| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mrna and protein than normal skin and cells. |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
to investigate whether this fibrogenic cytokine is involved in development of hypertrophic scar, transforming growth factor-beta1 gene expression was evaluated in small skin samples. |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
because a sufficient quantity of normal skin from patients with hypertrophic scar is not readily available, a reverse transcription-polymerase chain reaction technique was used. |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
we examined the transforming growth factor-beta1 mrna in hypertrophic scar tissue and in normal skin and found that hypertrophic scar tissues expressed five-fold more transforming growth factor-beta1 mrna than normal skin per unit of wet weight. |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
we used this procedure to quantitate transforming growth factor-beta1 mrna expression in 5 pairs of fibroblast cultures derived from hypertrophic scar and normal skin. |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
the results showed that hypertrophic scar fibroblast cultures contain significantly more molecules of mrna for transforming growth factor-beta1 than normal cells (116 +/- 6 vs. 97 +/- 7, p = 0.017, n = 5). |
2000-07-18 |
2023-08-12 |
human |
| R Wang, A Ghahary, Q Shen, P G Scott, K Roy, E E Tredge. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 8. issue 2. 2000-07-18. PMID:10810039. |
in conclusion, hypertrophic scar tissue and fibroblasts produce more mrna and protein for transforming growth factor-beta1, which may be important in hypertrophic scar formation. |
2000-07-18 |
2023-08-12 |
human |
| Z R Yousef, M S Marbe. The open artery hypothesis: potential mechanisms of action. Progress in cardiovascular diseases. vol 42. issue 6. 2000-07-12. PMID:10871164. |
almost immediately, neurohormones are activated that alter hemodynamic load, and, later, stimulate myocyte hypertrophy, while locally, inflammatory processes clear necrotic debris, reorganize the extracellular matrix, and orchestrate scar formation. |
2000-07-12 |
2023-08-12 |
Not clear |
| P G Scott, A Ghahary, E E Tredge. Molecular and cellular aspects of fibrosis following thermal injury. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791173. |
the pathogenesis of hypertrophic scars following thermal injury remains a complex and incompletely understood process but recent investigations into the composition of the tissue itself, the activities of the scar fibroblasts, and the effects of various cytokines and growth factors, have all contributed to the emergence of an increasingly clear picture. |
2000-06-08 |
2023-08-12 |
Not clear |
| B Nedelec, A Ghahary, P G Scott, E E Tredge. Control of wound contraction. Basic and clinical features. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791174. |
one of the pivotal differences between wounds that proceed to normal scar compared with those that develop hypertrophic scars and scar contractures may be a lack (or late induction) of myofibroblast apoptotic cell death. |
2000-06-08 |
2023-08-12 |
Not clear |
| B Nedelec, A Ghahary, P G Scott, E E Tredge. Control of wound contraction. Basic and clinical features. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791174. |
the isometric application of contractile forces by myofibroblasts probably contributes to the formation of the whorls, nodules, and scar contractures characteristic of hypertrophic scars. |
2000-06-08 |
2023-08-12 |
Not clear |
| B Nedelec, A Ghahary, P G Scott, E E Tredge. Control of wound contraction. Basic and clinical features. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791174. |
because the prolonged presence of myofibroblasts, producing an imbalance in extracellular matrix proteins and proteases, probably exacerbates hypertrophic scars and wound contraction, accelerating the rate of apoptotic cell death to reduce the cell number to that seen in normal scar may be a useful strategy for providing effective and efficient treatment of scar contracture. |
2000-06-08 |
2023-08-12 |
Not clear |
| S Kossard, P Artem. Acitretin for hypertrophic lichen planus-like reaction in a burn scar. Archives of dermatology. vol 136. issue 5. 2000-05-30. PMID:10815851. |
acitretin for hypertrophic lichen planus-like reaction in a burn scar. |
2000-05-30 |
2023-08-12 |
Not clear |
| H Furuichi, K Yamashita, M Okada, T Toyoshima, Y Hata, S Suzuki, T Itano, T Shishibori, H Tokumitsu, R Kobayash. Identification of tranilast-binding protein as 36-kDa microfibril-associated glycoprotein by drug affinity chromatography, and its localization in human skin. Biochemical and biophysical research communications. vol 270. issue 3. 2000-05-22. PMID:10772941. |
in hypertrophic scar tissue, however, 36-kda magp was located on small bundles of microfibrils. |
2000-05-22 |
2023-08-12 |
human |
| Y Lee, E Lee, W J Par. Anchor epicanthoplasty combined with out-fold type double eyelidplasty for Asians: do we have to make an additional scar to correct the Asian epicanthal fold? Plastic and reconstructive surgery. vol 105. issue 5. 2000-05-19. PMID:10809119. |
to address the asian epicanthal fold without danger of hypertrophic scarring, the authors developed an anchor epicanthoplasty technique that leaves no additional scar when combined with a double eyelidplasty. |
2000-05-19 |
2023-08-12 |
Not clear |
| Y Sumi, H Muramatsu, K Hata, M Ueda, T Muramats. Secretory leukocyte protease inhibitor is a novel inhibitor of fibroblast-mediated collagen gel contraction. Experimental cell research. vol 256. issue 1. 2000-05-12. PMID:10739667. |
excessive gel contraction was observed when fibroblasts treated with tgf-beta1 and fibroblasts from hypertrophic and from keloid scar tissue were cultured in collagen gel. |
2000-05-12 |
2023-08-12 |
human |
| K Sayani, C M Dodd, B Nedelec, Y J Shen, A Ghahary, E E Tredget, P G Scot. Delayed appearance of decorin in healing burn scars. Histopathology. vol 36. issue 3. 2000-05-09. PMID:10692030. |
we have previously shown that hypertrophic scar tissue from burn patients contains abnormally high amounts of the proteoglycans versican and biglycan and reduced amounts of decorin, in comparison with normal dermis or mature scar. |
2000-05-09 |
2023-08-12 |
Not clear |
| E E Tredget, R Wang, Q Shen, P G Scott, A Ghahar. Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 20. issue 2. 2000-04-21. PMID:10714549. |
transforming growth factor-beta mrna and protein in hypertrophic scar tissues and fibroblasts: antagonism by ifn-alpha and ifn-gamma in vitro and in vivo. |
2000-04-21 |
2023-08-12 |
human |
| L Acarin, B González, B Castellan. STAT3 and NFkappaB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. Journal of neuropathology and experimental neurology. vol 59. issue 2. 2000-04-19. PMID:10749104. |
in the cortex, astrocytes show stat3 and nfkappab activation already at 2 to 4 hours post-lesion, preceding cell hypertrophy and gfap upregulation, and being maintained in the long-term formed glial scar. |
2000-04-19 |
2023-08-12 |
rat |
| E M Koźma, K Olczyk, A Głowacki, R Bobińsk. An accumulation of proteoglycans in scarred fascia. Molecular and cellular biochemistry. vol 203. issue 1-2. 2000-04-12. PMID:10724338. |
the obtained results have shown that the scar formation is accompanied by quantitative and qualitative alterations in gags/pgs resembling those observed in hypertrophic skin scars. |
2000-04-12 |
2023-08-12 |
Not clear |