| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Imai, J Yoshin. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, obesity & metabolism. vol 15 Suppl 3. 2014-04-14. PMID:24003918. |
in the past decade, an accumulating body of evidence has demonstrated that sirt1 and nampt, two essential components in the nad world, play a critical role in regulating insulin sensitivity and insulin secretion throughout the body. |
2014-04-14 |
2023-08-12 |
Not clear |
| Robert Spinnler, Theresa Gorski, Katharina Stolz, Susanne Schuster, Antje Garten, Annette G Beck-Sickinger, Marten A Engelse, Eelco J P de Koning, Antje Körner, Wieland Kiess, Kathrin Maedle. The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342086. |
the adipocytokine nampt and its product nmn have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. |
2013-08-02 |
2023-08-12 |
Not clear |
| X Julia Xu, Marie-Soleil Gauthier, Donald T Hess, Caroline M Apovian, Jose M Cacicedo, Noyan Gokce, Melissa Farb, Rudy J Valentine, Neil B Ruderma. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. Journal of lipid research. vol 53. issue 4. 2012-07-02. PMID:22323564. |
a custom pcr array revealed increases in mrna levels of a wide variety of genes associated with inflammation and decreases in pgc-1α and nampt in omental fat of the insulin resistant group. |
2012-07-02 |
2023-08-12 |
Not clear |
| Claire Jacques, Martin Holzenberger, Zvezdana Mladenovic, Colette Salvat, Emilie Pecchi, Francis Berenbaum, Marjolaine Gosse. Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22399297. |
proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (nampt) involve regulation of insulin signaling pathway and nampt enzymatic activity. |
2012-07-02 |
2023-08-12 |
human |
| Elizabeth A Mazzio, Nawal Boukli, Nery Rivera, Karam F A Solima. Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer science. vol 103. issue 3. 2012-04-16. PMID:22320183. |
moreover, acidic phe corresponded to metabolic efficiency evidenced by a rise in mtor nutrient sensor gβl, its downstream target (eif4ebp1), insulin modulators (trib3 and fetub) and loss of catabolic (hadhb, bdh1 and pygl)/glycolytic processes (aldolase c, pyruvate kinase, nampt and aldose-reductase). |
2012-04-16 |
2023-08-12 |
Not clear |
| b' Susana Vallejo, Tania Romacho, Javier Angulo, Laura A Villalobos, Elena Cercas, Alejandra Leivas, Elena Bermejo, Raffaele Carraro, Carlos F S\\xc3\\xa1nchez-Ferrer, Concepci\\xc3\\xb3n Peir\\xc3\\xb. Visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activity. PloS one. vol 6. issue 11. 2012-03-26. PMID:22073309.' |
additionally, the nampt inhibitor apo866 (10 mmol/l to 10 µmol/l), but not an insulin receptor-blocking antibody, also prevented the stimulation of nadph oxidase and the relaxation impairment elicited by visfatin. |
2012-03-26 |
2023-08-12 |
human |
| Antje Garten, Stefanie Petzold, Susanne Schuster, Antje Körner, Jürgen Kratzsch, Wieland Kies. Nampt and its potential role in inflammation and type 2 diabetes. Handbook of experimental pharmacology. issue 203. 2011-05-18. PMID:21484571. |
nampt plays an important role in the regulation of insulin secretion insulin secretion in pancreatic β-cells. |
2011-05-18 |
2023-08-12 |
Not clear |
| Peristera Paschou, Asterios Kukuvitis, Maria P Yavropoulou, Athina Dritsoula, Vasilios Giapoutzidis, Olympia Anastasiou, Kyriakos Kazakos, John G Yovo. Genetic variation in the visfatin (PBEF1/NAMPT) gene and type 2 diabetes in the Greek population. Cytokine. vol 51. issue 1. 2010-09-01. PMID:20451405. |
visfatin (nampt formerly known as pbef1) is an adipokine that is strongly expressed in visceral fat and has caused much debate among researchers, regarding its involvement in glucose homeostasis and insulin resistance. |
2010-09-01 |
2023-08-12 |
Not clear |
| Antje Garten, Stefanie Petzold, Antje Körner, Shin-Ichiro Imai, Wieland Kies. Nampt: linking NAD biology, metabolism and cancer. Trends in endocrinology and metabolism: TEM. vol 20. issue 3. 2009-06-23. PMID:19109034. |
nampt also plays an important part in regulating insulin secretion in pancreatic beta-cells. |
2009-06-23 |
2023-08-12 |
Not clear |
| Shin-Ichiro Imai, Wieland Kies. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273250. |
for the past several years, studies on the mammalian nad-dependent protein deacetylase sirt1 and systemic nad biosynthesis mediated by nicotinamide phosphoribosyltransferase (nampt) have demonstrated that these two regulatory components together play a critical role in the regulation of glucose homeostasis, particularly in the regulation of glucose-stimulated insulin secretion in pancreatic beta cells. |
2009-04-07 |
2023-08-12 |
Not clear |
| Javier R Revollo, Antje Körner, Kathryn F Mills, Akiko Satoh, Tao Wang, Antje Garten, Biplab Dasgupta, Yo Sasaki, Cynthia Wolberger, R Reid Townsend, Jeffrey Milbrandt, Wieland Kiess, Shin-Ichiro Ima. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell metabolism. vol 6. issue 5. 2008-02-26. PMID:17983582. |
haplodeficiency and chemical inhibition of nampt cause defects in nad biosynthesis and glucose-stimulated insulin secretion in pancreatic islets in vivo and in vitro. |
2008-02-26 |
2023-08-12 |
mouse |
| Ping Wang, Marleen M J van Greevenbroek, Freek G Bouwman, Martijn C G J Brouwers, Carla J H van der Kallen, Egbert Smit, Jaap Keijer, Edwin C M Marima. The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflugers Archiv : European journal of physiology. vol 454. issue 6. 2008-01-24. PMID:17429683. |
visfatin with the official gene name pre-b cell colony-enhancing factor 1 (pbef) and the protein name nicotinamide phosphoribosyltransferase (nampt) is a recently discovered adipocyte-secreted protein that was shown by some to be associated with visceral fat and insulin resistance. |
2008-01-24 |
2023-08-12 |
human |