| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengyuan Li, Lin Hao, Shenghong Chen, Wenhan Fu, Hui Zhang, Zongsheng Yin, Yin Wang, Jun Wan. Forkhead box C1 promotes the pathology of osteoarthritis in subchondral bone osteoblasts via the Piezo1/YAP axis. Cellular signalling. 2024-10-13. PMID:39396563. |
mechanistically, the overexpression of foxc1 through piezo1 activation, in combination with downstream yap signaling, led to increased levels of alkaline phosphatase (alp), collagen type 1 (col1) a1, runx2, osteocalcin, matrix metalloproteinase (mmp) 3, and mmp9 expression. |
2024-10-13 |
2024-10-16 |
mouse |
| Xu Yan, Su Fu, Ying Xie, Chunlin Zhang, Xuejian W. Piezo1-driven mechanotransduction as a key regulator of cartilage degradation in early osteoarthritis. Biomolecules & biomedicine. 2024-10-10. PMID:39388709. |
using rat chondrocytes cultured in a 3d in vitro model, we found that fluid flow-induced physical stress activates constitutively expressed piezo1, leading to increased catabolic activity and apoptosis, which, in turn, disrupts the matrix structure. |
2024-10-10 |
2024-10-13 |
rat |
| Du Wenqiang, Ashkan Novin, Yamin Liu, Junaid Afzal, Yasir Suhail, Shaofei Liu, Nicole R Gavin, Jennifer R Jorgensen, Christopher M Morosky, Reinaldo Figueroa, Tannin A Schmidt, Melinda Sanders, Molly A Brewer, Kshiti. Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum. Nature communications. vol 15. issue 1. 2024-09-28. PMID:39333481. |
scar matrix drives piezo1 mediated stromal inflammation leading to placenta accreta spectrum. |
2024-09-28 |
2024-10-01 |
Not clear |
| Du Wenqiang, Ashkan Novin, Yamin Liu, Junaid Afzal, Yasir Suhail, Shaofei Liu, Nicole R Gavin, Jennifer R Jorgensen, Christopher M Morosky, Reinaldo Figueroa, Tannin A Schmidt, Melinda Sanders, Molly A Brewer, Kshiti. Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum. Nature communications. vol 15. issue 1. 2024-09-28. PMID:39333481. |
we created a model of uterine scar, recapitulating pas-like invasive phenotype, showing that scar matrix activates mechanosensitive ion channel, piezo1, through glycolysis-fueled cellular contraction. |
2024-09-28 |
2024-10-01 |
Not clear |
| Dongya Jiang, Jing Zhao, Jie Zheng, Yingmin Zhao, Meini Le, Dani Qin, Qiong Huang, Jinyu Huang, Qingshun Zhao, Long Wang, Xiaohua Don. LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX. Redox biology. vol 76. 2024-09-11. PMID:39260063. |
mechanistically, lox increases its catalytic substrates, the collagen i/iii components, promoting extracellular matrix (ecm) remodeling and possibly mediating ecm cross-linking, which leads to increased stiffness at the site of injury and subsequent activation of the piezo1 channel. |
2024-09-11 |
2024-09-14 |
Not clear |
| Kyung-A Byun, Je Hyuk Lee, So Young Lee, Seyeon Oh, Sosorburam Batsukh, Gwahn-Woo Cheon, Dongun Lee, Jeong Hee Hong, Kuk Hui Son, Kyunghee Byu. Piezo1 Activation Drives Enhanced Collagen Synthesis in Aged Animal Skin Induced by Poly L-Lactic Acid Fillers. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000341. |
piezo1, an ion channel, responds to mechanical stimuli, including changes in extracellular matrix stiffness, by mediating ca |
2024-07-13 |
2024-07-15 |
Not clear |
| Lei Lei, Zhenkang Wen, Mingde Cao, Haozhi Zhang, Samuel Ka-Kin Ling, Bruma Sai-Chuen Fu, Ling Qin, Jiankun Xu, Patrick Shu-Hang Yun. The emerging role of Piezo1 in the musculoskeletal system and disease. Theranostics. vol 14. issue 10. 2024-07-12. PMID:38994033. |
this review aims to provide a comprehensive summary of the current research on piezo1 in the musculoskeletal system, highlighting its impact on bone formation, myogenesis, chondrogenesis, intervertebral disc homeostasis, tendon matrix cross-linking, and physical activity. |
2024-07-12 |
2024-07-14 |
Not clear |
| Chelsea G Johansen, Keifer Holcomb, Amit Sela, Stephanie Morrall, Daewon Park, Nikki L Farnswort. Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca Matrix biology plus. vol 22. 2024-05-29. PMID:38803329. |
extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive piezo1 channel regulated ca the pancreatic islet is surrounded by ecm that provides both biochemical and mechanical cues to the islet β-cell to regulate cell survival and insulin secretion. |
2024-05-29 |
2024-06-03 |
Not clear |
| Chelsea G Johansen, Keifer Holcomb, Amit Sela, Stephanie Morrall, Daewon Park, Nikki L Farnswort. Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca Matrix biology plus. vol 22. 2024-05-29. PMID:38803329. |
we hypothesized that increasing matrix stiffness will lead to insulin secretion dysfunction by opening the mechanosensitive ion channel piezo1 and disrupting intracellular ca |
2024-05-29 |
2024-06-03 |
Not clear |
| Feng Mei, Yaru Guo, Yu Wang, Yingying Zhou, Boon Chin Heng, Mengru Xie, Xiaofei Huang, Shihan Zhang, Shuai Ding, Fangyong Liu, Xuliang Deng, Lili Chen, Cheng Yan. Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis. Cell proliferation. 2024-04-01. PMID:38556840. |
it is further observed that matrix stiffening increases piezo1 expression, as well as leads to subsequent activation of the mechanotransduction signalling effector yap, thus favouring m1 polarisation whilst suppressing m2 polarisation. |
