| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingxi Yao, Ajay Tijore, Delfine Cheng, Jinyuan Vero Li, Anushya Hariharan, Boris Martinac, Guy Tran Van Nhieu, Charles D Cox, Michael Sheet. Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry. Science advances. vol 8. issue 45. 2022-11-09. PMID:36351022. |
we report here unexpectedly that the mechanosensitive calcium-permeable channel piezo1, previously perceived to be diffusive on plasma membranes, binds to matrix adhesions in a force-dependent manner, promoting cell spreading, adhesion dynamics, and calcium entry in normal but not in most cancer cells tested except some glioblastoma lines. |
2022-11-09 |
2023-08-14 |
Not clear |
| Miao Li, Xi Zhang, Mimi Wang, Yaohui Wang, Jiali Qian, Xiaoxia Xing, Zhiming Wang, Yang You, Kun Guo, Jie Chen, Dongmei Gao, Yan Zhao, Lan Zhang, Rongxin Chen, Jiefeng Cui, Zhenggang Re. Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma. Cancer communications (London, England). 2022-10-01. PMID:36181398. |
activation of piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma. |
2022-10-01 |
2023-08-14 |
Not clear |
| Miao Li, Xi Zhang, Mimi Wang, Yaohui Wang, Jiali Qian, Xiaoxia Xing, Zhiming Wang, Yang You, Kun Guo, Jie Chen, Dongmei Gao, Yan Zhao, Lan Zhang, Rongxin Chen, Jiefeng Cui, Zhenggang Re. Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma. Cancer communications (London, England). 2022-10-01. PMID:36181398. |
here, we explored the interplay between piezo1 and integrin β1 in the mechanosensory pathway and their effects on hcc angiogenesis to better understand matrix stiffness-induced angiogenesis. |
2022-10-01 |
2023-08-14 |
Not clear |
| Austin Lai, Peter Thurgood, Charles D Cox, Chanly Chheang, Karlheinz Peter, Anthony Jaworowski, Khashayar Khoshmanesh, Sara Baratch. Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix. ACS applied materials & interfaces. 2022-09-01. PMID:36047858. |
piezo1 response to shear stress is controlled by the components of the extracellular matrix. |
2022-09-01 |
2023-08-14 |
Not clear |
| Maria Velasco-Estevez, Nina Koch, Ilona Klejbor, Fionä Caratis, Aleksandra Rutkowsk. Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes Frontiers in cellular neuroscience. vol 16. 2022-06-20. PMID:35722613. |
mechanoreceptor piezo1 is downregulated in multiple sclerosis brain and is involved in the maturation and migration of oligodendrocytes mechanical properties of the brain such as intracranial pressure or stiffness of the matrix play an important role in the brain's normal physiology and pathophysiology. |
2022-06-20 |
2023-08-14 |
human |
| Sandip M Swain, Joelle M-J Romac, Steven R Vigna, Rodger A Liddl. Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice. JCI insight. vol 7. issue 8. 2022-04-22. PMID:35451372. |
we found that pancreatic stellate cells (pscs), the source of the extracellular matrix proteins in fibrosis, express the mechanically activated ion channel piezo1. |
2022-04-22 |
2023-08-13 |
mouse |
| Hui Wang, Ze Yuan, Bianbian Wang, Bochuan Li, Huizhen Lv, Jinlong He, Yaqian Huang, Zhen Cui, Qiannan Ma, Ting Li, Yi Fu, Xiaoli Tan, Yangping Liu, Shengpeng Wang, Changhe Wang, Wei Kong, Yi Zh. COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure. Hypertension (Dallas, Tex. : 1979). 2022-01-05. PMID:34983194. |
comp (cartilage oligomeric matrix protein), a novel piezo1 regulator that controls blood pressure. |
2022-01-05 |
2023-08-13 |
Not clear |
| Mingzhi Luo, Grace Cai, Kenneth K Y Ho, Kang Wen, Zhaowen Tong, Linhong Deng, Allen P Li. Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation. BMC molecular and cell biology. vol 23. issue 1. 2022-01-04. PMID:34979904. |
compression enhances invasive phenotype and matrix degradation of breast cancer cells via piezo1 activation. |
