| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tahani K Alshammari, Hajar Alghamdi, Thomas A Green, Abdurahman Niazy, Lama Alkahdar, Nouf Alrasheed, Khalid Alhosaini, Mohammed Alswayyed, Ramesh Elango, Fernanda Laezza, Musaad A Alshammari, Hazar Yacou. Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions. PloS one. vol 14. issue 10. 2020-03-11. PMID:31647818. |
the mrna expression of the tlr 7 pathway in the hippocampus showed that tlr 7, myd88, and traf6 were elevated in isolated rats compared to the standard group, and that acute treatment with an antidepressant and anti-inflammatory drugs reversed these effects. |
2020-03-11 |
2023-08-13 |
rat |
| Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. MicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29380367. |
it reveals that mir-421 targeting myd88 could inhibit the apoptosis and autophagy of hippocampal neurons in epilepsy mice by down-regulating the tlr/myd88 pathway. |
2019-09-30 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Malabendu Jana, Avik Roy, Grant T Corbett, Madhuchhanda Kundu, Sujyoti Chandra, Susanta Mondal, Sridevi Dasarathi, Elliott J Mufson, Rama K Mishra, Chi-Hao Luan, David A Bennett, Kalipada Paha. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. The Journal of clinical investigation. vol 128. issue 10. 2019-09-11. PMID:29990310. |
we have found that tlr2 and myd88 levels are elevated in the hippocampus and cortex of patients with alzheimer's disease (ad) and in a 5xfad mouse model of ad. |
2019-09-11 |
2023-08-13 |
mouse |
| Yan Zhang, Yuliang Jiang, Dongjie L. Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30914630. |
in the rat hippocampal tissue, levels of akt, pi3k, myd88 and nf-kappab, and the number of tunel-positive apoptotic cells were significantly reduced in the diosmetin-treated group compared with negative control group (p<0.01). |
2019-09-10 |
2023-08-13 |
rat |
| Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuan. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 4. 2019-03-12. PMID:30112701. |
inhibition of myd88 signaling skews microglia/macrophage polarization and attenuates neuronal apoptosis in the hippocampus after status epilepticus in mice. |
2019-03-12 |
2023-08-13 |
mouse |
| Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuan. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 4. 2019-03-12. PMID:30112701. |
myd88 inhibition also augmented glutamate transporter 1 expression and reduced n-methyl-d-aspartate receptor nr1 subunit expression in the hippocampus to protect pyramidal neurons from apoptosis. |
2019-03-12 |
2023-08-13 |
mouse |
| Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuan. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 4. 2019-03-12. PMID:30112701. |
these data suggest that mg/mΦ polarization after se impacts the pathological outcome of the hippocampus via myd88 signaling and point to myd88 as a potential neuroprotective target for epilepsy therapy. |
2019-03-12 |
2023-08-13 |
mouse |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
the present study aimed to investigate the effect of α7 nicotinic acetylcholine receptor (α7nachr) agonist on the damage of hippocampal neurons and the expression of toll like receptor 4 (tlr4)/myeloid differentiation primary response 88 (myd88)/nuclear factor (nf)‑κb signal pathway‑associated factors in cardiopulmonary bypass (cpb). |
2018-05-21 |
2023-08-13 |
rat |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
quantitative polymerase chain reaction and western blot assays were used to determine the expression of tlr4, myd88 and nf‑κb mrna, and protein in the hippocampus. |
2018-05-21 |
2023-08-13 |
rat |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
the expression of tlr4, myd88 and nf‑κb mrna, and protein in the hippocampus of cpb, mla and cpt groups were significantly higher compared with that in the sham group, and the pha group expression was significantly lower compared with the cpb group (p<0.05). |
2018-05-21 |
2023-08-13 |
rat |
| Jingyi Yan, Jianing Bai, Chen Gao, Yanling Liang, Baohua Zhao, Yanqing Bia. Chronic unpredictable stress abrogates the endotoxin tolerance induced by repeated peripheral LPS challenge via the TLR4 signaling pathway. Neuroscience letters. vol 645. 2017-10-10. PMID:28254553. |
the mrna expression of tlr4 and myd88 and the protein levels of tlr4 and nf-κbp65 were significantly increased, but the protein levels of pi3k and p-akt were significantly decreased in the hippocampus of the mice. |
2017-10-10 |
2023-08-13 |
mouse |
| Na Wang, Xiong Han, Haipeng Liu, Ting Zhao, Jie Li, Yan Feng, Xiujuan Mi, Yanke Zhang, Yanan Chen, Xuefeng Wan. Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats. Experimental neurology. vol 295. 2017-08-14. PMID:28529112. |
