| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Koren, G Goresky, P Crean, J Klein, S M MacLeo. Pediatric fentanyl dosing based on pharmacokinetics during cardiac surgery. Anesthesia and analgesia. vol 63. issue 6. 1984-06-25. PMID:6731878. |
the calculated values for t1/2 alpha (12 +/- 9 min) (mean +/- sd), t1/2 beta (141 +/- 98 min) and total body clearance (12.8 +/- 7.3 ml x min-1 x kg-1) were similar to adult values. |
1984-06-25 |
2023-08-12 |
Not clear |
| C R Gardner, M H Richards, J Möhrin. Normotensive and spontaneously-hypertensive rats show differences in sensitivity to arginine-vasopressin as a modulator of noradrenaline release from brainstem slices. Brain research. vol 292. issue 1. 1984-04-03. PMID:6697213. |
in normotensive sprague-dawley (sd) and wistar kyoto (wky) rats, avp inhibited release of [3h]na in a dose-dependent fashion, the magnitude and time course of inhibition at 10(-12)m avp being similar to that observed using the alpha 2-adrenoceptor agonist, clonidine at 10(-7) m. however, it is unlikely that avp functions through alpha-receptors since its effect is not blocked by phentolamine (10(-6) m). |
1984-04-03 |
2023-08-12 |
rat |
| S Kimura, Y Miura, M Adachi, M Adachi, M Nezu, S Toriyabe, T Sugawara, Y Ishizuka, T Noshiro, M Takahash. The effect of sodium depletion on plasma norepinephrine kinetics in patients with essential hypertension. Japanese circulation journal. vol 47. issue 10. 1983-12-20. PMID:6632176. |
the calculated half time of rapid removal phase (t 1/2 alpha) of plasma ne was significantly delayed in the hypertensives (1.20 +/- 0.22 min, mean +/- sd) than in normal subjects (0.89 +/- 0.14) (p less than 0.01). |
1983-12-20 |
2023-08-12 |
human |
| L E Shapir. Regulation of a thyroid hormone-dependent protein by growth hormone: the induction of hepatic alpha 2U globulin and its messenger ribonucleic acid in adult male hypothyroid rats. Endocrinology. vol 113. issue 4. 1983-11-23. PMID:6193954. |
alpha 2u-globulin levels in vehicle-treated controls were 1.3 +/- 0.7 micrograms (+/- sd) alpha 2u-globulin/mg protein. |
1983-11-23 |
2023-08-12 |
rat |
| B B Grill, T Tinghitella, C Hillemeier, J Grybosk. Increased intestinal clearance of alpha 1-antitrypsin in patients with alpha 1-antitrypsin deficiency. Journal of pediatric gastroenterology and nutrition. vol 2. issue 1. 1983-10-08. PMID:6604150. |
three of the alpha 1-at deficiency patients had values for c-alpha 1-at greater than the mean plus 3 sd of the control, but these were not in the range seen in patients with protein losing enteropathy. |
1983-10-08 |
2023-08-12 |
Not clear |
| I W Reimann, J C Frölic. Mechanism of antihypertensive action of ketanserin in man. British medical journal (Clinical research ed.). vol 287. issue 6389. 1983-09-23. PMID:6135489. |
steady state plasma ketanserin concentrations (mean 88 (sd 19) micrograms/1) and cardiovascular responses measured in five healthy volunteers showed that therapeutic doses of ketanserin significantly antagonised the alpha 1 receptor mediated increase in arterial blood pressure after treatment with methoxamine. |
1983-09-23 |
2023-08-12 |
human |
| K Spencer, E J Coombes, P J Woo. The measurement of amniotic fluid alpha 2 macroglobulin by fixed time kinetic immunoturbidimetry. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. vol 21. issue 3. 1983-07-08. PMID:6854223. |
the data indicates no significant variation of alpha 2 macroglobulin with gestational age and that the results in none neural tube defect pregnancies showed a narrow reference range with a mean of 1.67 mg/l and -/+ 2 sd range of 0.23--3.11 mg/l (99 percentile = 3.65 mg/l). |
1983-07-08 |
2023-08-12 |
Not clear |
| P K Liu, C C Chang, J E Trosko, D K Dube, G M Martin, L A Loe. Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha. Proceedings of the National Academy of Sciences of the United States of America. vol 80. issue 3. 1983-04-15. PMID:6402775. |
the apparent km for dctp with dna polymerase alpha is 1.0 +/- 0.4 microm (mean +/- sd) for the mutant enzyme. |
1983-04-15 |
2023-08-12 |
Not clear |
| J E Zerwekh, K Sakhaee, K Glass, C Y Pa. Long term 25-hydroxyvitamin D3 therapy in postmenopausal osteoporosis: demonstration of responsive and nonresponsive subgroups. The Journal of clinical endocrinology and metabolism. vol 56. issue 2. 1983-03-11. PMID:6600460. |
in those who responded (n = 7), alpha increased from 0.36 +/- 0.05 to 0.49 +/- 0.08 (+/- sd; p less than 0.005) while no significant change was observed for the nonresponders (0.44 +/- 0.03 to 0.48 +/- 0.07). |
1983-03-11 |
2023-08-12 |
Not clear |
| B Wiman, T Nilsson, B Cedergre. Studies on a form of alpha 2-antiplasmin in plasma which does not interact with the lysine-binding sites in plasminogen. Thrombosis research. vol 28. issue 2. 1983-02-25. PMID:6817454. |
