| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cu. A Peculiar Tau Accumulation Pattern Identified Via 18F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene. Clinical nuclear medicine. 2024-07-16. PMID:39010313. |
a peculiar tau accumulation pattern identified via 18f-florzolotau pet imaging in a patient with frontotemporal dementia caused by a mutation in the mapt gene. |
2024-07-16 |
2024-07-18 |
Not clear |
| Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cu. A Peculiar Tau Accumulation Pattern Identified Via 18F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene. Clinical nuclear medicine. 2024-07-16. PMID:39010313. |
we reported imaging findings with a peculiar tau accumulation pattern in a 56 year-old woman with frontotemporal dementia caused by q351r mutation in the microtubule-associated protein tau (mapt) gene. |
2024-07-16 |
2024-07-18 |
Not clear |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
aggregation of the microtubule-associated protein tau (mapt) is the hallmark pathology in a spectrum of neurodegenerative disorders collectively called tauopathies. |
2024-07-12 |
2024-07-14 |
Not clear |
| b' Elka Stefanova, Ana Marjanovi\\xc4\\x87, Valerija Dobri\\xc4\\x8di\\xc4\\x87, Gorana Mandi\\xc4\\x87-Stojmenovi\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Marija Brankovi\\xc4\\x87, Maksim \\xc5\\xa0ar\\xc4\\x8devi\\xc4\\x87, Ivana Novakovi\\xc4\\x87, Vladimir S Kosti\\xc4\\x8. Frequency of C9orf72, GRN, and MAPT pathogenic variants in patients recruited at the Belgrade Memory Center. Neurogenetics. 2024-06-07. PMID:38847891.' |
most of the heritability in frontotemporal dementia (ftd) is accounted for by autosomal dominant hexanucleotide expansion in the chromosome 9 open reading frame 72 (c9orf72), pathogenic/likely pathogenic variants in progranulin (grn), and microtubule-associated protein tau (mapt) genes. |
2024-06-07 |
2024-06-10 |
human |
| Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C Saido, Benjamin Wolozi. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APP Frontiers in neuroscience. vol 18. 2024-04-04. PMID:38572146. |
β-amyloid accumulation enhances microtubule associated protein tau pathology in an app the study of the pathophysiology study of alzheimer's disease (ad) has been hampered by lack animal models that recapitulate the major ad pathologies, including extracellular -amyloid (a) deposition, intracellular aggregation of microtubule associated protein tau (mapt), inflammation and neurodegeneration. |
2024-04-04 |
2024-04-06 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein tau, encoded by the gene mapt. |
2024-03-30 |
2024-04-02 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
a neurodegenerative disease is considered a primary tauopathy when mapt mutations/haplotypes are its primary cause and/or tau is the main pathological feature. |
2024-03-30 |
2024-04-02 |
Not clear |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Amanda Pasqualotto, Vinícius da Silva, Felipe Mateus Pellenz, Artur Francisco Schumacher Schuh, Ida Vanessa Doederlein Schwartz, Marina Sieber. Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach. Metabolic brain disease. 2024-02-02. PMID:38305999. |
as a hypothesis, we highlight as possible key genes for ap the mapt (microtubule associated protein tau), apoe (apolipoprotein e), snca (synuclein alpha) and app (amyloid beta precursor protein) genes. |
2024-02-02 |
2024-02-04 |
Not clear |
| Giorgi Margvelani, Justin R Welden, Andrea Arizaca Maquera, Jennifer E Van Eyk, Christopher Murray, Sandra C Miranda Sardon, Stefan Stam. Influence of FTDP-17 mutants on circular tau RNAs. Biochimica et biophysica acta. Molecular basis of disease. 2024-01-29. PMID:38286213. |
at least 53 mutations in the microtubule associated protein tau gene (mapt) have been identified that cause frontotemporal dementia. |
2024-01-29 |
2024-02-01 |
human |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |
| Michel Goedert, R Anthony Crowther, Sjors H W Scheres, Maria Grazia Spillantin. Tau and neurodegeneration. Cytoskeleton (Hoboken, N.J.). 2023-12-14. PMID:38073060. |
in 1998, mutations in mapt, the gene that encodes tau, were identified as the cause of a dominantly inherited form of frontotemporal dementia with abundant filamentous tau inclusions. |
2023-12-14 |
2023-12-17 |
human |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
point mutations in the microtubule associated protein tau (mapt) gene cause dominantly inherited tauopathies, and most predispose it to aggregate. |
2023-11-11 |
2023-11-20 |
mouse |
| Amanda L Edwards, Jessica A Collins, Candice Junge, Holly Kordasiewicz, Laurence Mignon, Shuang Wu, Yumeng Li, Lin Lin, Jonathan DuBois, R Matthew Hutchison, Nick Ziogas, Melanie Shulman, Laurent Martarello, Danielle Graham, Roger Lane, Samantha Budd Haeberlein, John Beave. Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. 2023-10-30. PMID:37902726. |
accumulation of hyperphosphorylated, tangled microtubule-associated protein tau (mapt) is a pathological hallmark of alzheimer disease (ad) associated with disease progression and cognitive decline. |
2023-10-30 |
2023-11-08 |
Not clear |
| Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. |
sarkosyl-insoluble-proteomic analyses of the ckd mouse hippocampus revealed an accumulation of insoluble mapt (microtubule-associated protein tau) and rna-binding proteins such as small nuclear ribonucleoprotein u1 subunit 70 (snrnp70). |
2023-10-27 |
2023-11-08 |
mouse |
| Chenxi He, Jinying Gu, Danni Wang, Keran Wang, Yuxuan Wang, Qidong You, Lei Wan. Small molecules targeting molecular chaperones for tau regulation: Achievements and challenges. European journal of medicinal chemistry. vol 261. 2023-10-15. PMID:37839344. |
abnormal post-translational modification of microtubule-associated protein tau (mapt) is a prominent pathological feature in alzheimer's disease (ad). |
2023-10-15 |
2023-11-08 |
Not clear |
| Lukai Zheng, Anna Rubinski, Jannis Dennecke, Ying Luan, Ruben Smith, Olof Strandberg, Erik Stomrud, Rik Ossenkoppele, Diana Otero Svaldi, Ixavier Alonzo Higgins, Sergey Shcherbinin, Michael J Pontecorvo, Oskar Hansson, Nicolai Franzmeier, Michael Ewer. Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer's Disease. Annals of neurology. 2023-10-14. PMID:37837382. |
combined connectomics, mapt gene expression, and amyloid deposition to explain regional tau deposition in alzheimer's disease. |
2023-10-14 |
2023-11-08 |
Not clear |
| Giorgi Margvelani, Justin R Welden, Andrea Arizaca Maquera, Jennifer E Van Eyk, Christopher Murray, Sandra C Miranda Sardon, Stefan Stam. Influence of FTDP-17 mutants on circular Tau RNAs. bioRxiv : the preprint server for biology. 2023-10-03. PMID:37786725. |
at least 53 mutations in the microtubule associated protein tau gene (mapt) have been identified that cause frontotemporal dementia. |
2023-10-03 |
2023-10-07 |
human |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |