| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alan M Pittman, Hon-Chung Fung, Rohan de Silv. Untangling the tau gene association with neurodegenerative disorders. Human molecular genetics. vol 15 Spec No 2. 2006-11-20. PMID:16987883. |
mutations in the tau gene, mapt, cause familial frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), and common variation in mapt is strongly associated with the risk of psp, corticobasal degeneration and, to a lesser extent, ad and parkinson's disease (pd), implicating the involvement of tau in common neurodegenerative pathway(s). |
2006-11-20 |
2023-08-12 |
Not clear |
| Maria Grazia Spillantini, Jill R Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghett. Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD). Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914875. |
mutations in the tau gene (mapt) in ftdp-17: the family with multiple system tauopathy with presenile dementia (mstd). |
2006-10-19 |
2023-08-12 |
Not clear |
| Marc Cruts, Ilse Gijselinck, Julie van der Zee, Sebastiaan Engelborghs, Hans Wils, Daniel Pirici, Rosa Rademakers, Rik Vandenberghe, Bart Dermaut, Jean-Jacques Martin, Cornelia van Duijn, Karin Peeters, Raf Sciot, Patrick Santens, Tim De Pooter, Maria Mattheijssens, Marleen Van den Broeck, Ivy Cuijt, Krist'l Vennekens, Peter P De Deyn, Samir Kumar-Singh, Christine Van Broeckhove. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature. vol 442. issue 7105. 2006-09-22. PMID:16862115. |
frontotemporal dementia (ftd) with ubiquitin-immunoreactive neuronal inclusions (both cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 region (ftdu-17) containing mapt (microtubule-associated protein tau). |
2006-09-22 |
2023-08-12 |
Not clear |
| A-M Shiarli, R Jennings, J Shi, K Bailey, Y Davidson, J Tian, E H Bigio, B Ghetti, J R Murrell, M B Delisle, S Mirra, B Crain, P Zolo, K Arima, E Iseki, S Murayama, H Kretzschmar, M Neumann, C Lippa, G Halliday, J Mackenzie, N Khan, R Ravid, D Dickson, Z Wszolek, T Iwatsubo, S M Pickering-Brown, D M A Man. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and applied neurobiology. vol 32. issue 4. 2006-09-19. PMID:16866983. |
in order to gain insight into the pathogenesis of frontotemporal lobar degeneration (ftld), the mean tau load in frontal cortex was compared in 34 patients with frontotemporal dementia linked to chromosome 17 (ftdp-17) with 12 different mutations in the tau gene (mapt), 11 patients with sporadic ftld with pick bodies and 25 patients with early onset alzheimer's disease (eoad). |
2006-09-19 |
2023-08-12 |
Not clear |
| Rohan de Silva, Tammaryn Lashley, Catherine Strand, Anna-Maria Shiarli, Jing Shi, Jinzhou Tian, Kathryn L Bailey, Peter Davies, Eileen H Bigio, Kunimasa Arima, Eizo Iseki, Shigeo Murayama, Hans Kretzschmar, Manuela Neumann, Carol Lippa, Glenda Halliday, James MacKenzie, Rivka Ravid, Dennis Dickson, Zbigniew Wszolek, Takeshi Iwatsubo, Stuart M Pickering-Brown, Janice Holton, Andrew Lees, Tamas Revesz, David M A Man. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16552612. |
patients with familial ftld associated with exon 10 n279k, n296h or +16 splice site mutations showed tau pathology characterised by neuronal neurofibrillary tangles (nft) and glial cell tangles that contained only 4r-tau isoforms, as did the nft in p301l mapt mutation. |
2006-08-24 |
2023-08-12 |
Not clear |
| Roberta Ghidoni, Simona Signorini, Laura Barbiero, Elena Sina, Paola Cominelli, Aldo Villa, Luisa Benussi, Giuliano Binett. The H2 MAPT haplotype is associated with familial frontotemporal dementia. Neurobiology of disease. vol 22. issue 2. 2006-07-25. PMID:16410051. |
there is now considerable evidence that the gene encoding for tau protein (mapt) is implicated in frontotemporal dementia (ftd). |
2006-07-25 |
2023-08-12 |
Not clear |
| Zbigniew K Wszołek, Jerzy Słowiński, Maciej Golan, Dennis W Dickso. Frontotemporal dementia and parkinsonism linked to chromosome 17. Folia neuropathologica. vol 43. issue 4. 2006-04-21. PMID:16416390. |
frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) is an autosomal dominant neurodegenerative disorder caused by mutations in the mapt gene which encodes the microtubule-associated protein tau. |
2006-04-21 |
2023-08-12 |
Not clear |
| Minoru Yasuda, Yoshitsugu Nakamura, Toshio Kawamata, Hiroshi Kaneyuki, Kiyoshi Maeda, Osamu Komur. Phenotypic heterogeneity within a new family with the MAPT p301s mutation. Annals of neurology. vol 58. issue 6. 2006-01-31. PMID:16240366. |
mutations in the gene encoding the microtubule-associated protein tau (mapt) cause frontotemporal dementia and parkinsonism linked to chromosome 17. |
2006-01-31 |
2023-08-12 |
Not clear |
