| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zhang, Haonan Li, Fang Qi, Qian Yu, Hong Jiang, Buyi Lin, Hexuan Dong, Hongzhi Li, Jun Y. T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification. International immunopharmacology. vol 143. issue Pt 2. 2024-10-19. PMID:39426235. |
mettl3-mediated m6a methylation levels were correlated with cartilage extracellular matrix (ecm) degradation, which was exacerbated following mettl3 silencing. |
2024-10-19 |
2024-10-22 |
Not clear |
| Ying He, Wei Wang, Ping Luo, Yan Wang, Zhenru He, Wei Dong, Meie Jia, Xijie Yu, Beining Yang, Jiawei Wan. Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m Bone. 2022-08-18. PMID:35981698. |
mechanically, dmp1 (dentin matrix protein 1) was proved to be the downstream direct target of mettl3 for m |
2022-08-18 |
2023-08-14 |
Not clear |
| Liang Xiao, Bo Hu, Baiyang Ding, Quanlai Zhao, Chen Liu, Fetullah Cumhur Öner, Hongguang X. N(6)-Methyladenosine RNA Methyltransferase Like 3 Inhibits Extracellular Matrix Synthesis of Endplate Chondrocytes by Downregulating Sex-Determining Region Y-Box Transcription Factor 9 Expression Under Tension. Osteoarthritis and cartilage. 2022-01-10. PMID:35007741. |
this study was the first to reveal the mechanism by which methyltransferase-like 3 (mettl3)-mediated n(6)-methyladenosine (m6a) modification affected the extracellular matrix anabolism by tension-induced endplate chondrocytes. |
2022-01-10 |
2023-08-13 |
Not clear |
| Jianmin Liu, Ming Chen, Longyang Ma, Xingbo Dang, Gongliang D. piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification. Aging. vol 13. issue 19. 2021-11-03. PMID:34645714. |
moreover, interference with pir-36741 or mettl3 markedly hindered the osteogenic differentiation of bmscs, which was manifested by a reduction in osteoblast marker expression (including runx2, col1a1, opn and ocn), osteogenic phenotype and matrix mineralization. |
2021-11-03 |
2023-08-13 |
mouse |
| Weilin Sang, Song Xue, Yafei Jiang, Haiming Lu, Libo Zhu, Cong Wang, Jinzhong M. METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response. Life sciences. vol 278. 2021-07-06. PMID:33894271. |
mettl3 overexpression may affect extracellular matrix degradation in oa by adjusting the balance between timps and mmps. |
2021-07-06 |
2023-08-13 |
Not clear |
| Ujwal Dahal, Kang Le, Mamta Gupt. RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2. Melanoma research. vol 29. issue 4. 2020-06-05. PMID:30762711. |
rna m6a methyltransferase mettl3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2. |
2020-06-05 |
2023-08-13 |
human |