| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junke Jia, Wanjiang Tao, Ting Chen, Qi Zhong, Jiahui Sun, Yutong Xu, Xiaokai Sui, Chang Chen, Zongze Zhan. SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats. Molecular neurobiology. 2023-09-05. PMID:37668962. |
this study aims to investigate the role of sirt6 in modulating hippocampal neurogenesis following sleep deprivation during development, and elucidate the underlying mechanism. |
2023-09-05 |
2023-09-07 |
rat |
| Junke Jia, Wanjiang Tao, Ting Chen, Qi Zhong, Jiahui Sun, Yutong Xu, Xiaokai Sui, Chang Chen, Zongze Zhan. SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats. Molecular neurobiology. 2023-09-05. PMID:37668962. |
sirt6 improves hippocampal neurogenesis following prolonged sleep deprivation through modulating energy metabolism in developing rats. |
2023-09-05 |
2023-09-07 |
rat |
| Ayman A Ibrahim, Sherif S Abdel Mageed, Marwa M Safar, Mohammed F El-Yamany, Mamdouh A Orab. MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation. Life sciences. 2023-06-29. PMID:37385372. |
mitoq alleviates hippocampal damage after cerebral ischemia: the potential role of sirt6 in regulating mitochondrial dysfunction and neuroinflammation. |
2023-06-29 |
2023-08-14 |
Not clear |
| Yanning Li, Yujie Ma, Lijie Gao, Ting Wang, Yuchen Zhuang, Yuping Zhang, Long Zheng, Xifu Li. Upregulation of microglial Sirt6 and inhibition of microglial activation by vitamin D3 in lipopolysaccharide-stimulated mice and BV-2 cells. Neuroscience. 2023-06-23. PMID:37352968. |
the effects of lower, normal, and higher dosages (1, 10 and 100 \xce\xbcg/kg/day) of vitamin d3 on behavioral and neuromorphological changes, brain inflammatory factors, sirt6 and h3k9ac levels, and microglial sirt6 distribution in hippocampus were evaluated in lipopolysaccharide (lps)-stimulated mice. |
2023-06-23 |
2023-08-14 |
mouse |
| Yanning Li, Yujie Ma, Lijie Gao, Ting Wang, Yuchen Zhuang, Yuping Zhang, Long Zheng, Xifu Li. Upregulation of microglial Sirt6 and inhibition of microglial activation by vitamin D3 in lipopolysaccharide-stimulated mice and BV-2 cells. Neuroscience. 2023-06-23. PMID:37352968. |
moreover, vitamin d3 promoted microglial sirt6 distribution and attenuated microglia displaying an activated morphology in the hippocampus of lps-stimulated mice. |
2023-06-23 |
2023-08-14 |
mouse |
| Dong Peng, Xia Qing, Li Guan, Hong-Ying Li, Lijun Qiao, Yun-Bo Chen, Ye-Feng Cai, Qi Wang, Shi-Jie Zhan. Carnosine improves cognitive impairment through promoting SIRT6 expression and inhibiting ER stress in a diabetic encephalopathy model. Rejuvenation research. 2022-03-18. PMID:35302398. |
besides, the expressions of sirtuin 6 (sirt6), binding immunoglobulin protein (bip), protein kinase r-like endoplasmic reticulum kinase (perk), phospho-protein kinase r-like endoplasmic reticulum kinase (p-perk), inositol-requiring enzyme-1\xce\xb1 (ire1\xce\xb1), phospho-inositol-requiring enzyme-1\xce\xb1 (p-ire1\xce\xb1), activating transcription factor 6 (atf6), c/ebp-homologous protein (chop) in the hippocampus of the brain were detected. |
2022-03-18 |
2023-08-13 |
mouse |
| Hitomi Matsuno, Shoko Tsuchimine, Noriko Fukuzato, Kazunori O'Hashi, Hiroshi Kunugi, Kazuhiro Sohy. Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33444676. |
in this study, we tried to elucidate molecular roles of sirt6 on neurite development by using primary-cultured hippocampal neurons. |
2021-11-18 |
2023-08-13 |
rat |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
we studied the expression of sirt1, sirt3, sirt5, and sirt6 in the hippocampus and saliva of humans without neurological pathologies and in patients with alzheimer's disease of elderly and senile age. |
2021-08-23 |
2023-08-13 |
Not clear |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
in healthy senile persons, the expression of sirt6 in the hippocampus and saliva was 2.5-4.5-fold lower than in healthy elderly individuals. |
2021-08-23 |
2023-08-13 |
Not clear |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
in elderly and senile patients, the expression of sirt1, sirt3, and sirt6 in the hippocampus and saliva was 1.5-4.9-fold reduced in comparison with healthy individuals of the corresponding age. |
