| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bariş O Yildirim, Jan J L Derkse. Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy. Neuroscience and biobehavioral reviews. vol 37. issue 7. 2013-12-31. PMID:23644029. |
next, it is examined how various polymorphisms in serotonergic genes (e.g., tph, 5htt, htr1a, htr2a, htr2c, and htr3) might contribute either individually or interactively to the development of these disorders and through which specific biological and behavioral endophenotypes this effect could be mediated. |
2013-12-31 |
2023-08-12 |
Not clear |
| Jae-Won Kim, Hyo-Sang Ahn, Ja-Hyun Baik, Bong-June Yoo. Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. Journal of psychopharmacology (Oxford, England). vol 27. issue 2. 2013-09-30. PMID:22992375. |
an analysis of the expression of serotonergic genes after exposure to social defeat stress revealed small but significant changes in the expression of 5-ht1a receptor gene (htr1a) and 5-htt gene (slc6a4) in the mice treated with clomipramine compared with the mice injected with saline. |
2013-09-30 |
2023-08-12 |
mouse |
| Gilda Baccini, Boris Mlinar, Enrica Audero, Cornelius Thilo Gross, Renato Corradett. Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028768. |
impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1a (htr1a) receptors. |
2013-02-26 |
2023-08-12 |
mouse |
| Gilda Baccini, Boris Mlinar, Enrica Audero, Cornelius Thilo Gross, Renato Corradett. Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028768. |
we recently created a transgenic mouse line in which a functional deficit in serotonin homeostasis due to excessive serotonin autoinhibition was produced by inducing serotonin 1a receptor (htr1a) overexpression selectively in serotonergic neurons (htr1a raphe-overexpressing or htr1a(ro) mice). |
2013-02-26 |
2023-08-12 |
mouse |
| Gilda Baccini, Boris Mlinar, Enrica Audero, Cornelius Thilo Gross, Renato Corradett. Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028768. |
htr1a(ro) mice exhibit episodes of autonomic dysregulation, cardiovascular crises and death, resembling those of sudden infant death syndrome (sids) and revealing a life-supporting role of serotonergic system in autonomic control. |
2013-02-26 |
2023-08-12 |
mouse |
| Gilda Baccini, Boris Mlinar, Enrica Audero, Cornelius Thilo Gross, Renato Corradett. Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028768. |
since midbrain serotonergic neurons are chemosensitive and are implicated in arousal we hypothesized that their chemosensitivity might be impaired in htr1a(ro) mice. |
2013-02-26 |
2023-08-12 |
mouse |
| Fredrik Lindstedt, Bianka Karshikoff, Martin Schalling, Caroline Olgart Höglund, Martin Ingvar, Mats Lekander, Eva Kose. Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952650. |
the minor g-allele of the htr1a single nucleotide polymorphism (snp) rs6295 attenuates firing of serotonergic neurons and reduces postsynaptic expression of the receptor. |
2013-02-19 |
2023-08-12 |
human |
| Gabor Varga, Anna Szekely, Peter Antal, Peter Sarkozy, Zsofia Nemoda, Zsolt Demetrovics, Maria Sasvari-Szekel. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 3. 2012-10-05. PMID:22259185. |
here we report an association study of both dopaminergic (comt rs4680, drd4 48 bp vntr, drd2/ankk1 rs1800497) and serotonergic (htr1a rs6925, htr1b rs13212041, slc6a4 5-httlpr) gene polymorphisms and trait impulsivity assessed with the barratt impulsiveness scale (bis-11) in a sample of 687 caucasian young adults. |
2012-10-05 |
2023-08-12 |
Not clear |
| Yuka Abe, Takeshi Suganuma, Masakazu Ishii, Gou Yamamoto, Tomohiko Gunji, Glenn T Clark, Tetsuhiko Tachikawa, Yuji Kiuchi, Yoshimasa Igarashi, Kazuyoshi Bab. Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. Journal of sleep research. vol 21. issue 3. 2012-10-04. PMID:22545912. |
in addition, 13 polymorphisms in four genes related to serotonergic neurotransmission (slc6a4, htr1a, htr2a and htr2c) were genotyped. |
2012-10-04 |
2023-08-12 |
human |
| Zhi Xu, Zhijun Zhang, Yanyan Shi, Mengjia Pu, Yonggui Yuan, Xiangrong Zhang, Lingjiang Li, Gavin P Reynold. Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. Journal of psychopharmacology (Oxford, England). vol 26. issue 3. 2012-08-03. PMID:21937687. |
in total, 14 single nucleotide polymorphisms (snps) in coding regions of 10 serotonergic genes (htr1a, htr1b, htr1d, htr2a, htr3a, htr3c, htr3d, htr3e, htr5a and tph2) were genotyped in 308 chinese han patients with major depressive disorder. |
2012-08-03 |
2023-08-12 |
human |
| Yu-Chen Jiang, Hung-Ming Wu, Kai-Hsin Cheng, H Sunny Su. Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene. Human mutation. vol 33. issue 1. 2012-04-23. PMID:21990073. |
