| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Cheryl A Hawkes, Christopher J Heath, Matthew M Sharp, Dariusz C Górecki, Roxana O Carar. α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta neuropathologica communications. vol 10. issue 1. 2022-08-31. PMID:36045406. |
mrna levels of mor1were significantly decreased in the caudate-putamen and nucleus accumbens of α-db ko compared to wt animals, but protein levels were unaltered. |
2022-08-31 |
2023-08-14 |
mouse |
| Rose B Creed, Rosalinda C Roberts, Charlene B Farmer, Lori L McMahon, Matthew S Goldber. Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats. Neurobiology of disease. vol 150. 2021-06-14. PMID:33387634. |
while pink1 knockout (ko) rats have mitochondrial dysfunction, locomotor deficits, and α-synuclein aggregates in several brain regions such as cerebral cortex, dorsal striatum, and substantia nigra, the functional ramifications on synaptic circuits are unknown. |
2021-06-14 |
2023-08-13 |
rat |
| Rose B Creed, Matthew S Goldber. Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils. Neuroscience. vol 437. 2021-05-14. PMID:32353461. |
herein, we report that intracranial injection of α-synuclein pffs into the dorsal striatum induced more abundant ps129 α-synuclein in pink1 ko rat brains compared to wt littermate controls. |
2021-05-14 |
2023-08-13 |
mouse |
| Danielle M Giangrasso, Teri M Furlong, Kristen A Keef. Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31734455. |
further, preprotachykinin mrna expression, a post-synaptic indicator of da signaling, was significantly decreased in 4-month dj-1 ko rats, while da transporter binding in the dorsal striatum did not differ between genotypes at any of the ages examined. |
2021-01-13 |
2023-08-13 |
rat |
| Giulia Costa, Annalisa Pinna, Pier Francesca Porceddu, Maria Antonietta Casu, Anna Di Maio, Francesco Napolitano, Alessandro Usiello, Micaela Morell. Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29904346. |
adult male rhes ko mice showed a decrease in th and an increase in cd11b, both in the caudate putamen (cpu) and substantia nigra pars compacta (snc), and an increase in gfap in the cpu. |
2020-09-30 |
2023-08-13 |
mouse |
| Maximiliano Rapanelli, Luciana Frick, Kantiya Jindachomthong, Jian Xu, Hiroshi Ohtsu, Angus C Nairn, Christopher Pittenge. Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology. Neuroscience. vol 392. 2019-03-06. PMID:30278251. |
the h3r histamine receptor is elevated in the striatum of hdc ko mice, and h3r agonists, acting in the dorsal striatum, trigger tic-like movements in the model. |
2019-03-06 |
2023-08-13 |
mouse |
| Yunjin Lee, Hannah Kim, Ji-Eun Kim, Jin-Young Park, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Pyung-Lim Ha. Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:29027111. |
moreover, the sirna-mediated inhibition of d2 dopamine receptors in the dorsal striatum was sufficient to replicate autistic-like phenotypes in d2 ko mice. |
2019-02-26 |
2023-08-13 |
mouse |
| Hannah Kim, Yunjin Lee, Jin-Young Park, Ji-Eun Kim, Tae-Kyung Kim, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Daesoo Kim, Kyoung-Shim Kim, Pyung-Lim Ha. Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878759. |
notably, the autistic-like behaviors of ac5 ko mice are rescued by blocking mglur5 glutamate receptors within the dorsal striatum. |
2018-07-27 |
2023-08-13 |
mouse |
| Hannah Kim, Yunjin Lee, Jin-Young Park, Ji-Eun Kim, Tae-Kyung Kim, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Daesoo Kim, Kyoung-Shim Kim, Pyung-Lim Ha. Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878759. |
optogenetic inhibition of the prelimbic cortical neurons projecting to the dorsal striatum in ac5 ko mice rescues the deficits in social and object novelty preferences. |
2018-07-27 |
2023-08-13 |
mouse |
| Hannah Kim, Yunjin Lee, Jin-Young Park, Ji-Eun Kim, Tae-Kyung Kim, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Daesoo Kim, Kyoung-Shim Kim, Pyung-Lim Ha. Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878759. |
ac5 knockout (ko) mice exhibit increased repetitive behaviors and sociability deficits, the two core domains of asd, and that sirna-mediated suppression of ac5 within the dorsal striatum is sufficient to replicate these behavioral phenotypes. |
2018-07-27 |
2023-08-13 |
mouse |
