| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myunghyun Cheon, Hoyong Park, ChiHye Chun. Protein kinase C mediates neuropeptide Y-induced reduction in inhibitory neurotransmission in the lateral habenula. Neuropharmacology. vol 180. 2021-08-27. PMID:32882226. |
instead, pharmacological blockade of phospholipase c (plc) or protein kinase c (pkc) activity abolished the decrease of gabaergic transmission by npy in the lhb. |
2021-08-27 |
2023-08-13 |
Not clear |
| Michael L Wallace, Kee Wui Huang, Daniel Hochbaum, Minsuk Hyun, Gianna Radeljic, Bernardo L Sabatin. Anatomical and single-cell transcriptional profiling of the murine habenular complex. eLife. vol 9. 2021-04-02. PMID:32043968. |
in the lhb, we describe four neuronal subtypes and show that they differentially target dopaminergic and gabaergic cells in the ventral tegmental area (vta). |
2021-04-02 |
2023-08-13 |
mouse |
| Yanfei Sun, Jing Cao, Chunpeng Xu, Xiaofeng Liu, Zicheng Wang, Hua Zha. Rostromedial tegmental nucleus-substantia nigra pars compacta circuit mediates aversive and despair behavior in mice. Experimental neurology. vol 333. 2021-03-05. PMID:32791155. |
gabaergic neurons in the rostromedial tegmental nucleus (rmtg) receive major input from the lateral habenula (lhb), which conveys negative reward and motivation related information, and project intensively to midbrain dopamine neurons, including those in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-03-05 |
2023-08-13 |
mouse |
| Marjorie R Levinstein, Kevin R Coffey, Russell G Marx, Atom J Lesiak, John F Neumaie. Stress induces divergent gene expression among lateral habenula efferent pathways. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344721. |
reduced pi3k signaling in rmtg-projecting lhb neurons may be a compensatory adaptation that alters the functional balance of lhb outputs to gabaergic vs. monoaminergic neurons following repeated stress exposure. |
2020-12-22 |
2023-08-13 |
rat |
| Mariana Brizuela, Steven J Swoap, James Ang, William W Blessing, Youichirou Ootsuk. Neurons in ventral tegmental area tonically inhibit sympathetic outflow to brown adipose tissue: possible mediation of thermogenic signals from lateral habenula. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30406672. |
lhb-mediated behavioral responses involve inhibitory control over the dopamine neurons in the ventral tegmental area (vta), mediated via an excitatory drive from the lhb to gabaergic neurons in the tail of the vta. |
2019-11-19 |
2023-08-13 |
Not clear |
| Yujie Guo, Xun Tang, Jichuan Zhang, Sen Jin, Jinnan Li, Lufeng Ding, Keming Zhang, Chaoyu Yang, Hua Zhou, Xiaobin He, Fuqiang Xu, Guo-Qiang Bi, Lin Xu, Pak-Ming La. Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 23. 2019-10-16. PMID:29760181. |
furthermore, suppressing the lhb activity or modulating the gabaergic transmission in the vta could significantly reduce the occurrence of sib. |
2019-10-16 |
2023-08-13 |
rat |
| Guang-Wei Zhang, Li Shen, Wen Zhong, Ying Xiong, Li I Zhang, Huizhong W Ta. Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway. Neuron. vol 99. issue 5. 2019-08-01. PMID:30122379. |
cell-type-specific screening reveals that glutamatergic ms projections to the lateral habenula (lhb) are responsible for the induction of aversion, which can be antagonized by gabaergic ms projections to lhb. |
2019-08-01 |
2023-08-13 |
Not clear |
| Limei Zhang, Vito S Hernández, Jerome D Swinny, Anil K Verma, Torsten Giesecke, Andrew C Emery, Kerim Mutig, Luis M Garcia-Segura, Lee E Eide. A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29479060. |
here, we report a cell type in the medial division of the lhb (lhbm) in male rats that is distinguished by: (1) a molecular signature for gabaergic neurotransmission (slc32a1/vgat) and estrogen receptor (esr1/erα) expression, at both mrna and protein levels, as well as the mrna for vesicular glutamate transporter slc17a6/vglut2, which we term the gabaergic estrogen-receptive neuron (gern); (2) its axonal projection patterns, identified by in vivo juxtacellular labeling, to both local lhb and to midbrain modulatory systems; and (3) its somatic expression of receptors for vasopressin, serotonin and dopamine, and mrna for orexin receptor 2. |
2018-12-12 |
2023-08-13 |
rat |
| Wanhong Zuo, Cheng Xiao, Ming Gao, F Woodward Hopf, Krešimir Krnjević, J Michael McIntosh, Rao Fu, Jie Wu, Alex Bekker, Jiang-Hong Y. Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms. Scientific reports. vol 6. 2018-06-27. PMID:27596561. |
in addition, nicotine activates gabaergic inputs to lhb via α4β2-nachrs, at lower concentrations but with more rapid desensitization relative to α6*-nachrs. |
2018-06-27 |
2023-08-13 |
mouse |
| Agustin Zapata, Eun-Kyung Hwang, Carl R Lupic. Lateral Habenula Involvement in Impulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 5. 2018-01-08. PMID:28025973. |
