| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karel Erion, Barbara E Corke. β-Cell Failure or β-Cell Abuse? Frontiers in endocrinology. vol 9. 2019-11-20. PMID:30271382. |
data from our lab and others document that several nutrients and environmental toxins can stimulate insulin secretion at non-stimulatory glucose in the absence of insulin resistance. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jianping Y. Role of adipose hypoxia in endocrine alterations: a possible new anti-inflammatory therapeutic target in obesity? Expert review of endocrinology & metabolism. vol 3. issue 1. 2019-11-20. PMID:30743779. |
recent work from his lab reported that adipose hypoxia may contribute to chronic inflammation and insulin resistance in obesity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jingying Liu, Ulrich Werner, Mario Funke, Melissa Besenius, Lasse Saaby, Mathias Fanø, Huiling Mu, Anette Müllert. SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats. International journal of pharmaceutics. vol 560. 2019-06-12. PMID:30790612. |
to face the challenges of oral delivery of peptide and protein (p/p) drugs, self-emulsifying drug delivery systems (seddss) containing monoacyl phosphatidylcholine (mapc), labrasol (lab) and medium-chain (mc) monoglycerides as permeation enhancers (pes) were evaluated for their effect on intestinal absorption of insulin. |
2019-06-12 |
2023-08-13 |
rat |
| Yun-Ju Cho, Hyeon Gyu Lee, Kun-Ho Seo, Wallace Yokoyama, Hyunsook Ki. Antiobesity Effect of Prebiotic Polyphenol-Rich Grape Seed Flour Supplemented with Probiotic Kefir-Derived Lactic Acid Bacteria. Journal of agricultural and food chemistry. vol 66. issue 47. 2018-12-11. PMID:30392364. |
in comparison to con, all gsf and lab groups showed a reduction ( p < 0.05) in hf-induced weight gain, liver and adipose tissue weights, plasma lipid concentrations, insulin resistance, and glucose intolerance. |
2018-12-11 |
2023-08-13 |
mouse |
| Yun-Ju Cho, Hyeon Gyu Lee, Kun-Ho Seo, Wallace Yokoyama, Hyunsook Ki. Antiobesity Effect of Prebiotic Polyphenol-Rich Grape Seed Flour Supplemented with Probiotic Kefir-Derived Lactic Acid Bacteria. Journal of agricultural and food chemistry. vol 66. issue 47. 2018-12-11. PMID:30392364. |
the combination of 10% gsf and lab showed synergistic effects ( p < 0.05) on body weight gain, plasma insulin and total cholesterol concentrations, and cecum propionate contents. |
2018-12-11 |
2023-08-13 |
mouse |
| E Nicole Dover, Naishal Y Patel, Miroslav Stýbl. Impact of in vitro heavy metal exposure on pancreatic β-cell function. Toxicology letters. vol 299. 2018-11-09. PMID:30300733. |
previous evidence from our lab has shown that ias can increase dm risk by impairing mitochondrial metabolism, one of the key steps in the regulation of glucose-stimulated insulin secretion (gsis) in pancreatic β-cells. |
2018-11-09 |
2023-08-13 |
Not clear |
| Brenton T Laing, Khoa Do, Tomoko Matsubara, David W Wert, Michael J Avery, Erin M Langdon, Donghai Zheng, Hu Huan. Voluntary exercise improves hypothalamic and metabolic function in obese mice. The Journal of endocrinology. vol 229. issue 2. 2017-06-08. PMID:26931136. |
metabolic function was examined by the comprehensive lab animal monitoring system and magnetic resonance imaging; phenotypic analysis included measurements of body weight, food intake, glucose and insulin tolerance tests, as well as insulin and leptin sensitivity studies. |
2017-06-08 |
2023-08-13 |
mouse |
| Ruifeng Mao, Dongli Wu, Shimeng Hu, Kangping Zhou, Man Wang, Yefu Wan. Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria. Applied microbiology and biotechnology. vol 101. issue 8. 2017-04-25. PMID:28120013. |
in order to use the food-grade bacteria lactic acid bacteria (lab) as oral delivery vehicles, a new and bioactive single-chain insulin (sci-59) analog, containing the insulin b- and a-chains connected by an eight-residue linker (rsrglpfr), was secretory expressed in lactococcus lactis nz3900 without using an antibiotic resistance gene and displayed onto the surface of various non-viable bacteria (nvbs) without genetic modification. |
2017-04-25 |
2023-08-13 |
Not clear |
| Christian Mangrum, Eric Rush, Vijay Shivaswam. Genetically Targeted Dipeptidyl Peptidase-4 Inhibitor Use in a Patient with a Novel Mutation of MODY type 4. Clinical medicine insights. Endocrinology and diabetes. vol 8. 2015-11-06. PMID:26543388. |
lab work showed a blood glucose of 511 mg/dl, no ketones or antibodies (insulin, islet cell, and glutamic acid decarboxylase [gad]), c-peptide of 1.6 ng/ml, and a1c 9.3%. |
2015-11-06 |
2023-08-13 |
Not clear |
| Saleh Aldasouqi, George Grunberge. The traditions and risks of fasting for lipid profiles in patients with diabetes. Postgraduate medicine. vol 126. issue 7. 2015-01-27. PMID:25387218. |
at the same time, recent reports have alerted the medical community to the risk of hypoglycemia in patients with diabetes on antidiabetic medications (particularly insulin and sulfonylureas) who are asked to fast for lab tests. |
