All Relations between sirt6 and hippocampus

Publication Sentence Publish Date Extraction Date Species
Morgan K Foret, Chiara Orciani, Lindsay A Welikovitch, Chunwei Huang, A Claudio Cuello, Sonia Do Carm. Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. Communications biology. vol 7. issue 1. 2024-07-14. PMID:39004677. dna damage was further evidenced by increased neuronal levels of xpd (ercc2) and γh2ax foci, indicative of dna double stranded breaks (dsbs), and by increased expression of ercc6, rad51, and fen1, and decreased sirt6 in hippocampal homogenates. 2024-07-14 2024-07-18 rat
Jin Zhang, Yong-Wei Xiong, Hua-Long Zhu, Lu-Lu Tan, Huan Zhou, Xin-Mei Zheng, Yu-Feng Zhang, Wei Chang, De-Xiang Xu, Tian Wei, Su-Zhen Guan, Hua Wan. Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of hazardous materials. vol 476. 2024-07-13. PMID:39002485. overexpression of larp7 reversed the combined exposure-induced sirt6 decrease and senescence in mouse hippocampal neuronal cells. 2024-07-13 2024-07-16 mouse
Jin Zhang, Yong-Wei Xiong, Hua-Long Zhu, Lu-Lu Tan, Huan Zhou, Xin-Mei Zheng, Yu-Feng Zhang, Wei Chang, De-Xiang Xu, Tian Wei, Su-Zhen Guan, Hua Wan. Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of hazardous materials. vol 476. 2024-07-13. PMID:39002485. further investigation revealed that co-exposure obviously reduced the levels of la ribonucleoprotein 7 (larp7), disrupted the interaction between larp7 and sirt6, ultimately decreasing sirt6 expression in mouse hippocampal neuronal cells. 2024-07-13 2024-07-16 mouse
Jin Zhang, Yong-Wei Xiong, Hua-Long Zhu, Lu-Lu Tan, Huan Zhou, Xin-Mei Zheng, Yu-Feng Zhang, Wei Chang, De-Xiang Xu, Tian Wei, Su-Zhen Guan, Hua Wan. Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of hazardous materials. vol 476. 2024-07-13. PMID:39002485. collectively, adolescent co-exposure to cd and hfd causes hippocampal senescence and cognitive decline in mice by inhibiting larp7-mediated sirt6 expression in an m6a-dependent manner. 2024-07-13 2024-07-16 mouse
Junke Jia, Wanjiang Tao, Ting Chen, Qi Zhong, Jiahui Sun, Yutong Xu, Xiaokai Sui, Chang Chen, Zongze Zhan. SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats. Molecular neurobiology. 2023-09-05. PMID:37668962. this study aims to investigate the role of sirt6 in modulating hippocampal neurogenesis following sleep deprivation during development, and elucidate the underlying mechanism. 2023-09-05 2023-09-07 rat
Junke Jia, Wanjiang Tao, Ting Chen, Qi Zhong, Jiahui Sun, Yutong Xu, Xiaokai Sui, Chang Chen, Zongze Zhan. SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats. Molecular neurobiology. 2023-09-05. PMID:37668962. sirt6 improves hippocampal neurogenesis following prolonged sleep deprivation through modulating energy metabolism in developing rats. 2023-09-05 2023-09-07 rat
Ayman A Ibrahim, Sherif S Abdel Mageed, Marwa M Safar, Mohammed F El-Yamany, Mamdouh A Orab. MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation. Life sciences. 2023-06-29. PMID:37385372. mitoq alleviates hippocampal damage after cerebral ischemia: the potential role of sirt6 in regulating mitochondrial dysfunction and neuroinflammation. 2023-06-29 2023-08-14 Not clear
Yanning Li, Yujie Ma, Lijie Gao, Ting Wang, Yuchen Zhuang, Yuping Zhang, Long Zheng, Xifu Li. Upregulation of microglial Sirt6 and inhibition of microglial activation by vitamin D3 in lipopolysaccharide-stimulated mice and BV-2 cells. Neuroscience. 2023-06-23. PMID:37352968. moreover, vitamin d3 promoted microglial sirt6 distribution and attenuated microglia displaying an activated morphology in the hippocampus of lps-stimulated mice. 2023-06-23 2023-08-14 mouse
Yanning Li, Yujie Ma, Lijie Gao, Ting Wang, Yuchen Zhuang, Yuping Zhang, Long Zheng, Xifu Li. Upregulation of microglial Sirt6 and inhibition of microglial activation by vitamin D3 in lipopolysaccharide-stimulated mice and BV-2 cells. Neuroscience. 2023-06-23. PMID:37352968. the effects of lower, normal, and higher dosages (1, 10 and 100 μg/kg/day) of vitamin d3 on behavioral and neuromorphological changes, brain inflammatory factors, sirt6 and h3k9ac levels, and microglial sirt6 distribution in hippocampus were evaluated in lipopolysaccharide (lps)-stimulated mice. 2023-06-23 2023-08-14 mouse