2022-01-04 |
2023-08-13 |
Not clear |
| Wataru Morozumi, Kota Aoshima, Satoshi Inagaki, Yuki Iwata, Yuya Takagi, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazaw. Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade. Experimental eye research. 2022-01-02. PMID:34973946. |
activation of piezo1 in htmc showed increased expression of matrix metalloproteinase-2 (mmp-2) and cyclooxygenase (cox)-2, and decreased fibronectin expression. |
2022-01-02 |
2023-08-13 |
mouse |
| Ramona Emig, Wiebke Knodt, Mario J Krussig, Callum M Zgierski-Johnston, Oliver Gorka, Olaf Groß, Peter Kohl, Ursula Ravens, Rémi Peyronne. Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells. vol 10. issue 3. 2021-10-18. PMID:33809739. |
piezo1 channels contribute to the regulation of human atrial fibroblast mechanical properties and matrix stiffness sensing. |
2021-10-18 |
2023-08-13 |
human |
| Ramona Emig, Wiebke Knodt, Mario J Krussig, Callum M Zgierski-Johnston, Oliver Gorka, Olaf Groß, Peter Kohl, Ursula Ravens, Rémi Peyronne. Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells. vol 10. issue 3. 2021-10-18. PMID:33809739. |
further, we show that piezo1 is instrumental for fibroblast adaptation to changes in matrix stiffness, and that piezo1-induced cell stiffening is transmitted in a paracrine manner to other cells by a signaling mechanism requiring interleukin-6. |
2021-10-18 |
2023-08-13 |
human |
| Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenbin Hua, Xinghuo Wu, Yukun Zhang, Xianlin Zeng, Cao Yan. Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2021. 2021-09-09. PMID:33628392. |
mechanosensitive ion channel piezo1 activated by matrix stiffness regulates oxidative stress-induced senescence and apoptosis in human intervertebral disc degeneration. |
2021-09-09 |
2023-08-13 |
human |
| Tim Rolvien, Michael Amlin. Disuse Osteoporosis: Clinical and Mechanistic Insights. Calcified tissue international. 2021-03-19. PMID:33738515. |
osteocytic mechanosensors include the osteocyte cytoskeleton and dendritic processes within the lacuno-canalicular system (lcs), ion channels (e.g., piezo1), extracellular matrix, primary cilia, focal adhesions (integrin-based) and hemichannels and gap junctions (connexin-based). |
2021-03-19 |
2023-08-13 |
Not clear |
| Wenjianlong Zhou, Xiangxiang Liu, Jan Willem Maurits van Wijnbergen, Linhao Yuan, Yuan Liu, Chuanbao Zhang, Wang Ji. Identification of PIEZO1 as a potential prognostic marker in gliomas. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:32999349. |
gene ontology analysis showed that expression of piezo1 was correlated with tumour microenvironment-related genes that encode proteins involved in extracellular matrix (ecm) organization, angiogenesis and cell migration. |
2021-01-04 |
2023-08-13 |
Not clear |
| Xin Chen, Siyi Wanggou, Ankur Bodalia, Min Zhu, Weifan Dong, Jerry J Fan, Wen Chi Yin, Hyun-Kee Min, Malini Hu, Diana Draghici, Wenkun Dou, Feng Li, Fiona J Coutinho, Heather Whetstone, Michelle M Kushida, Peter B Dirks, Yuanquan Song, Chi-Chung Hui, Yu Sun, Lu-Yang Wang, Xuejun Li, Xi Huan. A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. vol 100. issue 4. 2019-08-12. PMID:30344046. |
piezo1 localizes at focal adhesions to activate integrin-fak signaling, regulate extracellular matrix, and reinforce tissue stiffening. |
2019-08-12 |
2023-08-13 |
mouse |
| Benjamin M Gaub, Daniel J Mülle. Mechanical Stimulation of Piezo1 Receptors Depends on Extracellular Matrix Proteins and Directionality of Force. Nano letters. vol 17. issue 3. 2018-11-12. PMID:28164706. |
mechanical stimulation of piezo1 receptors depends on extracellular matrix proteins and directionality of force. |
2018-11-12 |
2023-08-13 |
Not clear |