2015-01-27 |
2023-08-13 |
Not clear |
| Thomas Kampfrath, Daniel A Rosenblatt, Rainer Lenhardt, Lynn Nelson, Saeed A Jortan. Undetected hypoglycemia in a patient receiving TPN. Clinica chimica acta; international journal of clinical chemistry. vol 424. 2014-04-10. PMID:23732402. |
the lab sample was always drawn 1-2h after insulin was given to the patient and resulted in a lower blood glucose value. |
2014-04-10 |
2023-08-12 |
Not clear |
| Daniel M Kem. Does chronic low-grade endotoxemia define susceptibility of obese humans to insulin resistance via dietary effects on gut microbiota? Adipocyte. vol 2. issue 3. 2013-08-30. PMID:23991367. |
recent studies, including one from our own lab, report that different subpopulations of obese individuals display a variable inflammatory signature in their visceral adipose tissue that may contribute significantly to their risk for developing insulin resistance, type 2 diabetes, and other metabolic diseases. |
2013-08-30 |
2023-08-12 |
Not clear |
| Wayne Gade, Jessica Schmit, Melissa Collins, Jean Gad. Beyond obesity: the diagnosis and pathophysiology of metabolic syndrome. Clinical laboratory science : journal of the American Society for Medical Technology. vol 23. issue 1. 2010-04-22. PMID:20218095. |
metabolic syndrome (msx) identifies clinical symptoms and lab results, including abdominal obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hypertension, that lead to an increased risk of cardiovascular disease (cvd). |
2010-04-22 |
2023-08-12 |
Not clear |
| Jarbas S Roriz-Filho, Ticiana M Sá-Roriz, Idiane Rosset, Ana L Camozzato, Antonio C Santos, Márcia L F Chaves, Júlio César Moriguti, Matheus Roriz-Cru. (Pre)diabetes, brain aging, and cognition. Biochimica et biophysica acta. vol 1792. issue 5. 2009-07-07. PMID:19135149. |
how can clinical hyperinsulinism be a risk factor for ad whereas lab experiments evidence insulin to be an important neurothrophic factor? |
2009-07-07 |
2023-08-12 |
human |
| Si-Wei Chen, Jin Zhong, Lian-Dong Hua. [Expression of human insulin in lactic acid bacteria and its oral administration in non-obese diabetic mice]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271251. |
to express human insulin gene (ins) in lactic acid bacteria (lab) for oral vaccine, ins gene was replaced by lab bias codon and an 8-amino-acid-residue linker peptide forming a beta-turn was designed to link insulin chain a and b. |
2009-05-05 |
2023-08-12 |
mouse |
| Si-Wei Chen, Jin Zhong, Lian-Dong Hua. [Expression of human insulin in lactic acid bacteria and its oral administration in non-obese diabetic mice]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271251. |
expression of insulin in the food-grade vehicle lab could induce oral immune tolerance in nod mice and protect it from pancreas injury, suggesting it might be a new way to the treatment of t1dm. |
2009-05-05 |
2023-08-12 |
mouse |
| Carla da S Benetti, Patrícia P Silveira, André K Portella, Luisa A Diehl, Edelvan Nunes, Vanessa S de Oliveira, Carla Dalmaz, Marcelo Z Goldan. Could preference for palatable foods in neonatally handled rats alter metabolic patterns in adult life? Pediatric research. vol 62. issue 4. 2007-11-13. PMID:17667857. |
we measured the consumption of foods (standard lab chow and chocolate), body weight gain, abdominal fat deposition, and levels of plasma lipids, glucose, insulin, and corticosterone in adult neonatally handled (10 min/d, first 10 d of life) and nonhandled rats. |
2007-11-13 |
2023-08-12 |
rat |
| Yannick Le Marchand-Brustel, Philippe Gual, Myriam Aouadi, Thierry Grémeaux, Bernard Binétruy, Frédéric Bost, Jean-François Tant. [Obesity, diabetes and insulin resistance. Alterations of insulin signalling]. Journal de la Societe de biologie. vol 200. issue 1. 2007-01-29. PMID:17144167. |
this review summarizes evidence obtained in our lab on the role of the serine phosphorylation of the insulin receptor substrate 1 in the down regulation of insulin signalling. |
2007-01-29 |
2023-08-12 |
Not clear |
| C Lelliott, A J Vidal-Pui. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 28 Suppl 4. 2005-05-09. PMID:15592482. |
work from our lab and others suggests that defective adipose tissue is a key link between obesity, insulin resistance and type 2 diabetes mellitus by promoting the development of lipotoxicity in peripheral tissues. |
2005-05-09 |
2023-08-12 |
mouse |
| Virginia Fernández, Luz Marina Morales, Emperatriz Molero-Conejo, Angel Casanova, Gilberto Campos, Xiomara Raleigh, Maria Esther Gómez, Elena Ryde. [Levels of apoproteins B, A1 and CIII as markers for cardiovascular risk in lean and obese adolescents]. Investigacion clinica. vol 45. issue 1. 2004-12-14. PMID:15058756. |
in both, boys and girls, basal insulin levels were higher than the cutoff insulin value for our lab (>12 microu/ml), with the girls having higher insulin levels than the boys. |
2004-12-14 |
2023-08-12 |
human |