| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeqin Wu, Jiufei Li, Minglian Zhong, Zhiyuan Xu, Mulan Yang, Chenyang X. HTR3A Promotes Non-small Cell Lung Cancer Through the FOXH1/Wnt3A Signaling Pathway. Biochemical genetics. 2024-07-24. PMID:39046651. |
this study aimed to investigate the relationship between 5-hydroxytryptamine receptor 3a (htr3a) and nsclc development. |
2024-07-24 |
2024-07-26 |
mouse |
| Yeong-Min Yoo, Seong Soo Jo. Serotonin Influences Insulin Secretion in Rat Insulinoma INS-1E Cells. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:38999937. |
in this condition, serotonin receptors, gαq-coupled 5-ht2b receptor (htr2b), and ligand-gated ion channel receptor htr3a were significantly decreased by serotonin treatment. |
2024-07-13 |
2024-07-15 |
rat |
| Polina Kameneva, Victoria I Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V Artemov, Tatiana S Kalinina, Nikita V Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D Yakushov, Boris I Sheftel, Tomas Zikmund, Jozef Kaiser, Kaj Fried, Natalia Alenina, Elena E Voronezhskaya, Igor Adameyk. Serotonin limits generation of chromaffin cells during adrenal organ development. Nature communications. vol 13. issue 1. 2022-05-25. PMID:35614045. |
here we revealed that serotonin (5ht) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3a (htr3a), and the aggressive htr3a |
2022-05-25 |
2023-08-13 |
Not clear |
| Qin Ru, Qi Xiong, Xiang Tian, Congyue Xu, Can Li, Lin Chen, Yuxiang W. Candidate Chinese Herbal Medicine Alleviates Methamphetamine Addiction Frontiers in molecular neuroscience. vol 15. 2022-04-15. PMID:35422687. |
according to the network pharmacology analysis, ten hub targets including d(2) dopamine receptor (drd2) and 5-hydroxytryptamine receptor 3a (htr3a) were screened. |
2022-04-15 |
2023-08-13 |
mouse |
| Tao Li, Bin Fu, Xin Zhang, Yunjiang Zhou, Mengdi Yang, Mengran Cao, Yaxin Chen, Yingying Tan, Rong H. Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation. Cancer immunology research. vol 9. issue 9. 2021-09-02. PMID:34285037. |
colorectal cancer cell-originated 5-ht enhanced nlrp3 inflammasome activation in thp-1 cells and immortalized bone marrow-derived macrophages (ibmdm) via its ion channel receptor, htr3a. |
2021-09-02 |
2023-08-13 |
mouse |
| Jin-Yun Wu, Hong-Zhi Liu, Yan-Qing Qi, Xiao-Yang Wu, Yang Chen, Jiang-Teng Lyu, Ling Gong, Miao H. [Cortical 5-hydroxytryptamine receptor 3A (Htr3a) positive inhibitory neurons: diversity in type and function]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 2. 2021-04-28. PMID:33903891. |
[cortical 5-hydroxytryptamine receptor 3a (htr3a) positive inhibitory neurons: diversity in type and function]. |
2021-04-28 |
2023-08-13 |
Not clear |
| Jin-Yun Wu, Hong-Zhi Liu, Yan-Qing Qi, Xiao-Yang Wu, Yang Chen, Jiang-Teng Lyu, Ling Gong, Miao H. [Cortical 5-hydroxytryptamine receptor 3A (Htr3a) positive inhibitory neurons: diversity in type and function]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 2. 2021-04-28. PMID:33903891. |
cortical gabaergic inhibitory neurons are composed of three major classes, each expressing parvalbumin (pv), somatostatin (som) and 5-hydroxytryptamine receptor 3a (htr3a), respectively. |
2021-04-28 |
2023-08-13 |
Not clear |
| Mitsuyo Tone, Shinichiro Tahara, Satoshi Nojima, Daisuke Motooka, Daisuke Okuzaki, Eiichi Mori. HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma. Cancer science. vol 111. issue 10. 2020-12-15. PMID:32736413. |
htr3a is the main subunit of 5-hydroxytryptamine 3 (5-ht3) receptors, which are the only ligand-gated ion channels in seven families of 5-ht receptors. |
2020-12-15 |
2023-08-13 |
Not clear |
| Fangfang Chen, Meng Xiao, Cheng Chen, Chen Chen, Ziwei Yan, Huijie Han, Shuailei Zhang, Feilong Yue, Rui Gao, Xiaoyi L. Discrimination of alcohol dependence based on the convolutional neural network. PloS one. vol 15. issue 10. 2020-12-15. PMID:33108388. |
in this paper, a total of 20 sites of single nucleotide polymorphisms (snps) on the serotonin 3 receptor a gene (htr3a) and b gene (htr3b) are used for feature fusion with age, education and marital status information, and the grid search-support vector machine (gs-svm), the convolutional neural network (cnn) and the convolutional neural network combined with long and short-term memory (cnn-lstm) are used to classify and discriminate between alcohol-dependent patients (ad) and the non-alcohol-dependent control group. |
2020-12-15 |
2023-08-13 |
Not clear |
| Chaowen Wu, Liyuan Ma, Hongfa Wei, Furong Nie, Jie Ning, Tao Jian. MiR-1256 inhibits cell proliferation and cell cycle progression in papillary thyroid cancer by targeting 5-hydroxy tryptamine receptor 3A. Human cell. vol 33. issue 3. 2020-09-07. PMID:32130678. |
luciferase reporter assay and biotin-avidin pull-down assay showed mir-1256 can directly target 5-hydroxytryptamine receptor 3a (htr3a) in ptc cells. |
2020-09-07 |
2023-08-13 |
Not clear |
| Jochen Winterer, David Lukacsovich, Lin Que, Andrea M Sartori, Wenshu Luo, Csaba Föld. Single-cell RNA-Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines. The European journal of neuroscience. vol 50. issue 11. 2020-09-02. PMID:31420995. |
