| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-Na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-En Deng, Yuanyuan Zhang, Yimeng Feng, Junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Gen. Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. European journal of pharmacology. 2024-10-19. PMID:39426465. |
pathological changes in the hippocampal regions were identified through nissl staining, and western blotting was used to quantify the protein levels of bdnf, trkb, creb, tlr4, myd88, and nf-κb. |
2024-10-19 |
2024-10-22 |
rat |
| Masoud Kaboutari, Masoumeh Asle-Rousta, Sanaz Mahmaz. Protective effect of menthol against thioacetamide-induced hepatic encephalopathy by suppressing oxidative stress and inflammation, augmenting expression of BDNF and α7-nACh receptor, and improving spatial memory. European journal of pharmacology. 2024-08-18. PMID:39154831. |
likewise, this monoterpene reduced the expression of tlr4, myd88, and nf-κb in the hippocampus while increasing the expression of bdnf and α7-nach receptor. |
2024-08-18 |
2024-08-21 |
rat |
| Yuan Chen, Yi Zhou, Jinhan Cai, Jiayi Xu, Chenwei Hu, Huiyue Chen, Yirui Hong, Nanyi Pan, Yujie Jiang, Chenhui Zhou, Hua Wei, Zhipeng Xu, Lin Liu, Xiang Wu, Wei Cu. The activation of RARα prevents surgery-induced cognitive impairments via the inhibition of neuroinflammation and the restoration of synaptic proteins in elderly mice. International immunopharmacology. vol 130. 2024-03-03. PMID:38432148. |
both agonists inhibited the expression of toll-like receptor 4 (tlr4), myeloid differentiation factor 88 (myd88) and the phosphorylation of nuclear factorkappa-b (nf-κb), leading to the prevention of microglial over-activation and pro-inflammatory cytokines secretion in the hippocampal regions of elderly mice after surgery. |
2024-03-03 |
2024-03-06 |
mouse |
| Lulu Ren, Huazheng Liang, Li Zhu, Xiao Yang, Hong Zhang, Nianyi Sun, Dunbing Huang, Jing Feng, Yufeng Wu, Lize Xiong, Xiaohua Ke, Min Li, Anren Zhan. Dietary restriction improves perioperative neurocognitive disorders by inhibiting neuroinflammation and gut microbial dysbiosis. Neuroscience. 2024-01-25. PMID:38272300. |
the western blot technique was utilized to assess expression levels of hippocampal psd 95, synaptophysin, tlr4, myd88, and nf-kb p65. |
2024-01-25 |
2024-01-28 |
mouse |
| Huili Jiang, Xianqi Long, Yu Wang, Xuhui Zhang, Lu Chen, Xinjing Yang, Bingcong Zhao, Ye Zhang, Yemao Chai, Tuya Ba. Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress. Molecular neurobiology. 2023-11-02. PMID:37917302. |
the expression of key proteins on tlr4 signaling pathway of tlr4, myd88, traf6, nf-κb p65, tnf-α, and mrna of tlr4 in the hippocampus was detected by western blot and real-time quantitative polymerase chain reaction to investigate the effect of acupuncture on stress-induced activation of neuroinflammation. |
2023-11-02 |
2023-11-08 |
rat |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the expression levels of tlr4, myd88, nf-κb p65, tnf-α, inos, occludin and zo-1 in hippocampal and colonic tissues were detected by western-blot method. |
2023-06-02 |
2023-08-14 |
mouse |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the results showed that cb improved the cognitive dysfunction of icv-stz mice, restored the structure and cell number of hippocampal and cortical neurons, decreased the protein levels of pser404-tau protein in hippocampal tissues and tlr4, myd88, nf-κb p65 and inos in hippocampal and colonic tissues, and increased the protein levels of occludin and zo-1 in colonic tissues. |
2023-06-02 |
2023-08-14 |
mouse |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Bo Wu, Anna Gan, Ruixuan Wang, Fei Lin, Tingxu Yan, Ying Ji. Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001682. |
moreover, aovo was found to inhibit the hippocampal damage, decrease inflammatory cytokines (reduced il-1β, il-6, and tnf-α by 19.97%, 22.87%, and 24.13%, respectively), and downregulate the expression of tlr4/myd88/nf-κb signaling pathway-related proteins in the hippocampus of cums-exposed mice (reduced tlr4, myd88, and nf-κb by 46.14%, 42.48%, and 38.08%, respectively). |
2023-03-31 |
2023-08-14 |
mouse |
| Xinye Qian, Shanshan Zheng, Yingfang Y. CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression. Neurotoxicity research. 2022-12-30. PMID:36585543. |
circube3b high expression participates in sevoflurane-induced human hippocampal neuron injury via targeting mir-326 and regulating myd88 expression. |
2022-12-30 |
2023-08-14 |
