| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Uri Bright, Irit Akira. Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768376. |
cbd also restored the ucms-induced decrease in htr1a, the gene that encodes for the serotonergic 5ht1a receptor; using a pharmacological approach, we found that the 5ht1a receptor antagonist way100135 blocked the antidepressant-like effect of cbd on immobility time. |
2023-02-11 |
2023-08-14 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Maria Jose Ortuno, Marc Schneeberger, Anoj Ilanges, François Marchildon, Kyle Pellegrino, Jeffrey M Friedman, Patricia Duc. Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal of clinical investigation. 2021-10-21. PMID:34673574. |
within hours, flx decreased the activity of a subset of brainstem serotonergic neurons by triggering autoinhibitory signaling through the htr1a receptor. |
2021-10-21 |
2023-08-13 |
mouse |
| Kadi Tulver, Madis Bachmann, Mariliis Vaht, Jaanus Harro, Talis Bachman. Effects of HTR1A rs6295 polymorphism on emotional attentional blink. Acta neurobiologiae experimentalis. vol 80. issue 4. 2021-09-30. PMID:33350992. |
we also disrupted right‑hemisphere dorsolateral prefrontal cortex by rtms (repetitive transcranial magnetic stimulation) to look for the possible role of dlpfc (dorsolateral prefrontal cortex; known to be involved in cognitive control of responses to affective stimuli) in serotonergic regulation mediated by the htr1a rs6295 polymorphism. |
2021-09-30 |
2023-08-13 |
human |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| Liang Xie, Jin Chen, Yong-Min Ding, Xian-Wei Gui, Lan-Xiang Wu, Sheng Tian, Wei W. MicroRNA-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor HTR1A. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30808545. |
microrna-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor htr1a. |
2019-12-16 |
2023-08-13 |
mouse |
| Liang Xie, Jin Chen, Yong-Min Ding, Xian-Wei Gui, Lan-Xiang Wu, Sheng Tian, Wei W. MicroRNA-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor HTR1A. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30808545. |
previous research on serotonergic (5-ht) neurons identified microrna-26a (mir-26a) targeting of the serotonin autoreceptor, 5-ht receptor 1a (htr1a). |
2019-12-16 |
2023-08-13 |
mouse |
| Liang Xie, Jin Chen, Yong-Min Ding, Xian-Wei Gui, Lan-Xiang Wu, Sheng Tian, Wei W. MicroRNA-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor HTR1A. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30808545. |
our findings suggest that mir-26a-2 functions as an endogenous antidepressant by targeting htr1a in serotonergic neurons. |
2019-12-16 |
2023-08-13 |
mouse |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
the aim of this study was to investigate the potential role of single nucleotide polymorphisms (snps) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1a (htr1a) and tryptophan hydroxylase 2 (tph2) in the pathogenesis of ptsd and comorbid psychopathology. |
2019-09-16 |
2023-08-13 |
Not clear |
| J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Er. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 3. 2019-01-29. PMID:29358097. |
while effects of 5-httlpr and of a serotonergic multi-marker score (5-httlpr, tph1(rs1800532), tph2(rs4570625), htr1a(rs6295) and htr2a(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, dlpfc, and acc. |
2019-01-29 |
2023-08-13 |
human |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
a secondary objective was to analyze 17 other variants in serotonergic system genes (htr1a, htr2a, htr1b, htr2c, tph1, tph2) potentially involved in the mechanism of action of venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Lindsay N Douglas, Austen B McGuire, Ann M Manzardo, Merlin G Butle. High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. Gene. vol 586. issue 1. 2017-01-03. PMID:27063557. |
the identified genes impacted a broad range of biological pathways and processes including cellular signaling pathways particularly camp and calcium (e.g., cacna1c, camk2a, camk2d, adcy1, adcy2); glutamatergic (e.g., grik1, grm3, grm7), dopaminergic (e.g., drd2, drd4, comt, maoa) and serotonergic (e.g., htr1a, htr2a, htr3b) neurotransmission; molecular transporters (e.g., slc39a3, slc6a3, slc8a1); and neuronal growth (e.g., bdnf, igfbp1, nrg1, nrg3). |
2017-01-03 |
2023-08-13 |
human |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Ah Young Choe, Borah Kim, Kang Soo Lee, Ji Eun Lee, Jun-Yeob Lee, Tai Kiu Choi, Sang-Hyuk Le. Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder. Neuropsychobiology. vol 67. issue 4. 2014-06-20. PMID:23635830. |
serotonergic genes (5-htt and htr1a) and separation life events: gene-by-environment interaction for panic disorder. |
2014-06-20 |
2023-08-12 |
Not clear |
| Ah Young Choe, Borah Kim, Kang Soo Lee, Ji Eun Lee, Jun-Yeob Lee, Tai Kiu Choi, Sang-Hyuk Le. Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder. Neuropsychobiology. vol 67. issue 4. 2014-06-20. PMID:23635830. |
the polymorphisms of serotonergic genes (5-httlpr and htr1a rs6295) and separation life events have been studied to find an association with panic disorder, respectively. |
2014-06-20 |
2023-08-12 |
Not clear |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Ul'yana A Boyarskikh, Natalya P Bondar, Maxim L Filipenko, Natalia N Kudryavtsev. Downregulation of serotonergic gene expression in the Raphe nuclei of the midbrain under chronic social defeat stress in male mice. Molecular neurobiology. vol 48. issue 1. 2014-02-12. PMID:23392607. |
the serotonergic genes were the tph2, sert, maoa, and htr1a. |
2014-02-12 |
2023-08-12 |
mouse |
| Bariş O Yildirim, Jan J L Derkse. Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy. Neuroscience and biobehavioral reviews. vol 37. issue 7. 2013-12-31. PMID:23644029. |
next, it is examined how various polymorphisms in serotonergic genes (e.g., tph, 5htt, htr1a, htr2a, htr2c, and htr3) might contribute either individually or interactively to the development of these disorders and through which specific biological and behavioral endophenotypes this effect could be mediated. |
2013-12-31 |
2023-08-12 |
Not clear |