| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
tph1 and htr3a gene expression in pancreatic islets was not affected by an hfd, and immunostaining could not detect 5-ht in pancreatic islets from mice fed an hfd. |
2015-03-24 |
2023-08-13 |
mouse |
| Jiekun Yang, Ming D L. Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. Human genetics. vol 133. issue 7. 2014-08-04. PMID:24590108. |
previous studies have implicated genes encoding the 5-ht3ab receptors (htr3a and htr3b) and the serotonin transporter (slc6a4), both independently and interactively, in alcohol (ad), cocaine (cd), and nicotine dependence (nd). |
2014-08-04 |
2023-08-12 |
human |
| Zhongli Yang, Chamindi Seneviratne, Shaolin Wang, Jennie Z Ma, Thomas J Payne, Jundong Wang, Ming D L. Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. Drug and alcohol dependence. vol 129. issue 3. 2014-01-21. PMID:23290502. |
pharmacologic studies implicate a significant role of genes encoding the serotonin transporter (slc6a4) and the 5-ht3ab subunits htr3a and htr3b in nicotine dependence (nd). |
2014-01-21 |
2023-08-12 |
Not clear |
| Xiao-Xu Ma, Qi-Xing Chen, Shui-Jing Wu, Yan Hu, Xiang-Ming Fan. Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population. Journal of clinical pharmacy and therapeutics. vol 38. issue 2. 2014-01-14. PMID:23464988. |
the serotoninergic receptor 5-hydroxytryptamine (serotonin) receptor 3 (htr3) is instrumental in the regulation of nausea and emesis (vomiting).this study investigated whether common genomic variations of the a and b subunits of htr3 (htr3a, htr3b) are associated with the incidence of post-operative vomiting in a chinese han population. |
2014-01-14 |
2023-08-12 |
Not clear |
| Chamindi Seneviratne, Jason Franklin, Katherine Beckett, Jennie Z Ma, Nassima Ait-Daoud, Thomas J Payne, Bankole A Johnson, Ming D L. Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. Human genetics. vol 132. issue 10. 2013-11-04. PMID:23757001. |
on the basis of the converging evidence showing regulation of drinking behavior by 5-ht3ab receptors and the serotonin transporter, we hypothesized that the interactive effects of genetic variations in the genes htr3a, htr3b, and slc6a4 confer greater susceptibility to alcohol dependence (ad) than do their effects individually. |
2013-11-04 |
2023-08-12 |
Not clear |
| M-A Enoch, E Gorodetsky, C Hodgkinson, A Roy, D Goldma. Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20838391. |
in this study, 360 treatment-seeking african american male patients with single and comorbid dsm-iv lifetime diagnoses of alcohol, cocaine and heroin dependence and 187 african american male controls were genotyped for the triallelic 5-httlpr functional polymorphism in the 5-ht transporter gene (slc6a4) and 16 haplotype-tagging single-nucleotide polymorphisms (snps) across htr3b (including the functional rs1176744 tyr129ser) and htr3a, genes encoding 5-ht3 receptors. |
2012-03-05 |
2023-08-12 |
Not clear |
| Renan P Souza, Vincenzo De Luca, Mirko Manchia, James L Kenned. Are serotonin 3A and 3B receptor genes associated with suicidal behavior in schizophrenia subjects? Neuroscience letters. vol 489. issue 3. 2011-04-29. PMID:21184810. |
we evaluated whether genetic variants in the serotonin receptors htr3a (rs897692, rs1150226, rs1176724, rs2276302, rs3737457, rs897687 and rs1176713) and htr3b (rs3758987, rs10502180, rs11606194, rs17116121, rs1176744, rs17116138, rs2276307, rs3782025 and rs1176761) were susceptibility components for suicidal behavior in 154 caucasians schizophrenia subjects (20.1% of suicide attempters). |
