| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian Berman, Oliver A Perez, Sailesh Konda, Bruce E Kohut, Martha H Viera, Suzette Delgado, Deborah Zell, Qing L. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 33. issue 11. 2007-11-29. PMID:17958580. |
a review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. |
2007-11-29 |
2023-08-12 |
Not clear |
| Brian Berman, Oliver A Perez, Sailesh Konda, Bruce E Kohut, Martha H Viera, Suzette Delgado, Deborah Zell, Qing L. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 33. issue 11. 2007-11-29. PMID:17958580. |
the precise mechanism of action of silicone elastomer sheeting has not been defined, but clinical trials report that this device is safe and effective for the treatment and prevention of hypertrophic and keloid scars if worn over the scar for 12 to 24 hours per day for at least 2 to 3 months. |
2007-11-29 |
2023-08-12 |
Not clear |
| Shahram Aarabi, Michael T Longaker, Geoffrey C Gurtne. Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS medicine. vol 4. issue 9. 2007-11-21. PMID:17803351. |
hypertrophic scar formation following burns and trauma: new approaches to treatment. |
2007-11-21 |
2023-08-12 |
Not clear |
| E Bölke, M Peiper, W Budach, C Matuschek, A Schwarz, K Orth, S Grip. Unilateral keloid formation after bilateral breast surgery and unilateral radiation. European journal of medical research. vol 12. issue 7. 2007-11-06. PMID:17933706. |
keloid is a hypertrophic scar that may arise within 6 months after injury in susceptible individuals. |
2007-11-06 |
2023-08-12 |
Not clear |
| Patricia A Sharp, Mary E Dougherty, Richard J Kaga. The effect of positioning devices and pressure therapy on outcome after full-thickness burns of the neck. Journal of burn care & research : official publication of the American Burn Association. vol 28. issue 3. 2007-10-15. PMID:17438506. |
the postoperative management of full-thickness burns of the neck can be a challenge for burn therapists despite the availability of many treatment modalities to minimize scar hypertrophy and contracture. |
2007-10-15 |
2023-08-12 |
human |
| Loren H Engrav, Warren L Garner, Edward E Tredge. Hypertrophic scar, wound contraction and hyper-hypopigmentation. Journal of burn care & research : official publication of the American Burn Association. vol 28. issue 4. 2007-10-12. PMID:17665520. |
hypertrophic scar, wound contraction and hyper-hypopigmentation. |
2007-10-12 |
2023-08-12 |
Not clear |
| Bruna De Felice, L F Ciarmiello, P Mondola, S Damiano, R Seru, C Argenziano, M Nacca, M Santoriello, C Garb. Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. DNA and cell biology. vol 26. issue 8. 2007-10-02. PMID:17688405. |
differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. |
2007-10-02 |
2023-08-12 |
human |
| Bruna De Felice, L F Ciarmiello, P Mondola, S Damiano, R Seru, C Argenziano, M Nacca, M Santoriello, C Garb. Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. DNA and cell biology. vol 26. issue 8. 2007-10-02. PMID:17688405. |
differently from hypertrophic scar, our results show that deltanp63 has a nuclear localization and is overexpressed only in keloid fibroblasts, suggesting an essential role of deltanp63 in vivo in human keloids. |
2007-10-02 |
2023-08-12 |
human |
| Mara Fumagalli, Tiziana Musso, William Vermi, Sara Scutera, Roberta Daniele, Daniela Alotto, Irene Cambieri, Alessia Ostorero, Francesca Gentili, Patrizia Caposio, Mario Zucca, Silvano Sozzani, Maurizio Stella, Carlotta Castagnol. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Experimental dermatology. vol 16. issue 7. 2007-08-31. PMID:17576240. |
imbalance between activin a and follistatin drives postburn hypertrophic scar formation in human skin. |
2007-08-31 |
2023-08-12 |
human |
| Mara Fumagalli, Tiziana Musso, William Vermi, Sara Scutera, Roberta Daniele, Daniela Alotto, Irene Cambieri, Alessia Ostorero, Francesca Gentili, Patrizia Caposio, Mario Zucca, Silvano Sozzani, Maurizio Stella, Carlotta Castagnol. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Experimental dermatology. vol 16. issue 7. 2007-08-31. PMID:17576240. |
immunostaining of sections obtained from active phase hypertrophic scars (ahs) revealed the presence of a high number of alpha-sma(+) myofibroblasts and dc-sign(+) dendritic cells coexpressing activin a. ex-vivo ahs fibroblasts produced more activin and less follistatin than normal skin or remission phase hypertrophic scar (hs) fibroblasts, both in basal conditions and upon tgf-betas stimulation. |
2007-08-31 |
2023-08-12 |
human |
| D A Ladin, W L Garner, D J Smit. Excessive scarring as a consequence of healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 1. 2007-08-30. PMID:17168858. |
however, in certain individuals, the result of wound healing is the excessive accumulation of collagen, resulting in a hypertrophic scar or keloid. |
2007-08-30 |
2023-08-12 |
Not clear |
| S M Alaish, D A Bettinger, O O Olutoye, L J Gould, D R Yager, A Davis, M C Crossland, R F Diegelmann, I K Cohe. Comparison of the polyvinyl alcohol sponge and expanded polytetrafluoroethylene subcutaneous implants as models to evaluate wound healing potential in human beings. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 3. 2007-08-30. PMID:17173555. |
for example, human beings have a tendency to either "overheal," as seen in keloids and hypertrophic scar formation, or have deficient healing, as seen in chronic ulcer formation. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
we have recently shown that both interferon gamma (gamma) and interferon alpha-2b (alpha-2b) markedly depress the expression of messenger rna for type i procollagen and fibronectin in postburn hypertrophic scar and normal dermal fibroblasts. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
twelve different fibroblast cell strains, six from postburn hypertrophic scar and six from the normal dermis of the same patients, were established in cell culture. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
quantitative analysis showed increases in tissue inhibitor of metalloproteinase-1 and collagenase mrna (81% and 54%, respectively) in interferon-alpha-2b-treated hypertrophic scar fibroblasts. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
cells treated with interferon-gamma showed increases in tissue inhibitor of metalloproteinase-1 mrna (78% in hypertrophic scar and 56% in normal dermal fibroblasts) but decreases (59% and 42%, respectively) in collagenase mrna. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
significantly greater collagenase activity was found in conditioned medium from interferon-alpha-2b-treated hypertrophic scar cells compared with that from interferon-gamma-treated cells. |
2007-08-30 |
2023-08-12 |
human |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblasts. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173646. |
these findings suggest that interferon alpha-2b would have some advantages over interferon-gamma for the treatment of dermal fibroproliferative disorders, such as postburn hypertrophic scar. |
2007-08-30 |
2023-08-12 |
human |
| W L Garner, T Rittenberg, H P Ehrlich, S Karmiol, J L Rodriguez, D J Smith, S H Pha. Hypertrophic scar fibroblasts accelerate collagen gel contraction. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173647. |
hypertrophic scar fibroblasts accelerate collagen gel contraction. |
2007-08-30 |
2023-08-12 |
Not clear |
| W L Garner, T Rittenberg, H P Ehrlich, S Karmiol, J L Rodriguez, D J Smith, S H Pha. Hypertrophic scar fibroblasts accelerate collagen gel contraction. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 3. issue 2. 2007-08-30. PMID:17173647. |
excessive contraction of hypertrophic scar and subsequent contracture formation are a formidable problem after thermal injury. |
2007-08-30 |
2023-08-12 |
Not clear |