| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shibo Zhang, Hei Ip Hong, Victor C Y Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W T Cheun. Vertical inhibition of p110α/AKT and N-cadherin enhances treatment efficacy in PIK3CA-aberrated ovarian cancer cells. Molecular oncology. 2024-11-15. PMID:39543937. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [pik3ca, encoding pi3kalpha (also known as p110α)] is one of the most commonly aberrated genes in human cancers. |
2024-11-15 |
2024-11-17 |
human |
| Ding Gao, Jian Shi, Siyu Lu, Junyi Li, Kehan Lv, Yongqing Xu, Muguo Son. METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-11-07. PMID:39506767. |
in addition, we demonstrated that phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) was a downstream target of mir-320a, upregulation of pik3ca alleviated mir-320a-induced inhibition of osteogenic differentiation, and upregulation of oxidative stress and inflammatory responses during spa infection. |
2024-11-07 |
2024-11-09 |
human |
| Hiroshi Tada, Minoru Miyashita, Narumi Harada-Shoji, Akiko Ebata, Miku Sato, Tokiwa Motonari, Mika Yanagaki, Tomomi Kon, Aru Sakamoto, Takanori Ishid. Clinicopathogenomic analysis of PI3K/AKT/PTEN-altered luminal metastatic breast cancer in Japan. Breast cancer (Tokyo, Japan). 2024-10-28. PMID:39466567. |
this rapid communication highlights the correlation between protein kinase b alpha (akt1)-phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)- phosphatase and tensin homolog (pten) alterations and clinicopathological factors in japanese patients with metastatic recurrent breast cancer (mbc). |
2024-10-28 |
2024-10-31 |
Not clear |
| Thuy Ha Vu, Keiichiro Nakamura, Kunitoshi Shigeyasu, Chiaki Kashino, Kazuhiro Okamoto, Kotaro Kubo, Yasuhiko Kamada, Hisashi Masuyam. Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis. Scientific reports. vol 14. issue 1. 2024-10-24. PMID:39443671. |
this study investigated the correlation of apolipoprotein-b mrna-editing complex 3b (apobec3b) expression with hypoxia inducible factor 1α (hif-1α), kirsten rat sarcoma virus (kras) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) in endometriosis patients, and the inhibitory effects of apobec3b knockdown in a human endometriotic cell line. |
2024-10-24 |
2024-10-26 |
human |
| Richard Wismayer, Rosie Matthews, Celina Whalley, Julius Kiwanuka, Fredrick Elishama Kakembo, Steve Thorn, Henry Wabinga, Michael Odida, Ian Tomlinso. Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer. BMC cancer. vol 24. issue 1. 2024-10-01. PMID:39350061. |
in our population, there is a scarcity of genetic oncological studies, therefore, we investigated the mutational status of crc tissues, focusing in particular on the adenomatous polyposis coli (apc), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and smad4 genes. |
2024-10-01 |
2024-10-03 |
Not clear |
| Sibapriya Chaudhuri, Scott Thomas, Pamela Munste. Immunotherapy in breast cancer: A clinician's perspective. Journal of the National Cancer Center. vol 1. issue 2. 2024-07-22. PMID:39035768. |
other novel treatment strategies for select subgroups of patients include the cyclin-dependent kinase 4/6 (cdk4/6) inhibitors for women with estrogen receptor positive tumors, the poly adp ribose polymerase (parp) inhibitors for those with brca mutations, and phosphoinositide 3-kinase (pi3k) inhibitors for women with tumors harboring phophatidylinositol-4,5-bisphosphate 3 kinase catalytic subunit alpha (pik3ca) mutations. |
2024-07-22 |
2024-07-24 |
human |
| Carmen Maria Ardeleanu, Maria Victoria Olinca, Cristian Gabriel Viişoreanu, Horaţiu Alin Mureşan, Adriana Tecuceanu-Vulpe, Georgiana Manole, Iulia Elena Gune, Bianca Gălăţeanu, Andreea Corina Ilie-Petrov, Flavia Ultimesc. NGS mutational status on first diagnostic tissue, liquid biopsy and mastectomy in G2-G3 breast cancer. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 2. 2024-07-18. PMID:39020533. |
