| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shadi Nouri, Mahsa Navari, Fatemeh Zarei, Mitra Rostami, Touraj Mahmoudi, Gholamreza Rezamand, Asadollah Asadi, Hossein Nobakht, Reza Dabiri, Seidamir Pasha Tabaeia. NAMPT gene rs2058539 variant is a risk factor for nonalcoholic fatty liver disease. Revista da Associacao Medica Brasileira (1992). vol 70. issue 7. 2024-07-24. PMID:39045924. |
the aim of this study was to investigate the association between a visfatin gene (nampt) variant and nonalcoholic fatty liver disease, owing to the connection between this disease and insulin resistance, obesity, inflammation, and oxidative stress, and the role of visfatin in these metabolic disorders. |
2024-07-24 |
2024-07-26 |
Not clear |
| Peng Lyu, Shengrong Li, Ying Han, Shengnan Shen, Zheling Feng, Piliang Hao, Zhengqiu Li, Ligen Li. Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator. Bioorganic chemistry. vol 133. 2023-02-25. PMID:36841049. |
taken together, myricanol sensitizes insulin action in myotubes through binding with and activating nampt. |
2023-02-25 |
2023-08-14 |
Not clear |
| . Correction: The Adipocytokine Nampt and Its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion. PloS one. vol 17. issue 6. 2022-06-16. PMID:35709079. |
correction: the adipocytokine nampt and its product nmn have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. |
2022-06-16 |
2023-08-14 |
Not clear |
| Michael P Franczyk, Nathan Qi, Kelly L Stromsdorfer, Chengcheng Li, Shintaro Yamaguchi, Hiroshi Itoh, Mihoko Yoshino, Yo Sasaki, Rita T Brookheart, Brian N Finck, Brian J DeBosch, Samuel Klein, Jun Yoshin. Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility. Endocrinology. vol 162. issue 3. 2021-09-10. PMID:33543238. |
data obtained from rna-sequencing of wat suggest that loss of nampt increases inflammation, and impairs insulin sensitivity, glucose oxidation, lipolysis, branched-chain amino acid catabolism, and mitochondrial function in wat, which are features of metabolic inflexibility. |
2021-09-10 |
2023-08-13 |
mouse |
| Xi Huang, Chenchen Wang, Sai Tian, Rong Huang, Dan Guo, Haoqiang Zhang, Jijing Shi, Shaohua Wan. Higher Plasma Level of Nampt Presaging Memory Dysfunction in Chinese Type 2 Diabetes Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 70. issue 1. 2020-09-16. PMID:31177228. |
in addition to glucose metabolism, adipocytokine nicotinamide phosphoribosyltransferase (nampt) has been proposed as a multifunctional protein involved in insulin resistance. |
2020-09-16 |
2023-08-13 |
Not clear |
| Bora Jeong, Jeong Woo Park, Jae Geun Kim, Byung Ju Le. FOXO1 functions in the regulation of nicotinamide phosphoribosyltransferase (Nampt) expression. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30799084. |
nampt expression was increased by insulin and downstream phosphatidylinositol 3-kinase (pi3k)/akt signaling, which was inhibited by foxo1 overexpression. |
2019-12-16 |
2023-08-13 |
human |
| Esra Nurten, Mandy Vogel, Thomas Michael Kapellen, Sandy Richter, Antje Garten, Melanie Penke, Susanne Schuster, Antje Körner, Wieland Kiess, Jürgen Kratzsc. Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls. Journal of pediatric endocrinology & metabolism : JPEM. vol 31. issue 9. 2019-05-29. PMID:30179852. |
(2) we investigated the influence of insulin treatment on serum concentrations of nampt, omentin-1 and ck-18 in groups of patients with type 1 diabetes stratified according to the duration of their disease: at onset (n=50), ≥6 months and <5 years (n=185), ≥5 and <10 years (n=98), and ≥10 years (n=52). |
2019-05-29 |
2023-08-13 |
Not clear |
| Esra Nurten, Mandy Vogel, Thomas Michael Kapellen, Sandy Richter, Antje Garten, Melanie Penke, Susanne Schuster, Antje Körner, Wieland Kiess, Jürgen Kratzsc. Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls. Journal of pediatric endocrinology & metabolism : JPEM. vol 31. issue 9. 2019-05-29. PMID:30179852. |
conclusions altered serum levels of nampt, omentin-1 and ck-18 in pediatric type 1 diabetes patients indicate metabolic changes caused by adipose tissue dysregulation which do not normalize during insulin therapy. |
2019-05-29 |
2023-08-13 |
Not clear |
| Shengbing Li, Cong Wang, Ke Li, Ling Li, Mingyuan Tian, Jing Xie, Mengliu Yang, Yanjun Jia, Junying He, Lin Gao, Guenther Boden, Hua Liu, Gangyi Yan. NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. Scientific reports. vol 6. 2018-04-02. PMID:27229177. |
nampt knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in apoe ko mice with high-fat-induced insulin resistance. |
2018-04-02 |
2023-08-13 |
mouse |
| Shengbing Li, Cong Wang, Ke Li, Ling Li, Mingyuan Tian, Jing Xie, Mengliu Yang, Yanjun Jia, Junying He, Lin Gao, Guenther Boden, Hua Liu, Gangyi Yan. NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. Scientific reports. vol 6. 2018-04-02. PMID:27229177. |
nampt has been suggested association with atherosclerosis and insulin resistance. |
2018-04-02 |
2023-08-13 |
mouse |