2024-04-01 |
2024-04-03 |
Not clear |
| Marta Drobnik, Jakub Smólski, Łukasz Grądalski, Szymon Niemirka, Ewelina Młynarska, Jacek Rysz, Beata Franczy. Mechanosensitive Cation Channel Piezo1 Is Involved in Renal Fibrosis Induction. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338996. |
administration of the piezo1 unspecific inhibitor or activators to unilateral ureter obstruction (uuo) mice or animals with folic acid-induced fibrosis modulates extracellular matrix deposition and influences kidney function. |
2024-02-10 |
2024-02-12 |
mouse |
| Wenqiang Yan, Maihemuti Maimaitimin, Yue Wu, Yifei Fan, Shuang Ren, Fengyuan Zhao, Chenxi Cao, Xiaoqing Hu, Jin Cheng, Yingfang A. Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process. Science advances. vol 9. issue 45. 2023-11-08. PMID:37939174. |
mechanistically, the biomechanics and matrix stiffness up-regulated piezo1 expression, facilitating concerted activation of calcineurin and nfatc1, further activated yap-psmad2/3-sox9 axis, and consequently facilitated fibrochondrogenesis of mscs during meniscal regeneration. |
2023-11-08 |
2023-11-20 |
mouse |
| Wenqiang Yan, Maihemuti Maimaitimin, Yue Wu, Yifei Fan, Shuang Ren, Fengyuan Zhao, Chenxi Cao, Xiaoqing Hu, Jin Cheng, Yingfang A. Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process. Science advances. vol 9. issue 45. 2023-11-08. PMID:37939174. |
in addition, piezo1 induced by biomechanics and matrix stiffness up-regulated collagen cross-link enzyme expression, which catalyzed collagen cross-link and thereby enhanced mechanical properties of regenerated tissue. |
2023-11-08 |
2023-11-20 |
mouse |
| Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua, Cao Yan. Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration. Journal of translational medicine. vol 21. issue 1. 2023-10-10. PMID:37817199. |
matrix stiffness induces drp1-mediated mitochondrial fission through piezo1 mechanotransduction in human intervertebral disc degeneration. |
2023-10-10 |
2023-10-15 |
human |
| Delfine Cheng, Junfan Wang, Mingxi Yao, Charles D Co. Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions. Biochemical Society transactions. 2023-09-29. PMID:37772664. |
however, an emerging picture is developing based on spatial crosstalk between fas and piezo1 revealing a synergistic model involving the cytoskeleton, extracellular matrix (ecm) and calcium-dependent signaling. |
2023-09-29 |
2023-10-07 |
Not clear |
| Katherine M Young, Cynthia A Reinhart-Kin. Cellular mechanosignaling for sensing and transducing matrix rigidity. Current opinion in cell biology. vol 83. 2023-07-20. PMID:37473514. |
in the past two years, there has been expansion of our knowledge of commonly studied pathways, such as yap/taz, fak/src, rhoa/rock, and piezo1 signaling, as well as the discovery of new interactions, such as the effect of matrix rigidity of cell mitochondrial function and metabolism, which represent a new and exciting direction for the field as a whole. |
2023-07-20 |
2023-08-14 |
Not clear |
| Yanqiu Wu, Xinxin Xu, Fengyi Liu, Zheng Jing, Danfeng Shen, Ping He, Tao Chen, Tianli Wu, Hengji Jia, Dingqiang Mo, Yuzhou Li, He Zhang, Sheng Yan. Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation. ACS biomaterials science & engineering. 2023-07-10. PMID:37428711. |
here, for the first time, we constructed a 3d culture environment by gelma hydrogels with different amino substitution degrees and found that piezo1 expression was significantly stimulated by the stiff matrix with high substitution; meanwhile, the expressions of osteogenic markers osx, runx2, and alp were also observably improved. |
2023-07-10 |
2023-08-14 |
Not clear |
| Yanqiu Wu, Xinxin Xu, Fengyi Liu, Zheng Jing, Danfeng Shen, Ping He, Tao Chen, Tianli Wu, Hengji Jia, Dingqiang Mo, Yuzhou Li, He Zhang, Sheng Yan. Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation. ACS biomaterials science & engineering. 2023-07-10. PMID:37428711. |
moreover, knockdown of piezo1 in the stiff matrix revealed significant reduction of the abovementioned osteogenic markers. |
2023-07-10 |
2023-08-14 |
Not clear |
| Yanqiu Wu, Xinxin Xu, Fengyi Liu, Zheng Jing, Danfeng Shen, Ping He, Tao Chen, Tianli Wu, Hengji Jia, Dingqiang Mo, Yuzhou Li, He Zhang, Sheng Yan. Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation. ACS biomaterials science & engineering. 2023-07-10. PMID:37428711. |
in addition, in this 3d biomimetic ecm, we also observed that piezo1 can be activated by the static mechanical conditions of the stiff matrix, leading to the increase of the intracellular calcium content and accompanied with a continuous change in cellular energy levels as atp was consumed during cellular differentiation. |
2023-07-10 |
2023-08-14 |
Not clear |
| Xu Feng, Siwen Li, Shuangshuang Wang, Yuan Meng, Shize Zheng, Cangwei Liu, Bei Chang, Ce Shi, Hongchen Su. Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA. Oral diseases. 2023-05-15. PMID:37184045. |
piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced tmjoa. |
2023-05-15 |
2023-08-14 |
Not clear |