the plasma concentration of npb-ap in healthy individuals was determined as 0.40 mumol/1 +/- 0.14 (sd), constituting 35% +/- 11 (sd) of the total plasma alpha 2-antiplasmin concentration. |
1983-02-25 |
2023-08-12 |
Not clear |
| R C Urtasun, H R Rabin, J Partingto. Human pharmacokinetics and toxicity of high-dose metronidazole administered orally and intravenously. Surgery. vol 93. issue 1 Pt 2. 1983-02-25. PMID:6849198. |
the mean (+/- sd) for alpha half-life was 1.2 +/- 1.3 hours, and that for the beta half-life was 9.8 +/- 5.9 hours. |
1983-02-25 |
2023-08-12 |
human |
| O Ylikorkala, T Osterman, I B Lindén, L Viinikk. The effect of age on circulating 6-keto-prostaglandin F1 alpha in humans. Prostaglandins, leukotrienes, and medicine. vol 9. issue 5. 1983-02-25. PMID:6960379. |
the 6-keto-pgf1 alpha concentrations (mean +/- sd) in subjects between 10-20 years of age were higher (126 +/- 63 pg/ml, n = 24) than the levels in subjects between 21-30 years of age (88 +/- 30 pg/ml, n = 16), or in subjects between 51-70 years of age (88 +/- 30 pg/ml, n = 17), whereas in subjects between 71-90 years of age, the 6-keto-pgf1 alpha levels 100 +/- 59 pg/ml, n = 36) did not differ from those in subjects under 20 years of age. |
1983-02-25 |
2023-08-12 |
human |
| D J Morgan, B B Koay, J D Paul. Plasma protein binding of etidocaine during pregnancy and labour. European journal of clinical pharmacology. vol 22. issue 5. 1982-12-02. PMID:7117359. |
etidocaine (1 microgram/ml) was found to bind avidly to a physiological concentration (74 mg/dl) of alpha 1-acid glycoprotein (alpha 1-agp) (7.23 +/- 0.64%, mean +/- sd, unbound). |
1982-12-02 |
2023-08-12 |
Not clear |
| P Hadjiisky, J Renais, L Sceba. A comparative study of the arterial tissue metabolism in atherosensitive and atheroresistant species. I. Comparison between rabbit and rat aortas. Paroi arterielle. vol 7. issue 4. 1982-12-02. PMID:7347389. |
the rat aortas (atheroresistant) had a better supply of aerobic oxidoreductases [linked to the pentose pathway (g6pd, 6pgd) as well as to the krebs cycle (sd, icd)], lipolytic enzymes (acid esterases, cholinesterase, lipase), lysosomal enzymes (acid ph/ase, aryl-sulf/ase - betaglu/ase), adpase - atpase - alk ph/ase alpha gpd and acid lipids. |
1982-12-02 |
2023-08-12 |
rat |
| E N Koullapis, K H Nicolaides, W P Collins, C H Rodeck, S Campbel. Plasma prostanoids in pregnancy-induced hypertension. British journal of obstetrics and gynaecology. vol 89. issue 8. 1982-10-21. PMID:6896650. |
the concentrations (pmol/l; means +/- sd) were pgfm 373 +/- 105, 6-oxo-pgf1 alpha 391 +/- 104 and t x b2 373 +/- 121. |
1982-10-21 |
2023-08-12 |
Not clear |
| b' H Rantala, K Finni, S Simil\\xc3\\xa. Alpha-1-antitrypsin: the PiM subtypes and serum concentrations in Finnish newborns. Human heredity. vol 32. issue 3. 1982-10-21. PMID:6980821.' |
the serum concentration (mean +/- sd) of alpha-1-antitrypsin (alpha 1-at) in the whole study group was 2.72 +/- 0.61 g/l. |
1982-10-21 |
2023-08-12 |
Not clear |
| J Teulon, T Anagnostopoulo. Proximal cell K+ activity: technical problems and dependence on plasma K+ concentration. The American journal of physiology. vol 243. issue 1. 1982-08-26. PMID:6283914. |
the control alpha ki value averaged 57.9 +/- 8.5 mm (mean +/- sd, n = 38) and the basolateral membrane potential was -70.4 +/- 5.8 mv. |
1982-08-26 |
2023-08-12 |
Not clear |
| O Ylikorkala, J Puolakka, L Viinikk. The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. American journal of obstetrics and gynecology. vol 142. issue 5. 1982-04-22. PMID:7036746. |
the plasma concentrations of 6-keto-pgf1 alpha in women with combined oral contraceptives (65.5 +/- 16.1 pg/ml, mean +/- sd) was lower (p less than 0.01) than that in the control subjects (77.4 +/- 26.4 pg/ml), whereas the use of combined oral contraceptives was associated with no changes in txb2 levels in plasma or serum, in women with progestogen-only oral contraceptives, the plasma levels of 6-keto-pgf1 alpha and txb2 were normal, but the capacity of the platelets to release txb2 during spontaneous clotting was decreased (113.6 +/- 77.6 ng/ml versus 179.9 +/- 81.9 ng/ml, p less than 0.05). |
1982-04-22 |
2023-08-12 |
human |
| R P Hartshorne, W A Catteral. Purification of the saxitoxin receptor of the sodium channel from rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 7. 1981-12-21. PMID:6270687. |
two polypeptides, alpha (mr approximately equal to 270,000 +/- 10,000) and beta (mr approximately equal to 38,300 +/- 2000) (mean +/- sd) copurify with stx binding activity. |
1981-12-21 |
2023-08-12 |
rat |
| D Ylikorkala, L Viinikk. Measurement of 6-keto-prostaglandin E1 alpha in human plasma with radioimmunoassay: effect of prostacyclin infusion. Prostaglandins and medicine. vol 6. issue 4. 1981-11-24. PMID:7025068. |
the mean mass of added 6-keto-pgf1 alpha required to displace zero-point binding by 50 % was 55.6 +/- 5.1 pg (mean +/- sd, n = 10). |
1981-11-24 |
2023-08-12 |
human |