| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luqi Qiu, Haijiao Xu, Binglin Sui, Pengwei Jiang, Jiaqi Wang, Dandan Xu, Feng Liang, Tao Ma, Hongda Wang, Junling Che. Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging. Analytical chemistry. 2024-05-06. PMID:38708542. |
furthermore, we discovered that the spatial distribution morphology of ptk7 was also subject to the hydrolysis ability and activation state of the related hydrolase matrix metallopeptidase14 (mmp14). |
2024-05-06 |
2024-05-08 |
human |
| Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsue. Loss of MTA2-mediated downregulation of PTK7 inhibits hepatocellular carcinoma metastasis progression by modulating the FAK-MMP7 axis. Environmental toxicology. 2023-12-05. PMID:38050825. |
in addition, matrix metalloproteinase 7 (mmp7) expression was closely regulated by ptk7, and the mrna and protein expression levels of mta2 and ptk7 correlated positively with lower os. |
2023-12-05 |
2023-12-10 |
human |
| Bingfang Xu, Sérgio A A Santos, Barry T Hinto. Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis. Developmental biology. vol 438. issue 1. 2018-05-29. PMID:29580943. |
to understand the mechanism by which ptk7 regulates cell rearrangement/intercalation, we investigated the integrity of the extracellular matrix (ecm) and the activity of intracellular cytoskeleton mediators following loss of ptk7. |
2018-05-29 |
2023-08-13 |
Not clear |
| Vladislav S Golubkov, Natalie L Prigozhina, Yong Zhang, Konstantin Stoletov, John D Lewis, Phillip E Schwartz, Robert M Hoffman, Alex Y Strongi. Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis. The Journal of biological chemistry. vol 289. issue 35. 2015-01-22. PMID:25006253. |
in cancer, the functionality of ptk7 is selectively regulated by membrane type-1 matrix metalloproteinase (mt1-mmp), adams (a disintegrin domain and metalloproteinases), and γ-secretase proteolysis. |
2015-01-22 |
2023-08-13 |
mouse |
| Vladislav S Golubkov, Alex Y Strongi. Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). The Journal of biological chemistry. vol 287. issue 50. 2013-02-12. PMID:23095747. |
we also demonstrated that in ht1080 cells the cleavage of the ptk7 ectodomain by an adam proteinase was coupled with the membrane type-1 matrix metalloproteinase (mt1-mmp) cleavage of the pkp(621)↓li site in the seventh ig-like domain of ptk7. |
2013-02-12 |
2023-08-12 |
Not clear |
| Vladislav S Golubkov, Alexander E Aleshin, Alex Y Strongi. Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21518755. |
potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (ptk7) chuzhoi by membrane type 1 matrix metalloproteinase (mt1-mmp) to congenital defects. |
2011-08-05 |
2023-08-12 |
mouse |
| Vladislav S Golubkov, Alexander E Aleshin, Alex Y Strongi. Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21518755. |
we hypothesized and then proved that the chz mutation caused an insertion of an additional membrane type 1 matrix metalloproteinase cleavage site in ptk7 and that the resulting aberrant proteolysis of chz affected the migratory parameters of the cells. |
2011-08-05 |
2023-08-12 |
mouse |
| Vladislav S Golubkov, Alexei V Chekanov, Piotr Cieplak, Alexander E Aleshin, Andrei V Chernov, Wenhong Zhu, Ilian A Radichev, Danhua Zhang, P Duc Dong, Alex Y Strongi. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. The Journal of biological chemistry. vol 285. issue 46. 2011-02-09. PMID:20837484. |
the wnt/planar cell polarity protein-tyrosine kinase-7 (ptk7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. |
2011-02-09 |
2023-08-12 |
zebrafish |
| Vladislav S Golubkov, Alexei V Chekanov, Piotr Cieplak, Alexander E Aleshin, Andrei V Chernov, Wenhong Zhu, Ilian A Radichev, Danhua Zhang, P Duc Dong, Alex Y Strongi. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. The Journal of biological chemistry. vol 285. issue 46. 2011-02-09. PMID:20837484. |
here, we demonstrate that membrane type-1 matrix metalloproteinase (mt1-mmp), a key proinvasive proteinase, functions as a principal sheddase of ptk7. |
2011-02-09 |
2023-08-12 |
zebrafish |