| M Rapanelli, L Frick, V Pogorelov, H Ohtsu, H Bito, C Pittenge. Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28117842. |
we used a novel chemogenetic strategy to demonstrate that this dorsal striatal activity is necessary and sufficient for the development of stereotypy: when ramh-activated cells in the dorsal striatum were chemogenetically activated (in the absence of ramh), stereotypy was recapitulated in ko animals, and when they were silenced the ability of ramh to produce stereotypy was blocked. |
2017-11-16 |
2023-08-13 |
mouse |
| Emmanuel N Anyetei-Anum, Alissa Blum, Nabil G Seidah, Margery C Beinfel. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27923657. |
substantial decreases in brain levels of cck are found in the prefrontal, frontal, parietal-insular-pyriform, and temporal cortex, caudate-putamen, basal forebrain, thalamus, hippocampus, septum, and medulla of pc7 knock-out (ko) mice. |
2017-06-06 |
2023-08-13 |
mouse |
| Hannah Kim, Yunjin Lee, Ji-Eun Kim, Pyung-Lim Ha. Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs. Experimental neurobiology. vol 25. issue 2. 2016-04-28. PMID:27122994. |
ac5 ko mice had increased level of phospho-camkiiα in the dorsal striatum, and wt mice with whiskers cut on either side also showed increased p-camkiiα level in the dorsal striatum. |
2016-04-28 |
2023-08-13 |
mouse |
| Hannah Kim, Yunjin Lee, Ji-Eun Kim, Pyung-Lim Ha. Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs. Experimental neurobiology. vol 25. issue 2. 2016-04-28. PMID:27122994. |
the sirna-mediated inhibition of camkiiα in the dorsal striatum in either the right or the left hemisphere in ac5 ko mice and d2 ko mice blocked the behavioral preference for ac5 ko pellets. |
2016-04-28 |
2023-08-13 |
mouse |
| Christopher B Divito, Kathy Steece-Collier, Daniel T Case, Sean-Paul G Williams, Jennifer A Stancati, Lianteng Zhi, Maria E Rubio, Caryl E Sortwell, Timothy J Collier, David Sulzer, Robert H Edwards, Hui Zhang, Rebecca P Sea. Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 45. 2016-02-22. PMID:26558771. |
using a conditional vglut3 ko mouse, we show that deletion of the transporter from cins, surprisingly, does not alter evoked da release in the dorsal striatum or baseline locomotor activity. |
2016-02-22 |
2023-08-13 |
mouse |
| Christopher B Divito, Kathy Steece-Collier, Daniel T Case, Sean-Paul G Williams, Jennifer A Stancati, Lianteng Zhi, Maria E Rubio, Caryl E Sortwell, Timothy J Collier, David Sulzer, Robert H Edwards, Hui Zhang, Rebecca P Sea. Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 45. 2016-02-22. PMID:26558771. |
remarkably, after a partial 6-hydroxydopamine (6-ohda)-mediated da depletion (∼70% in dorsal striatum), ko mice, in contrast to wt mice, showed normal motor behavior across the entire circadian cycle. |
2016-02-22 |
2023-08-13 |
mouse |
| Mateusz Michalik, Andrew D Steele, Ralph E Mistlberge. A sex difference in circadian food-anticipatory rhythms in mice: Interaction with dopamine D1 receptor knockout. Behavioral neuroscience. vol 129. issue 3. 2016-02-16. PMID:26030433. |
an important role for dopamine signaling and the dorsal striatum is suggested by a confluence of observations, including shifting of faa rhythms by dopamine receptor agonists and attenuation by antagonists and d1 receptor knockout (d1r ko). |
2016-02-16 |
2023-08-13 |
mouse |
| Alanna C Easton, Andrea Rotter, Anbarasu Lourdusamy, Sylvane Desrivières, Alberto Fernández-Medarde, Teresa Biermann, Cathy Fernandes, Eugenio Santos, Johannes Kornhuber, Gunter Schumann, Christian P Mülle. Rasgrf2 controls dopaminergic adaptations to alcohol in mice. Brain research bulletin. vol 109. 2015-07-10. PMID:25454123. |
using in vivo microdialysis we found that alcohol induces alterations in dopamine levels in the dorsal striatum between wildtype (wt) and rasgrf2 ko mice. |
2015-07-10 |
2023-08-13 |
mouse |
| Christian M Gallardo, Martin Darvas, Mia Oviatt, Chris H Chang, Mateusz Michalik, Timothy F Huddy, Emily E Meyer, Scott A Shuster, Antonio Aguayo, Elizabeth M Hill, Karun Kiani, Jonathan Ikpeazu, Johan S Martinez, Mari Purpura, Andrea N Smit, Danica F Patton, Ralph E Mistlberger, Richard D Palmiter, Andrew D Steel. Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. eLife. vol 3. 2015-07-02. PMID:25217530. |
within the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in d1r ko mice. |
2015-07-02 |
2023-08-13 |
mouse |