| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
oral administration of imi resulted in apparent cerebellar histopathological alterations, oxidative stress, predominance of m1 microglia phenotype, significantly upregulated nlrp3, caspase-1, gsdmd, il-18 and aβ deposits and significantly decreased neprilysin expression. |
2024-07-29 |
2024-08-02 |
rat |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
next, increased levels of nlrp3, pro-casp 1, cleaved casp 1 (c-casp 1), full-length gsdmd, and cleaved gdsmd revealed nlrp3 inflammasome activation in wobbler spinal cords, but not in the cerebellum. |
2024-06-26 |
2024-06-29 |
mouse |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
following lps stimulation, we observed microglia activation and subsequent elevation in proinflammatory cytokines (m1; tnf-α, ifn-γ) with nlrp3 activationand a concomitant reduction in the expression of anti-inflammatory markers (m2; ym1, tgf-β1) in the cerebellar tissue of aged mice compared with the young lps and aged controls. |
2023-04-28 |
2023-08-14 |
mouse |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Jiuyang Ding, Lingyi Shen, Yuanliang Ye, Shanshan Hu, Zheng Ren, Ting Liu, Jialin Dai, Zhu Li, Jiawen Wang, Ya Luo, Qiaojun Zhang, Xiali Zhang, Xiaolan Qi, Jiang Huan. Inflammasome Inhibition Prevents Motor Deficit and Cerebellar Degeneration Induced by Chronic Methamphetamine Administration. Frontiers in molecular neuroscience. vol 15. 2022-04-18. PMID:35431795. |
using the nlrp3 inhibitor mcc950, we found that inhibiting nlrp3 alleviated the above-mentioned motor deficits and cerebellar pathologies. |
2022-04-18 |
2023-08-13 |
mouse |
| Jiuyang Ding, Lingyi Shen, Yuanliang Ye, Shanshan Hu, Zheng Ren, Ting Liu, Jialin Dai, Zhu Li, Jiawen Wang, Ya Luo, Qiaojun Zhang, Xiali Zhang, Xiaolan Qi, Jiang Huan. Inflammasome Inhibition Prevents Motor Deficit and Cerebellar Degeneration Induced by Chronic Methamphetamine Administration. Frontiers in molecular neuroscience. vol 15. 2022-04-18. PMID:35431795. |
this study aims to determine the consequences of nlrp3 modulation and the underlying mechanism of chronic meth-induced cerebellar pc degeneration. |
2022-04-18 |
2023-08-13 |
mouse |
| Jiuyang Ding, Lingyi Shen, Yuanliang Ye, Shanshan Hu, Zheng Ren, Ting Liu, Jialin Dai, Zhu Li, Jiawen Wang, Ya Luo, Qiaojun Zhang, Xiali Zhang, Xiaolan Qi, Jiang Huan. Inflammasome Inhibition Prevents Motor Deficit and Cerebellar Degeneration Induced by Chronic Methamphetamine Administration. Frontiers in molecular neuroscience. vol 15. 2022-04-18. PMID:35431795. |
furthermore, decreased mature il-1β expression mediated by caspase 1 in the cerebellum may be associated with the neuroprotective effects of nlrp3 inflammasome inhibition. |
2022-04-18 |
2023-08-13 |
mouse |
| Sunny Malhotra, Carme Costa, Herena Eixarch, Christian W Keller, Lukas Amman, Helios Martínez-Banaclocha, Luciana Midaglia, Eduard Sarró, Isabel Machín-Díaz, Luisa M Villar, Juan Carlos Triviño, Begoña Oliver-Martos, Laura Navarro Parladé, Laura Calvo-Barreiro, Fuencisla Matesanz, Koen Vandenbroeck, Elena Urcelay, María-Luisa Martínez-Ginés, Amalia Tejeda-Velarde, Nicolás Fissolo, Joaquín Castilló, Alex Sanchez, Avril A B Robertson, Diego Clemente, Marco Prinz, Pablo Pelegrin, Jan D Lünemann, Carmen Espejo, Xavier Montalban, Manuel Comabell. NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32282893. |
nlrp3 inflammasome-specific inhibition was also effective in reducing axonal damage in a model of lipopolysaccharide-neuroinflammation using organotypic cerebellar cultures. |
2020-12-14 |
2023-08-13 |
mouse |
| Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A Genovesi, Christelle Adolphe, Darren L Brown, Jennifer L Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J Wainwrigh. Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature communications. vol 9. issue 1. 2018-12-26. PMID:30097576. |
in addition, we show that substantial microgliosis is triggered by the nlrp3 inflammasome pathway in the cerebellum and that blocking nlrp3 function in vivo significantly delays neuronal degeneration and the onset of ataxia in mutant animals. |
2018-12-26 |
2023-08-13 |
mouse |