| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melissa A Herman, Harpreet Sidhu, David G Stouffer, Max Kreifeldt, David Le, Chelsea Cates-Gatto, Michaelanne B Munoz, Amanda J Roberts, Loren H Parsons, Marisa Roberto, Kevin Wickman, Paul A Slesinger, Candice Conte. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 22. 2015-10-13. PMID:25964320. |
in addition, girk3 ko mice showed a blunted response of the mesolimbic dopaminergic (da) pathway to ethanol, as assessed by ethanol-induced excitation of vta neurons and da release in the nucleus accumbens. |
2015-10-13 |
2023-08-13 |
mouse |
| Alanna C Easton, Andrea Rotter, Anbarasu Lourdusamy, Sylvane Desrivières, Alberto Fernández-Medarde, Teresa Biermann, Cathy Fernandes, Eugenio Santos, Johannes Kornhuber, Gunter Schumann, Christian P Mülle. Rasgrf2 controls dopaminergic adaptations to alcohol in mice. Brain research bulletin. vol 109. 2015-07-10. PMID:25454123. |
rasgrf2 knock out (ko) mice do not develop a dopamine response in the nucleus accumbens after an alcohol challenge and show a reduced consumption of alcohol. |
2015-07-10 |
2023-08-13 |
mouse |
| Emily N Lum, Rianne R Campbell, Charlotte Rostock, Karen K Szumlinsk. mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions. Neuropharmacology. vol 79. 2014-12-03. PMID:24467847. |
jnj-16259685 (0-30 pg/side) was infused into the shell subregion of the nucleus accumbens (nac) of c57bl/6j and homer2 knock-out (ko) mice, either alone or in combination with the plc inhibitor u-73122 (5.8 fg/side). |
2014-12-03 |
2023-08-12 |
mouse |
| J L Harenza, P P Muldoon, M De Biasi, M I Damaj, M F Mile. Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. Genes, brain, and behavior. vol 13. issue 2. 2014-09-25. PMID:24289814. |
to identify molecular events downstream of chrna7 that may modulate nicotine preference, we performed microarray analysis of α7 knock-out (ko) and wild-type (wt) nucleus accumbens (nac) tissue, followed by confirmation with quantitative polymerase chain reaction (pcr) and immunoblotting. |
2014-09-25 |
2023-08-12 |
mouse |
| Yoshiyuki Kasahara, Yumiko Kubo, Ichiro Sor. [Analysis of dopamine transporter knockout mice as an animal model of AD/HD]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069256. |
dat ko mice exhibit persistently and profoundly elevated extracellular dopamine levels in the striatum and nucleus accumbens. |
2014-09-25 |
2023-08-13 |
mouse |
| Vladimir I Chefer, Cristina M Bäckman, Eduardo D Gigante, Toni S Shippenber. Kappa opioid receptors on dopaminergic neurons are necessary for kappa-mediated place aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23921954. |
in addition, in vivo microdialysis showed that systemic u69,593 decreased overflow of da in the nucleus accumbens (nac) in wt mice, but had no effect in datcre-kor ko mice. |
2014-07-01 |
2023-08-12 |
mouse |
| Joanna I Giza, Yonwoo Jung, Rachel A Jeffrey, Nichole M Neugebauer, Marina R Picciotto, Thomas Biedere. The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 4. 2013-10-29. PMID:23169347. |
our studies now reveal that the loss of syncam 1 in knockout (ko) mice reduces excitatory synapse number in nucleus accumbens (nac). |
2013-10-29 |
2023-08-12 |
mouse |
| Yonwoo Jung, Patrick J Mulholland, Shari L Wiseman, L Judson Chandler, Marina R Picciott. Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine. The European journal of neuroscience. vol 37. issue 1. 2013-06-11. PMID:23106536. |
using diolistic labeling with the lipophilic dye dii, we found that the density of mature mushroom-shaped spines was significantly decreased in the nucleus accumbens (nac) in brain slices from βadd-knockout (ko) mice as compared to their wildtype (wt) siblings. |
2013-06-11 |
2023-08-12 |
mouse |
| Yosefu Arime, Yoshiyuki Kasahara, F Scott Hall, George R Uhl, Ichiro Sor. Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 11. 2013-02-26. PMID:22781838. |
to clarify these mechanisms, ppi was tested after microinjections of nisoxetine into the medial prefrontal cortex (mpfc) or nucleus accumbens (nac) in wildtype (wt) and dat ko mice. |
2013-02-26 |
2023-08-12 |
mouse |
| Yoshiyuki Kasahara, Yosefu Arime, Yumiko Kubo, Asami Fukui, Ichiro Sor. [Neuronal development of the hyperdopaminergic animal model]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 5-6. 2012-02-16. PMID:22256607. |
dopamine transporter knockout (dat ko) mice exhibited hyperdopaminergic tone in the nucleus accumbens and striatum, whereas they showed normal levels of extracellular dopamine in the prefrontal cortex. |
