| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Ga. Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice. Cerebral cortex (New York, N.Y. : 1991). 2023-01-10. PMID:36627245. |
moreover, the expression levels of rack1 and the membrane glun2b were significantly reduced in the nucleus accumbens of ko mice compared with those in the control mice, which may be attributed to the decreased hdac4 in the hippocampus of ko mice. |
2023-01-10 |
2023-08-14 |
mouse |
| Cheryl A Hawkes, Christopher J Heath, Matthew M Sharp, Dariusz C Górecki, Roxana O Carar. α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta neuropathologica communications. vol 10. issue 1. 2022-08-31. PMID:36045406. |
mrna levels of mor1were significantly decreased in the caudate-putamen and nucleus accumbens of α-db ko compared to wt animals, but protein levels were unaltered. |
2022-08-31 |
2023-08-14 |
mouse |
| Cheryl A Hawkes, Christopher J Heath, Matthew M Sharp, Dariusz C Górecki, Roxana O Carar. α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta neuropathologica communications. vol 10. issue 1. 2022-08-31. PMID:36045406. |
however, cb1 protein levels were significantly increased in the prefrontal cortex and decreased in the nucleus accumbens of α-db ko mice. |
2022-08-31 |
2023-08-14 |
mouse |
| Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuk. Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice. Behavioural brain research. vol 396. 2021-11-09. PMID:32653557. |
increases in 5-ht and dopamine release in the nucleus accumbens induced by mdma were not altered by knockout of orexin; the steady-state level of g protein activation was higher in the limbic forebrain of orexin ko mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Jessica L Huebschman, Megan C Davis, Catherina Tovar Pensa, Yuhong Guo, Laura N Smit. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34133054. |
additionally, we find an fmrp target, the activity-regulated cytoskeleton-associated protein (arc), to be significantly reduced in synaptic cellular fractions prepared from the nucleus accumbens of fmr1 ko, compared with wt, mice following operant tasks reinforced with cocaine but not food. |
2021-08-20 |
2023-08-13 |
mouse |
| Gang Lei, Fei Liu, Peng Liu, Tong Jiao, Liu Yang, Zheng Chu, Li-Sha Deng, Yan Li, Yong-Hui Dan. Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors? Schizophrenia research. vol 222. 2021-06-17. PMID:32439293. |
total glutamate was decreased in the medial prefrontal cortex, nucleus accumbens (nac), and hip of ko mice. |
2021-06-17 |
2023-08-13 |
mouse |
| Kuisheng Sun, Feng Wang, Lin Ma, Xiaofan Ren, Chun Zhang, Weifang Rong, Tao Su. Genetic knockout of the G protein-coupled estrogen receptor 1 facilitates the acquisition of morphine-induced conditioned place preference and aversion in mice. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32184017. |
our study used gper1 knockout (gper1 ko) and wild-type (wt) mice to compare the sensitivity differences of morphine- and sucrose-induced conditioned place preference (cpp) and naloxone-induced conditioned place aversion (cpa), and differences in dopamine (da) content in the nucleus accumbens (nac) were determined by high performance liquid chromatography (hplc). |
2020-12-28 |
2023-08-13 |
mouse |
| Francisco J Pavón, Antonia Serrano, David G Stouffer, Ilham Polis, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parson. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30421483. |
extracellular levels of endocannabinoids and relevant neurotransmitters were measured by in vivo microdialysis in the nucleus accumbens (nac) of faah knockout (ko) and wild-type (wt) mice during an ethanol (etoh; 2 g/kg, ip) challenge in etoh-naive and repeated (r) etoh-treated mice. |
2020-10-28 |
2023-08-13 |
mouse |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
extracellular dopamine and glutamic acid concentrations were also measured in the dialysate obtained by intracerebral microdialysis from the nucleus accumbens (acb) shell of dat ko, het and wt rats, which underwent five copulatory tests, when put in the presence of an inaccessible sexually receptive female rat and when copulation was allowed. |
2020-09-28 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
these differences occurred with differential changes in dopamine and glutamic acid concentrations in acb dialysates during sexual behavior, with lower increases of dopamine and glutamic acid in dat ko vs. wt and het rats, and a lower expression of the markers investigated, mainly in the mpfc, in dat ko vs. wt rats. |
2020-09-28 |
2023-08-13 |
rat |
