| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William J Flerlage, Sarah C Simmons, Emily H Thomas, Shawn Gouty, Brian M Cox, Fereshteh S Nugen. Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury. Pharmacology, biochemistry, and behavior. 2024-07-27. PMID:39067532. |
following mtbi, while responses to kor activation at lhb glutamatergic synapses remained intact, lhb gabaergic synapses acquired an additional sensitivity to kor-mediated inhibition where we observed a reduction in gaba release probability in response to kor stimulation in lhb neurons of mtbi mice. |
2024-07-27 |
2024-08-02 |
mouse |
| William J Flerlage, Sarah C Simmons, Emily H Thomas, Shawn Gouty, Brian M Cox, Fereshteh S Nugen. Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury. Pharmacology, biochemistry, and behavior. 2024-07-27. PMID:39067532. |
kor activation generally suppressed spontaneous glutamatergic transmission without altering gabaergic transmission, resulting in a significant but sex-similar reduction in net spontaneous e/i and synaptic drive ratios in lhb neurons of sham mice. |
2024-07-27 |
2024-08-02 |
mouse |
| William J Flerlage, Sarah C Simmons, Emily H Thomas, Shawn Gouty, Brian M Cox, Fereshteh S Nugen. Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury. Pharmacology, biochemistry, and behavior. 2024-07-27. PMID:39067532. |
the additional engagement of kor-mediated action on lhb gabaergic transmission by mtbi could contribute to the e/i imbalance after mtbi, with dyn/kor signaling serving as a disinhibitory mechanism for lhb neurons of a subset of mtbi mice. |
2024-07-27 |
2024-08-02 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
lhb pv neurons comprise three subsets: glutamatergic, gabaergic, and double-positive for glutamatergic and gabaergic machinery. |
2024-07-03 |
2024-07-10 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
by comparing the percentages of the subsets, we found that the lhb was topographically organized anteroposteriorly; the gabaergic and glutamatergic pv neurons were preferentially distributed in the anterior and posterior lhb, respectively, uncovering the anteroposterior topography of the lhb. |
2024-07-03 |
2024-07-10 |
mouse |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
we found that compared to sham lesions, lesions of the lhb increased the firing rate of da neurons in the vta and 5-ht neurons in the drn, but decreased the firing rate of gabaergic neurons in the same nucleus. |
2024-04-08 |
2024-04-11 |
rat |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873336. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens (nac), glutamatergic neurons projecting from the ventral pallidum (vp) to the lateral habenula (lhb), dopaminergic neurons in the ventral tegmental area (vta), and parvalbumin (pv)-positive proprioceptive neurons in the periphery. |
2023-10-24 |
2023-11-08 |
mouse |
| Soo Hyun Yang, Esther Yang, Jaekwang Lee, Jin Yong Kim, Hyeijung Yoo, Hyung Sun Park, Jin Taek Jung, Dongmin Lee, Sungkun Chun, Yong Sang Jo, Gyeong Hee Pyeon, Jae-Yong Park, Hyun Woo Lee, Hyun Ki. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature communications. vol 14. issue 1. 2023-04-27. PMID:37105975. |
chronic stress drives depression by excitation of the lateral habenula (lhb), which silences dopaminergic neurons in the ventral tegmental area (vta) via gabaergic neuronal projection from the rostromedial tegmental nucleus (rmtg). |
2023-04-27 |
2023-08-14 |
mouse |
| Soo Hyun Yang, Esther Yang, Jaekwang Lee, Jin Yong Kim, Hyeijung Yoo, Hyung Sun Park, Jin Taek Jung, Dongmin Lee, Sungkun Chun, Yong Sang Jo, Gyeong Hee Pyeon, Jae-Yong Park, Hyun Woo Lee, Hyun Ki. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature communications. vol 14. issue 1. 2023-04-27. PMID:37105975. |
here, we used fluorescent in situ hybridisation and in vivo electrophysiology in mice to show that lhb aromatic l-amino acid decarboxylase-expressing neurons (d-neurons) are activated by acute stressors and suppress rmtg gabaergic neurons via trace aminergic signalling, thus activating vta dopaminergic neurons. |
2023-04-27 |