the ngs assessment showed that phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) mutations were the most frequent across all sample types. |
2024-07-18 |
2024-07-20 |
human |
| Hongrui Chen, Bin Sun, Shih-Jen Chang, Zhang Yu, Yajing Qiu, Chen Hua, Xiaoxi Li. Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis. Stem cell research & therapy. vol 15. issue 1. 2024-07-17. PMID:39020442. |
its etiology is associated with somatic phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) variants, but the specific mechanisms are not yet fully understood. |
2024-07-17 |
2024-07-20 |
Not clear |
| Jean Helmijr, Gianmarco Motta, Lisa Jongbloed, Vanja de Weerd, Lotte van Bergen, Noortje Verschoor, Stefania Stella, Corine Beaufort, Paolo Vigneri, John W M Martens, Saskia M Wilting, Maurice P H M Janse. A Multiplex Assay for Fast PIK3CA Hotspot Mutation Characterization in a Single Specimen by 3-Color Digital PCR Analysis. The journal of applied laboratory medicine. 2024-07-16. PMID:39012846. |
activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) gene have been detected often in solid tumors. |
2024-07-16 |
2024-07-19 |
Not clear |
| Ali Ebrahimi, Masomeh Mehrabi, Seyyed Shahram Miraghaee, Pantea Mohammadi, Fatemeh Fatehi Kafash, Mohana Delfani, Reza Khodarahm. Flavonoid compounds and their synergistic effects: Promising approaches for the prevention and treatment of psoriasis with emphasis on keratinocytes - A systematic and mechanistic review. International immunopharmacology. vol 138. 2024-06-28. PMID:38941673. |
the ten genes with the highest scores, including interleukin (il)-10, il-12a, il-1β, il-6, tumor necrosis factor-α (tnf-α), janus kinase 2 (jak 2), jun n-terminal kinase (jun), proto-oncogene tyrosine-protein kinase src (src), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and signal transducer and activator of transcription 3 (stat3), were identified as the hub genes. |
2024-06-28 |
2024-07-01 |
Not clear |
| Adedeji K Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatr. Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies. iScience. vol 27. issue 6. 2024-06-14. PMID:38872973. |
physioxia caused pdgfrβ-mediated activation of akt and extracellular regulated kinase (erk) that reduced sensitivity to egfr and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) inhibition and maintained pdgfrβ+ epithelial-mesenchymal hybrid cells with potential cancer stem cell (csc) properties. |
2024-06-14 |
2024-06-16 |
Not clear |
| L M Kudaeva, E E Kozhedub, V O Kupryshina, T Z Aliyev, E A Troshin. [Toxic manifestations of alpelisib in endocrinology. Description of the clinical case]. Problemy endokrinologii. vol 70. issue 2. 2024-05-26. PMID:38796763. |
about 40% of patients with er+/her2- mbc have mutations in the pik3ca gene, leading to hyperactivation of the alpha isoform (p110α) of phosphatidylinositol 3-kinase (pi3k). |
2024-05-26 |
2024-05-31 |
human |
| Nga Thi Thanh Nguyen, Sang Yoon Le. Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction. Biochemical pharmacology. 2024-04-19. PMID:38641308. |
gain-of-function mutation in the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k) catalytic subunit alpha gene (pik3ca) is a significant factor in head and neck cancer (hnc). |
2024-04-19 |
2024-04-22 |
Not clear |
| Prisca K Lin, Zheying Sun, George E Davi. Defining the Functional Influence of Endothelial Cell-Expressed Oncogenic Activating Mutations on Vascular Morphogenesis and Capillary Assembly. The American journal of pathology. vol 194. issue 4. 2024-03-23. PMID:37838010. |