2011-04-29 |
2023-08-12 |
human |
| Justine M Gatt, Leanne M Williams, Peter R Schofield, Carol Dobson-Stone, Robert H Paul, Stuart M Grieve, C Richard Clark, Evian Gordon, Charles B Nemerof. Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood. Depression and anxiety. vol 27. issue 8. 2010-12-28. PMID:20694966. |
the role of serotonin 3a receptor gene (htr3a -42c>t polymorphism) and its interaction with early life stress (els) was investigated in view of the receptor's localization to brain regions central to emotion processing. |
2010-12-28 |
2023-08-12 |
Not clear |
| Andrea Rinaldi, Anna Maria Chiaravalli, Michael Mian, Emanuele Zucca, Maria Grazia Tibiletti, Carlo Capella, Francesco Berton. Serotonin receptor 3A expression in normal and neoplastic B cells. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 77. issue 3. 2010-08-30. PMID:20516728. |
we identified htr3a, the gene coding for 5-hydroxytryptamine receptor 3a, as the most frequently differentially expressed. |
2010-08-30 |
2023-08-12 |
human |
| Virginia R Falkenberg, Mangalathu S Rajeeva. Identification of a potential molecular link between the glucocorticoid and serotonergic signaling systems. Journal of molecular neuroscience : MN. vol 41. issue 2. 2010-07-09. PMID:20052562. |
bioinformatic analysis identified nine binding sites in various serotonin receptors (htr1d, htr1f, htr2a, htr3a, and htr6) for transcription factors in the gr family. |
2010-07-09 |
2023-08-12 |
Not clear |
| J M Wheeler, C Reed, S Burkhart-Kasch, N Li, C L Cunningham, A Janowsky, F H Franken, K M Wiren, J G Hashimoto, A C Scibelli, T J Phillip. Genetically correlated effects of selective breeding for high and low methamphetamine consumption. Genes, brain, and behavior. vol 8. issue 8. 2010-02-10. PMID:19689456. |
genes differentially expressed in the drug-naï ve state, including slc6a4 (serotonin transporter), htr3a (serotonin receptor 3a), rela [nuclear factor kappab (nfkappab)] and fos (cfos), represent candidates whose expression levels may predict methamphetamine consumption and susceptibility to methamphetamine reward and aversion. |
2010-02-10 |
2023-08-12 |
mouse |
| O Levran, D Londono, K O'Hara, M Randesi, J Rotrosen, P Casadonte, S Linzy, J Ott, M Adelson, M J Kree. Heroin addiction in African Americans: a hypothesis-driven association study. Genes, brain, and behavior. vol 8. issue 5. 2009-11-10. PMID:19500151. |
these snps are from genes encoding several receptors: adrenergic (adra1a), arginine vasopressin (avpr1a), cholinergic (chrm2), dopamine (drd1), gaba-a (gabrb3), glutamate (grin2a) and serotonin (htr3a) as well as alcohol dehydrogenase (adh7), glutamic acid decarboxylase (gad1 and gad2), the nucleoside transporter (slc29a1) and diazepam-binding inhibitor (dbi). |
2009-11-10 |
2023-08-12 |
Not clear |
| Alicia K Smith, Elizabeth M Maloney, Virginia R Falkenberg, Irina Dimulescu, Mangalathu S Rajeeva. An angiotensin-1 converting enzyme polymorphism is associated with allostatic load mediated by C-reactive protein, interleukin-6 and cortisol. Psychoneuroendocrinology. vol 34. issue 4. 2009-06-10. PMID:19081678. |
polymorphisms in angiotensin-1 converting enzyme (ace), corticotropin-releasing hormone receptor 1 (crhr1), and serotonin receptors (htr3a and htr4) were associated with al (p=0.0007-0.0486), but only one polymorphism, rs4968591, in ace remained significant after correction for multiple comparisons. |