2023-08-14 |
mouse |
| Soo Hyun Yang, Esther Yang, Jaekwang Lee, Jin Yong Kim, Hyeijung Yoo, Hyung Sun Park, Jin Taek Jung, Dongmin Lee, Sungkun Chun, Yong Sang Jo, Gyeong Hee Pyeon, Jae-Yong Park, Hyun Woo Lee, Hyun Ki. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature communications. vol 14. issue 1. 2023-04-27. PMID:37105975. |
we show that the lhb regulates rmtg gabaergic neurons biphasically under acute stress. |
2023-04-27 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
a small population of neurons within the medial subnucleus of the mouse lhb express the gabaergic synthesizing enzyme gad2, and they can inhibit nearby lhb projection neurons; however, these neurons lack markers of classic inhibitory interneurons and they co-express the vesicular glutamate transporter vglut2. |
2023-01-30 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
our data confirm that gad2+/vglut2+ neurons intrinsic to the lhb co-express markers of both glutamatergic and gabaergic transmission and that they are transcriptionally distinct from either gabaergic interneurons or habenular glutamatergic neurons. |
2023-01-30 |
2023-08-14 |
mouse |
| Michel A Companion, David A Gonzalez, Stacey L Robinson, Melissa A Herman, Todd E Thiel. Lateral habenula-projecting central amygdala circuits expressing GABA and NPY Y1 receptor modulate binge-like ethanol intake in mice. Addiction neuroscience. vol 3. 2022-09-05. PMID:36059430. |
here we assessed the roles of gabaergic and y1r+ circuits arising from the cea and innervating the lateral habenula (lhb), a brain region that modulates the aversive properties of ethanol, in modulating binge-like ethanol intake in mice using "drinking in the dark" (did) procedures. |
2022-09-05 |
2023-08-14 |
mouse |
| William J Flerlage, Ludovic D Langlois, Milan Rusnak, Sarah C Simmons, Shawn Gouty, Regina C Armstrong, Brian M Cox, Aviva Symes, Mumeko C Tsuda, Fereshteh Nugen. Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits. Journal of neurotrauma. 2022-08-16. PMID:35972745. |
additionally, mtbi diminished spontaneous glutamatergic and gabaergic synaptic activity onto lhb neurons, while synaptic excitation and inhibition (e/i) balance was shifted toward excitation through a greater suppression of gabaergic transmission. |
2022-08-16 |
2023-08-14 |
Not clear |
| Jian Xu, Andrew Jo, Raina P DeVries, Sercan Deniz, Suraj Cherian, Idris Sunmola, Xingqi Song, John J Marshall, Katherine A Gruner, Tanya L Daigle, Anis Contractor, Talia N Lerner, Hongkui Zeng, Yongling Zh. Intersectional mapping of multi-transmitter neurons and other cell types in the brain. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793636. |
focusing on the lateral habenula (lhb) as a target, we identified glutamatergic, gabaergic, or co-glutamatergic/gabaergic innervations from ∼40 brain regions. |
2022-07-06 |
2023-08-14 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
more interestingly, we found a stronger gabaergic projection from the medial septum to the lhb in males than in females. |
2022-06-01 |
2023-08-13 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
our results reveal a comprehensive connectivity atlas of glutamatergic and gabaergic inputs to the lhb in both sexes, which may facilitate a better understanding of sexual dimorphism in physiological and pathological brain functions. |
2022-06-01 |
2023-08-13 |
mouse |
| Myunghyun Cheon, Hoyong Park, ChiHye Chun. Protein kinase C mediates neuropeptide Y-induced reduction in inhibitory neurotransmission in the lateral habenula. Neuropharmacology. vol 180. 2021-08-27. PMID:32882226. |
we previously reported that npy decreases gabaergic transmission in the lateral habenula (lhb). |
2021-08-27 |
2023-08-13 |
Not clear |
| Myunghyun Cheon, Hoyong Park, ChiHye Chun. Protein kinase C mediates neuropeptide Y-induced reduction in inhibitory neurotransmission in the lateral habenula. Neuropharmacology. vol 180. 2021-08-27. PMID:32882226. |
here, we revealed that y1 receptors (y1rs) but not y2rs mediate npy-induced decrease of gabaergic transmission in the lhb. |
2021-08-27 |
2023-08-13 |
Not clear |