our results revealed that myd88 was up-regulated in the hippocampus of rats in the lithium-pilocarpine model of acute seizures. |
2017-08-14 |
2023-08-13 |
rat |
| Yan Feng, Junling Gao, Ying Cui, Minghang Li, Ran Li, Changmeng Cui, Jianzhong Cu. Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26961544. |
in addition, the expression of tlr4 downstream signaling molecules, including myd88, trif, nf-κb, tnf-α, and il-1β, was significantly downregulated in hippocampus tissue by western blot analysis. |
2017-02-13 |
2023-08-13 |
rat |
| Gerard Honig, Simone Mader, Huiyi Chen, Amit Porat, Mahendar Ochani, Ping Wang, Bruce T Volpe, Betty Diamon. Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve. PloS one. vol 11. issue 1. 2016-07-29. PMID:26790027. |
blood-brain barrier deterioration and hippocampal gene expression in polymicrobial sepsis: an evaluation of endothelial myd88 and the vagus nerve. |
2016-07-29 |
2023-08-13 |
human |
| Jin-Tao Liu, Bei-Yu Chen, Jie-Qiong Zhang, Fang Kuang, Liang-Wei Che. Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4-MyD88-NFκB signaling cascades. Toxicology letters. vol 239. issue 2. 2016-01-25. PMID:26386401. |
it revealed that (1) significant microglial activation occurred in hippocampus soon following pb exposure; (2) increased levels of tlr4, myd88, nfκb expression were concomitantly detected; (3) brdu-incorporated progenitor cells were observed in dentate gyrus with significantly-increased numbers at d28 in pb insult group; (4) obvious astrogliogenesis was observed while these doublecortin-labeled differentiated neurons were not significantly changed in hippocampus; (5) administration of myd88 inhibitory peptide attenuated or relieved above effects; (6) enhanced expression levels of il-1β, tnfα, p38mapk and erk1/2 were also detected in hippocampus, indicating potential implication of inflammatory response and mapk signaling activation in lead-induced microgliosis and astrogliosis. |
2016-01-25 |
2023-08-13 |
mouse |
| Shun-Mei Lu, Chan-Juan Yu, Ya-Hua Liu, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Feng Zhang, Yan-Ning Qian, Bo Gu. S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway. Brain, behavior, and immunity. vol 44. 2015-08-13. PMID:25449673. |
furthermore, the increased expression of s100a8 protein in the hippocampus induced by surgery sharply decreased in both tlr4 and myd88 genetically deficient mice. |
2015-08-13 |
2023-08-13 |
mouse |
| Yi Wang, Huijuan He, Dan Li, Wenjing Zhu, Kaiming Duan, Yuan Le, Yan Liao, Yangwen O. The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats. Molecular medicine reports. vol 7. issue 4. 2014-07-25. PMID:23426570. |
shortly after surgery, aged rats demonstrated significant deficits in memory and learning, accompanied by the activation of microglia, marked upregulation of tlr4 on microglia in the hippocampus, as well as an increased expression of two downstream factors [myeloid differentiation factor 88 (myd88) and tir-domain-containing adapter-inducing interferon-β (trif)] and pro-inflammatory cytokines [including tumor necrosis factor α (tnf-α) and interleukin 1β (il-1β)]. |
2014-07-25 |
2023-08-12 |
rat |
| Guo-Xia Zhang, Ai-Ling Zhou, Gui-Ping Zhang, Ya-E Hu, Jia-Hui Ma. [The role of TLR4-mediated MyD88-dependent pathway in neuroinflammation in hippocampal neurons of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 29. issue 1. 2014-01-23. PMID:23662405. |
to investigate weather there is a toll-like receptor 4 (tlr4)-mediated myeloid differentiation factor 88 (myd88)-dependent pathway in hippocampal neurons of rats and the probable role of the pathway in neuroinflammation. |
2014-01-23 |
2023-08-12 |
rat |
| Shan-Shan Mao, Rong Hua, Xiao-Ping Zhao, Xia Qin, Zhen-Quan Sun, Yang Zhang, Yu-Qing Wu, Meng-Xing Jia, Jun-Li Cao, Yong-Mei Zhan. Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway. Journal of neurotrauma. vol 29. issue 10. 2013-05-22. PMID:22583372. |
pretreatment with pacap inhibited upregulation of tlr4 and its downstream signaling molecules myd88, p-iκb, and nf-κb, and suppressed increases in the levels of the downstream inflammatory agents interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), in the brain tissue around the injured cortex and in the hippocampus. |
2013-05-22 |
2023-08-12 |
rat |
| Subhash C Pande. TLR4-MyD88 signalling: a molecular target for alcohol actions. British journal of pharmacology. vol 165. issue 5. 2012-09-07. PMID:21955082. |
the deletions of tlr4 or myd88 gene or pharmacological inhibition of tlr4 by (+)-naloxone were able to attenuate alcohol-induced sedation, motor impairment and acute alcohol-induced increases in ikbα protein levels in the hippocampus of mice. |
2012-09-07 |
2023-08-12 |
mouse |