Dong Peng, Xia Qing, Li Guan, Hong-Ying Li, Lijun Qiao, Yun-Bo Chen, Ye-Feng Cai, Qi Wang, Shi-Jie Zhan. Carnosine improves cognitive impairment through promoting SIRT6 expression and inhibiting ER stress in a diabetic encephalopathy model. Rejuvenation research. 2022-03-18. PMID:35302398. besides, the expressions of sirtuin 6 (sirt6), binding immunoglobulin protein (bip), protein kinase r-like endoplasmic reticulum kinase (perk), phospho-protein kinase r-like endoplasmic reticulum kinase (p-perk), inositol-requiring enzyme-1α (ire1α), phospho-inositol-requiring enzyme-1α (p-ire1α), activating transcription factor 6 (atf6), c/ebp-homologous protein (chop) in the hippocampus of the brain were detected. 2022-03-18 2023-08-13 mouse
Hitomi Matsuno, Shoko Tsuchimine, Noriko Fukuzato, Kazunori O'Hashi, Hiroshi Kunugi, Kazuhiro Sohy. Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33444676. in this study, we tried to elucidate molecular roles of sirt6 on neurite development by using primary-cultured hippocampal neurons. 2021-11-18 2023-08-13 rat
A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. we studied the expression of sirt1, sirt3, sirt5, and sirt6 in the hippocampus and saliva of humans without neurological pathologies and in patients with alzheimer's disease of elderly and senile age. 2021-08-23 2023-08-13 Not clear
A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. in healthy senile persons, the expression of sirt6 in the hippocampus and saliva was 2.5-4.5-fold lower than in healthy elderly individuals. 2021-08-23 2023-08-13 Not clear
A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. in elderly and senile patients, the expression of sirt1, sirt3, and sirt6 in the hippocampus and saliva was 1.5-4.9-fold reduced in comparison with healthy individuals of the corresponding age. 2021-08-23 2023-08-13 Not clear
Wang Li, Xin Liu, Hui Qia. Downregulation of hippocampal SIRT6 activates AKT/CRMP2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. Acta pharmacologica Sinica. vol 41. issue 12. 2021-08-16. PMID:32265492. downregulation of hippocampal sirt6 activates akt/crmp2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. 2021-08-16 2023-08-13 mouse
Wang Li, Xin Liu, Hui Qia. Downregulation of hippocampal SIRT6 activates AKT/CRMP2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. Acta pharmacologica Sinica. vol 41. issue 12. 2021-08-16. PMID:32265492. here, we confirmed that knockdown of hippocampal sirt6 alleviated depression-like behaviors induced by chronic unpredictable stress (cus) in mice. 2021-08-16 2023-08-13 mouse
Vishal Kumar, Satyabrata Kundu, Arti Singh, Shamsher Sing. Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. Current neuropharmacology. 2021-06-21. PMID:34151764. sirtuins are localized in the different parts of the brain and neuron -sirt1 (nucleus), sirt2 (cortex, striatum, hippocampus and spinal cord), sirt3 (mitochondria and cytoplasm), sirt4, sirt5 & sirt6 (mitochondria), sirt7 (nucleus) and sirt8 (nucleolus). 2021-06-21 2023-08-13 Not clear
Mozhgan Aghajanzadeh, Sina Andalib, Hossein Danafar, Kobra Rostamizadeh, Ali Sharaf. The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer. International journal of pharmaceutics. vol 586. 2021-03-05. PMID:32544519. the effect of baicalein-loaded y-shaped miktoarm copolymer on spatial memory and hippocampal expression of dhcr24, seladin and sirt6 genes in rat model of alzheimer. 2021-03-05 2023-08-13 rat
Eun Sun Jung, Hyunjung Choi, Hyundong Song, Yu Jin Hwang, Ahbin Kim, Hoon Ryu, Inhee Mook-Jun. p53-dependent SIRT6 expression protects Aβ42-induced DNA damage. Scientific reports. vol 6. 2018-03-26. PMID:27156849. aβ42, a major component of senile plaques, decreases sirt6 expression, and aβ42-induced dna damage is prevented by the overexpression of sirt6 in ht22 mouse hippocampal neurons. 2018-03-26 2023-08-13 mouse
Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. furthermore, via a lentivirus-mediated transfection in hippocampal neurons, we aimed to detect how sirt6 influence the function of hippocampus. 2017-12-13 2023-08-13 rat