the serotonin receptor 1a (encoded by the htr1a gene) plays a critical role in serotonergic transmission and was linked with many human diseases. |
2012-04-23 |
2023-08-12 |
human |
| Paul R Albert, Brice Le François, Anne M Milla. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Molecular brain. vol 4. 2011-11-30. PMID:21619616. |
extensive characterization of the transcriptional regulation of the 5-ht1a gene (htr1a) using cell culture systems has revealed a gc-rich "housekeeping" promoter that non-selectively drives its expression; this is flanked by a series of upstream repressor elements for rest, freud-1/cc2d1a and freud-2/cc2d1b factors that not only restrict its expression to neurons, but may also regulate the level of expression of 5-ht1a receptors in various subsets of neurons, including serotonergic neurons. |
2011-11-30 |
2023-08-12 |
Not clear |
| Paul R Albert, Brice Le François, Anne M Milla. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Molecular brain. vol 4. 2011-11-30. PMID:21619616. |
a separate set of allele-specific factors, including deaf1, hes1 and hes5 repress at the htr1a c(-1019)g (rs6295) polymorphism in serotonergic neurons in culture, as well as in vivo. |
2011-11-30 |
2023-08-12 |
Not clear |
| S Martin, C Lino-de-Oliveira, S R L Joca, R Weffort de Oliveira, M B Echeverry, C A Da Silva, L Pardo, W Stühmer, E D Be. Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats. Genes, brain, and behavior. vol 9. issue 8. 2011-03-02. PMID:20662937. |
as the long-lasting alterations in emotional and behavioral regulation after stress have been related to changes in serotonergic neurotransmission, expressions of serotonin htr1a and htr2a receptors in male wistar rats' brain were also investigated. |
2011-03-02 |
2023-08-12 |
rat |
| Carolina Blaya, Giovanni A Salum, Priya Moorjani, Ana Carolina Seganfredo, Elizeth Heldt, Sandra Leistner-Segal, Jordan W Smoller, Gisele Gus Manfr. Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20817074. |
panic disorder and serotonergic genes (slc6a4, htr1a and htr2a): association and interaction with childhood trauma and parenting. |
2011-01-04 |
2023-08-12 |
Not clear |
| Christian P Jacob, Thuy Trang Nguyen, Astrid Dempfle, Monika Heine, Christine Windemuth-Kieselbach, Katarina Baumann, Florian Jacob, Julian Prechtl, Maike Wittlich, Martin J Herrmann, Silke Gross-Lesch, Klaus-Peter Lesch, Andreas Rei. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. European archives of psychiatry and clinical neuroscience. vol 260. issue 4. 2010-08-24. PMID:19894072. |
the present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-htt; the serotonin autoreceptor, htr1a; and the enzyme which synthesizes serotonin in the brain, tph2) with the burden of life events (#le) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aadhd). |
2010-08-24 |
2023-08-12 |
human |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Sandra Dehning, Norbert Müller, Judith Matz, Andreas Bender, Irina Kerle, Jens Benninghoff, Richard Musil, Ilja Spellmann, Brigitta Bondy, Hans-Juergen Möller, Michael Riedel, Peter Zil. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. Psychiatric genetics. vol 20. issue 1. 2010-02-24. PMID:20010450. |
as neuroimaging studies allude to dopaminergic and serotonergic dysfunction in gts and serotonin as an important factor for dopamine release, genotyping of common polymorphisms in the serotonergic receptor (htr1a: c-1019g; htr2a: t102c, his452tyr, a-1438g; htr2c: c-759t, g-697c) and transporter genes (slc6a4) was carried out in 87 patients with gts, compared with 311 matched controls. |
2010-02-24 |
2023-08-12 |
Not clear |
| A Heck, R Lieb, A Ellgas, H Pfister, S Lucae, D Roeske, B Pütz, B Müller-Myhsok, M Uhr, F Holsboer, M Isin. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19566713. |
to overcome this limitation, we performed an extended genetic association study analyzing 17 serotonergic (slc6a4, htr1a, htr1b, htr2a, htr2c, htr3a, htr6, maoa, tph1, tph2) and dopaminergic genes (slc6a3, drd2, drd3, drd4, comt, maoa, th, dbh), which have been previously reported to be implicated with personality traits. |
2009-09-11 |
2023-08-12 |
Not clear |
| Alja Videtic, Tomaz Zupanc, Peter Pregelj, Joze Balazic, Martina Tomori, Radovan Kome. Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims. European archives of psychiatry and clinical neuroscience. vol 259. issue 4. 2009-07-15. PMID:19224112. |
the suggestion that the g allele depresses htr1a autoreceptor expression, and therefore reduces serotonergic neurotransmission that might predispose to depression and suicide, made the promoter polymorphism -1019c>g a very promising candidate gene. |
2009-07-15 |
2023-08-12 |
Not clear |