| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morgan K Foret, Chiara Orciani, Lindsay A Welikovitch, Chunwei Huang, A Claudio Cuello, Sonia Do Carm. Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. Communications biology. vol 7. issue 1. 2024-07-14. PMID:39004677. |
using laser microdissected hippocampal neurons extracted from mcgill-r-thy1-app transgenic rats we found that intraneuronal amyloid beta (iaβ)-burdened neurons had increased expression of genes related to oxidative stress and dna damage responses including ercc2, fancc, sod2, gsr, and idh1. |
2024-07-14 |
2024-07-18 |
rat |
| Dominic Osei, Eveline Baumgart-Vogt, Barbara Ahlemeyer, Christiane Herde. Tumor Necrosis Factor-α Receptor 1 Mediates Borna Disease Virus 1-Induced Changes in Peroxisomal and Mitochondrial Dynamics in Neurons. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339126. |
using different mouse lines-i.e., tumor necrosis factor-α transgenic (tnftg; to pro-inflammatory status), tnf receptor-1 knockout (tnfr1ko), and tnfr2ko mice in comparison to wild-type (wt) mice-we analyzed the abundances of both organelles and their main antioxidant enzymes, catalase and superoxide dismutase 2 (sod2), in neurons of the hippocampal, cerebral, and cerebellar cortices. |
2024-02-10 |
2024-02-12 |
mouse |
| Octavio Fabián Mercado-Gómez, Virginia Selene Arriaga-Ávila, Angélica Vega-García, Sandra Orozco-Suarez, Vadim Pérez-Koldenkova, Juan José Camarillo-Sánchez, Marcelino Álvarez-Herrera, Rosalinda Guevara-Guzmá. Daytime-Restricted Feeding Ameliorates Oxidative Stress by Increasing NRF2 Transcriptional Factor in the Rat Hippocampus in the Pilocarpine-Induced Acute Seizure Model. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891811. |
the cellular distribution of the nrf2 and sod2 proteins in the pyramidal cell layer of both the ca1 and ca3 hippocampal subfields and astrocytes (gfap marker) were quantified using immunofluorescence and immunohistochemistry, respectively. |
2023-10-30 |
2023-11-08 |
rat |
| Dongmei Wang, Quan Yuan, Shuwen Liu, Pu Zhao, Chen Liang, Yilu Ma, Sanqiang Li, Xiaoying Zhu, Xueqin Hao, Jian Shi, Hua Fa. BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol. Environmental pollution (Barking, Essex : 1987). 2023-07-10. PMID:37429494. |
bde-47 exposure downregulated sirt3 expression and decreased the activity and expression level of sod2, thereby inhibiting mtros scavenging and activating nlrp3 inflammasome-mediated pyroptosis in the mouse hippocampus and bv-2 cells. |
2023-07-10 |
2023-08-14 |
mouse |
| Ji-Ren An, Jun-Tong Liu, Xiao-Meng Gao, Qing-Feng Wang, Gui-Yan Sun, Jia-Nan Su, Chi Zhang, Jia-Xiang Yu, Yu-Feng Yang, Yan Sh. Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress. Frontiers in cellular neuroscience. vol 17. 2023-06-16. PMID:37323581. |
in addition, liraglutide reduced iron deposition in the hippocampus by reducing the expression of tfr1 and dmt1 and increasing the expression of fpn1; at the same time, liraglutide by up-regulating the levels of sod, gsh, and sod2 expression, as well as downregulation of mda levels and nox2 and nox4 expression to reduce oxidative stress and lipid peroxidation. |
2023-06-16 |
2023-08-14 |
mouse |
| Roshini Sathiaseelan, Bumsoo Ahn, Michael B Stout, Sreemathi Logan, Jonathan Wanagat, Hoang Van M Nguyen, Norman G Hord, Amy R Vandiver, Ramasamy Selvarani, Rojina Ranjit, Hannah Yarbrough, Anthony Masingale, Benjamin F Miller, Roman F Wolf, Steven N Austad, Arlan Richardso. A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-02-10. PMID:36762848. |
mitochondrial genotype and sex differences were also observed in features of brain-specific antioxidant response to a high-fat diet and 17α-estradiol as shown by hippocampal levels of sod2 acetylation, jnk, and foxo3a. |
2023-02-10 |
2023-08-14 |
mouse |
| Hao-Yuan Li, Jing Wang, Ling-Feng Liang, Shi-Yu Shen, Wei Li, Xiao-Rong Chen, Bing Li, Yu-Qiu Zhang, Jin Y. Sirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290610. |
the results show that kaempferol has potential beneficial effects on vcd-induced rodent model of menopausal depression and produces antioxidant effects as well as increases the deacetylation of superoxide dismutase 2 (sod2) and the protein level of sirtuin3 (sirt3) in the hippocampus. |
2022-10-27 |
2023-08-14 |
Not clear |
| Nur Hanisah Azmi, Norsharina Ismail, Mustapha Umar Imam, Der Jiun Ooi, Siti Nur Hazwani Osla. Modulation of High-Fat Diet-Induced Brain Oxidative Stress by Ferulate-Rich Germinated Brown Rice Ethyl Acetate Extract. Molecules (Basel, Switzerland). vol 27. issue 15. 2022-08-12. PMID:35956857. |
elevated mrna expressions of sod1, sod2, sod3, catalase, and gpx were demonstrated in the frontal cortex and hippocampus of gbr-ea treated animals. |
2022-08-12 |
2023-08-14 |
rat |
| Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. |
when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. |
2022-08-11 |
2023-08-14 |
mouse |
