J Martin, Pierre D Mourad, Raymond Bennett, Brian C Kraemer, Ibolja Cernak, Eric C Petrie, Michael J Emery, Erik R Swenson, Cynthia Mayer, Edin Mehic, Elaine R Peskind, David G Coo. Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury. Journal of Alzheimer's disease : JAD. vol 37. issue 2. 2014-04-15. PMID:23948882. |
in hippocampus, aberrant tau species persisted for at least 30 days post-exposure, while sod2 levels returned to sham control levels. |
2014-04-15 |
2023-08-12 |
mouse |
| Natalie Noe, Lloye Dillon, Veronika Lellek, Francisca Diaz, Aline Hida, Carlos T Moraes, Tina Wen. RETRACTED: Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. Mitochondrion. vol 13. issue 5. 2014-03-10. PMID:23261681. |
specifically, western blot images in figure 5f (tubulin in cortex), 2f (coxi in hippocampus) and 3b (sod2 in hippocampus) were re-used from an earlier article published elsewhere [increased muscle pgc-1alpha expression protects from sarcopenia and metabolic disease during aging" wenz t, rossi sg, rotundo rl, spiegelman bm, and moraes ct. proc natl acad sci u s a. |
2014-03-10 |
2023-08-12 |
mouse |
| Rikki Corniola, Yani Zou, David Leu, John R Fike, Ting-Ting Huan. Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects. PloS one. vol 7. issue 11. 2013-06-25. PMID:23145165. |
consequently, mutant mice with reduced levels of the mitochondrial antioxidant enzyme, mn superoxide dismutase (mnsod or sod2), are expected to be more sensitive to radiation-induced changes in hippocampal neurogenesis and the related functions. |
2013-06-25 |
2023-08-12 |
mouse |
| Irena Baranowska-Bosiacka, Izabela Gutowska, Mariola Marchlewicz, Carla Marchetti, Mateusz Kurzawski, Viotetta Dziedziejko, Agnieszka Kolasa, Maria Olszewska, Marta Rybicka, Krzysztof Safranow, Przemysław Nowacki, Barbara Wiszniewska, Dariusz Chlube. Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead. Brain research. vol 1435. 2012-11-07. PMID:22197700. |
we also measured glutathione (gsh) concentrations in selected structures of the rat brain (forebrain cortex, fc, cerebellum, c, and hippocampus, h) and showed cellular localization of gpx4, sod1 and sod2 expressions in the hippocampus by immunohistochemical examinations. |
2012-11-07 |
2023-08-12 |
rat |
| Wei-Hua Lee, Ashok Kumar, Asha Rani, Jose Herrera, Jinze Xu, Shinichi Someya, Thomas C Foste. Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging. Antioxidants & redox signaling. vol 16. issue 4. 2012-09-14. PMID:21942371. |
we used adeno-associated virus to deliver antioxidant enzymes (sod1, sod2, catalase [cat], and sod1+cat) to the hippocampus of young (4 months) and aged (19 months) f344/bn f1 male rats and examined memory-related behavioral performance 1 month and 4 months postinjection. |
2012-09-14 |
2023-08-12 |
mouse |
| Hyun-Pil Lee, Neel Pancholi, Luke Esposito, Laura A Previll, Xinglong Wang, Xiongwei Zhu, Mark A Smith, Hyoung-gon Le. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276093. |
sod2 reduction in young happ mice resulted in significantly increased oxidative stress in the pyramidal neurons of the hippocampus. |
2012-06-04 |
2023-08-12 |
mouse |
| Jeong-Ho Park, Boe-Hyun Kim, Seok-Joo Park, Jae-Kwang Jin, Yong-Chul Jeon, Guang Y Wen, Hae-Young Shin, Richard I Carp, Yong-Sun Ki. Association of endothelial nitric oxide synthase and mitochondrial dysfunction in the hippocampus of scrapie-infected mice. Hippocampus. vol 21. issue 3. 2012-04-02. PMID:20082297. |