human |
| Yosuke Yamawaki, Hitomi Kimura, Susumu Nagata, Koichiro Ozawa, Toru Hoso. Peripheral Immune Activation in Mice Elicits Unfolded Protein Responses Independent on MyD88 Pathway in the Liver but not the Hypothalamus and Hippocampus. Frontiers in physiology. vol 13. 2022-05-16. PMID:35574480. |
peripheral immune activation in mice elicits unfolded protein responses independent on myd88 pathway in the liver but not the hypothalamus and hippocampus. |
2022-05-16 |
2023-08-13 |
mouse |
| Yu Bu, Wen-Shuang Li, Ji Lin, Yu-Wei Wei, Qiu-Ying Sun, Shi-Jie Zhu, Zhong-Sheng Tan. Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway. Chinese journal of integrative medicine. 2021-12-16. PMID:34913150. |
to investigate whether electroacupuncture (ea) alleviates cognitive impairment by suppressing the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88) signaling pathway, which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia (vad). |
2021-12-16 |
2023-08-13 |
rat |
| Tian Tang, Yujie Guo, Xiaoyan Xu, Libo Zhao, Xia Shen, Lin Sun, Peng Xi. BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats. Journal of medical virology. vol 93. issue 11. 2021-10-29. PMID:34260072. |
the expression of tlr4, myd88, and irf5 in the hippocampus was significantly changed in the bodv-1 group. our results indicate that bodv-1 infection stimulates tlr4/myd88/irf5 pathway activation, causing the release of downstream inflammatory factors, which leads to neuroinflammation in rats. |
2021-10-29 |
2023-08-13 |
rat |
| Walaa Yehia Abdelzaher, Hanaa H Mohammed, Nermeen N Welson, Gaber El-Saber Batiha, Roua S Baty, Asmaa Mohamed Abdel-Azi. Rivaroxaban Modulates TLR4/Myd88/NF-Kβ Signaling Pathway in a Dose-Dependent Manner With Suppression of Oxidative Stress and Inflammation in an Experimental Model of Depression. Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630092. |
cums showed a significant decrease in hypothalamic neurotransmitters, hippocampal gsh, sod, bndf, and vegf-a with a significant increase in hippocampal mda, nox, nf-kβ, myd88, tlr4, tnf-α, and gfap immunoexpression. |
2021-10-12 |
2023-08-13 |
rat |
| Xinfei Ma, Zhenhua Zhu, Sheng Guo, Jinao Dua. The effect of deoxyschizandrin on chronic unpredictable mild stress-induced depression. Biotechnology and applied biochemistry. vol 68. issue 1. 2021-07-06. PMID:31985079. |
additionally, the expressions of tlr4, myd88, traf6, p-nf-κbp65, nlrp3, cleaved caspase-1, cleaved il-1β, glur, and psd95 in hippocampus were detected by western blot. |
2021-07-06 |
2023-08-13 |
mouse |
| Lijun Jiang, Zhenxing Xu, Hui Li, Mingfu Wu, Fudong Wang, Shunying Liu, Jianlan Tao, Xing Fen. TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32627010. |
furthermore, tak‑242 decreased the protein expression levels of tlr4, myd88, tir‑domain‑containing adapter‑inducing interferon‑β (trif), nf‑κb, tumor necrosis factor α (tnf‑α) and interleukin‑1β in the hippocampus. |
2021-05-03 |
2023-08-13 |
rat |
| Toru Hosoi, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozaw. Possible Involvement of MyD88 in Regulating Stress Response in Mice. Frontiers in neuroscience. vol 15. 2021-04-02. PMID:33790733. |
on the other hand, stress exposure in myd88 deficient mice did not cause decrease in its level in the hippocampus. |
2021-04-02 |
2023-08-13 |
mouse |
| Toru Hosoi, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozaw. Possible Involvement of MyD88 in Regulating Stress Response in Mice. Frontiers in neuroscience. vol 15. 2021-04-02. PMID:33790733. |
furthermore, immobilization stress-induced reduction of brain-derived neurotrophic factor (bdnf) levels in the hippocampus was ameliorated by myd88 deficiency. |
2021-04-02 |
2023-08-13 |
mouse |
| Jing Yang, Rongjun Liu, Fan Lu, Fang Xu, Jinwei Zheng, Zhao Li, Wei Cui, Chuang Wang, Junfang Zhang, Shujun Xu, Wenhua Zhou, Qinwen Wang, Junping Chen, Xiaowei Che. Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31139084. |
fast green fcf decreased the mrna and protein levels of toll-like receptor 4 (tlr4) and myeloid differentiation primary response 88 (myd88) and suppressed the phosphorylation of nuclear factor-κb (nf-κb) in the hippocampus of lps-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Pen. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway. Stem cells international. vol 2020. 2020-09-28. PMID:32300366. |
furthermore, amsc-derived exosomes were found to reduce hippocampal neuronal apoptosis and the expression of tlr2, tlr4, myd88, and nf- |
2020-09-28 |
2023-08-13 |
rat |