| Matthew P Baier, Raghavendra Y Nagaraja, Hannah P Yarbrough, Daniel B Owen, Anthony M Masingale, Rojina Ranjit, Megan A Stiles, Ashley Murphy, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherry, Michael T Kinter, Holly Van Remmen, Sreemathi Loga. Selective ablation of The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-06-27. PMID:35760531. |
female asod2-ko showed no learning and memory deficits compared to age-matched controls despite significant reduction in hippocampal sod2 expression. |
2022-06-27 |
2023-08-14 |
mouse |
| Nagalakshmi Balasubramanian, Sneha Sagarkar, Amit G Choudhary, Dadasaheb M Kokare, Amul J Sakharka. Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33099744. |
epigenetic blockade of hippocampal sod2 via dnmt3b-mediated dna methylation: implications in mild traumatic brain injury-induced persistent oxidative damage. |
2021-10-13 |
2023-08-13 |
Not clear |
| Nagalakshmi Balasubramanian, Sneha Sagarkar, Amit G Choudhary, Dadasaheb M Kokare, Amul J Sakharka. Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33099744. |
the oxidative damage, neurodegenerative indicators, and sod2 function and its regulation in the hippocampus were analyzed after 48 h and 30 days of rmtbi. |
2021-10-13 |
2023-08-13 |
Not clear |
| Nagalakshmi Balasubramanian, Sneha Sagarkar, Amit G Choudhary, Dadasaheb M Kokare, Amul J Sakharka. Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33099744. |
in conclusion, dnmt3b-mediated dna methylation plays a critical role in sod2 gene regulation in the hippocampus, and the perturbations therein post rmtbi are detrimental to redox homeostasis manifesting into neurological consequences. |
2021-10-13 |
2023-08-13 |
Not clear |
| Paulina Wigner, Ewelina Synowiec, Piotr Czarny, Michal Bijak, Paweł Jóźwiak, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwińsk. Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress. Journal of cellular and molecular medicine. vol 24. issue 10. 2021-09-07. PMID:32281745. |
cms increased the methylation of the gpx1 promoter in pbmcs, the second gpx4 promoter in midbrain and basal ganglia, and sod1 and sod2 in hippocampus. |
2021-09-07 |
2023-08-13 |
human |
| Ji-Ren An, Jia-Nan Su, Gui-Yan Sun, Qing-Feng Wang, Ya-Dong Fan, Nan Jiang, Yu-Feng Yang, Yan Sh. Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis. Neurochemical research. 2021-09-04. PMID:34480710. |
furthermore, lira significantly decreased oxidative stress and lipid peroxidation levels by downregulating the production of ros and mda and upregulating sod and gsh-px in the serum and hippocampus, and the upregulation of sod2 expression was also proven. |
2021-09-04 |
2023-08-13 |
mouse |
| Keiko Kobayashi, Yanchen Liu, Hiroshi Ichikawa, Shigekazu Takemura, Yukiko Minamiyam. Effects of Bisphenol A on Oxidative Stress in the Rat Brain. Antioxidants (Basel, Switzerland). vol 9. issue 3. 2020-09-28. PMID:32187996. |
at that time, sod1 was significantly induced, but no changes in sod2 expression were apparent in the hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| Leandro Severo, Douglas Godinho, Felipe Machado, Diane Hartmann, Michele Rechia Fighera, Félix Alexandre Soares, Ana Flavia Furian, Mauro Schneider Oliveira, Luiz Fernando Roye. The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life sciences. vol 257. 2020-09-11. PMID:32569782. |
the experimental data revealed, for the first time, that the present protocol of recurrent concussions (4, 7, and 10 injuries) in mice did not alter immobility time during tail suspension tests (tsts), but decreased hippocampal mitochondrial respiration and increased expression of proteins such as nuclear factor erythroid 2-related factor 2 (nrf2) and superoxide (sod2). |
2020-09-11 |
2023-08-13 |
mouse |
| Ery Hermawati, Nur Arfian, Mustofa, Ginus Partadiredj. Spatial Memory Disturbance Following Transient Brain Ischemia is Associated with Vascular Remodeling in Hippocampus. The Kobe journal of medical sciences. vol 64. issue 3. 2019-05-28. PMID:30666039. |
the mrna expressions of sod2, bcl-2, neun, enos, endothelin-1 (et-1), cd31, ve-cadherin and vascular remodeling of the hippocampus were examined. |
2019-05-28 |
2023-08-13 |
rat |
| b' Nata\\xc5\\xa1a Popovi\\xc4\\x87, Vesna Stojiljkovi\\xc4\\x87, Sne\\xc5\\xbeana Peji\\xc4\\x87, Ana Todorovi\\xc4\\x87, Ivan Pavlovi\\xc4\\x87, Ljubica Gavrilovi\\xc4\\x87, Sne\\xc5\\xbeana B Pajovi\\xc4\\x8. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative medicine and cellular longevity. vol 2019. 2019-04-15. PMID:30911352.' |
this study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (sod1), manganese superoxide dismutase (sod2), catalase (cat), glutathione peroxidase (gpx), and glutathione reductase (gr) in the hippocampus of chronically stressed rats. |
2019-04-15 |
2023-08-13 |
rat |
| Ji Hyeon Ahn, Yoohun Noh, Bich Na Shin, Sung-Su Kim, Joon Ha Park, Tae-Kyeong Lee, Minah Song, Hyunjung Kim, Jae-Chul Lee, Jun-Hwan Yong, Il Jun Kang, Yun Lyul Lee, Moo-Ho Won, Jong Dai Ki. Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30272360. |
intermittent fasting increases sod2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils. |
2019-01-28 |
2023-08-13 |
cat |