in association with the accumulation of enos in mitochondria, we showed that mitochondrial superoxide dismutase (mn-sod or sod2), cytochrome c, and atp activity were downregulated both in whole brain and in the hippocampal region. |
2012-04-02 |
2023-08-12 |
mouse |
| Maithili Sashindranath, Karen J McLean, Ian A Trounce, Richard G H Cotton, Mark J Coo. Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model. Epilepsy research. vol 90. issue 3. 2010-11-02. PMID:20609565. |
a 10-fold increase in superoxide production was seen in the sod2 +/- ca2 neurons, indicating that sod2 plays an important role in protecting the ca2 region of the hippocampus from seizure-induced free radical damage. |
2010-11-02 |
2023-08-12 |
mouse |
| Maithili Sashindranath, Karen J McLean, Ian A Trounce, Richard G H Cotton, Mark J Coo. Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model. Epilepsy research. vol 90. issue 3. 2010-11-02. PMID:20609565. |
early hippocampal cell death was undetectable in wildtype or sod2 +/- mice post-seizures. |
2010-11-02 |
2023-08-12 |
mouse |
| Maithili Sashindranath, Karen J McLean, Ian A Trounce, Richard G H Cotton, Mark J Coo. Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model. Epilepsy research. vol 90. issue 3. 2010-11-02. PMID:20609565. |
our data indicates that a possible upregulation of endogenous antioxidant activity might exist within selective hippocampal sectors in the sod2 +/- mice that are as yet unknown. |
2010-11-02 |
2023-08-12 |
mouse |
| b' AnnaMaria Cimini, Sandra Moreno, Marcello D\'Amelio, Loredana Cristiano, Barbara D\'Angelo, Stefano Falone, Elisabetta Benedetti, Paolo Carrara, Francesca Fanelli, Francesco Cecconi, Fernanda Amicarelli, Maria Paola Cer\\xc3\\xb. Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer\'s disease: a role for peroxisomes. Journal of Alzheimer\'s disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19749434.' |
the expression and localization of peroxisomal (pmp70, cat, aox, and thl) and peroxisome-related proteins (pex5p, gpx1, sod1, and sod2) were studied in the neocortex and hippocampus of transgenic and wild-type animals. |
2010-09-16 |
2023-08-12 |
mouse |
| Shang-Der Chen, Tsu-Kung Lin, Ding-I Yang, Su-Ying Lee, Fu-Zen Shaw, Chia-Wei Liou, Yao-Chung Chuan. Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19774674. |
in addition, knock-down of pgc-1alpha expression by pretreatment with a specific antisense oligodeoxynucleotide in the hippocampal ca1 subfield downregulated the expression of ucp2 and sod2 with resultant exacerbation of oxidative stress and augmentation of delayed neuronal cell death in the hippocampus after tgi. |
2010-03-30 |
2023-08-12 |
rat |
| Shang-Der Chen, Tsu-Kung Lin, Ding-I Yang, Su-Ying Lee, Fu-Zen Shaw, Chia-Wei Liou, Yao-Chung Chuan. Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19774674. |
overall, our results indicate that pgc-1alpha is induced by cerebral ischemia leading to upregulation of ucp2 and sod2, thereby providing a neuroprotective effect against ischemic brain injury in the hippocampus by ameliorating oxidative stress. |
2010-03-30 |
2023-08-12 |
rat |
| Kelly Fishman, Jennifer Baure, Yani Zou, Ting-Ting Huang, Marta Andres-Mach, Radoslaw Rola, Tatiana Suarez, Munjal Acharya, Charles L Limoli, Kathleen R Lamborn, John R Fik. Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD. Free radical biology & medicine. vol 47. issue 10. 2010-01-11. PMID:19703553. |
this study addressed what impact a deficiency in cytoplasmic (sod1) or mitochondrial (sod2) sod has on radiation effects on hippocampal neurogenesis. |
2010-01-11 |
2023-08-12 |
mouse |