2012-02-16 |
2023-08-12 |
mouse |
| Diane A Lane, June Chan, Carl R Lupica, Virginia M Picke. Cannabinoid-1 receptor gene deletion has a compartment-specific affect on the dendritic and axonal availability of μ-opioid receptors and on dopamine axons in the mouse nucleus accumbens. Synapse (New York, N.Y.). vol 64. issue 12. 2011-08-15. PMID:20939059. |
to test this hypothesis, we examined the electron microscopic immunolabeling of the μ-or and the dopamine-synthesizing enzyme, tyrosine hydroxylase (th) in acb shell, and core of adult c57bl/6j wild-type (wt) and cb1-knock-out (ko) mice. |
2011-08-15 |
2023-08-12 |
mouse |
| Stuart L Gibb, Jerome Jeanblanc, Segev Barak, Quinn V Yowell, Rami Yaka, Dorit Ro. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 6. 2011-03-25. PMID:21307254. |
activation of ventral tegmental area (vta) daergic neurons results in da overflow in the nucleus accumbens (nac), and we found that the evoked release of da was higher in the nac of lyn knock-out (lyn ko) mice compared with wild-type littermate (lyn wt) controls. |
2011-03-25 |
2023-08-12 |
mouse |
| b' Mikko K\\xc3\\xa4enm\\xc3\\xa4ki, Anne Tammim\\xc3\\xa4ki, Timo My\\xc3\\xb6h\\xc3\\xa4nen, Kaisa Pakarinen, Carolina Amberg, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626558.' |
in quantitative no-net-flux microdialysis, da levels were increased by 60% in the pfc of comt-knockout (ko) mice, but not in the striatum and nucleus accumbens. |
2010-10-19 |
2023-08-12 |
mouse |
| Benjamin B Land, Michael R Bruchas, Selena Schattauer, William J Giardino, Megumi Aita, Daniel Messinger, Thomas S Hnasko, Richard D Palmiter, Charles Chavki. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 45. 2010-01-06. PMID:19864633. |
drn serotonergic neurons project broadly throughout the brain, but the inactivation of kor in the nucleus accumbens (nac) coupled with viral re-expression in the drn of kor ko mice demonstrated that aversion was encoded by a drn to nac projection. |
2010-01-06 |
2023-08-12 |
mouse |
| Eleni T Tzavara, Aldemar Degroot, Mark R Wade, Richard J Davis, George G Nomiko. CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19116182. |
however, cb1r ko and wild-type mice showed a similar d-amphetamine-induced increase in nucleus accumbens da release. |
2009-05-20 |
2023-08-12 |
mouse |
| Elisabeth Barbier, Agustin Zapata, Eric Oh, Qing Liu, Fei Zhu, Ashiwel Undie, Toni Shippenberg, Jia Bei Wan. Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17203012. |
quantitative microdialysis studies revealed no alteration in basal da dynamics in the striatum or nucleus accumbens of ko mice. |
2007-09-26 |
2023-08-12 |
mouse |
| Yosuke Morishima, Tsuyoshi Miyakawa, Tomoyuki Furuyashiki, Yasuhiro Tanaka, Hiroshi Mizuma, Shigetada Nakanish. Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 11. 2005-05-09. PMID:15753323. |
upon in vivo microdialysis analysis after cocaine administration, not only did extracellular levels of dopamine increase but also the response pattern of glutamate release markedly changed in the nucleus accumbens of mglur2-/- ko mice. |
2005-05-09 |
2023-08-12 |
mouse |
| V I Chefer, B L Kieffer, T S Shippenber. Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine. Neuroscience. vol 127. issue 2. 2004-11-09. PMID:15262338. |
conventional brain microdialysis was used to assess basal and cocaine-induced dopamine (da) levels in the nucleus accumbens of wildtype (wt) c57bl/6j mice and mice with constitutive deletion of ether mu- or delta-opioid receptors (mor or dor knockout [ko], respectively). |
2004-11-09 |
2023-08-12 |
mouse |
| Alex V Yarkov, Diane Hanger, Maria Reploge, Jeffrey N Joyc. Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D3 receptor knockout mice. Pharmacology, biochemistry, and behavior. vol 76. issue 3-4. 2004-08-24. PMID:14643855. |
mptp treatment produced equivalent 70% losses of dopamine fibers in the caudate putamen (cpu) and nucleus accumbens (nac) of wt and d(3) ko mice as compared to their control (vehicle injected) counterparts. |
2004-08-24 |
2023-08-12 |
mouse |
| J V Trinh, D L Nehrenberg, J P R Jacobsen, M G Caron, W C Wetse. Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699766. |
amphetamine and cocaine produced similar changes to that for methylphenidate, except these psychostimulants also induced fos-li in the nucleus accumbens of the ko animals. |
2003-06-16 |
2023-08-12 |
mouse |