the morphogenic impact of endothelial cell (ec) expression of activating mutants of kirsten rat sarcoma virus (kras), mitogen-activated protein kinase 1 (mek1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), akt serine/threonine kinase 1 (akt1), ras homolog enriched in brain (rheb) janus kinase 2 (jak2), or signal transducer and activator of transcription 3 (stat3) expression versus controls was evaluated, along with ec signaling events, pharmacologic inhibitor assays, and sirna suppression experiments. |
2024-03-23 |
2024-03-25 |
rat |
| Feng Lin, Kewei Yang, Jiadong Xu, Gang Wang, Lixia Yang, Jinrong Huang, Dan L. Recurrent hematuria involving urinary system with Klippel-Trenaunay syndrome: A case report. Medicine. vol 103. issue 7. 2024-02-16. PMID:38363945. |
klippel-trenaunay syndrome (kts) is a rare congenital venous malformation, it had been found to be caused by mutations of the phosphatidylinositol 4, 5-diphosphate 3-kinase catalytic subunit alpha (pik3ca) gene. |
2024-02-16 |
2024-02-19 |
Not clear |
| Grace Q Gong, Bart Vanhaesebroec. Precision Targeting of Mutant PI3Kα. Cancer discovery. vol 14. issue 2. 2024-02-08. PMID:38327193. |
pik3ca, which encodes the p110α catalytic subunit of pi 3-kinase alpha (pi3kα), is one of the most frequently genetically activated kinases in solid tumors. |
2024-02-08 |
2024-02-10 |
Not clear |
| Shixin Zhao, Hengdeng Liu, Hanwen Wang, Xuefeng He, Jinming Tang, Shaohai Qi, Ronghua Yang, Julin Xi. Inhibition of phosphatidylinositol 3-kinase catalytic subunit alpha by miR-203a-3p reduces hypertrophic scar formation via phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway. Burns & trauma. vol 12. 2024-01-05. PMID:38179473. |
given the importance of phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) in hypertrophic scar formation, the development of therapeutic strategies for endogenous inhibitors against pik3ca is of great interest. |
2024-01-05 |
2024-01-07 |
Not clear |
| Parnia Saeedi, Gilda Eslami, Masoud Tohidfar, AbbasAli Jafari-Nodushan, Mahmood Vakil. Differential gene expression (DGE) analysis in persons with a history of giardiasis. AMB Express. vol 14. issue 1. 2024-01-03. PMID:38170269. |
in addition to the candidate genes, the gene expression of some other genes, including serine/threonine kinase 1 (akt1), cyclin dependent kinase inhibitor 2a (cdkn2a), kirsten rat sarcoma (kras), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) were also examined. |
2024-01-03 |
2024-01-06 |
human |
| Baoguo Chen, Yaxin Li, Wei Li, Shuhong Ye, Lin Zhu, Yan Din. Antitumor Activity and Mechanism of Terpenoids in Seaweeds Based on Literature Review and Network Pharmacology. Advanced biology. 2023-12-22. PMID:38134388. |
proto-oncogene tyrosine-protein kinase src(src), signal transducer and activator of transcription 3 (stat3), mitogen-activated protein kinase (mapk3, mapk1), heat shock protein hsp 90-alpha (hsp90aa1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and rac-alpha serine/threonine-protein kinase (akt1) are defined as core targets. |
2023-12-22 |
2023-12-25 |
Not clear |
| Xiao-Qin Zhong, Da-Feng Hu, Yu Wang, Zhen-Qiu Ning, Min-Zhen Den. [Mechanism of Zhongfeng Xingnao Decoction in improving microcirculatory disorders in cerebral hemorrhage based on network pharmacology and molecular docking techniques]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114219. |
molecular docking results revealed that the common components β-sitosterol of rhei radix et rhizoma, notoginseng radix et rhizoma, and ginseng radix et rhizoma rubra showed good docking with proto-oncogene tyrosine-protein kinase(src), signal transducer and activator of transcription 3(stat3), phosphoinositide-3-kinase catalytic alpha polypeptide gene(pik3ca), recombinant protein tyrosine phosphatase non receptor type 11(ptpn11), akt1, epidermal growth factor receptor(egfr), calcium adhesion-associated protein beta 1(ctnnb1), vascular endothelial growth factor a(vegfa), and tumor protein p53(tp53). |
2023-12-19 |
2023-12-23 |
mouse |