2021-08-23 |
2023-08-13 |
Not clear |
| Wang Li, Xin Liu, Hui Qia. Downregulation of hippocampal SIRT6 activates AKT/CRMP2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. Acta pharmacologica Sinica. vol 41. issue 12. 2021-08-16. PMID:32265492. |
here, we confirmed that knockdown of hippocampal sirt6 alleviated depression-like behaviors induced by chronic unpredictable stress (cus) in mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Wang Li, Xin Liu, Hui Qia. Downregulation of hippocampal SIRT6 activates AKT/CRMP2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. Acta pharmacologica Sinica. vol 41. issue 12. 2021-08-16. PMID:32265492. |
downregulation of hippocampal sirt6 activates akt/crmp2 signaling and ameliorates chronic stress-induced depression-like behavior in mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Vishal Kumar, Satyabrata Kundu, Arti Singh, Shamsher Sing. Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. Current neuropharmacology. 2021-06-21. PMID:34151764. |
sirtuins are localized in the different parts of the brain and neuron -sirt1 (nucleus), sirt2 (cortex, striatum, hippocampus and spinal cord), sirt3 (mitochondria and cytoplasm), sirt4, sirt5 & sirt6 (mitochondria), sirt7 (nucleus) and sirt8 (nucleolus). |
2021-06-21 |
2023-08-13 |
Not clear |
| Mozhgan Aghajanzadeh, Sina Andalib, Hossein Danafar, Kobra Rostamizadeh, Ali Sharaf. The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer. International journal of pharmaceutics. vol 586. 2021-03-05. PMID:32544519. |
the effect of baicalein-loaded y-shaped miktoarm copolymer on spatial memory and hippocampal expression of dhcr24, seladin and sirt6 genes in rat model of alzheimer. |
2021-03-05 |
2023-08-13 |
rat |
| Eun Sun Jung, Hyunjung Choi, Hyundong Song, Yu Jin Hwang, Ahbin Kim, Hoon Ryu, Inhee Mook-Jun. p53-dependent SIRT6 expression protects A\\xce\\xb242-induced DNA damage. Scientific reports. vol 6. 2018-03-26. PMID:27156849. |
a\xce\xb242, a major component of senile plaques, decreases sirt6 expression, and a\xce\xb242-induced dna damage is prevented by the overexpression of sirt6 in ht22 mouse hippocampal neurons. |
2018-03-26 |
2023-08-13 |
mouse |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3\\xce\\xb2 signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
furthermore, via a lentivirus-mediated transfection in hippocampal neurons, we aimed to detect how sirt6 influence the function of hippocampus. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3\\xce\\xb2 signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
thus, our data indicates that sirt6 is involved in the modulation of depressive-like behaviors and affects the survival and synaptic plasticity of hippocampal neuron via inhibitory activation of akt-gsk3\xce\xb2 signaling. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3\\xce\\xb2 signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
up-regulation of sirt6 in the hippocampus induced rats with depression-like behavior via the block akt/gsk3\xce\xb2 signaling pathway. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3\\xce\\xb2 signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
the sirt6 overexpression significantly inhibited expressions of proteins and/or phosphoproteins (e.g akt, p-akt, p-gsk3\xce\xb2), decreased the ratios of p-gsk3\xce\xb2/gsk3\xce\xb2 and p-akt/akt in the primary hippocampus neurons. |
2017-12-13 |
2023-08-13 |
rat |
| Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xi. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3\\xce\\xb2 signaling pathway. Behavioural brain research. vol 323. 2017-12-13. PMID:28130175. |
hence, western blotting and rt-qpcr were used to investigate whether sirts (sirt1-7) expression levels were altered in the hippocampus of rats, which followed 5 weeks of chronic unpredictable mild stress (cums) treatment, the results showed depressive-like behaviors: like body weight, forced swim test and sucrose preference test and sirt6 was a significant increase in the hippocampal of cums rats. |
2017-12-13 |
2023-08-13 |
rat |