although an anatomically- and biophysically homogenous population, olms presumably comprise of two functionally distinct types with different developmental origins, inferred from the expression pattern of serotonin type-3a (5-ht3a, or htr3a) receptor subunit and 5-ht excitability in a set of olms. |
2020-09-02 |
2023-08-13 |
mouse |
| Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowsk. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The journal of pain. vol 19. issue 10. 2020-04-06. PMID:29723560. |
polymorphisms in 5 genes were associated with membership in the mild pain class: ** beta-2-adrenergic receptor (adrb2) rs2400707, beta adrenergic receptor kinase 2 (adrbk2) hapa04, 5-hydroxytryptamine receptor 3a (htr3a) rs10160548, solute-like carrier (slc) family 6 member 2-noradrenaline transporter (slc6a2) rs1566652, and tryptophan hydroxylase 2 (tph2) rs11179000. |
2020-04-06 |
2023-08-13 |
Not clear |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
'we found that genes, related with serotonin (tph2, maob, sic6a4, htr4, htr1a) were upregulated but expression of htr3a gene was downregulated in the ventral tegmental area of depressive mice in comparison with the control. |
2019-02-19 |
2023-08-13 |
mouse |
| Shanyu Cui, Hyewon Park, Hyelim Park, Dasom Mun, Seung Hyun Lee, Hyoeun Kim, Nuri Yun, Hail Kim, Michael Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joun. The Role of Serotonin in Ventricular Repolarization in Pregnant Mice. Yonsei medical journal. vol 59. issue 2. 2018-04-23. PMID:29436197. |
we evaluated the role of serotonin in ventricular repolarization in mice hearts via 5htr3 receptor (htr3a) and investigated the mechanism of qt-prolongation during pregnancy. |
2018-04-23 |
2023-08-13 |
mouse |
| Daniel S Schechter, Dominik A Moser, Virginie C Pointet, Tatjana Aue, Ludwig Stenz, Ariane Paoloni-Giacobino, Wafae Adouan, Aurélia Manini, Francesca Suardi, Marylene Vital, Ana Sancho Rossignol, Maria I Cordero, Molly Rothenberg, François Ansermet, Sandra Rusconi Serpa, Alexandre G Daye. The association of serotonin receptor 3A methylation with maternal violence exposure, neural activity, and child aggression. Behavioural brain research. vol 325. issue Pt B. 2018-03-06. PMID:27720744. |
methylation of the serotonin 3a receptor gene (htr3a) has been linked to child maltreatment and adult psychopathology. |
2018-03-06 |
2023-08-13 |
Not clear |
| Chih-Yuan Ko, Yia-Ping Li. Disruptions of sensorimotor gating, cytokines, glycemia, monoamines, and genes in both sexes of rats reared in social isolation can be ameliorated by oral chronic quetiapine administration. Brain, behavior, and immunity. vol 51. 2017-01-10. PMID:26254231. |
therefore, we employed ir rats of both sexes to examine whether chronic quetiapine (qtp, a second-generation antipsychotic medication) treatment induces disruptions of metabolism (body weight, blood pressure, and the glycemic and lipid profiles) or cytokines [interleukin (il)-1 beta, il-6, il-10, interferon-gamma, and tumor necrosis factor (tnf)-alpha], and further, whether it reverses deficits of behaviors [locomotor activity and prepulse inhibition (ppi)] and the expression of monoamines (dopamine and serotonin) and related genes (htr1a, htr2a, htr3a, drd1a, and gabbr2). |
2017-01-10 |
2023-08-13 |
rat |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
in this study, analysis of the 5-ht type 3a receptor subunit-deficient (htr3a(-/-)) mice revealed that lack of the 5-ht type 3 (5-ht3) receptor resulted in loss of exercise-induced hippocampal neurogenesis and antidepressant effects, but not of learning enhancement. |
2016-08-02 |
2023-08-13 |
mouse |
| Luis Rodrigo Cataldo, Víctor Antonio Cortés, José Eduardo Galgani, Pablo Roberto Olmos, José Luis Santo. [Role of peripheral serotonin in the insulin secretion and glucose homeostasis]. Nutricion hospitalaria. vol 30. issue 3. 2016-07-28. PMID:25238823. |
the expression of enzymes involved in 5ht synthesis and their receptors varied markedly in β-pancreatic cells during pregnancy, in parallel with an increase in their insulin secretion potential (probably through the action of htr3a) and an increase in β-cell mass (through the action of htr2b and htr1d). |
2016-07-28 |
2023-08-13 |
Not clear |
| Yi-Mei Joy Lin, Cheng-Da Hsu, Hsiao-Yen Hsieh, Chia-Chih Alex Tseng, H Sunny Su. Sequence variants of the HTR3A gene contribute to the genetic prediction of postoperative nausea in Taiwan. Journal of human genetics. vol 59. issue 12. 2015-08-21. PMID:25339231. |
current clinical and basic research suggests that the 5-hydroxytryptamine type 3a receptor (htr3a) may be important in the occurrence of pon. |
2015-08-21 |
2023-08-13 |
Not clear |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
gsis was impaired in islets isolated from hfd-fed htr3a ko and tph1 βko mice, and 5-ht treatment improved insulin secretion from tph1 βko islets but not from htr3a ko islets. |
2015-03-24 |
2023-08-13 |
mouse |