| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lichen Yin, Xin Zhao, Shizhao Ji, Chunbai He, Guangyi Wang, Cui Tang, Shaohua Gu, Chunhua Yi. The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar. Biomaterials. vol 35. issue 8. 2014-09-10. PMID:24388384. |
hypertrophic scar (hs) originates from the over-expression of transforming growth factor β (tgf-β) and downstream smad2. |
2014-09-10 |
2023-08-12 |
Not clear |
| Lichen Yin, Xin Zhao, Shizhao Ji, Chunbai He, Guangyi Wang, Cui Tang, Shaohua Gu, Chunhua Yi. The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar. Biomaterials. vol 35. issue 8. 2014-09-10. PMID:24388384. |
normal skin fibroblasts (nsfs) and hypertrophic scar fibroblasts (hsfs) were allowed to infiltrate and proliferate in gam; at the meantime they were transfected with tmcc/psuper-smad2 polyplexes to display remarkably reduced smad2 levels that lasted for up to 10 days, consequently inhibiting the over-production of type i and type iii collagen. |
2014-09-10 |
2023-08-12 |
Not clear |
| Hu Xiao, Dechang Wang, Ran Huo, Yibing Wang, Yongqiang Feng, Qiang L. Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression. Neural regeneration research. vol 8. issue 17. 2014-09-10. PMID:25206453. |
these experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension. |
2014-09-10 |
2023-08-13 |
rat |
| Lv Yaundong, Wang Dongyan, Hao Lijun, Xiao Zhib. Effects of downregulation of S100A8 protein expression on cell cycle and apoptosis of fibroblasts derived from hypertrophic scars. Aesthetic surgery journal. vol 34. issue 1. 2014-09-02. PMID:24334497. |
uncontrolled growth and lack of apoptosis in fibroblasts derived from a hypertrophic scar play an important role in pathology. |
2014-09-02 |
2023-08-12 |
Not clear |
| Nicolas Kluger, Virve Koljone. Chemical burn and hypertrophic scar due to misuse of a wart ointment for tattoo removal. International journal of dermatology. vol 53. issue 1. 2014-08-21. PMID:22804801. |
chemical burn and hypertrophic scar due to misuse of a wart ointment for tattoo removal. |
2014-08-21 |
2023-08-12 |
Not clear |
| Yi-Wen Wang, Nien-Hsien Liou, Juin-Hong Cherng, Shu-Jen Chang, Kuo-Hsing Ma, Earl Fu, Jiang-Chuan Liu, Niann-Tzyy Da. siRNA-targeting transforming growth factor-β type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. The Journal of investigative dermatology. vol 134. issue 7. 2014-08-19. PMID:24670383. |
our results demonstrate that downregulating tgfbri expression in cultured human hypertrophic scar fibroblasts significantly suppressed cell proliferation and reduced type i collagen, type iii collagen, fibronectin, and connective tissue growth factor (ctgf) mrna, and type i collagen and fibronectin protein expression. |
2014-08-19 |
2023-08-12 |
human |
| Leyre Falto-Aizpurua, Yazdani Abyaneh M, Robert D Griffith, Keyvan Nour. Cells to surgery quiz: July 2014. Hypertrophic scar. The Journal of investigative dermatology. vol 134. issue 7. 2014-08-19. PMID:24924766. |
hypertrophic scar. |
2014-08-19 |
2023-08-13 |
Not clear |
| Guofang Zeng, Fang Zhong, Jin Li, Shaojun Luo, Peihua Zhan. Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Bioscience, biotechnology, and biochemistry. vol 77. issue 12. 2014-08-18. PMID:24317052. |
resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. |
2014-08-18 |
2023-08-12 |
human |
| Guofang Zeng, Fang Zhong, Jin Li, Shaojun Luo, Peihua Zhan. Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Bioscience, biotechnology, and biochemistry. vol 77. issue 12. 2014-08-18. PMID:24317052. |
hypertrophic scar (hs) is a dermal fibroproliferative disorder characterized by excessive deposition of extracellular matrix. |
2014-08-18 |
2023-08-12 |
human |
| Saeid Amini-Nik, Elizabeth Cambridge, Winston Yu, Anne Guo, Heather Whetstone, Puviindran Nadesan, Raymond Poon, Boris Hinz, Benjamin A Alma. β-Catenin-regulated myeloid cell adhesion and migration determine wound healing. The Journal of clinical investigation. vol 124. issue 6. 2014-08-18. PMID:24837430. |
evaluation of scar tissue collected from patients with hypertrophic and normal scars revealed a correlation between the number of macrophages within the wound, β-catenin levels, and cellularity. |
2014-08-18 |
2023-08-13 |
mouse |
| Kwang Seog Kim, Eui Sik Kim, Jae Ha Hwang, Sam Yong Le. Internal mammary artery perforator-based V-Y advancement flap for the reconstruction of soft tissue defects in the sternal region. Journal of plastic surgery and hand surgery. vol 47. issue 6. 2014-07-25. PMID:23848419. |