we find that inhibition of the lhb with gabaergic agonists did not alter cocaine sa under progressive ratio or seeking/taking chained reinforcement schedules, or during punishment-induced suppression of cocaine-reinforced responding. |
2018-01-08 |
2023-08-13 |
rat |
| P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepar. Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053043. |
activation of gabaergic neurons in the rostromedial tegmental nucleus (rmtg), a region that receives dense projections from the lhb and projects strongly to midbrain monoaminergic nuclei, is believed to underlie the transient inhibition of da neurons attributed to activation of the lhb. |
2017-07-24 |
2023-08-13 |
rat |
| Phillip M Baker, Thomas Jhou, Bo Li, Masayuki Matsumoto, Sheri J Y Mizumori, Marcus Stephenson-Jones, Aleksandra Vicenti. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 45. 2017-07-17. PMID:27911751. |
the lhb gets major inputs from the habenula-projecting globus pallidus and the mpfc, sending its efferents to the dopaminergic vta and snc, serotonergic dorsal raphe nuclei, and the gabaergic rostromedial tegmental nucleus. |
2017-07-17 |
2023-08-13 |
Not clear |
| Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Y. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27678415. |
gabaergic transmission, a major target of ethanol in many brain regions, also tightly regulates lhb activity. |
2017-06-30 |
2023-08-13 |
rat |
| Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Y. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27678415. |
this study assessed the action of ethanol on lhb gabaergic transmission in rat brain slices. |
2017-06-30 |
2023-08-13 |
rat |
| Sam A Golden, Mitra Heshmati, Meghan Flanigan, Daniel J Christoffel, Kevin Guise, Madeline L Pfau, Hossein Aleyasin, Caroline Menard, Hongxing Zhang, Georgia E Hodes, Dana Bregman, Lena Khibnik, Jonathan Tai, Nicole Rebusi, Brian Krawitz, Dipesh Chaudhury, Jessica J Walsh, Ming-Hu Han, Matt L Shapiro, Scott J Russ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. vol 534. issue 7609. 2016-07-26. PMID:27357796. |
furthermore, we identify a functional gabaergic projection from the basal forebrain (bf) to the lateral habenula (lhb) that bi-directionally controls the valence of aggressive interactions. |
2016-07-26 |
2023-08-13 |
mouse |
| Sam A Golden, Mitra Heshmati, Meghan Flanigan, Daniel J Christoffel, Kevin Guise, Madeline L Pfau, Hossein Aleyasin, Caroline Menard, Hongxing Zhang, Georgia E Hodes, Dana Bregman, Lena Khibnik, Jonathan Tai, Nicole Rebusi, Brian Krawitz, Dipesh Chaudhury, Jessica J Walsh, Ming-Hu Han, Matt L Shapiro, Scott J Russ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. vol 534. issue 7609. 2016-07-26. PMID:27357796. |
circuit-specific silencing of gabaergic bf-lhb terminals of aggressors with halorhodopsin (nphr3.0) increases lhb neuronal firing and abolishes cpp to the intruder-paired context. |
2016-07-26 |
2023-08-13 |
mouse |
| Sam A Golden, Mitra Heshmati, Meghan Flanigan, Daniel J Christoffel, Kevin Guise, Madeline L Pfau, Hossein Aleyasin, Caroline Menard, Hongxing Zhang, Georgia E Hodes, Dana Bregman, Lena Khibnik, Jonathan Tai, Nicole Rebusi, Brian Krawitz, Dipesh Chaudhury, Jessica J Walsh, Ming-Hu Han, Matt L Shapiro, Scott J Russ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. vol 534. issue 7609. 2016-07-26. PMID:27357796. |
activation of gabaergic bf-lhb terminals of non-aggressors with channelrhodopsin (chr2) decreases lhb neuronal firing and promotes cpp to the intruder-paired context. |
2016-07-26 |
2023-08-13 |
mouse |
| Leora Yetnikoff, Anita Y Cheng, Heather N Lavezzi, Kenneth P Parsley, Daniel S Zah. Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat. The Journal of comparative neurology. vol 523. issue 16. 2016-06-21. PMID:25940654. |
profound inhibitory control exerted on midbrain dopaminergic neurons by the lateral habenula (lhb), which has mainly excitatory outputs, is mediated by the gabaergic rostromedial tegmental nucleus (rmtg), which strongly innervates dopaminergic neurons in the ventral midbrain. |
2016-06-21 |
2023-08-13 |
rat |
| Philip Jean-Richard Dit Bressel, Gavan P McNall. The role of the lateral habenula in punishment. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365401. |
the lhb is known to modulate midbrain dopamine (da) neurons, including inhibition of ventral tegmental area (vta) neurons via glutamatergic excitation of the gabaergic rostromedial tegmental nucleus (rmtg). |
2015-08-18 |
2023-08-13 |
rat |
| David H Root, Carlos A Mejias-Aponte, Jia Qi, Marisela Morale. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 42. 2015-02-06. PMID:25319687. |
recent findings indicate that vta gabaergic neurons that coexpress tyrosine hydroxylase (th) projecting to lateral habenula (lhb) play a role in reward. |
2015-02-06 |
2023-08-13 |
mouse |