| Qiang Zhou, Bo Chen, Tianxing Ji, Miaoshan Luo, Jiandong Lu. Association of genetic variants in RETN, NAMPT and ADIPOQ gene with glycemic, metabolic traits and diabetes risk in a Chinese population. Gene. vol 642. 2017-12-26. PMID:29101068. |
moreover, the rs34861192 and rs13237989 of nampt gene synergistically affected the levels of insulin and glycemic index. |
2017-12-26 |
2023-08-13 |
human |
| Kelly L Stromsdorfer, Shintaro Yamaguchi, Myeong Jin Yoon, Anna C Moseley, Michael P Franczyk, Shannon C Kelly, Nathan Qi, Shin-Ichiro Imai, Jun Yoshin. NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell reports. vol 16. issue 7. 2017-11-13. PMID:27498863. |
we found that adipocyte-specific nampt knockout mice had severe insulin resistance in adipose tissue, liver, and skeletal muscle and adipose tissue dysfunction, manifested by increased plasma free fatty acid concentrations and decreased plasma concentrations of a major insulin-sensitizing adipokine, adiponectin. |
2017-11-13 |
2023-08-13 |
mouse |
| Nadia Sawicka-Gutaj, Bartłomiej Budny, Ariadna Zybek-Kocik, Jerzy Sowiński, Katarzyna Ziemnicka, Joanna Waligórska-Stachura, Marek Ruchał. Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves' opthalmopathy. Endocrine. vol 53. issue 2. 2017-06-29. PMID:26767650. |
when nampt leukocyte expression was used as a dependent variable, simple regression analysis found association with trab, fasting insulin level, homa-ir, gd, and go. |
2017-06-29 |
2023-08-13 |
human |
| J Feng, H-Y Li, X-L Wang, Y Huo, S-X Liu, L L. Nicotinamide phosphoribosyltransferase enhances beta cell expansion during pregnancy. European review for medical and pharmacological sciences. vol 20. issue 23. 2017-06-21. PMID:27981536. |
previous studies have demonstrated the effects of nampt on insulin resistance during gdm, while the effects of nampt on beta cells remain unknown. |
2017-06-21 |
2023-08-13 |
Not clear |
| Aleksander J Owczarek, Magdalena Olszanecka-Glinianowicz, Piotr Kocełak, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chude. The relationship between circulating visfatin/nicotinamide phosphoribosyltransferase, obesity, inflammation and lipids profile in elderly population, determined by structural equation modeling. Scandinavian journal of clinical and laboratory investigation. vol 76. issue 8. 2017-03-23. PMID:27712122. |
the available literature suggests that circulating visfatin/nicotinamide phosphoribosyltransferase (nampt) level variability in humans is related to obesity, insulin resistance, inflammation, and lipid profile. |
2017-03-23 |
2023-08-13 |
Not clear |
| Maxime Reverchon, Christelle Rame, Audrey Bunel, Wenyong Chen, Pascal Froment, Joëlle Dupon. VISFATIN (NAMPT) Improves In Vitro IGF1-Induced Steroidogenesis and IGF1 Receptor Signaling Through SIRT1 in Bovine Granulosa Cells. Biology of reproduction. vol 94. issue 3. 2016-12-13. PMID:26792944. |
visfatin is a novel adipokine, also known as a nicotinamide phosphorybosyltransferase (nampt), that is able to modulate different processes, including lipid and glucose metabolism, oxidative stress, inflammation, and insulin resistance. |
2016-12-13 |
2023-08-13 |
human |
| Antje Garten, Susanne Schuster, Melanie Penke, Theresa Gorski, Tommaso de Giorgis, Wieland Kies. Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nature reviews. Endocrinology. vol 11. issue 9. 2016-03-21. PMID:26215259. |
nampt is able to modulate processes involved in the pathogenesis of obesity and related disorders such as nonalcoholic fatty liver disease (nafld) and type 2 diabetes mellitus (t2dm) by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance. |
2016-03-21 |
2023-08-13 |
human |
| Gesine Flehmig, Markus Scholz, Nora Klöting, Mathias Fasshauer, Anke Tönjes, Michael Stumvoll, Byung-Soo Youn, Matthias Blühe. Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation. PloS one. vol 9. issue 6. 2015-10-26. PMID:24968098. |
we identified two major adipokine clusters related to either (1) body fat mass and inflammation (leptin, angptl3, dll1, chemerin, nampt, resistin) or insulin sensitivity/hyperglycemia, and lipid metabolism (vaspin, clusterin, glypican 4, progranulin, angptl6, gpx3, rbp4, dlk1, sfrp5, bmp7, adiponectin, ctrp3 and 5, omentin). |
2015-10-26 |
2023-08-13 |
Not clear |
| Pedro Saddi-Rosa, Carolina Oliveira, Felipe Crispim, Fernando M A Giuffrida, Valter de Lima, José Vieira, Alessandro Doria, Gilberto Velho, André Rei. Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects. Cardiovascular diabetology. vol 12. 2015-03-30. PMID:23968400. |
associations of circulating nampt levels with cardiovascular disease (cvd) and insulin resistance have been reported. |
2015-03-30 |
2023-08-12 |
human |
| Zeynep Goktas, Shannon Owens, Mallory Boylan, David Syn, Chwan-Li Shen, Debra B Reed, Susan San Francisco, Shu Wan. Associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (Nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects. Mediators of inflammation. vol 2013. 2014-10-14. PMID:24367155. |
associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects. |
2014-10-14 |
2023-08-12 |
human |