we successfully reconstructed a large defect that had been created by resection of an unstable, contracted, and hypertrophic scar with a chronic ulcer on the lower sternal area of a 67-year-old man. |
2014-07-25 |
2023-08-12 |
Not clear |
| Dariush Honardoust, Peter Kwan, Moein Momtazi, Jie Ding, Edward E Tredge. Novel methods for the investigation of human hypertrophic scarring and other dermal fibrosis. Methods in molecular biology (Clifton, N.J.). vol 1037. 2014-07-18. PMID:24029937. |
hypertrophic scar (hts) represents the dermal equivalent of fibroproliferative disorders that occur after injury involving the deep dermis while superficial wounds to the skin heal with minimal or no scarring. |
2014-07-18 |
2023-08-12 |
mouse |
| Dariush Honardoust, Peter Kwan, Moein Momtazi, Jie Ding, Edward E Tredge. Novel methods for the investigation of human hypertrophic scarring and other dermal fibrosis. Methods in molecular biology (Clifton, N.J.). vol 1037. 2014-07-18. PMID:24029937. |
we also describe a nude mouse model of transplanted human skin that develops a hypertrophic proliferative scar consistent morphologically and histologically with human hts, which can be used to test novel treatment options for these dermal fibrotic conditions. |
2014-07-18 |
2023-08-12 |
mouse |
| Ayelet Levy, Kara Kopplin, Amit Gefe. Simulations of skin and subcutaneous tissue loading in the buttocks while regaining weight-bearing after a push-up in wheelchair users. Journal of the mechanical behavior of biomedical materials. vol 28. 2014-07-02. PMID:23706990. |
we further found that the edges of a pre-existing scar are more susceptible to injury, and the greater risk for that is when a hypertrophic scar is present. |
2014-07-02 |
2023-08-12 |
human |
| Qi-cui Du, Wen-lin Xiao, Ling-fa Xue, Shuang-yi Wang, Jin Yue, Yao-xiang X. [Role of p38 mitogen activated protein kinase on cyclic stretch in human facial hypertrophic scar fibroblasts differentiation into myofibroblasts]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 48. issue 10. 2014-07-02. PMID:24438570. |
[role of p38 mitogen activated protein kinase on cyclic stretch in human facial hypertrophic scar fibroblasts differentiation into myofibroblasts]. |
2014-07-02 |
2023-08-12 |
human |
| Qi-cui Du, Wen-lin Xiao, Ling-fa Xue, Shuang-yi Wang, Jin Yue, Yao-xiang X. [Role of p38 mitogen activated protein kinase on cyclic stretch in human facial hypertrophic scar fibroblasts differentiation into myofibroblasts]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 48. issue 10. 2014-07-02. PMID:24438570. |
to explore the signal transduction mechanism of p38 mitogen activated protein kinase (p38mapk) in human facial hypertrophic scar fibroblast (fb) differentiation into myofibroblasts (mfb). |
2014-07-02 |
2023-08-12 |
human |
| Theodore T Foley, H Paul Ehrlic. Mast cells prevent dexamethasone-induced cell death of cultured fibroblasts: relationship to gap junctional intercellular communications. Plastic and reconstructive surgery. vol 133. issue 5. 2014-06-26. PMID:24776565. |
dexamethasone, a common therapy for reducing hypertrophic scar, sometimes fails. |
2014-06-26 |
2023-08-13 |
Not clear |
| JieXing Zheng, Fei Song, Shu-Liang Lu, Xi-Qiao Wan. Dynamic hypoxia in scar tissue during human hypertrophic scar progression. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 40. issue 5. 2014-06-25. PMID:24684437. |
dynamic hypoxia in scar tissue during human hypertrophic scar progression. |
2014-06-25 |
2023-08-12 |
human |
| JieXing Zheng, Fei Song, Shu-Liang Lu, Xi-Qiao Wan. Dynamic hypoxia in scar tissue during human hypertrophic scar progression. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 40. issue 5. 2014-06-25. PMID:24684437. |
the skin color of human hypertrophic scar changes dynamically during scar progression. |
2014-06-25 |
2023-08-12 |
human |
| Zhongwen Gao, Qingsan Zhu, Yiping Zhang, Yingzheng Zhao, Lu Cai, Christopher B Shields, Jun Ca. Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23613214. |
reactive gliosis, also known as glial scar formation, is an inflammatory response characterized by the proliferation of microglia and astrocytes as well as astrocytic hypertrophy following injury in the central nervous system (cns). |
2014-06-18 |
2023-08-12 |
Not clear |