| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chitrakshi Pant, Genji Sukumar, Vidya Jyothi Alli, Surender Singh Jadav, Srihari Pabbaraja, Shasi V Kalivend. Allosteric Activation of SIRT1 by 2,4-Dihydroxy-azaflavanone Averts MPP ACS chemical neuroscience. 2024-07-29. PMID:39074306. |
allosteric activation of sirt1 by 2,4-dihydroxy-azaflavanone averts mpp parkinson's disease (pd) is a complex neurodegenerative disorder that affects dopamine neurons of the substantia nigra pars compacta (snpc), resulting in motor dysfunction. |
2024-07-29 |
2024-08-02 |
Not clear |
| Wessam H Elesawy, Ayman E El-Sahar, Rabab H Sayed, Ahmed M Ashour, Shuruq E Alsufyani, Hany H Arab, Esraa A Kandi. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy. International immunopharmacology. vol 138. 2024-07-09. PMID:38981225. |
ezetimibe ameliorated the motor impairments in open field, rotarod and grip strength tests, restored striatal dopamine and tyrosine hydroxylase in the sn, up-regulated p-ampk, sirt1, and pgc1α striatal expression, upsurged the expression of ulk1, beclin1, and lc3ii/i, reduced bax/bcl2 ratio, and alleviated rotenone-induced histopathological changes in striatum and sn. |
2024-07-09 |
2024-07-12 |
rat |
| Saba Ubaid, Mohammad Rumman, Babita Singh, Mohd Sohail Akhtar, Abbas A Mahdi, Shivani Pande. Elucidating the Neuroprotective Role of Formulated Camel α-Lactalbumin-Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson's Disease Model. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33253528. |
moreover, cloa complex treatment reduced the oxidative stress and increased the cell viability by enhancing the level of dopamine and the expression of sirt1, foxo3a, hif-1α, and hsf-1. |
2021-06-18 |
2023-08-13 |
Not clear |
| Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L Neve, Eric J Nestler, Deveroux Ferguso. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511015. |
using a cre-inducible viral vector system to overexpress sirt1 selectively in dopamine d1 or d2 subpopulations of medium spiny neurons (msns) in the nac, we found that sirt1 promotes depressive-like behaviors only when overexpressed in d1 msns, with no effect seen in d2 msns. |
2017-07-14 |
2023-08-13 |
mouse |
| Yasuko Kitao, Natsumi Ageta-Ishihara, Ryosuke Takahashi, Makoto Kinoshita, Osamu Hor. Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism. F1000Research. vol 4. 2015-07-13. PMID:26167274. |
transgenic supplementation of sirt1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of mptp-induced parkinsonism. |
2015-07-13 |
2023-08-13 |
mouse |
| Jae-Yong Lee, Kyungsook Ahn, Bong Geom Jang, Seong-Hoon Park, Hong-Jun Kang, Jee-In Heo, Yoon-Jung Ko, Moo-Ho Won, Tae-Cheon Kang, Sangmee Ahn Jo, Min-Ju Ki. Nicotinamide reduces dopamine in postnatal hypothalamus and causes dopamine-deficient phenotype. Neuroscience letters. vol 461. issue 2. 2009-09-23. PMID:19539713. |
the present study suggests that the regulation of dopamine metabolism during the postnatal development is important and the underlying molecular mechanisms may be associated with sirt1 signaling. |
2009-09-23 |
2023-08-12 |
mouse |