| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
we characterised the behavioural phenotype of mice heterozygous (oxtr(+/-)) for the oxytocin receptor gene (oxtr) and compared it with that of oxtr null mice (oxtr(-/-)), which display autistic-like behaviours, including impaired sociability and preference for social novelty, impaired cognitive flexibility, and increased aggression. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
by autoradiography, oxtr(+/-) mice were found to have approximately 50% fewer oxytocin receptors (oxtrs) in all of the examined brain regions. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
we then investigated the rescue of the oxtr(+/-) social deficits by oxytocin (ot) and thr(4)gly(7)ot (tgot) administered i.c.v. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
in line with this, a low dose of the selective oxytocin antagonist desglydtyrovt blocks the rescue effect of tgot only in the oxtr(+/-) genotype, whereas the less selective antagonist sr49059 blocks rescue in both genotypes. |
2013-07-12 |
2023-08-12 |
mouse |
| Christiane Montag, Eva-Maria Brockmann, Anja Lehmann, Daniel J Müller, Dan Rujescu, Jürgen Gallina. Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia. PloS one. vol 7. issue 12. 2013-06-25. PMID:23284802. |
the nonapeptide oxytocin (oxt) and its receptor (oxtr) have been implicated in social cognition, empathy, emotion and stress regulation in humans. |
2013-06-25 |
2023-08-12 |
Not clear |
| Robert Kumsta, Elisabeth Hummel, Frances S Chen, Markus Heinrich. Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Frontiers in neuroscience. vol 7. 2013-06-05. PMID:23734094. |
we provide an overview of the functional importance of oxytocin receptor gene (oxtr) promoter methylation and summarize studies that have investigated the role of oxtr methylation in behavioral phenotypes. |
2013-06-05 |
2023-08-12 |
human |
| Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Masako Shibuya, Jun Egawa, Toshiyuki Somey. Oxytocin receptor (OXTR) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a Japanese population. Psychiatry and clinical neurosciences. vol 66. issue 7. 2013-05-29. PMID:23252931. |
oxytocin receptor (oxtr) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a japanese population. |
2013-05-29 |
2023-08-12 |
Not clear |
| Roger L H Pobbe, Brandon L Pearson, D Caroline Blanchard, Robert J Blanchar. Oxytocin receptor and Mecp2 308/Y knockout mice exhibit altered expression of autism-related social behaviors. Physiology & behavior. vol 107. issue 5. 2013-05-17. PMID:22406388. |
this report reviews the behaviors of oxytocin receptor (oxtr) and mecp2(308/y) wild-type (wt) and knockout (ko) mice, in a number of tests specifically designed to provide information on behaviors that may show functional parallels to the core symptoms of asd. |
2013-05-17 |
2023-08-12 |
mouse |
| Abigail A Marsh, Henry H Yu, Daniel S Pine, Elena K Gorodetsky, David Goldman, R J R Blai. The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22763666. |
the influence of oxytocin administration on responses to infant faces and potential moderation by oxtr genotype. |
2013-05-10 |
2023-08-12 |
Not clear |
| Abigail A Marsh, Henry H Yu, Daniel S Pine, Elena K Gorodetsky, David Goldman, R J R Blai. The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22763666. |
in addition, given that preliminary evidence suggests that a single-nucleotide polymorphism of the oxytocin receptor (oxtr) gene, rs53576, may influence behaviors associated with parental sensitivity, we assessed whether such responses vary according to oxtr rs53576 genotype. |
2013-05-10 |
2023-08-12 |
Not clear |
| M C Cornelis, M M Glymour, S-C Chang, E J T Tchetgen, L Liang, K C Koenen, J H Kang, L R Pasquale, E B Rimm, I Kawachi, L D Kubzansk. Oxytocin receptor (OXTR) is not associated with optimism in the Nurses' Health Study. Molecular psychiatry. vol 17. issue 12. 2013-05-07. PMID:22212599. |
oxytocin receptor (oxtr) is not associated with optimism in the nurses' health study. |
2013-05-07 |
2023-08-12 |
Not clear |
| G L Poirier, M I Cordero, C Sand. Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression. Frontiers in behavioral neuroscience. vol 7. 2013-05-06. PMID:23641204. |
expression was examined by analyses of targeted candidate genes, serotonin transporter (slc6a4), vasopressin receptor 1a, (avpr1a), and oxytocin receptor (oxtr). |
2013-05-06 |
2023-08-12 |
rat |
| Sau-Yeen Loke, Kazuhiro Tanaka, Wei-Yi On. Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. Journal of neurochemistry. vol 124. issue 6. 2013-04-29. PMID:23294445. |
western blots confirmed down-regulation of oxytocin receptor (oxtr) at 1 day post-7β-hc treatment. |
2013-04-29 |
2023-08-12 |
rat |
| E Unternaehrer, P Luers, J Mill, E Dempster, A H Meyer, S Staehli, R Lieb, D H Hellhammer, G Meinlschmid. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress. Translational psychiatry. vol 2. 2013-03-14. PMID:22892716. |
we investigated quantitative dna methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (oxtr) and brain-derived neurotrophic factor (bdnf ). |
2013-03-14 |
2023-08-12 |
human |
| Ada Johansson, Lars Westberg, Kenneth Sandnabba, Patrick Jern, Benny Salo, Pekka Santtil. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22421562. |
associations between oxytocin receptor gene (oxtr) polymorphisms and self-reported aggressive behavior and anger: interactions with alcohol consumption. |
2013-01-14 |
2023-08-12 |
Not clear |
| Ada Johansson, Lars Westberg, Kenneth Sandnabba, Patrick Jern, Benny Salo, Pekka Santtil. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22421562. |
oxytocin has been implicated in the regulation of social as well as aggressive behaviors, and in a recent study we found that the effect of alcohol on aggressive behavior was moderated by the individual's genotype on an oxytocin receptor gene (oxtr) polymorphism (johansson et al., 2012). |
2013-01-14 |
2023-08-12 |
Not clear |
| Ruth Feldman, Orna Zagoory-Sharon, Omri Weisman, Inna Schneiderman, Ilanit Gordon, Rina Maoz, Idan Shalev, Richard P Ebstei. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological psychiatry. vol 72. issue 3. 2012-11-20. PMID:22336563. |
sensitive parenting is associated with plasma oxytocin and polymorphisms in the oxtr and cd38 genes. |
2012-11-20 |
2023-08-12 |
human |
| Nan Wu, Zhi Li, Yanjie S. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Journal of affective disorders. vol 138. issue 3. 2012-11-20. PMID:22357335. |
the association between oxytocin receptor gene polymorphism (oxtr) and trait empathy. |
2012-11-20 |
2023-08-12 |
Not clear |
| Nan Wu, Zhi Li, Yanjie S. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Journal of affective disorders. vol 138. issue 3. 2012-11-20. PMID:22357335. |
however, the effect of diverse gene locus haplotypes of oxytocin receptor gene (oxtr) on trait empathy lacks reliable evidence. |
2012-11-20 |
2023-08-12 |
Not clear |
| A I Malik, C C Zai, Z Abu, B Nowrouzi, J H Beitchma. The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22372486. |
we used polymerase chain reaction (pcr) to determine the genotype for three oxytocin gene (oxt) single nucleotide polymorphisms (snps): rs3761248, rs4813625 and rs877172; and five oxytocin receptor gene (oxtr) snps: rs6770632, rs11476, rs1042778, rs237902 and rs53576. |
2012-11-20 |
2023-08-12 |
Not clear |