| I F Bronner, B C ter Meulen, A Azmani, L A Severijnen, R Willemsen, W Kamphorst, R Ravid, P Heutink, J C van Swiete. Hereditary Pick's disease with the G272V tau mutation shows predominant three-repeat tau pathology. Brain : a journal of neurology. vol 128. issue Pt 11. 2005-11-28. PMID:16014652. |
frontotemporal dementia and parkinsonism linked to chromosome 17 have been associated with mutations in the microtubule associated protein tau (mapt or tau) gene. |
2005-11-28 |
2023-08-12 |
Not clear |
| A J Myers, M Kaleem, L Marlowe, A M Pittman, A J Lees, H C Fung, J Duckworth, D Leung, A Gibson, C M Morris, R de Silva, J Hard. The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Human molecular genetics. vol 14. issue 16. 2005-10-20. PMID:16000317. |
although it is clear that microtubule associated protein tau (mapt) is involved in alzheimer's disease (ad) pathology, it has not been clear whether it is involved genetically. |
2005-10-20 |
2023-08-12 |
Not clear |
| Marc Cruts, Rosa Rademakers, Ilse Gijselinck, Julie van der Zee, Bart Dermaut, Tim de Pooter, Peter de Rijk, Jurgen Del-Favero, Christine van Broeckhove. Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region. Human molecular genetics. vol 14. issue 13. 2005-10-11. PMID:15888485. |
familial frontotemporal dementia (ftd), characterized by tau-negative, ubiquitin-positive inclusions at autopsy, is linked to a chromosomal region at 17q21 (ftdu-17), encompassing the gene encoding the microtubule associated protein tau, mapt. |
2005-10-11 |
2023-08-12 |
human |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
the role of tau (mapt) in frontotemporal dementia and related tauopathies. |
2005-03-31 |
2023-08-12 |
mouse |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
in patients diagnosed with frontotemporal dementia and parkinsonism linked to chromosome 17, mutations in the gene encoding tau (mapt) have been identified that disrupt the normal binding of tau to tubulin resulting in pathological deposits of hyperphosphorylated tau. |
2005-03-31 |
2023-08-12 |
mouse |
| Stuart Pickering-Brown, Matt Baker, Thomas Bird, John Trojanowski, Virginia Lee, Huw Morris, Martin Rossor, John C Janssen, David Neary, David Craufurd, Anna Richardson, Julie Snowden, John Hardy, David Mann, Mike Hutto. Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 125B. issue 1. 2005-03-21. PMID:14755449. |
the +16 exon 10 splice mutation of the tau gene (microtubule-associated protein tau, mapt) has been reported in numerous families with frontotemporal dementia (ftd). |
2005-03-21 |
2023-08-12 |
Not clear |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
the group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (mapt). |
2004-12-22 |
2023-08-12 |
Not clear |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
mutations of the tau gene (mapt) are the cause of frontotemporal dementia with parkinsonism linked to chromosome 17, giving tau a central role in the pathogenic process. |
2004-12-22 |
2023-08-12 |
Not clear |
| Bart Dermaut, Samir Kumar-Singh, Sebastian Engelborghs, Jessie Theuns, Rosa Rademakers, Jos Saerens, Barbara A Pickut, Karin Peeters, Marleen van den Broeck, Krist'l Vennekens, Stephen Claes, Marc Cruts, Patrick Cras, Jean-Jacques Martin, Christine Van Broeckhoven, Peter Paul De Dey. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. Annals of neurology. vol 55. issue 5. 2004-06-15. PMID:15122701. |
familial forms of frontotemporal dementia (ftd) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (mapt). |
2004-06-15 |
2023-08-12 |
Not clear |
| R Rademakers, B Dermaut, K Peeters, M Cruts, P Heutink, A Goate, C Van Broeckhove. Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. Human mutation. vol 22. issue 5. 2004-04-12. PMID:14517953. |
tau (mapt) mutation arg406trp presenting clinically with alzheimer disease does not share a common founder in western europe. |
2004-04-12 |
2023-08-12 |
Not clear |
| Brian C Kraemer, Bin Zhang, James B Leverenz, James H Thomas, John Q Trojanowski, Gerard D Schellenber. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12872001. |
frontotemporal dementia with parkinsonism chromosome 17 type (ftdp-17) is caused by mutations in mapt, the gene encoding tau. |
2003-10-29 |
2023-08-12 |
human |
| J R Streffer, A Papassotiropoulos, P Kurosinski, A Signorell, M A Wollmer, M Tsolaki, V Iakovidou, F Hörndli, J Bosset, J Götz, R M Nitsch, C Hoc. Saitohin gene is not associated with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 3. 2003-04-03. PMID:12588928. |
a polymorphic gene, saitohin (sth), nested within the tau gene (microtubule associated protein tau, mapt), was recently identified and an association of a non-synonymous polymorphism in sth with increased risk for alzheimer's disease was suggested. |
2003-04-03 |
2023-08-12 |
Not clear |