| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Louis Papageorgiou, Evangelia Christou, Effrosyni Louka, Eleni Papakonstantinou, Io Diakou, Katerina Pierouli, Konstantina Dragoumani, Flora Bacopoulou, George P Chrousos, Elias Eliopoulos, Dimitrios Vlachaki. ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525034. |
specifically, evolutionary and structural studies on the adrenoceptor alpha 2b (adra2b) and the 5-hydroxytryptamine receptor 1a (htr1a) have been carried out. |
2023-07-31 |
2023-08-14 |
Not clear |