| Kazuhito Nakao, Vivek Jeevakumar, Sunny Zhihong Jiang, Yuko Fujita, Noelia B Diaz, Carlos A Pretell Annan, Karen L Eskow Jaunarajs, Kenji Hashimoto, Juan E Belforte, Kazu Nakazaw. Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction. Schizophrenia bulletin. vol 45. issue 1. 2019-06-19. PMID:29394409. |
here, we report enhanced dopaminomimetic-induced locomotor activity in these mutants, along with bidirectional, site-specific changes in in vivo amphetamine-induced dopamine release: nucleus accumbens (nac) dopamine release was enhanced by amphetamine in postnatal ppp1r2-cre/grin1 knockout (ko) mice, whereas dopamine release was dramatically reduced in the medial pfc (mpfc) compared to controls. |
2019-06-19 |
2023-08-13 |
mouse |
| Samantha Mancino, Sueli Mendonça-Netto, Elena Martín-García, Rafael Maldonad. Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour. Addiction biology. vol 22. issue 5. 2018-05-16. PMID:27101941. |
for this purpose, we evaluated the specific role of this receptor in the behavioural and neuroplastic changes induced by palatable food in the prefrontal cortex (pfc), hippocampus (hcp) and nucleus accumbens (nac) in constitutive knockout (ko) mice deficient in dor. |
2018-05-16 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
furthermore, ko mice showed increased brain-derived neurotrophic factor (bdnf) and its receptor trkb signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (nac), although bdnf-trkb signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus. |
2018-05-14 |
2023-08-13 |
mouse |
| Joanna Y Ip, Masamitsu Sone, Chieko Nashiki, Qun Pan, Kiyoyuki Kitaichi, Kaori Yanaka, Takaya Abe, Keizo Takao, Tsuyoshi Miyakawa, Benjamin J Blencowe, Shinichi Nakagaw. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Scientific reports. vol 6. 2018-04-26. PMID:27251103. |
this hyperactive behavior was enhanced when the ko mice were treated with the psychostimulant methamphetamine, which was associated with an increase in dopamine release in the nucleus accumbens. |
2018-04-26 |
2023-08-13 |
mouse |
| R J Taugher, Y Lu, R Fan, A Ghobbeh, C J Kreple, F M Faraci, J A Wemmi. ASIC1A in neurons is critical for fear-related behaviors. Genes, brain, and behavior. vol 16. issue 8. 2018-02-22. PMID:28657172. |
in contrast, in the nucleus accumbens asic1a expression was relatively normal in synasic1a ko mice, and consistent with this observation, cocaine conditioned place preference (cpp) was normal. |
2018-02-22 |
2023-08-13 |
mouse |
| Amal Alachkar, Lamees Alhassen, Zhiwei Wang, Lien Wang, Kara Onouye, Nayna Sanathara, Olivier Civell. Inactivation of the melanin concentrating hormone system impairs maternal behavior. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 11. 2018-01-26. PMID:27617778. |
furthermore, following pups retrieval, mchr1 ko mice display a lower level of fos expression than wt mice in the ventral tegmental area, and nucleus accumbens. |
2018-01-26 |
2023-08-13 |
mouse |
| Nitish Mittal, Ani Minasyan, Nicole Romaneschi, Joshua K Hakimian, Gabriel Gonzalez-Fernandez, Ralph Albert, Nina Desai, Ian A Mendez, Timothy Schallert, Sean B Ostlund, Wendy Walwy. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PloS one. vol 12. issue 10. 2017-10-19. PMID:28973019. |
we then examined glutamatergic synaptic strength in wt and ko medium spiny neurons (msns) of the nucleus accumbens (nac) shell in naïve animals, and from those that underwent cocaine self-administration. |
2017-10-19 |
2023-08-13 |
mouse |
| R Adron Harris, Michal Bajo, Richard L Bell, Yuri A Blednov, Florence P Varodayan, Jay M Truitt, Giordano de Guglielmo, Amy W Lasek, Marian L Logrip, Leandro F Vendruscolo, Amanda J Roberts, Edward Roberts, Olivier George, Jody Mayfield, Timothy R Billiar, David J Hackam, R Dayne Mayfield, George F Koob, Marisa Roberto, Gregg E Homanic. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 5. 2017-07-24. PMID:27986929. |
members of the integrative neuroscience initiative on alcoholism (inia-neuroimmune) consortium tested the hypothesis that tlr4 mediates excessive ethanol drinking using the following models: (1) tlr4 knock-out (ko) rats, (2) selective knockdown of tlr4 mrna in mouse nucleus accumbens (nac), and (3) injection of the tlr4 antagonist (+)-naloxone in mice. |
2017-07-24 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, Emiliano Zamponi, Constanza García-Keller, María Amparo Assis, Miriam B Virgolini, Daniel H Mascó, Andreas Zimmer, Liliana M Cancel. Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addiction biology. vol 21. issue 2. 2016-12-20. PMID:25431310. |
we found that ko mice do not develop sensitization to the stimulating properties of cocaine on locomotor activity and on dopamine release in the nucleus accumbens (nac). |
2016-12-20 |
2023-08-13 |
mouse |