| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
furthermore, via a lentivirus-mediated transfection in hippocampal neurons, we aimed to detect how sirt6 influence the function of hippocampus. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
thus, our data indicates that sirt6 is involved in the modulation of depressive-like behaviors and affects the survival and synaptic plasticity of hippocampal neuron via inhibitory activation of akt-gsk3β signaling. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
up-regulation of sirt6 in the hippocampus induced rats with depression-like behavior via the block akt/gsk3β signaling pathway. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
hence, western blotting and rt-qpcr were used to investigate whether sirts (sirt1-7) expression levels were altered in the hippocampus of rats, which followed 5 weeks of chronic unpredictable mild stress (cums) treatment, the results showed depressive-like behaviors: like body weight, forced swim test and sucrose preference test and sirt6 was a significant increase in the hippocampal of cums rats. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
the sirt6 overexpression significantly inhibited expressions of proteins and/or phosphoproteins (e.g akt, p-akt, p-gsk3β), decreased the ratios of p-gsk3β/gsk3β and p-akt/akt in the primary hippocampus neurons. |
2017-12-13 |
2023-08-13 |
rat |
| Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y Cohe. Sirt6 alters adult hippocampal neurogenesis. PloS one. vol 12. issue 6. 2017-10-02. PMID:28644902. |
sirt6 alters adult hippocampal neurogenesis. |
2017-10-02 |
2023-08-13 |
mouse |
| Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y Cohe. Sirt6 alters adult hippocampal neurogenesis. PloS one. vol 12. issue 6. 2017-10-02. PMID:28644902. |
this implies of an involvement of sirt6 in neuronal differentiation and maturation within the hippocampus. |
2017-10-02 |
2023-08-13 |
mouse |
| Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y Cohe. Sirt6 alters adult hippocampal neurogenesis. PloS one. vol 12. issue 6. 2017-10-02. PMID:28644902. |
this work adds to the expanding body of knowledge on the regulatory mechanisms underlying adult hippocampal neurogenesis, and describes novel roles for sirt6 as a regulator of cell fate during adult hippocampal neurogenesis. |
2017-10-02 |
2023-08-13 |
mouse |
| Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y Cohe. Sirt6 alters adult hippocampal neurogenesis. PloS one. vol 12. issue 6. 2017-10-02. PMID:28644902. |
in this study we investigated the involvement of sirt6 in adult hippocampal neurogenesis. |
2017-10-02 |
2023-08-13 |
mouse |
| Xi Yin, Yuan Gao, Hai-Shui Shi, Li Song, Jie-Chao Wang, Juan Shao, Xu-Hong Geng, Gai Xue, Jian-Li Li, Yan-Ning Ho. Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory. Scientific reports. vol 6. 2016-12-13. PMID:26732053. |
our previous transcriptome data showed that expression of sirtuins 6 (sirt6), a member of histone deacetylases (hdacs) family in the hippocampal cornu ammonis 1 (ca1) was decreased after contextual fear conditioning. |
2016-12-13 |
2023-08-13 |
Not clear |
| Alessio Cardinale, Maria Chiara de Stefano, Cristiana Mollinari, Mauro Racaniello, Enrico Garaci, Daniela Merl. Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25366464. |
immunoblotting analysis on cortical and hippocampal neurons showed that sirt6 is downregulated during maturation in vitro, reaching the lowest expression at 11 days in vitro. |
2015-11-10 |
2023-08-13 |
Not clear |
| Alessio Cardinale, Maria Chiara de Stefano, Cristiana Mollinari, Mauro Racaniello, Enrico Garaci, Daniela Merl. Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25366464. |
here, we biochemically characterized sirt6 in brain tissues and primary neuronal cultures and found that it is highly expressed in cortical and hippocampal regions and enriched in the synaptosomal membrane fraction. |
2015-11-10 |
2023-08-13 |
Not clear |
| Alessio Cardinale, Maria Chiara de Stefano, Cristiana Mollinari, Mauro Racaniello, Enrico Garaci, Daniela Merl. Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25366464. |
in addition, sirt6 overexpression in terminally differentiated cortical and hippocampal neurons, mediated by a neuron-specific recombinant adeno-associated virus, downregulated cell viability under oxidative stress condition. |
2015-11-10 |
2023-08-13 |
Not clear |