2009-06-10 |
2023-08-12 |
human |
| Beate Niesler, Johannes Kapeller, Christian Hammer, Gudrun Rappol. Serotonin type 3 receptor genes: HTR3A, B, C, D, E. Pharmacogenomics. vol 9. issue 5. 2008-09-24. PMID:18466097. |
serotonin type 3 receptor genes: htr3a, b, c, d, e. the 5-ht(3) receptor is a ligand-gated ion channel composed of five subunits. |
2008-09-24 |
2023-08-12 |
human |
| Beate Niesler, Johannes Kapeller, Christian Hammer, Gudrun Rappol. Serotonin type 3 receptor genes: HTR3A, B, C, D, E. Pharmacogenomics. vol 9. issue 5. 2008-09-24. PMID:18466097. |
to date, five different human subunits are known, 5-ht(3ae), which are encoded by the serotonin receptor genes htr3a, htr3b, htr3c, htr3d and htr3e, respectively. |
2008-09-24 |
2023-08-12 |
human |
| N van Lelyveld, J T Linde, M Schipper, M Samso. Candidate genotypes associated with functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 7. 2008-08-12. PMID:18331431. |
polymorphisms in genes encoding the serotonin receptor type three a subunit (htr3a), the serotonin transporter (sert) and the g-protein beta3 subunit (gnb3) were analysed. |
2008-08-12 |
2023-08-12 |
Not clear |
| Sam-Woong Rho, Gi-Soon Choi, Eun-Jung Ko, Sun-Kwang Kim, Young-Seop Lee, Hye-Jung Lee, Moo-Chang Hong, Min-Kyu Shin, Byung-Il Min, Hyun-Jung Kee, Cheol-Koo Lee, Hyun-Su Ba. Molecular changes in remote tissues induced by electro-acupuncture stimulation at acupoint ST36. Molecules and cells. vol 25. issue 2. 2008-08-04. PMID:18413997. |
it also induced genes related to pain, including 5-hydroxytryptamine (serotonin) receptor 3a (htr3a) and endothelin receptor type b (ednrb) in the hypothalamus, and increased the activity of superoxide dismutase in the hypothalamus, liver, and red blood cells. |
2008-08-04 |
2023-08-12 |
rat |
| Alicia K Smith, Irina Dimulescu, Virginia R Falkenberg, Supraja Narasimhan, Christine Heim, Suzanne D Vernon, Mangalathu S Rajeeva. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. vol 33. issue 2. 2008-05-06. PMID:18079067. |
a total of 77 polymorphisms in genes related to serotonin synthesis (tph2), signaling (htr1a, htr1e, htr2a, htr2b, htr2c, htr3a, htr3b, htr4, htr5a, htr6, and htr7), transport (slc6a4), and catabolism (maoa) were examined in 137 clinically evaluated subjects (40 cfs, 55 with insufficient fatigue, and 42 non-fatigued, nf, controls) derived from a population-based cfs surveillance study in wichita, kansas. |
2008-05-06 |
2023-08-12 |
human |
| T Sugai, Y Suzuki, K Sawamura, N Fukui, Y Inoue, T Somey. The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. The pharmacogenomics journal. vol 6. issue 5. 2006-11-21. PMID:16534507. |
we investigated the effect of 5-hydroxytryptamine 3a and 3b receptor (htr3a and htr3b) gene polymorphisms on nausea induced by paroxetine in japanese psychiatric patients. |
2006-11-21 |
2023-08-12 |
Not clear |
| Masaki Kato, Tsuyoshi Fukuda, Masataka Wakeno, Kazuhiro Fukuda, Gaku Okugawa, Yuka Ikenaga, Megumi Yamashita, Yoshiteru Takekita, Kenji Nobuhara, Junichi Azuma, Toshihiko Kinoshit. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology. vol 53. issue 4. 2006-09-29. PMID:16874005. |
in this study, we tested the influence of the serotonin type 2a, 3a and 3b receptor genes (htr2a, htr3a, htr3b) in addition to a polymorphism in the promoter region of the serotonin transporter (sertpr), and investigated the different characteristics of clinical responses to paroxetine and fluvoxamine. |
2006-09-29 |
2023-08-12 |
Not clear |